{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:36:18Z","timestamp":1792571778878,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T00:00:00Z","timestamp":1239148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1007\/s00125-009-1329-4","type":"journal-article","created":{"date-parts":[[2009,4,7]],"date-time":"2009-04-07T09:44:52Z","timestamp":1239097492000},"page":"1102-1111","source":"Crossref","is-referenced-by-count":59,"title":["Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress"],"prefix":"10.1007","volume":"52","author":[{"given":"R. L.","family":"Hull","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zraika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Udayasankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Aston-Mourney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. E.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,4,8]]},"reference":[{"key":"1329_CR1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1517\/03009734000000014","volume":"77","author":"P Westermark","year":"1972","unstructured":"Westermark P (1972) Quantitative studies on amyloid in the islets of Langerhans. Ups J Med Sci 77:91\u201394","journal-title":"Ups J Med Sci"},{"key":"1329_CR2","first-page":"151","volume":"9","author":"A Clark","year":"1988","unstructured":"Clark A, Wells CA, Buley ID et al (1988) Islet amyloid, increased A-cells, reduced B cells and exocrine fibrosis - quantitative changes in the pancreas in type-2 diabetes. Diab Res Clin Exptl 9:151\u2013159","journal-title":"Diab Res Clin Exptl"},{"key":"1329_CR3","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/368756a0","volume":"368","author":"A Lorenzo","year":"1994","unstructured":"Lorenzo A, Razzaboni B, Weir GC, Yankner BA (1994) Pancreatic islet cell toxicity of amylin associated with type 2 diabetes mellitus. Nature 368:756\u2013760","journal-title":"Nature"},{"key":"1329_CR4","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1074\/jbc.271.4.1988","volume":"271","author":"TA Mirzabekov","year":"1996","unstructured":"Mirzabekov TA, Lin MC, Kagan BL (1996) Pore formation by the cytotoxic islet amyloid peptide amylin. J Biol Chem 271:1988\u20131992","journal-title":"J Biol Chem"},{"key":"1329_CR5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2337\/diabetes.48.3.491","volume":"48","author":"J Janson","year":"1999","unstructured":"Janson J, Ashley RH, Harrison D, McIntyre S, Butler PC (1999) The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes 48:491\u2013498","journal-title":"Diabetes"},{"key":"1329_CR6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1042\/bj3430053","volume":"343","author":"JZ Bai","year":"1999","unstructured":"Bai JZ, Saafi EL, Zhang S, Cooper GJ (1999) Role of Ca2+ in apoptosis evoked by human amylin in pancreatic islet beta-cells. Biochem J 343:53\u201361","journal-title":"Biochem J"},{"key":"1329_CR7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/cbir.2000.0643","volume":"25","author":"EL Saafi","year":"2001","unstructured":"Saafi EL, Konarkowska B, Zhang S, Kistler J, Cooper GJ (2001) Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet beta-cells. Cell Biol Int 25:339\u2013350","journal-title":"Cell Biol Int"},{"key":"1329_CR8","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1073\/pnas.87.13.5036","volume":"87","author":"P Westermark","year":"1990","unstructured":"Westermark P, Engstr\u00f6m U, Johnson KH, Westermark GT, Betsholtz C (1990) Islet amyloid polypeptide\u2014pinpointing amino acid residues linked to amyloid fibril formation. Proc Natl Acad Sci USA 87:5036\u20135040","journal-title":"Proc Natl Acad Sci USA"},{"key":"1329_CR9","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.2337\/diabetes.52.9.2304","volume":"52","author":"AE Butler","year":"2003","unstructured":"Butler AE, Janson J, Soeller WC, Butler PC (2003) Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes 52:2304\u20132314","journal-title":"Diabetes"},{"key":"1329_CR10","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1210\/jc.2004-0405","volume":"89","author":"RL Hull","year":"2004","unstructured":"Hull RL, Westermark GT, Westermark P, Kahn SE (2004) Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes. J Clin Endocrinol Metab 89:3629\u20133643","journal-title":"J Clin Endocrinol Metab"},{"key":"1329_CR11","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bbrc.2006.12.187","volume":"354","author":"S Zraika","year":"2007","unstructured":"Zraika S, Hull RL, Udayasankar J et al (2007) Glucose- and time-dependence of islet amyloid formation in vitro. Biochem Biophys Res Commun 354:234\u2013239","journal-title":"Biochem Biophys Res Commun"},{"key":"1329_CR12","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s00125-008-1255-x","volume":"52","author":"S Zraika","year":"2009","unstructured":"Zraika S, Hull RL, Udayasankar J et al (2009) Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis. Diabetologia 52:626\u2013635","journal-title":"Diabetologia"},{"key":"1329_CR13","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0014-4827(89)90407-2","volume":"183","author":"C Betsholtz","year":"1989","unstructured":"Betsholtz C, Svensson V, Rorsman F et al (1989) Islet amyloid polypeptide (IAPP): cDNA cloning and identification of an amyloidogenic region associated with the species-specific occurrence