{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:57:55Z","timestamp":1791187075925,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2010,4,6]],"date-time":"2010-04-06T00:00:00Z","timestamp":1270512000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1007\/s00125-010-1717-9","type":"journal-article","created":{"date-parts":[[2010,4,5]],"date-time":"2010-04-05T09:38:00Z","timestamp":1270460280000},"page":"1415-1427","source":"Crossref","is-referenced-by-count":35,"title":["Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3"],"prefix":"10.1007","volume":"53","author":[{"given":"E.","family":"Law","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Kieffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. L.","family":"Warnock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Marzban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,4,6]]},"reference":[{"key":"1717_CR1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/1566524053766004","volume":"5","author":"B Ahren","year":"2005","unstructured":"Ahren B (2005) Type 2 diabetes, insulin secretion and beta-cell mass. Curr Mol Med 5:275\u2013286","journal-title":"Curr Mol Med"},{"key":"1717_CR2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","volume":"52","author":"AE Butler","year":"2003","unstructured":"Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102\u2013110","journal-title":"Diabetes"},{"key":"1717_CR3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0531-5565(03)00004-4","volume":"38","author":"L Marzban","year":"2003","unstructured":"Marzban L, Park K, Verchere CB (2003) Islet amyloid polypeptide and type 2 diabetes. Exp Gerontol 38:347\u2013351","journal-title":"Exp Gerontol"},{"key":"1717_CR4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1210\/er.2007-0037","volume":"29","author":"L Haataja","year":"2008","unstructured":"Haataja L, Gurlo T, Huang CJ, Butler PC (2008) Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. Endocr Rev 29:303\u2013316","journal-title":"Endocr Rev"},{"key":"1717_CR5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00125-003-1304-4","volume":"47","author":"A Clark","year":"2004","unstructured":"Clark A, Nilsson MR (2004) Islet amyloid: a complication of islet dysfunction or an aetiological factor in type 2 diabetes? Diabetologia 47:157\u2013169","journal-title":"Diabetologia"},{"key":"1717_CR6","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1073\/pnas.84.11.3881","volume":"84","author":"P Westermark","year":"1987","unstructured":"Westermark P, Wernstedt C, Wilander E, Hayden DW, O\u2019Brien TD, Johnson KH (1987) Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc Natl Acad Sci USA 84:3881\u20133885","journal-title":"Proc Natl Acad Sci USA"},{"key":"1717_CR7","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1073\/pnas.84.23.8628","volume":"84","author":"GJ Cooper","year":"1987","unstructured":"Cooper GJ, Willis AC, Clark A, Turner RC, Sim RB, Reid KB (1987) Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 84:8628\u20138632","journal-title":"Proc Natl Acad Sci USA"},{"key":"1717_CR8","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.2337\/db08-0485","volume":"57","author":"L Marzban","year":"2008","unstructured":"Marzban L, Tomas A, Becker TC et al (2008) Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture. Diabetes 57:3045\u20133055","journal-title":"Diabetes"},{"key":"1717_CR9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S0026-0495(99)90102-6","volume":"48","author":"G Westermark","year":"1999","unstructured":"Westermark G, Westermark P, Eizirik DL et al (1999) Differences in amyloid deposition in islets of transgenic mice expressing human islet amyloid polypeptide vs human islets implanted into nude mice. Metabolism 48:448\u2013454","journal-title":"Metabolism"},{"key":"1717_CR10","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJMc0802893","volume":"359","author":"GT Westermark","year":"2008","unstructured":"Westermark GT, Westermark P, Berne C, Korsgren O (2008) Widespread amyloid deposition in transplanted human pancreatic islets. N Engl J Med 359:977\u2013979","journal-title":"N Engl J Med"},{"key":"1717_CR11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/BF00285291","volume":"32","author":"A Lukinius","year":"1989","unstructured":"Lukinius A, Wilander E, Westermark GT, Engstrom U, Westermark P (1989) Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets. Diabetologia 