{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:14:55Z","timestamp":1791087295854,"version":"4.1.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2009,4,18]],"date-time":"2009-04-18T00:00:00Z","timestamp":1240012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1007\/s00125-009-1359-y","type":"journal-article","created":{"date-parts":[[2009,4,17]],"date-time":"2009-04-17T08:51:17Z","timestamp":1239958277000},"page":"1240-1249","source":"Crossref","is-referenced-by-count":131,"title":["Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene"],"prefix":"10.1007","volume":"52","author":[{"given":"H.","family":"Mulder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. L. F.","family":"Nagorny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Lyssenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Groop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,4,18]]},"reference":[{"key":"1359_CR1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mce.2008.10.002","volume":"297","author":"M Ridderstr\u00e5le","year":"2009","unstructured":"Ridderstr\u00e5le M, Groop L (2009) Genetic dissection of type 2 diabetes. Mol Cell Endocrinol 297:10\u201317","journal-title":"Mol Cell Endocrinol"},{"key":"1359_CR2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cmet.2008.08.006","volume":"8","author":"A Doria","year":"2008","unstructured":"Doria A, Patti ME, Kahn CR (2008) The emerging genetic architecture of type 2 diabetes. Cell Metab 8:186\u2013200","journal-title":"Cell Metab"},{"key":"1359_CR3","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2008.08.022","volume":"134","author":"CB Green","year":"2008","unstructured":"Green CB, Takahashi JS, Bass J (2008) The meter of metabolism. Cell 134:728\u2013742","journal-title":"Cell"},{"key":"1359_CR4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.biochem.71.090501.142857","volume":"71","author":"J Rutter","year":"2002","unstructured":"Rutter J, Reick M, McKnight SL (2002) Metabolism and the control of circadian rhythms. Annu Rev Biochem 71:307\u2013331","journal-title":"Annu Rev Biochem"},{"key":"1359_CR5","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s001250051034","volume":"41","author":"E Peschke","year":"1998","unstructured":"Peschke E, Peschke D (1998) Evidence for a circadian rhythm of insulin release from perifused rat pancreatic islets. Diabetologia 41:1085\u20131092","journal-title":"Diabetologia"},{"key":"1359_CR6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1136\/oem.58.11.747","volume":"58","author":"B Karlsson","year":"2001","unstructured":"Karlsson B, Knutsson A, Lindahl B (2001) Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27,485 people. Occup Environ Med 58:747\u2013752","journal-title":"Occup Environ Med"},{"key":"1359_CR7","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1001\/archinte.166.16.1768","volume":"166","author":"KL Knutson","year":"2006","unstructured":"Knutson KL, Ryden AM, Mander BA, van Cauter E (2006) Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus. Arch Intern Med 166:1768\u20131774","journal-title":"Arch Intern Med"},{"key":"1359_CR8","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1073\/pnas.0808180106","volume":"106","author":"FA Scheer","year":"2009","unstructured":"Scheer FA, Hilton MF, Mantzoros CS, Shea SA (2009) Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A 106:4453\u20134458","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1359_CR9","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.131.3409.1312","volume":"131","author":"J Axelrod","year":"1960","unstructured":"Axelrod J, Weissbach H (1960) Enzymatic O-methylation of N-acetylserotonin to melatonin. Science 131:1312","journal-title":"Science"},{"key":"1359_CR10","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1210\/endo-99-2-641","volume":"99","author":"Y Ozaki","year":"1976","unstructured":"Ozaki Y, Lynch HJ (1976) Presence of melatonin in plasma and urine or pinealectomized rats. Endocrinology 