of age-related diabetes-mellitus. Exp Cell Res 183:484\u2013493","journal-title":"Exp Cell Res"},{"key":"1329_CR14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00018-003-3264-8","volume":"61","author":"S Ohnishi","year":"2004","unstructured":"Ohnishi S, Takano K (2004) Amyloid fibrils from the viewpoint of protein folding. Cell Mol Life Sci 61:511\u2013524","journal-title":"Cell Mol Life Sci"},{"key":"1329_CR15","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI0216781","volume":"110","author":"A Horwich","year":"2002","unstructured":"Horwich A (2002) Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions. J Clin Invest 110:1221\u20131232","journal-title":"J Clin Invest"},{"key":"1329_CR16","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0092-8674(00)80855-7","volume":"101","author":"K Mori","year":"2000","unstructured":"Mori K (2000) Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell 101:451\u2013454","journal-title":"Cell"},{"key":"1329_CR17","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI0216886","volume":"110","author":"RJ Kaufman","year":"2002","unstructured":"Kaufman RJ (2002) Orchestrating the unfolded protein response in health and disease. J Clin Invest 110:1389\u20131398","journal-title":"J Clin Invest"},{"key":"1329_CR18","doi-asserted-by":"crossref","first-page":"10845","DOI":"10.1073\/pnas.191207498","volume":"98","author":"S Oyadomari","year":"2001","unstructured":"Oyadomari S, Takeda K, Takiguchi M et al (2001) Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci USA 98:10845\u201310850","journal-title":"Proc Natl Acad Sci USA"},{"key":"1329_CR19","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1210\/en.2004-0478","volume":"145","author":"I Kharroubi","year":"2004","unstructured":"Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL (2004) Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology 145:5087\u20135096","journal-title":"Endocrinology"},{"key":"1329_CR20","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s00125-006-0590-z","volume":"50","author":"DR Laybutt","year":"2007","unstructured":"Laybutt DR, Preston AM, Akerfeldt MC et al (2007) Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 50:752\u2013763","journal-title":"Diabetologia"},{"key":"1329_CR21","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","volume":"11","author":"S Oyadomari","year":"2004","unstructured":"Oyadomari S, Mori M (2004) Roles of CHOP\/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11:381\u2013389","journal-title":"Cell Death Differ"},{"key":"1329_CR22","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.2337\/db07-0197","volume":"56","author":"CJ Huang","year":"2007","unstructured":"Huang CJ, Lin CY, Haataja L et al (2007) High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes. Diabetes 56:2016\u20132027","journal-title":"Diabetes"},{"key":"1329_CR23","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1007\/s00125-007-0816-8","volume":"50","author":"P Marchetti","year":"2007","unstructured":"Marchetti P, Bugliani M, Lupi R et al (2007) The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia 50:2486\u20132494","journal-title":"Diabetologia"},{"key":"1329_CR24","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/47513","volume":"403","author":"T Nakagawa","year":"2000","unstructured":"Nakagawa T, Zhu H, Morishima N et al (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403:98\u2013103","journal-title":"Nature"},{"key":"1329_CR25","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1093\/emboj\/cdg537","volume":"22","author":"C Hetz","year":"2003","unstructured":"Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C (2003) Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. Embo J 22:5435\u20135445","journal-title":"Embo J"},{"key":"1329_CR26","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.2337\/db07-0178","volume":"56","author":"S Casas","year":"2007","unstructured":"Casas S, Gomis R, Gribble FM, Altirriba J, Knuutila S, Novials A (2007) Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis. Diabetes 56:2284\u20132294","journal-title":"Diabetes"},{"key":"1329_CR27","doi-asserted-by":"crossref","first-page":"E1656","DOI":"10.1152\/ajpendo.00318.2007","volume":"293","author":"CJ Huang","year":"2007","unstructured":"Huang CJ, Haataja L, Gurlo T et al (2007) Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. Am J Physiol Endocrinol Metab 293:E1656\u2013E1662","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1329_CR28","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.2337\/diabetes.54.7.2235","volume":"54","author":"RL Hull","year":"2005","unstructured":"Hull RL, Shen Z, Watts MR et al (2005) Long term treatment with rosiglitazone and metformin reduce the extent of, but do not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide. Diabetes 54:2235\u20132244","journal-title":"Diabetes"},{"key":"1329_CR29","doi-asserted-by":"crossref","first-page":"304","DOI":"10.2337\/db06-0430","volume":"56","author":"S Zraika","year":"2007","unstructured":"Zraika S, Hull RL, Udayasankar J et al (2007) Identification of the amyloid-degrading enzyme neprilysin in mouse islets and potential role in islet amyloidogenesis. Diabetes 56:304\u2013310","journal-title":"Diabetes"},{"key":"1329_CR30","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2337\/diabetes.52.2.372","volume":"52","author":"RL