{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:02:00Z","timestamp":1772820120929,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T00:00:00Z","timestamp":1231372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1007\/s00125-008-1251-1","type":"journal-article","created":{"date-parts":[[2009,1,7]],"date-time":"2009-01-07T14:42:32Z","timestamp":1231339352000},"page":"381-384","source":"Crossref","is-referenced-by-count":15,"title":["Not for the eyes only: PAX6 and glucose metabolism"],"prefix":"10.1007","volume":"52","author":[{"given":"M.","family":"Laakso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,1,8]]},"reference":[{"key":"1251_CR1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1203\/00006450-199710000-00001","volume":"42","author":"M Mark","year":"1997","unstructured":"Mark M, Rijli FM, Chambon P (1997) Homeobox genes in embryogenesis and pathogenesis. Ped Res 42:421\u2013429","journal-title":"Ped Res"},{"key":"1251_CR2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/ng1192-232","volume":"2","author":"T Glaser","year":"1992","unstructured":"Glaser T, Walton DS, Maas RL (1992) Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene. Nat Genet 2:232\u2013239","journal-title":"Nat Genet"},{"key":"1251_CR3","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1242\/dev.122.9.2639","volume":"122","author":"S Jun","year":"1996","unstructured":"Jun S, Desplan C (1996) Cooperative interactions between paired domain and homeodomain. Development 122:2639\u20132650","journal-title":"Development"},{"key":"1251_CR4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.brainresbull.2007.10.046","volume":"75","author":"Z Kozmik","year":"2008","unstructured":"Kozmik Z (2008) The role of Pax genes in eye evolution. Brain Res Bull 75:335\u2013339","journal-title":"Brain Res Bull"},{"key":"1251_CR5","first-page":"707","volume":"376","author":"E Marsich","year":"2003","unstructured":"Marsich E, Vetere A, Di Piazza M, Tell G, Paoletti S (2003) The PAX6 gene is activated by the basic helix\u2013loop\u2013helix transcription factor NeuroD\/BETA2. Biohem J 376:707\u2013715","journal-title":"Biohem J"},{"key":"1251_CR6","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1101\/gad.11.13.1662","volume":"11","author":"M Sander","year":"1997","unstructured":"Sander M, Neubuser A, Kalamaras J, Ee HC, Martin GR, German MS (1997) Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev 11:1662\u20131673","journal-title":"Genes Dev"},{"key":"1251_CR7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ng0894-463","volume":"7","author":"T Glaser","year":"1994","unstructured":"Glaser T, Jepeal L, Edwards JG, Young SR, Favor J, Maas RL (1994) PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects. Nat Genet 7:463\u2013471","journal-title":"Nat Genet"},{"key":"1251_CR8","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/387406a0","volume":"387","author":"L St-Onge","year":"1997","unstructured":"St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P (1997) Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature 387:406\u2013409","journal-title":"Nature"},{"key":"1251_CR9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/90042","volume":"28","author":"SM Sisodiya","year":"2001","unstructured":"Sisodiya SM, Free SL, Wlliamson KA et al (2001) PAX6 haploinsufficiency causes cerebral malformation and olfactory dysfunction in humans. Nat Genet 28:214\u2013216","journal-title":"Nat Genet"},{"key":"1251_CR10","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2337\/diabetes.51.1.224","volume":"51","author":"T Yasuda","year":"2002","unstructured":"Yasuda T, Kajimoto Y, Fujitani Y et al (2002) PAX6 mutation as a genetic factor common to aniridia and glucose intolerance. Diabetes 51:224\u2013230","journal-title":"Diabetes"},{"key":"1251_CR11","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1464-5491.2005.01469.x","volume":"22","author":"M Nishi","year":"2005","unstructured":"Nishi M, Sasahara M, Shono T et al (2005) A case of novel de novo paired box gene 6 (PAX6) mutation with early-onset diabetes mellitus and aniridia. Diabet Med 22:641\u2013644","journal-title":"Diabet Med"},{"key":"1251_CR12","doi-asserted-by":"crossref","unstructured":"Wen JH, Chen YY, Song SJ et al (2008) Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1\/3 (PC1\/3). Diabetologia. doi: 