{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:40:28Z","timestamp":1791330028983,"version":"4.3.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2009,7,7]],"date-time":"2009-07-07T00:00:00Z","timestamp":1246924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1007\/s00125-009-1429-1","type":"journal-article","created":{"date-parts":[[2009,7,6]],"date-time":"2009-07-06T08:49:52Z","timestamp":1246870192000},"page":"1913-1924","source":"Crossref","is-referenced-by-count":37,"title":["WNT\/\u03b2-catenin increases the production of incretins by entero-endocrine cells"],"prefix":"10.1007","volume":"52","author":[{"given":"J. M.","family":"Garc\u00eda-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chocarro-Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Moya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Garc\u00eda-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,7,7]]},"reference":[{"key":"1429_CR1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1065-6995(02)00255-X","volume":"27","author":"VA Gault","year":"2003","unstructured":"Gault VA, Irwin N, Harriott P, Flatt PR, O'Harte FP (2003) DPP IV resistance and insulin releasing activity of a novel di-substituted analogue of glucose-dependent insulinotropic polypeptide, (Ser2-Asp13)GIP. Cell Biol Int 27:41\u201346","journal-title":"Cell Biol Int"},{"key":"1429_CR2","first-page":"E661","volume":"270","author":"CC Tseng","year":"1996","unstructured":"Tseng CC, Boylan MO, Jarboe LA, Usdin TB, Wolfe MM (1996) Chronic desensitization of the glucose-dependent insulinotropic polypeptide receptor in diabetic rats. Am J Physiol 270:E661\u2013E666","journal-title":"Am J Physiol"},{"key":"1429_CR3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1677\/jme.0.0020169","volume":"2","author":"B Beck","year":"1989","unstructured":"Beck B (1989) Gastric inhibitory polypeptide: a gut hormone with anabolic functions. J Mol Endocrinol 2:169\u2013174","journal-title":"J Mol Endocrinol"},{"key":"1429_CR4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1055\/s-2004-826162","volume":"36","author":"Y Yamada","year":"2004","unstructured":"Yamada Y, Seino Y (2004) Physiology of GIP\u2014a lesson from GIP receptor knockout mice. Horm Metab Res 36:771\u2013774","journal-title":"Horm Metab Res"},{"key":"1429_CR5","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.2337\/diabetes.53.5.1326","volume":"53","author":"T Hansotia","year":"2004","unstructured":"Hansotia T, Baggio LL, Delmeire D et al (2004) Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors. Diabetes 53:1326\u20131335","journal-title":"Diabetes"},{"key":"1429_CR6","doi-asserted-by":"crossref","first-page":"18365","DOI":"10.1074\/jbc.M710466200","volume":"283","author":"MC Althage","year":"2008","unstructured":"Althage MC, Ford EL, Wang S, Tso P, Polonsky KS, Wice BM (2008) Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet. J Biol Chem 283:18365\u201318376","journal-title":"J Biol Chem"},{"key":"1429_CR7","doi-asserted-by":"crossref","first-page":"E1746","DOI":"10.1152\/ajpendo.00460.2007","volume":"293","author":"PL McClean","year":"2007","unstructured":"McClean PL, Irwin N, Cassidy RS, Holst JJ, Gault VA, Flatt PR (2007) GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet. Am J Physiol Endocrinol Metab 293:E1746\u2013E1755","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1429_CR8","doi-asserted-by":"crossref","first-page":"14843","DOI":"10.1073\/pnas.96.26.14843","volume":"96","author":"K Miyawaki","year":"1999","unstructured":"Miyawaki K, Yamada Y, Yano H et al (1999) Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci U S A 96:14843\u201314847","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1429_CR9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbrc.2007.09.128","volume":"364","author":"C Yamada","year":"2007","unstructured":"Yamada C, Yamada Y, Tsukiyama K et al (2007) Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes. Biochem Biophys Res Commun 364:175\u2013180","journal-title":"Biochem Biophys Res Commun"},{"key":"1429_CR10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1172\/JCI25483","volume":"117","author":"T Hansotia","year":"2007","unstructured":"Hansotia T, Maida A, Flock G et al (2007) Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure. J Clin Invest 117:143\u2013152","journal-title":"J Clin Invest"},{"key":"1429_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-0115(02)00039-3","volume":"107","author":"JJ Meier","year":"2002","unstructured":"Meier JJ, Nauck MA, Schmidt WE, Gallwitz B (2002) Gastric inhibitory