{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:49:11Z","timestamp":1793155751663,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2009,7,8]],"date-time":"2009-07-08T00:00:00Z","timestamp":1247011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1007\/s00125-009-1436-2","type":"journal-article","created":{"date-parts":[[2009,7,7]],"date-time":"2009-07-07T13:08:42Z","timestamp":1246972122000},"page":"1858-1865","source":"Crossref","is-referenced-by-count":93,"title":["A susceptibility gene for type 2 diabetes confers substantial risk for diabetes complicating cystic fibrosis"],"prefix":"10.1007","volume":"52","author":[{"given":"S. M.","family":"Blackman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. E.","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Naughton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. A.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Drumm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. R.","family":"Cutting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"1436_CR1","first-page":"5121","volume-title":"The metabolic and molecular bases of inherited disease","author":"MJ Welsh","year":"2001","unstructured":"Welsh MJ, Ramsey BW, Accurso FJ, Cutting GR (2001) Cystic fibrosis. In: Scriver CR, Beaudet AL, Valle D, Sly WS (eds) The metabolic and molecular bases of inherited disease, 8th edn. McGraw-Hill, New York, pp 5121\u20135188","edition":"8"},{"key":"1436_CR2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0168-8227(99)00058-3","volume":"45","author":"A Moran","year":"1999","unstructured":"Moran A, Hardin D, Rodman D et al (1999) Diagnosis, screening and management of cystic fibrosis related diabetes mellitus: a consensus conference report. Diabetes Res Clin Pract 45:61\u201373","journal-title":"Diabetes Res Clin Pract"},{"key":"1436_CR3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1046\/j.1464-5491.2003.00924.x","volume":"20","author":"AD Mackie","year":"2003","unstructured":"Mackie AD, Thornton SJ, Edenborough FP (2003) Cystic fibrosis-related diabetes. Diabet Med 20:425\u2013436","journal-title":"Diabet Med"},{"key":"1436_CR4","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1164\/ajrccm.162.3.9904075","volume":"162","author":"CE Milla","year":"2000","unstructured":"Milla CE, Warwick WJ, Moran A (2000) Trends in pulmonary function in patients with cystic fibrosis correlate with the degree of glucose intolerance at baseline. Am J Respir Crit Care Med 162:891\u2013895","journal-title":"Am J Respir Crit Care Med"},{"key":"1436_CR5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000110206","volume":"76","author":"K Mohan","year":"2008","unstructured":"Mohan K, Israel KL, Miller H, Grainger R, Ledson MJ, Walshaw MJ (2008) Long-term effect of insulin treatment in cystic fibrosis-related diabetes. Respiration 76:181\u2013186","journal-title":"Respiration"},{"key":"1436_CR6","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.2337\/dc06-0062","volume":"29","author":"CC Cowie","year":"2006","unstructured":"Cowie CC, Rust KF, Byrd-Holt DD et al (2006) Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health and Nutrition Examination Survey 1999\u20132002. Diabetes Care 29:1263\u20131268","journal-title":"Diabetes Care"},{"key":"1436_CR7","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1136\/gut.52.8.1159","volume":"52","author":"N Ahmed","year":"2003","unstructured":"Ahmed N, Corey M, Forstner G et al (2003) Molecular consequences of cystic fibrosis transmembrane regulator (CFTR) gene mutations in the exocrine pancreas. Gut 52:1159\u20131164","journal-title":"Gut"},{"key":"1436_CR8","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1210\/jc.2008-2186","volume":"94","author":"SM Blackman","year":"2009","unstructured":"Blackman SM, Hsu S, Vanscoy LL et al (2009) Genetic modifiers play a substantial role in diabetes complicating cystic fibrosis. J Clin Endocrinol Metab 94:1302\u20131309","journal-title":"J Clin Endocrinol Metab"},{"key":"1436_CR9","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1515\/JPEM.2005.18.8.755","volume":"18","author":"L Minicucci","year":"2005","unstructured":"Minicucci L, Cotellessa M, Pittaluga L et al (2005) Beta-cell autoantibodies and diabetes mellitus family history in cystic fibrosis. J Pediatr Endocrinol Metab 18:755\u2013760","journal-title":"J Pediatr Endocrinol Metab"},{"key":"1436_CR10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1651-2227.1993.tb12628.x","volume":"82","author":"S Lanng","year":"1993","unstructured":"Lanng S, Thorsteinsson B, Pociot F et al (1993) Diabetes mellitus in cystic fibrosis: genetic and immunological markers. Acta Paediatr 82:150\u2013154","journal-title":"Acta Paediatr"},{"key":"1436_CR11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1515\/JPEM.2000.13.3.319","volume":"13","author":"S Nousia-Arvanitakis","year":"2000","unstructured":"Nousia-Arvanitakis S, Galli-Tsinopoulou