32:240\u2013244","journal-title":"Diabetologia"},{"key":"1717_CR12","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2337\/diab.39.5.634","volume":"39","author":"SE Kahn","year":"1990","unstructured":"Kahn SE, D\u2019Alessio DA, Schwartz MW et al (1990) Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells. Diabetes 39:634\u2013638","journal-title":"Diabetes"},{"key":"1717_CR13","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1210\/me.2004-0407","volume":"19","author":"L Marzban","year":"2005","unstructured":"Marzban L, Trigo-Gonzalez G, Verchere CB (2005) Processing of pro-islet amyloid polypeptide in the constitutive and regulated secretory pathways of beta cells. Mol Endocrinol 19:2154\u20132163","journal-title":"Mol Endocrinol"},{"key":"1717_CR14","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1073\/pnas.87.13.5036","volume":"87","author":"P Westermark","year":"1990","unstructured":"Westermark P, Engstrom U, Johnson KH, Westermark GT, Betsholtz C (1990) Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation. Proc Natl Acad Sci USA 87:5036\u20135040","journal-title":"Proc Natl Acad Sci USA"},{"key":"1717_CR15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2337\/diabetes.48.2.241","volume":"48","author":"SE Kahn","year":"1999","unstructured":"Kahn SE, Andrikopoulos S, Verchere CB (1999) Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes. Diabetes 48:241\u2013253","journal-title":"Diabetes"},{"key":"1717_CR16","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.2337\/db05-1566","volume":"55","author":"L Marzban","year":"2006","unstructured":"Marzban L, Rhodes CJ, Steiner DF, Haataja L, Halban PA, Verchere CB (2006) Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death. Diabetes 55:2192\u20132201","journal-title":"Diabetes"},{"key":"1717_CR17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s001250051138","volume":"42","author":"X Hou","year":"1999","unstructured":"Hou X, Ling Z, Quartier E et al (1999) Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors. Diabetologia 42:188\u2013194","journal-title":"Diabetologia"},{"key":"1717_CR18","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.2337\/diabetes.54.7.2117","volume":"54","author":"JF Paulsson","year":"2005","unstructured":"Paulsson JF, Westermark GT (2005) Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation. Diabetes 54:2117\u20132125","journal-title":"Diabetes"},{"key":"1717_CR19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2337\/diabetes.48.3.491","volume":"48","author":"J Janson","year":"1999","unstructured":"Janson J, Ashley RH, Harrison D, McIntyre S, Butler PC (1999) The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes 48:491\u2013498","journal-title":"Diabetes"},{"key":"1717_CR20","doi-asserted-by":"crossref","first-page":"17294","DOI":"10.1074\/jbc.M500997200","volume":"280","author":"A Demuro","year":"2005","unstructured":"Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG (2005) Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J Biol Chem 280:17294\u201317300","journal-title":"J Biol Chem"},{"key":"1717_CR21","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1073\/pnas.0708354105","volume":"105","author":"MF Engel","year":"2008","unstructured":"Engel MF, Khemtemourian L, Kleijer CC et al (2008) Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane. Proc Natl Acad Sci USA 105:6033\u20136038","journal-title":"Proc Natl Acad Sci USA"},{"key":"1717_CR22","doi-asserted-by":"crossref","first-page":"11338","DOI":"10.1021\/bi020314u","volume":"41","author":"M Anguiano","year":"2002","unstructured":"Anguiano M, Nowak RJ, Lansbury PT Jr (2002) Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes. Biochemistry 41:11338\u201311343","journal-title":"Biochemistry"},{"key":"1717_CR23","doi-asserted-by":"crossref","first-page":"10427","DOI":"10.1073\/pnas.0502066102","volume":"102","author":"A Quist","year":"2005","unstructured":"Quist A, Doudevski I, Lin H et al (2005) Amyloid ion channels: a common structural link for protein-misfolding disease. Proc Natl Acad Sci USA 102:10427\u201310432","journal-title":"Proc Natl Acad Sci USA"},{"key":"1717_CR24","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1515\/BC.2002.196","volume":"383","author":"L Rumora","year":"2002","unstructured":"Rumora L, Hadzija M, Barisic K, Maysinger D, Grubiic TZ (2002) Amylin-induced cytotoxicity is associated with activation of caspase-3 and MAP kinases. Biol