polypeptide: the neglected incretin revisited. Regul Pept 107:1\u201313","journal-title":"Regul Pept"},{"key":"1429_CR12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tem.2008.08.004","volume":"19","author":"HJ Welters","year":"2008","unstructured":"Welters HJ, Kulkarni RN (2008) Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol Metab 19:349\u2013355","journal-title":"Trends Endocrinol Metab"},{"key":"1429_CR13","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cell.2006.10.018","volume":"127","author":"H Clevers","year":"2006","unstructured":"Clevers H (2006) Wnt\/beta-catenin signaling in development and disease. Cell 127:469\u2013480","journal-title":"Cell"},{"key":"1429_CR14","first-page":"M23","volume":"1424","author":"J Roose","year":"1999","unstructured":"Roose J, Clevers H (1999) TCF transcription factors: molecular switches in carcinogenesis. Biochim Biophys Acta 1424:M23\u2013M37","journal-title":"Biochim Biophys Acta"},{"key":"1429_CR15","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.93.16.8455","volume":"93","author":"PS Klein","year":"1996","unstructured":"Klein PS, Melton DA (1996) A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci U S A 93:8455\u20138459","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1429_CR16","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1006\/dbio.1997.8552","volume":"185","author":"CM Hedgepeth","year":"1997","unstructured":"Hedgepeth CM, Conrad LJ, Zhang J, Huang HC, Lee VM, Klein PS (1997) Activation of the Wnt signaling pathway: a molecular mechanism for lithium action. Dev Biol 185:82\u201391","journal-title":"Dev Biol"},{"key":"1429_CR17","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1074\/jbc.M206006200","volume":"278","author":"Z Ni","year":"2003","unstructured":"Ni Z, Anini Y, Fang X, Mills G, Brubaker PL, Jin T (2003) Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells. J Biol Chem 278:1380\u20131387","journal-title":"J Biol Chem"},{"key":"1429_CR18","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1074\/jbc.M411487200","volume":"280","author":"F Yi","year":"2005","unstructured":"Yi F, Brubaker PL, Jin T (2005) TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. J Biol Chem 280:1457\u20131464","journal-title":"J Biol Chem"},{"key":"1429_CR19","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1007\/s00125-008-1109-6","volume":"51","author":"B Gustafson","year":"2008","unstructured":"Gustafson B, Smith U (2008) WNT signalling is both an inducer and effector of glucagon-like peptide-1. Diabetologia 51:1768\u20131770","journal-title":"Diabetologia"},{"key":"1429_CR20","doi-asserted-by":"crossref","first-page":"17438","DOI":"10.1074\/jbc.272.28.17438","volume":"272","author":"MO Boylan","year":"1997","unstructured":"Boylan MO, Jepeal LI, Jarboe LA, Wolfe MM (1997) Cell-specific expression of the glucose-dependent insulinotropic polypeptide gene in a mouse neuroendocrine tumor cell line. J Biol Chem 272:17438\u201317443","journal-title":"J Biol Chem"},{"key":"1429_CR21","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1210\/en.2004-0223","volume":"146","author":"LI Jepeal","year":"2005","unstructured":"Jepeal LI, Fujitani Y, Boylan MO, Wilson CN, Wright CV, Wolfe MM (2005) Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1. Endocrinology 146:383\u2013391","journal-title":"Endocrinology"},{"key":"1429_CR22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.mce.2008.01.024","volume":"287","author":"LI Jepeal","year":"2008","unstructured":"Jepeal LI, Boylan MO, Michael Wolfe M (2008) GATA-4 upregulates glucose-dependent insulinotropic polypeptide expression in cells of pancreatic and intestinal lineage. Mol Cell Endocrinol 287:20\u201329","journal-title":"Mol Cell Endocrinol"},{"key":"1429_CR23","doi-asserted-by":"crossref","first-page":"E648","DOI":"10.1152\/ajpendo.90440.2008","volume":"295","author":"Y Fujita","year":"2008","unstructured":"Fujita Y, Chui JW, King DS et al (2008) Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells. Am J Physiol Endocrinol Metab 295:E648\u2013E657","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1429_CR24","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1101\/gad.267103","volume":"17","author":"D Pinto","year":"2003","unstructured":"Pinto D, Gregorieff A, Begthel H, Clevers H (2003) Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev 17:1709\u20131713","journal-title":"Genes Dev"},{"key":"1429_CR25","doi-asserted-by":"crossref","first-page":"11328","DOI":"10.1073\/pnas.0702665104","volume":"104","author":"Y Wang","year":"2007","unstructured":"Wang