Hull","year":"2003","unstructured":"Hull RL, Andrikopoulos S, Verchere CB et al (2003) Increased dietary fat promotes islet amyloid formation and \u00df-cell secretory dysfunction in a transgenic mouse model of islet amyloid. Diabetes 52:372\u2013379","journal-title":"Diabetes"},{"key":"1329_CR31","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.2337\/db07-1802","volume":"57","author":"MC \u00c5kerfeldt","year":"2008","unstructured":"\u00c5kerfeldt MC, Howes J, Chan JY et al (2008) Cytokine-induced \u03b2-cell death is independent of endoplasmic reticulum stress signaling. Diabetes 57:3034\u20133044","journal-title":"Diabetes"},{"key":"1329_CR32","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1242\/jcs.026062","volume":"121","author":"DA Cunha","year":"2008","unstructured":"Cunha DA, Hekerman P, Ladriere L et al (2008) Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci 121:2308\u20132318","journal-title":"J Cell Sci"},{"key":"1329_CR33","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1007\/s00125-007-0674-4","volume":"50","author":"H Elouil","year":"2007","unstructured":"Elouil H, Bensellam M, Guiot Y et al (2007) Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets. Diabetologia 50:1442\u20131452","journal-title":"Diabetologia"},{"key":"1329_CR34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cmet.2006.07.007","volume":"4","author":"KL Lipson","year":"2006","unstructured":"Lipson KL, Fonseca SG, Ishigaki S et al (2006) Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab 4:245\u2013254","journal-title":"Cell Metab"},{"key":"1329_CR35","doi-asserted-by":"crossref","first-page":"738","DOI":"10.2337\/diab.42.5.738","volume":"42","author":"DL Eizirik","year":"1993","unstructured":"Eizirik DL, Bjorklund A, Cagliero E (1993) Genotoxic agents increase expression of growth arrest and DNA damage\u2013inducible genes gadd 153 and gadd 45 in rat pancreatic islets. Diabetes 42:738\u2013745","journal-title":"Diabetes"},{"key":"1329_CR36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12013-008-9019-2","volume":"51","author":"L Haataja","year":"2008","unstructured":"Haataja L, Gurlo T, Huang CJ, Butler PC (2008) Many commercially available antibodies for detection of CHOP expression as a marker of endoplasmic reticulum stress fail specificity evaluation. Cell Biochem Biophys 51:105\u2013107","journal-title":"Cell Biochem Biophys"},{"key":"1329_CR37","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2337\/diacare.25.2.292","volume":"25","author":"NG Knowles","year":"2002","unstructured":"Knowles NG, Landchild MA, Fujimoto WY, Kahn SE (2002) Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes. Diabetes Care 25:292\u2013297","journal-title":"Diabetes Care"},{"key":"1329_CR38","doi-asserted-by":"crossref","first-page":"752","DOI":"10.2337\/diab.39.6.752","volume":"39","author":"PC Butler","year":"1990","unstructured":"Butler PC, Chou J, Carter WB et al (1990) Effects of meal ingestion on plasma amylin concentration in NIDDM and non-diabetic humans. Diabetes 39:752\u2013756","journal-title":"Diabetes"},{"key":"1329_CR39","doi-asserted-by":"crossref","first-page":"640","DOI":"10.2337\/diabetes.47.4.640","volume":"47","author":"SE Kahn","year":"1998","unstructured":"Kahn SE, Verchere CB, Andrikopoulos S et al (1998) Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans. Diabetes 47:640\u2013645","journal-title":"Diabetes"},{"key":"1329_CR40","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2337\/diab.46.5.887","volume":"46","author":"M Yoshioka","year":"1997","unstructured":"Yoshioka M, Kayo T, Ikeda T, Koizumi A (1997) A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL\/6 (Akita) mutant mice. Diabetes 46:887\u2013894","journal-title":"Diabetes"},{"key":"1329_CR41","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.2337\/db06-0658","volume":"56","author":"N Herbach","year":"2007","unstructured":"Herbach N, Rathkolb B, Kemter E et al (2007) Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice. Diabetes 56:1268\u20131276","journal-title":"Diabetes"},{"key":"1329_CR42","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1086\/302429","volume":"64","author":"JR Riordan","year":"1999","unstructured":"Riordan JR (1999) Cystic fibrosis as a disease of misprocessing of the cystic fibrosis transmembrane conductance regulator glycoprotein. Am J Hum Genet 64:1499\u20131504","journal-title":"Am J Hum Genet"},{"key":"1329_CR43","first-page":"1504","volume":"24","author":"JH Teckman","year":"1996","unstructured":"Teckman JH, Qu D, Perlmutter DH (1996) Molecular pathogenesis of liver disease in alpha1-antitrypsin deficiency. Hepatology 24:1504\u20131516","journal-title":"Hepatology"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-009-1329-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-009-1329-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-009-1329-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T11:47:10Z","timestamp":1558612030000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-009-1329-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,8]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["1329"],"URL":"https:\/\/doi.org\/10.1007\/s00125-009-1329-4","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,8]]}}}