Chem 383:1751\u20131758","journal-title":"Biol Chem"},{"key":"1717_CR25","doi-asserted-by":"crossref","first-page":"52810","DOI":"10.1074\/jbc.M308244200","volume":"278","author":"S Zhang","year":"2003","unstructured":"Zhang S, Liu J, Dragunow M, Cooper GJ (2003) Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a caspase cascade and JNK1. J Biol Chem 278:52810\u201352819","journal-title":"J Biol Chem"},{"key":"1717_CR26","first-page":"951","volume":"116","author":"ID Young","year":"1992","unstructured":"Young ID, Ailles L, Narindrasorasak S, Tan R, Kisilevsky R (1992) Localization of the basement membrane heparan sulfate proteoglycan in islet amyloid deposits in type II diabetes mellitus. Arch Pathol Lab Med 116:951\u2013954","journal-title":"Arch Pathol Lab Med"},{"key":"1717_CR27","doi-asserted-by":"crossref","first-page":"16611","DOI":"10.1074\/jbc.M008423200","volume":"276","author":"K Park","year":"2001","unstructured":"Park K, Verchere CB (2001) Identification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide. Implications for islet amyloid formation. J Biol Chem 276:16611\u201316616","journal-title":"J Biol Chem"},{"key":"1717_CR28","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1007\/s00125-008-1111-z","volume":"51","author":"S Casas","year":"2008","unstructured":"Casas S, Novials A, Reimann F, Gomis R, Gribble FM (2008) Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4. Diabetologia 51:2252\u20132262","journal-title":"Diabetologia"},{"key":"1717_CR29","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.2337\/db06-1755","volume":"57","author":"WP Wong","year":"2008","unstructured":"Wong WP, Scott DW, Chuang CL et al (2008) Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance. Diabetes 57:2737\u20132744","journal-title":"Diabetes"},{"key":"1717_CR30","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.2337\/db07-0197","volume":"56","author":"CJ Huang","year":"2007","unstructured":"Huang CJ, Lin CY, Haataja L et al (2007) High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes. Diabetes 56:2016\u20132027","journal-title":"Diabetes"},{"key":"1717_CR31","doi-asserted-by":"crossref","first-page":"906","DOI":"10.2337\/db08-1464","volume":"58","author":"AV Matveyenko","year":"2009","unstructured":"Matveyenko AV, Gurlo T, Daval M, Butler AE, Butler PC (2009) Successful vs failed adaptation to high fat diet induced insulin resistance; the role of IAPP induced beta cell endoplasmic reticulum stress. Diabetes 58:906\u2013916","journal-title":"Diabetes"},{"key":"1717_CR32","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s00125-008-1255-x","volume":"52","author":"S Zraika","year":"2009","unstructured":"Zraika S, Hull RL, Udayasankar J et al (2009) Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis. Diabetologia 52:626\u2013635","journal-title":"Diabetologia"},{"key":"1717_CR33","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.bcp.2008.06.023","volume":"76","author":"G Gloire","year":"2008","unstructured":"Gloire G, Charlier E, Piette J (2008) Regulation of CD95\/APO-1\/Fas-induced apoptosis by protein phosphatases. Biochem Pharmacol 76:1451\u20131458","journal-title":"Biochem Pharmacol"},{"key":"1717_CR34","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cell.2005.05.019","volume":"121","author":"DR Green","year":"2005","unstructured":"Green DR (2005) Apoptotic pathways: ten minutes to dead. Cell 121:671\u2013674","journal-title":"Cell"},{"key":"1717_CR35","first-page":"293","volume":"7","author":"AA Welihinda","year":"1999","unstructured":"Welihinda AA, Tirasophon W, Kaufman RJ (1999) The cellular response to protein misfolding in the endoplasmic reticulum. Gene Expr 7:293\u2013300","journal-title":"Gene Expr"},{"key":"1717_CR36","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1073\/pnas.93.8.3492","volume":"93","author":"CB Verchere","year":"1996","unstructured":"Verchere CB, D\u2019Alessio DA, Palmiter RD et al (1996) Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. Proc Natl Acad Sci USA 93:3492\u20133496","journal-title":"Proc Natl Acad Sci USA"},{"key":"1717_CR37","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1101\/gad.12.6.806","volume":"12","author":"M Woo","year":"1998","unstructured":"Woo M, Hakem R, Soengas MS et al (1998) Essential contribution of caspase 3\/CPP32 to apoptosis and its associated nuclear changes. Genes Dev 12:806\u2013819","journal-title":"Genes