99:641\u2013644","journal-title":"Endocrinology"},{"key":"1359_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1003431122334","volume":"31","author":"IM Kvetnoy","year":"1999","unstructured":"Kvetnoy IM (1999) Extrapineal melatonin: location and role within diffuse neuroendocrine system. Histochem J 31:1\u201312","journal-title":"Histochem J"},{"key":"1359_CR12","first-page":"311","volume":"61","author":"H Tricoire","year":"2003","unstructured":"Tricoire H, Moller M, Chemineau P, Malpaux B (2003) Origin of cerebrospinal fluid melatonin and possible function in the integration of photoperiod. Reprod Suppl 61:311\u2013321","journal-title":"Reprod Suppl"},{"key":"1359_CR13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/oxfordjournals.jbchem.a002836","volume":"129","author":"T Hirota","year":"2001","unstructured":"Hirota T, Kagiwada S, Kasahara T, Okano T, Murata M, Fukada Y (2001) Effect of brefeldin A on melatonin secretion of chick pineal cells. J Biochem 129:51\u201359","journal-title":"J Biochem"},{"key":"1359_CR14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1124\/pr.55.2.2","volume":"55","author":"V Simonneaux","year":"2003","unstructured":"Simonneaux V, Ribelayga C (2003) Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 55:325\u2013395","journal-title":"Pharmacol Rev"},{"key":"1359_CR15","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.279.5355.1358","volume":"279","author":"JA Gastel","year":"1998","unstructured":"Gastel JA, Roseboom PH, Rinaldi PA, Weller JL, Klein DC (1998) Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation. Science 279:1358\u20131360","journal-title":"Science"},{"key":"1359_CR16","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.preteyeres.2005.01.003","volume":"24","author":"PM Iuvone","year":"2005","unstructured":"Iuvone PM, Tosini G, Pozdeyev N, Haque R, Klein DC, Chaurasia SS (2005) Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Prog Retin Eye Res 24:433\u2013456","journal-title":"Prog Retin Eye Res"},{"key":"1359_CR17","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1177\/074873049701200609","volume":"12","author":"H Illnerova","year":"1997","unstructured":"Illnerova H, Sumova A (1997) Photic entrainment of the mammalian rhythm in melatonin production. J Biol Rhythms 12:547\u2013555","journal-title":"J Biol Rhythms"},{"key":"1359_CR18","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1177\/074873001129002060","volume":"16","author":"TA Wehr","year":"2001","unstructured":"Wehr TA (2001) Photoperiodism in humans and other primates: evidence and implications. J Biol Rhythms 16:348\u2013364","journal-title":"J Biol Rhythms"},{"key":"1359_CR19","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1177\/0748730402238237","volume":"17","author":"EB Klerman","year":"2002","unstructured":"Klerman EB, Shanahan TL, Brotman DJ et al (2002) Photic resetting of the human circadian pacemaker in the absence of conscious vision. J Biol Rhythms 17:548\u2013555","journal-title":"J Biol Rhythms"},{"key":"1359_CR20","volume-title":"Melatonin and the mammalian pineal gland","author":"J Arendt","year":"1994","unstructured":"Arendt J (1994) Melatonin and the mammalian pineal gland. Chapman and Hall, London"},{"key":"1359_CR21","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0039-128X(99)00052-5","volume":"64","author":"BD Goldman","year":"1999","unstructured":"Goldman BD (1999) The circadian timing system and reproduction in mammals. Steroids 64:679\u2013685","journal-title":"Steroids"},{"key":"1359_CR22","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1177\/0748730406293854","volume":"21","author":"A Kalsbeek","year":"2006","unstructured":"Kalsbeek A, Palm IF, La Fleur SE et al (2006) SCN outputs and the hypothalamic balance of life. J Biol Rhythms 21:458\u2013469","journal-title":"J Biol Rhythms"},{"key":"1359_CR23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/0-306-46814-X_32","volume":"460","author":"DN Krause","year":"1999","unstructured":"Krause DN, Geary GG, Doolen S, Duckles SP (1999) Melatonin and cardiovascular function. Adv Exp Med Biol 460:299\u2013310","journal-title":"Adv Exp Med Biol"},{"key":"1359_CR24","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1749-6632.2000.tb05402.x","volume":"917","author":"RJ Reiter","year":"2000","unstructured":"Reiter RJ, Calvo JR, Karbownik M, Qi W, Tan DX (2000) Melatonin and its relation to the immune system and inflammation. Ann N Y Acad Sci 917:376\u2013386","journal-title":"Ann N Y Acad Sci"},{"key":"1359_CR25","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-079X.2007.00519.x","volume":"44","author":"E Peschke","year":"2008","unstructured":"Peschke E (2008) Melatonin, endocrine pancreas and diabetes. J Pineal Res 44:26\u201340","journal-title":"J Pineal Res"},{"key":"1359_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/jme.0.0180001","volume":"18","author":"I Kvetnoy","year":"1997","unstructured":"Kvetnoy I, Sandvik AK, Waldum HL (1997) The diffuse neuroendocrine system and extrapineal melatonin. J Mol Endocrinol 18:1\u20133","journal-title":"J Mol Endocrinol"},{"key":"1359_CR27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000014635","volume":"9","author":"DX Tan","year":"2000","unstructured":"Tan DX, Manchester LC, Reiter RJ, Qi WB, Karbownik M, Calvo JR (2000) Significance of melatonin in antioxidative defense system: reactions and products. Biol Signals Recept 9:137\u2013159","journal-title":"Biol Signals Recept"},{"key":"1359_CR28","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1177\/074873049701200613","volume":"12","author":"JR Redman","year":"1997","unstructured":"Redman JR (1997) Circadian entrainment and phase shifting in mammals with melatonin. J Biol Rhythms 12:581\u2013587","journal-title":"J Biol Rhythms"},{"key":"1359_CR29","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1177\/074873049701200620","volume":"12","author":"IV Zhdanova","year":"1997","unstructured":"Zhdanova IV, Wurtman RJ (1997) Efficacy of melatonin as a sleep-promoting agent. J Biol Rhythms 12:644\u2013650","journal-title":"J Biol Rhythms"},{"key":"1359_CR30","first-page":"550","volume":"332","author":"J Arendt","year":"2006","unstructured":"Arendt J (2006) Does melatonin improve sleep? Efficacy of melatonin. BMJ 332:550","journal-title":"BMJ"},{"key":"1359_CR31","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1177\/074873049701200616","volume":"12","author":"J Arendt","year":"1997","unstructured":"Arendt J, Skene DJ, Middleton B, Lockley SW, Deacon S (1997) Efficacy of melatonin treatment in jet lag, shift work, and blindness. J Biol Rhythms 12:604\u2013617","journal-title":"J Biol Rhythms"},{"key":"1359_CR32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00441-002-0581-4","volume":"309","author":"C Gall von","year":"2002","unstructured":"von Gall C, Stehle JH, Weaver DR (2002) Mammalian melatonin receptors: molecular biology and signal transduction. Cell Tissue Res 309:151\u2013162","journal-title":"Cell Tissue Res"},{"key":"1359_CR33","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1210\/endo-85-4-674","volume":"85","author":"K Abe","year":"1969","unstructured":"Abe K, Robison GA, Liddle GW, Butcher RW, Nicholson WE, Baird CE (1969) Role of cyclic AMP in mediating the effects of MSH, norepinephrine, and melatonin on frog skin color. Endocrinology 85:674\u2013682","journal-title":"Endocrinology"},{"key":"1359_CR34","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1152\/physrev.1998.78.3.687","volume":"78","author":"J Vanecek","year":"1998","unstructured":"Vanecek J (1998) Cellular mechanisms of melatonin action. Physiol Rev 78:687\u2013721","journal-title":"Physiol Rev"},{"key":"1359_CR35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00692359","volume":"157","author":"BH White","year":"1987","unstructured":"White BH, Sekura RD, Rollag MD (1987) Pertussis toxin blocks melatonin-induced pigment aggregation in Xenopus dermal melanophores. J Comp Physiol [B] 157:153\u2013159","journal-title":"J Comp Physiol [B]"},{"key":"1359_CR36","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0197-0186(95)00089-5","volume":"28","author":"PJ Morgan","year":"1996","unstructured":"Morgan PJ, Williams LM, Barrett P et al (1996) Differential regulation of melatonin receptors in sheep, chicken and lizard brains by cholera and pertussis toxins and guanine nucleotides. Neurochem Int 28:259\u2013269","journal-title":"Neurochem Int"},{"key":"1359_CR37","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1210\/endo.138.1.4824","volume":"138","author":"C Godson","year":"1997","unstructured":"Godson C, Reppert SM (1997) The Mel1a melatonin receptor is coupled to parallel signal transduction pathways. Endocrinology 138:397\u2013404","journal-title":"Endocrinology"},{"key":"1359_CR38","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0006-2952(99)00134-3","volume":"58","author":"L Petit","year":"1999","unstructured":"Petit L, Lacroix I, de Coppet P, Strosberg AD, Jockers R (1999) Differential signaling of human Mel1a and Mel1b melatonin receptors through the cyclic guanosine 3\u2032-5\u2032-monophosphate pathway. Biochem Pharmacol 58:633\u2013639","journal-title":"Biochem Pharmacol"},{"key":"1359_CR39","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1210\/mend.13.12.0390","volume":"13","author":"L Brydon","year":"1999","unstructured":"Brydon L, Roka F, Petit L et al (1999) Dual signaling of human Mel1a melatonin receptors via Gi2, Gi3, and Gq\/11 proteins. Mol Endocrinol 13:2025\u20132038","journal-title":"Mol Endocrinol"},{"key":"1359_CR40","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1210\/endo.137.8.8754776","volume":"137","author":"AL Roca","year":"1996","unstructured":"Roca AL, Godson C, Weaver DR, Reppert SM (1996) Structure, characterization, and expression of the gene encoding the mouse Mel1a melatonin receptor. Endocrinology 137:3469\u20133477","journal-title":"Endocrinology"},{"key":"1359_CR41","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1172\/JCI115396","volume":"88","author":"E Cauter van","year":"1991","unstructured":"van Cauter E, Blackman JD, Roland D, Spire JP, Refetoff S, Polonsky KS (1991) Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep. J Clin Invest 88:934\u2013942","journal-title":"J Clin Invest"},{"key":"1359_CR42","first-page":"E246","volume":"271","author":"G Boden","year":"1996","unstructured":"Boden G, Ruiz J, Urbain JL, Chen X (1996) Evidence for a circadian rhythm of insulin secretion. Am J Physiol 271:E246\u2013E252","journal-title":"Am J Physiol"},{"key":"1359_CR43","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1365-2265.1986.tb01639.x","volume":"24","author":"IA O'Brien","year":"1986","unstructured":"O'Brien IA, Lewin IG, O'Hare JP, Arendt J, Corrall RJ (1986) Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy. Clin Endocrinol (Oxf) 24:359\u2013364","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1359_CR44","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1600-079X.2005.00287.x","volume":"40","author":"E Peschke","year":"2006","unstructured":"Peschke E, Frese T, Chankiewitz E et al (2006) Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status. J Pineal Res 40:135\u2013143","journal-title":"J Pineal Res"},{"key":"1359_CR45","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1600-079X.2008.00612.x","volume":"45","author":"E Peschke","year":"2008","unstructured":"Peschke E, Wolgast S, Bazwinsky I, Ponicke K, Muhlbauer E (2008) Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes. J Pineal Res 45:439\u2013448","journal-title":"J Pineal Res"},{"key":"1359_CR46","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-079X.1985.tb00629.x","volume":"2","author":"SF Pang","year":"1985","unstructured":"Pang SF, Tang F, Tang PL (1985) Alloxan-induced diabetes and the pineal gland: differential effects on the levels of pineal N-acetylserotonin, pineal melatonin, and serum melatonin. J Pineal Res 2:79\u201385","journal-title":"J Pineal Res"},{"key":"1359_CR47","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1055\/s-2007-1012279","volume":"18","author":"B