A, Dracoulacos D, Karamouzis M, Demitriadou A (2000) Islet autoantibodies and insulin dependent diabetes mellitus in cystic fibrosis. J Pediatr Endocrinol Metab 13:319\u2013324","journal-title":"J Pediatr Endocrinol Metab"},{"key":"1436_CR12","first-page":"4047","volume":"86","author":"SE Kahn","year":"2001","unstructured":"Kahn SE (2001) Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 86:4047\u20134058","journal-title":"J Clin Endocrinol Metab"},{"issue":"540\u20135","key":"1436_CR13","first-page":"545","volume":"152","author":"E Bismuth","year":"2008","unstructured":"Bismuth E, Laborde K, Taupin P et al (2008) Glucose tolerance and insulin secretion, morbidity, and death in patients with cystic fibrosis. J Pediatr 152(540\u20135):545","journal-title":"J Pediatr"},{"key":"1436_CR14","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1210\/jc.2004-0405","volume":"89","author":"RL Hull","year":"2004","unstructured":"Hull RL, Westermark GT, Westermark P, Kahn SE (2004) Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes. J Clin Endocrinol Metab 89:3629\u20133643","journal-title":"J Clin Endocrinol Metab"},{"key":"1436_CR15","first-page":"1267","volume":"81","author":"M Couce","year":"1996","unstructured":"Couce M, O\u2019Brien TD, Moran A, Roche PC, Butler PC (1996) Diabetes mellitus in cystic fibrosis is characterized by islet amyloidosis. J Clin Endocrinol Metab 81:1267\u20131272","journal-title":"J Clin Endocrinol Metab"},{"key":"1436_CR16","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ng1732","volume":"38","author":"SF Grant","year":"2006","unstructured":"Grant SF, Thorleifsson G, Reynisdottir I et al (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320\u2013323","journal-title":"Nat Genet"},{"key":"1436_CR17","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1464-5491.2007.02258.x","volume":"24","author":"MN Weedon","year":"2007","unstructured":"Weedon MN (2007) The importance of TCF7L2. Diabet Med 24:1062\u20131066","journal-title":"Diabet Med"},{"key":"1436_CR18","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1053\/j.gastro.2006.07.016","volume":"131","author":"SM Blackman","year":"2006","unstructured":"Blackman SM, Deering-Brose R, McWilliams R et al (2006) Relative contribution of genetic and nongenetic modifiers to intestinal obstruction in cystic fibrosis. Gastroenterology 131:1030\u20131039","journal-title":"Gastroenterology"},{"key":"1436_CR19","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1164\/rccm.200608-1164OC","volume":"175","author":"LL Vanscoy","year":"2007","unstructured":"Vanscoy LL, Blackman SM, Collaco JM et al (2007) Heritability of lung disease severity in cystic fibrosis. Am J Respir Crit Care Med 175:1036\u20131043","journal-title":"Am J Respir Crit Care Med"},{"key":"1436_CR20","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0022-3476(98)70344-0","volume":"132","author":"BJ Rosenstein","year":"1998","unstructured":"Rosenstein BJ, Cutting GR (1998) The diagnosis of cystic fibrosis: a consensus statement. J Pediatr 132:589\u2013595","journal-title":"J Pediatr"},{"key":"1436_CR21","doi-asserted-by":"crossref","first-page":"796","DOI":"10.2337\/diacare.13.7.796","volume":"13","author":"LB Kahn","year":"1990","unstructured":"Kahn LB, Marshall JA, Baxter J, Shetterly SM, Hamman RF (1990) Accuracy of reported family history of diabetes mellitus. Results from San Luis Valley Diabetes Study. Diabetes Care 13:796\u2013798","journal-title":"Diabetes Care"},{"key":"1436_CR22","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/414782a","volume":"414","author":"P Zimmet","year":"2001","unstructured":"Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414:782\u2013787","journal-title":"Nature"},{"key":"1436_CR23","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1001\/jama.299.4.417","volume":"299","author":"JM Collaco","year":"2008","unstructured":"Collaco JM, Vanscoy L, Bremer L et al (2008) Interactions between secondhand smoke and genes that affect cystic fibrosis lung disease. JAMA 299:417\u2013424","journal-title":"JAMA"},{"key":"1436_CR24","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1056\/NEJMoa051469","volume":"353","author":"ML Drumm","year":"2005","unstructured":"Drumm ML, Konstan MW, Schluchter MD et al (2005) Genetic modifiers of lung disease in cystic fibrosis. N Engl J Med 353:1443\u20131453","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"1436_CR25","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1002\/1098-2272(2000)19:1+<::AID-GEPI6>3.0.CO;2-M","volume":"19","author":"NM Laird","year":"2000","unstructured":"Laird NM, Horvath S, Xu X (2000) Implementing a unified approach to family-based tests of association. Genet Epidemiol 19(Suppl 1):S36\u2013S42","journal-title":"Genet Epidemiol"},{"key":"1436_CR26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1479-7364-2-1-67","volume":"2","author":"KV Steen","year":"2005","unstructured":"Steen