Dev"},{"key":"1717_CR38","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/384368a0","volume":"384","author":"K Kuida","year":"1996","unstructured":"Kuida K, Zheng TS, Na S et al (1996) Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:368\u2013372","journal-title":"Nature"},{"key":"1717_CR39","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1128\/MCB.25.9.3620-3629.2005","volume":"25","author":"N Liadis","year":"2005","unstructured":"Liadis N, Murakami K, Eweida M et al (2005) Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus. Mol Cell Biol 25:3620\u20133629","journal-title":"Mol Cell Biol"},{"key":"1717_CR40","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/368756a0","volume":"368","author":"A Lorenzo","year":"1994","unstructured":"Lorenzo A, Razzaboni B, Weir GC, Yankner BA (1994) Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 368:756\u2013760","journal-title":"Nature"},{"key":"1717_CR41","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/cbir.2000.0643","volume":"25","author":"EL Saafi","year":"2001","unstructured":"Saafi EL, Konarkowska B, Zhang S, Kistler J, Cooper GJ (2001) Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet beta-cells. Cell Biol Int 25:339\u2013350","journal-title":"Cell Biol Int"},{"key":"1717_CR42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00125-008-1185-7","volume":"52","author":"J Udayasankar","year":"2009","unstructured":"Udayasankar J, Kodama K, Hull RL et al (2009) Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets. Diabetologia 52:145\u2013153","journal-title":"Diabetologia"},{"key":"1717_CR43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00549079","volume":"359","author":"P Westermark","year":"1973","unstructured":"Westermark P (1973) Fine structure of islets of Langerhans in insular amyloidosis. Virchows Arch A Pathol Anat 359:1\u201318","journal-title":"Virchows Arch A Pathol Anat"},{"key":"1717_CR44","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00125-006-0206-7","volume":"49","author":"JF Paulsson","year":"2006","unstructured":"Paulsson JF, Andersson A, Westermark P, Westermark GT (2006) Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets. Diabetologia 49:1237\u20131246","journal-title":"Diabetologia"},{"key":"1717_CR45","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/BF00400722","volume":"38","author":"P Westermark","year":"1995","unstructured":"Westermark P, Eizirik DL, Pipeleers DG, Hellerstrom C, Andersson A (1995) Rapid deposition of amyloid in human islets transplanted into nude mice. Diabetologia 38:543\u2013549","journal-title":"Diabetologia"},{"key":"1717_CR46","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2337\/db06-0734","volume":"56","author":"RA Ritzel","year":"2007","unstructured":"Ritzel RA, Meier JJ, Lin CY, Veldhuis JD, Butler PC (2007) Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets. Diabetes 56:65\u201371","journal-title":"Diabetes"},{"key":"1717_CR47","doi-asserted-by":"crossref","first-page":"12243","DOI":"10.1073\/pnas.91.25.12243","volume":"91","author":"A Lorenzo","year":"1994","unstructured":"Lorenzo A, Yankner BA (1994) Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci USA 91:12243\u201312247","journal-title":"Proc Natl Acad Sci USA"},{"key":"1717_CR48","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2337\/db07-0849","volume":"57","author":"S Zhang","year":"2007","unstructured":"Zhang S, Liu H, Yu H, Cooper GJ (2007) Fas-associated death receptor signaling evoked by human amylin in islet beta-cells. Diabetes 57:348\u2013356","journal-title":"Diabetes"},{"key":"1717_CR49","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bbrc.2006.12.187","volume":"354","author":"S Zraika","year":"2007","unstructured":"Zraika S, Hull RL, Udayasankar J et al (2007) Glucose- and time-dependence of islet amyloid formation in vitro. Biochem Biophys Res Commun 354:234\u2013239","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-010-1717-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-010-1717-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-010-1717-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T11:47:18Z","timestamp":1558612038000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-010-1717-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,6]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["1717"],"URL":"https:\/\/doi.org\/10.1007\/s00125-010-1717-9","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,6]]}}}