Diaz","year":"1986","unstructured":"Diaz B, Blazquez E (1986) Effect of pinealectomy on plasma glucose, insulin and glucagon levels in the rat. Horm Metab Res 18:225\u2013229","journal-title":"Horm Metab Res"},{"key":"1359_CR48","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1046\/j.1365-2826.2001.00717.x","volume":"13","author":"SE Fleur la","year":"2001","unstructured":"la Fleur SE, Kalsbeek A, Wortel J, van der Vliet J, Buijs RM (2001) Role for the pineal and melatonin in glucose homeostasis: pinealectomy increases night-time glucose concentrations. J Neuroendocrinol 13:1025\u20131032","journal-title":"J Neuroendocrinol"},{"key":"1359_CR49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000178615","volume":"5","author":"CJ Bailey","year":"1974","unstructured":"Bailey CJ, Atkins TW, Matty AJ (1974) Melatonin inhibition of insulin secretion in the rat and mouse. Horm Res 5:21\u201328","journal-title":"Horm Res"},{"key":"1359_CR50","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1034\/j.1600-079x.2002.10797.x","volume":"32","author":"S Nishida","year":"2002","unstructured":"Nishida S, Segawa T, Murai I, Nakagawa S (2002) Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of \u0394-5 desaturase activity. J Pineal Res 32:26\u201333","journal-title":"J Pineal Res"},{"key":"1359_CR51","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1034\/j.1600-079X.2001.280305.x","volume":"28","author":"E Peschke","year":"2000","unstructured":"Peschke E, Fauteck JD, Musshoff U, Schmidt F, Beckmann A, Peschke D (2000) Evidence for a melatonin receptor within pancreatic islets of neonate rats: functional, autoradiographic, and molecular investigations. J Pineal Res 28:156\u2013164","journal-title":"J Pineal Res"},{"key":"1359_CR52","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0303-7207(02)00064-3","volume":"191","author":"DM Kemp","year":"2002","unstructured":"Kemp DM, Ubeda M, Habener JF (2002) Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling. Mol Cell Endocrinol 191:157\u2013166","journal-title":"Mol Cell Endocrinol"},{"key":"1359_CR53","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1034\/j.1600-079X.2002.02919.x","volume":"33","author":"E Peschke","year":"2002","unstructured":"Peschke E, Muhlbauer E, Musshoff U, Csernus VJ, Chankiewitz E, Peschke D (2002) Receptor (MT1) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1. J Pineal Res 33:63\u201371","journal-title":"J Pineal Res"},{"key":"1359_CR54","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1600-079X.2006.00399.x","volume":"42","author":"E Muhlbauer","year":"2007","unstructured":"Muhlbauer E, Peschke E (2007) Evidence for the expression of both the MT1- and in addition, the MT2-melatonin receptor, in the rat pancreas, islet and beta-cell. J Pineal Res 42:105\u2013106","journal-title":"J Pineal Res"},{"key":"1359_CR55","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-079X.2007.00523.x","volume":"44","author":"RD Ramracheya","year":"2008","unstructured":"Ramracheya RD, Muller DS, Squires PE et al (2008) Function and expression of melatonin receptors on human pancreatic islets. J Pineal Res 44:273\u2013279","journal-title":"J Pineal Res"},{"key":"1359_CR56","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/ng.288","volume":"41","author":"V Lyssenko","year":"2009","unstructured":"Lyssenko V, Nagorny CL, Erdos MR et al (2009) Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 41:82\u201388","journal-title":"Nat Genet"},{"key":"1359_CR57","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1600-079X.1991.tb00470.x","volume":"11","author":"BJ Frankel","year":"1991","unstructured":"Frankel BJ, Strandberg MJ (1991) Insulin release from isolated mouse islets in vitro: no effect of physiological levels of melatonin or arginine vasotocin. J Pineal Res 11:145\u2013148","journal-title":"J Pineal Res"},{"key":"1359_CR58","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1600-079X.2005.00297.x","volume":"40","author":"E