10.1007\/s00125-008-1210-x","DOI":"10.1007\/s00125-008-1210-x"},{"key":"1251_CR13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ydbio.2004.01.040","volume":"269","author":"R Ashery-Padan","year":"2004","unstructured":"Ashery-Padan R, Zhou X, Marquardt T et al (2004) Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes. Dev Biol 269:479\u2013488","journal-title":"Dev Biol"},{"key":"1251_CR14","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrg2178","volume":"8","author":"TM Frayling","year":"2007","unstructured":"Frayling TM (2007) Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 8:657\u2013662","journal-title":"Nat Rev Genet"},{"key":"1251_CR15","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s00125-008-1006-z","volume":"51","author":"BM Lyttle","year":"2008","unstructured":"Lyttle BM, Li J, Krishnamurthy M, Fellows F et al (2008) Transcription factor expression in the developing human fetal endocrine pancreas. Diabetologia 51:1169\u20131180","journal-title":"Diabetologia"},{"key":"1251_CR16","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ydbio.2003.10.018","volume":"266","author":"J Wang","year":"2004","unstructured":"Wang J, Elghazi L, Parker SE et al (2004) The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol 266:178\u2013189","journal-title":"Dev Biol"},{"key":"1251_CR17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1016-8478(23)13114-1","volume":"18","author":"B Sosa-Pineda","year":"2004","unstructured":"Sosa-Pineda B (2004) The gene Pax4 is an essential regulator of pancreatic beta-cell development. Mol Cells 18:289\u2013294","journal-title":"Mol Cells"},{"key":"1251_CR18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bbrc.2006.11.105","volume":"353","author":"A Hamasaki","year":"2007","unstructured":"Hamasaki A, Yamada Y, Kurose T et al (2007) Adult pancreatic islets require different pax6 gene dosage. Biochem Biophys Res Commun 353:40\u201346","journal-title":"Biochem Biophys Res Commun"},{"key":"1251_CR19","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1210\/en.2004-0051","volume":"145","author":"SE Schonhoff","year":"2004","unstructured":"Schonhoff SE, Giel-Moloney M, Leiter AB (2004) Minireview: development and differentiation of gut endocrine cells. Endocrinology 145:2639\u20132644","journal-title":"Endocrinology"},{"key":"1251_CR20","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1124\/mol.107.035568","volume":"73","author":"R Kr\u00e4tzner","year":"2008","unstructured":"Kr\u00e4tzner R, Fr\u00f6lich F, Lepler K et al (2008) A peroxisome proliferator-activated receptor gamma-retinoid X receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagons gene transcription. Mol Pharmacol 73:509\u2013517","journal-title":"Mol Pharmacol"},{"key":"1251_CR21","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1210\/mend.13.9.0340","volume":"13","author":"ME Hill","year":"1999","unstructured":"Hill ME, Asa SL, Drucker DJ (1999) Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription. Mol Endocrinol 13:1474\u20131486","journal-title":"Mol Endocrinol"},{"key":"1251_CR22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0925-4773(98)00182-8","volume":"79","author":"LI Larsson","year":"2008","unstructured":"Larsson LI, St-Onge L, Hougaard DM, Sosa-Pineda B, Gruss P (2008) Pax4 and 6 regulate gastrointestinal endocrine cell development. Mech Dev 79:153\u2013159","journal-title":"Mech Dev"},{"key":"1251_CR23","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1210\/en.2002-0049","volume":"144","author":"X Cao","year":"2003","unstructured":"Cao X, Flock G, Choi C, Irwin DM, Drucker DJ (2003) Aberrant regulation of human intestinal proglucagon gene expression in the NCI-H716 cell line. Endocrinology 144:2025\u20132033","journal-title":"Endocrinology"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-008-1251-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-008-1251-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-008-1251-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T20:23:53Z","timestamp":1709929433000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-008-1251-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,8]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["1251"],"URL":"https:\/\/doi.org\/10.1007\/s00125-008-1251-1","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,8]]}}}