Y, Giel-Moloney M, Rindi G, Leiter AB (2007) Enteroendocrine precursors differentiate independently of Wnt and form serotonin expressing adenomas in response to active beta-catenin. Proc Natl Acad Sci U S A 104:11328\u201311333","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1429_CR26","first-page":"1349","volume":"136","author":"G Rindi","year":"1990","unstructured":"Rindi G, Grant SG, Yiangou Y et al (1990) Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expression. Am J Pathol 136:1349\u20131363","journal-title":"Am J Pathol"},{"key":"1429_CR27","doi-asserted-by":"crossref","unstructured":"Schug J (2008) Using TESS to predict transcription factor binding sites in DNA sequence. Curr Protoc Bioinformatics Chapter 2: Unit 2.6","DOI":"10.1002\/0471250953.bi0206s21"},{"key":"1429_CR28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3233\/JAD-1999-1602","volume":"1","author":"JR Munoz-Montano","year":"1999","unstructured":"Munoz-Montano JR, Lim F, Moreno FJ, Avila J, Diaz-Nido J (1999) Glycogen synthase kinase-3 modulates neurite outgrowth in cultured neurons: possible implications for neurite pathology in Alzheimer's disease. J Alzheimers Dis 1:361\u2013378","journal-title":"J Alzheimers Dis"},{"key":"1429_CR29","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1093\/nar\/19.9.2499","volume":"19","author":"NC Andrews","year":"1991","unstructured":"Andrews NC, Faller DV (1991) A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res 19:2499","journal-title":"Nucleic Acids Res"},{"key":"1429_CR30","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1128\/MCB.24.7.2915-2922.2004","volume":"24","author":"J Goodall","year":"2004","unstructured":"Goodall J, Martinozzi S, Dexter TJ et al (2004) Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. Mol Cell Biol 24:2915\u20132922","journal-title":"Mol Cell Biol"},{"key":"1429_CR31","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"1429_CR32","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0165-6147(03)00206-2","volume":"24","author":"RS Jope","year":"2003","unstructured":"Jope RS (2003) Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes. Trends Pharmacol Sci 24:441\u2013443","journal-title":"Trends Pharmacol Sci"},{"key":"1429_CR33","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1006\/bbrc.2000.4169","volume":"280","author":"WJ Ryves","year":"2001","unstructured":"Ryves WJ, Harwood AJ (2001) Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. Biochem Biophys Res Commun 280:720\u2013725","journal-title":"Biochem Biophys Res Commun"},{"key":"1429_CR34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1254\/jphs.CRJ05009X","volume":"99","author":"A Wada","year":"2005","unstructured":"Wada A, Yokoo H, Yanagita T, Kobayashi H (2005) Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative diseases. J Pharmacol Sci 99:307\u2013321","journal-title":"J Pharmacol Sci"},{"key":"1429_CR35","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.neuropharm.2007.08.018","volume":"53","author":"T Yanagita","year":"2007","unstructured":"Yanagita T, Maruta T, Uezono Y et al (2007) Lithium inhibits function of voltage-dependent sodium channels and catecholamine secretion independent of glycogen synthase kinase-3 in adrenal chromaffin cells. Neuropharmacology 53:881\u2013889","journal-title":"Neuropharmacology"},{"key":"1429_CR36","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.mcn.2007.10.017","volume":"37","author":"MH Liang","year":"2008","unstructured":"Liang MH, Wendland JR, Chuang DM (2008) Lithium inhibits Smad3\/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling. Mol Cell Neurosci 37:440\u2013453","journal-title":"Mol Cell Neurosci"},{"key":"1429_CR37","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1126\/science.275.5307.1784","volume":"275","author":"V Korinek","year":"1997","unstructured":"Korinek V, Barker N, Morin PJ et al (1997) Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC\u2212\/\u2212 colon carcinoma. Science 275:1784\u20131787","journal-title":"Science"},{"key":"1429_CR38","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0960-9822(03)00240-9","volume":"13","author":"MT Veeman","year":"2003","unstructured":"Veeman MT, Slusarski DC, Kaykas A, Louie SH, Moon RT (2003) Zebrafish prickle, a modulator of noncanonical Wnt\/Fz signaling, regulates gastrulation movements. Curr Biol 13:680\u2013685","journal-title":"Curr Biol"},{"key":"1429_CR39","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.yexcr.2005.05.011","volume":"308","author":"M Asally","year":"2005","unstructured":"Asally