Peschke","year":"2006","unstructured":"Peschke E, Bach AG, Muhlbauer E (2006) Parallel signaling pathways of melatonin in the pancreatic beta-cell. J Pineal Res 40:184\u2013191","journal-title":"J Pineal Res"},{"key":"1359_CR59","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1600-079X.1997.tb00349.x","volume":"23","author":"E Peschke","year":"1997","unstructured":"Peschke E, Peschke D, Hammer T, Csernus V (1997) Influence of melatonin and serotonin on glucose-stimulated insulin release from perifused rat pancreatic islets in vitro. J Pineal Res 23:156\u2013163","journal-title":"J Pineal Res"},{"key":"1359_CR60","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1034\/j.1600-079X.2002.02903.x","volume":"33","author":"MC Picinato","year":"2002","unstructured":"Picinato MC, Haber EP, Cipolla-Neto J, Curi R, de Oliveira Carvalho CR, Carpinelli AR (2002) Melatonin inhibits insulin secretion and decreases PKA levels without interfering with glucose metabolism in rat pancreatic islets. J Pineal Res 33:156\u2013160","journal-title":"J Pineal Res"},{"key":"1359_CR61","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1600-079X.2008.00593.x","volume":"45","author":"I Stumpf","year":"2008","unstructured":"Stumpf I, Muhlbauer E, Peschke E (2008) Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells. J Pineal Res 45:318\u2013327","journal-title":"J Pineal Res"},{"key":"1359_CR62","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1600-079X.2005.00253.x","volume":"39","author":"AG Bach","year":"2005","unstructured":"Bach AG, Wolgast S, Muhlbauer E, Peschke E (2005) Melatonin stimulates inositol-1,4,5-trisphosphate and Ca2+ release from INS1 insulinoma cells. J Pineal Res 39:316\u2013323","journal-title":"J Pineal Res"},{"key":"1359_CR63","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1600-079X.2007.00426.x","volume":"42","author":"E Peschke","year":"2007","unstructured":"Peschke E, Stumpf I, Bazwinsky I, Litvak L, Dralle H, Muhlbauer E (2007) Melatonin and type 2 diabetes\u2014a possible link? J Pineal Res 42:350\u2013358","journal-title":"J Pineal Res"},{"key":"1359_CR64","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/ng.277","volume":"41","author":"N Bouatia-Naji","year":"2009","unstructured":"Bouatia-Naji N, Bonnefond A, Cavalcanti-Proenca C et al (2009) A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet 41:89\u201394","journal-title":"Nat Genet"},{"key":"1359_CR65","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ng.290","volume":"41","author":"I Prokopenko","year":"2009","unstructured":"Prokopenko I, Langenberg C, Florez JC et al (2009) Variants in MTNR1B influence fasting glucose levels. Nat Genet 41:77\u201381","journal-title":"Nat Genet"},{"key":"1359_CR66","doi-asserted-by":"crossref","unstructured":"R\u00f6nn T, Wen J, Yang Z, et al. (2009) A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia doi: 10.1007\/s00125-009-1297-8","DOI":"10.1007\/s00125-009-1297-8"},{"key":"1359_CR67","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.diabres.2008.04.025","volume":"81","author":"JE Shaw","year":"2008","unstructured":"Shaw JE, Punjabi NM, Wilding JP, Alberti KG, Zimmet PZ (2008) Sleep-disordered breathing and type 2 diabetes: a report from the International Diabetes Federation Taskforce on Epidemiology and Prevention. Diabetes Res Clin Pract 81:2\u201312","journal-title":"Diabetes Res Clin Pract"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-009-1359-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-009-1359-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-009-1359-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T17:54:26Z","timestamp":1710266066000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-009-1359-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,18]]},"references-count":67,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["1359"],"URL":"https:\/\/doi.org\/10.1007\/s00125-009-1359-y","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,18]]}}}