KV, Lange C (2005) PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies. Hum Genome 2:67\u201369","journal-title":"Hum Genome"},{"key":"1436_CR27","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1086\/302782","volume":"66","author":"KL Lunetta","year":"2000","unstructured":"Lunetta KL, Faraone SV, Biederman J, Laird NM (2000) Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions. Am J Hum Genet 66:605\u2013614","journal-title":"Am J Hum Genet"},{"key":"1436_CR28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/79216","volume":"26","author":"D Altshuler","year":"2000","unstructured":"Altshuler D, Hirschhorn JN, Klannemark M et al (2000) The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26:76\u201380","journal-title":"Nat Genet"},{"key":"1436_CR29","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.2337\/db07-1731","volume":"57","author":"KJ Gaulton","year":"2008","unstructured":"Gaulton KJ, Willer CJ, Li Y et al (2008) Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Diabetes 57:3136\u20133144","journal-title":"Diabetes"},{"key":"1436_CR30","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00109-007-0203-4","volume":"85","author":"S Cauchi","year":"2007","unstructured":"Cauchi S, El Achhab Y, Choquet H et al (2007) TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J Mol Med 85:777\u2013782","journal-title":"J Mol Med"},{"key":"1436_CR31","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jpeds.2004.12.039","volume":"146","author":"BC Marshall","year":"2005","unstructured":"Marshall BC, Butler SM, Stoddard M, Moran AM, Liou TG, Morgan WJ (2005) Epidemiology of cystic fibrosis-related diabetes. J Pediatr 146:681\u2013687","journal-title":"J Pediatr"},{"key":"1436_CR32","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/j.1464-5491.2007.02252.x","volume":"24","author":"AI Adler","year":"2007","unstructured":"Adler AI, Gunn E, Haworth CS, Bilton D (2007) Characteristics of adults with and without cystic fibrosis-related diabetes. Diabet Med 24:1143\u20131148","journal-title":"Diabet Med"},{"key":"1436_CR33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1464-5491.2002.00624.x","volume":"19","author":"CF Weijnen","year":"2002","unstructured":"Weijnen CF, Rich SS, Meigs JB, Krolewski AS, Warram JH (2002) Risk of diabetes in siblings of index cases with Type 2 diabetes: implications for genetic studies. Diabet Med 19:41\u201350","journal-title":"Diabet Med"},{"key":"1436_CR34","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/ng1960","volume":"39","author":"A Helgason","year":"2007","unstructured":"Helgason A, Palsson S, Thorleifsson G et al (2007) Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 39:218\u2013225","journal-title":"Nat Genet"},{"issue":"13","key":"1436_CR35","doi-asserted-by":"crossref","first-page":"8723","DOI":"10.1074\/jbc.M706105200","volume":"283","author":"Z Liu","year":"2008","unstructured":"Liu Z, Habener JF (2008) Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta-cell proliferation. J Biol Chem 283(13):8723\u20138735","journal-title":"J Biol Chem"},{"key":"1436_CR36","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1210\/jc.2008-0855","volume":"93","author":"L Wegner","year":"2008","unstructured":"Wegner L, Hussain MS, Pilgaard K et al (2008) Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins. J Clin Endocrinol Metab 93:4013\u20134019","journal-title":"J Clin Endocrinol Metab"},{"key":"1436_CR37","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1056\/NEJMoa062418","volume":"355","author":"JC Florez","year":"2006","unstructured":"Florez JC, Jablonski KA, Bayley N et al (2006) TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355:241\u2013250","journal-title":"N Engl J Med"},{"key":"1436_CR38","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1056\/NEJMoa0804742","volume":"359","author":"JB Meigs","year":"2008","unstructured":"Meigs JB, Shrader P, Sullivan LM et al (2008) Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med 359:2208\u20132219","journal-title":"N Engl J Med"},{"key":"1436_CR39","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1056\/NEJMoa0801869","volume":"359","author":"V Lyssenko","year":"2008","unstructured":"Lyssenko V, Jonsson A, Almgren P et al (2008) Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 359:2220\u20132232","journal-title":"N Engl J Med"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-009-1436-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-009-1436-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-009-1436-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T11:47:13Z","timestamp":1558612033000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-009-1436-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,8]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["1436"],"URL":"https:\/\/doi.org\/10.1007\/s00125-009-1436-2","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,8]]}}}