M, Yoneda Y (2005) Beta-catenin can act as a nuclear import receptor for its partner transcription factor, lymphocyte enhancer factor-1 (lef-1). Exp Cell Res 308:357\u2013363","journal-title":"Exp Cell Res"},{"key":"1429_CR40","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1172\/JCI30706","volume":"117","author":"V Lyssenko","year":"2007","unstructured":"Lyssenko V, Lupi R, Marchetti P et al (2007) Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117:2155\u20132163","journal-title":"J Clin Invest"},{"key":"1429_CR41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1056\/NEJMoa062418","volume":"355","author":"JC Florez","year":"2006","unstructured":"Florez JC, Jablonski KA, Bayley N et al (2006) TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355:241\u2013250","journal-title":"N Engl J Med"},{"key":"1429_CR42","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nm727","volume":"8","author":"K Miyawaki","year":"2002","unstructured":"Miyawaki K, Yamada Y, Ban N et al (2002) Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med 8:738\u2013742","journal-title":"Nat Med"},{"key":"1429_CR43","doi-asserted-by":"crossref","first-page":"536","DOI":"10.2337\/diab.33.6.536","volume":"33","author":"CB Chan","year":"1984","unstructured":"Chan CB, Pederson RA, Buchan AM, Tubesing KB, Brown JC (1984) Gastric inhibitory polypeptide (GIP) and insulin release in the obese Zucker rat. Diabetes 33:536\u2013542","journal-title":"Diabetes"},{"key":"1429_CR44","first-page":"461","volume":"15","author":"RA Pederson","year":"1991","unstructured":"Pederson RA, Campos RV, Buchan AM, Chisholm CB, Russell JC, Brown JC (1991) Comparison of the enteroinsular axis in two strains of obese rat, the fatty Zucker and the JCR:LA-corpulent. Int J Obes 15:461\u2013470","journal-title":"Int J Obes"},{"key":"1429_CR45","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/BF01654758","volume":"3","author":"JC Brown","year":"1979","unstructured":"Brown JC, Otte S (1979) Clinical studies with gastric inhibitory polypeptide. World J Surg 3:553\u2013558","journal-title":"World J Surg"},{"key":"1429_CR46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1055\/s-2007-1009141","volume":"21","author":"IR Jones","year":"1989","unstructured":"Jones IR, Owens DR, Luzio S, Hayes TM (1989) Glucose dependent insulinotropic polypeptide (GIP) infused intravenously is insulinotropic in the fasting state in type 2 (non-insulin dependent) diabetes mellitus. Horm Metab Res 21:23\u201326","journal-title":"Horm Metab Res"},{"key":"1429_CR47","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/BF00274255","volume":"32","author":"IR Jones","year":"1989","unstructured":"Jones IR, Owens DR, Luzio S, Williams S, Hayes TM (1989) The glucose dependent insulinotropic polypeptide response to oral glucose and mixed meals is increased in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 32:668\u2013677","journal-title":"Diabetologia"},{"key":"1429_CR48","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.regpep.2007.07.002","volume":"144","author":"FK Knop","year":"2007","unstructured":"Knop FK, Vilsboll T, Hojberg PV et al (2007) The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance. Regul Pept 144:123\u2013130","journal-title":"Regul Pept"},{"key":"1429_CR49","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.2337\/diabetes.50.11.2497","volume":"50","author":"JJ Meier","year":"2001","unstructured":"Meier JJ, Hucking K, Holst JJ, Deacon CF, Schmiegel WH, Nauck MA (2001) Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes. Diabetes 50:2497\u20132504","journal-title":"Diabetes"},{"key":"1429_CR50","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jad.2007.04.006","volume":"105","author":"B Kim","year":"2008","unstructured":"Kim B, Kim SJ, Son JI, Joo YH (2008) Weight change in the acute treatment of bipolar I disorder: a naturalistic observational study of psychiatric inpatients. J Affect Disord 105:45\u201352","journal-title":"J Affect Disord"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-009-1429-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-009-1429-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-009-1429-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T07:47:13Z","timestamp":1558597633000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-009-1429-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,7]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["1429"],"URL":"https:\/\/doi.org\/10.1007\/s00125-009-1429-1","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,7]]}}}