{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:46:40Z","timestamp":1791978400042,"version":"4.4.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T00:00:00Z","timestamp":1272412800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1007\/s00125-010-1733-9","type":"journal-article","created":{"date-parts":[[2010,4,27]],"date-time":"2010-04-27T13:52:07Z","timestamp":1272376327000},"page":"1656-1668","source":"Crossref","is-referenced-by-count":289,"title":["Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion"],"prefix":"10.1007","volume":"53","author":[{"given":"N.","family":"Wijesekara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. F.","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. R.","family":"Giglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Koshkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Chimienti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Y.","family":"Gaisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. A.","family":"Rutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. B.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,4,28]]},"reference":[{"key":"1733_CR1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05616","volume":"445","author":"R Sladek","year":"2007","unstructured":"Sladek R, Rocheleau G, Rung J et al (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881\u2013885","journal-title":"Nature"},{"key":"1733_CR2","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1126\/science.1142358","volume":"316","author":"R Saxena","year":"2007","unstructured":"Saxena R, Voight BF, Lyssenko V et al (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331\u20131336","journal-title":"Science"},{"key":"1733_CR3","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.1142382","volume":"316","author":"LJ Scott","year":"2007","unstructured":"Scott LJ, Mohlke KL, Bonnycastle LL et al (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341\u20131345","journal-title":"Science"},{"key":"1733_CR4","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.1142364","volume":"316","author":"E Zeggini","year":"2007","unstructured":"Zeggini E, Weedon MN, Lindgren CM et al (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336\u20131341","journal-title":"Science"},{"key":"1733_CR5","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/ng2043","volume":"39","author":"V Steinthorsdottir","year":"2007","unstructured":"Steinthorsdottir V, Thorleifsson G, Reynisdottir I et al (2007) A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39:770\u2013775","journal-title":"Nat Genet"},{"key":"1733_CR6","doi-asserted-by":"crossref","first-page":"17040","DOI":"10.1073\/pnas.0705894104","volume":"104","author":"JM Wenzlau","year":"2007","unstructured":"Wenzlau JM, Juhl K, Yu L et al (2007) The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA 104:17040\u201317045","journal-title":"Proc Natl Acad Sci USA"},{"key":"1733_CR7","doi-asserted-by":"crossref","first-page":"e832","DOI":"10.1371\/journal.pone.0000832","volume":"2","author":"H Staiger","year":"2007","unstructured":"Staiger H, Machicao F, Stefan N et al (2007) Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS One 2:e832","journal-title":"PLoS One"},{"key":"1733_CR8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00109-007-0295-x","volume":"86","author":"S Cauchi","year":"2008","unstructured":"Cauchi S, Proenca C, Choquet H et al (2008) Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. Study. J Mol Med 86:341\u2013348","journal-title":"J Mol Med"},{"key":"1733_CR9","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/BF00275265","volume":"19","author":"SO Emdin","year":"1980","unstructured":"Emdin SO, Dodson GG, Cutfield JM, Cutfield SM (1980) Role of zinc in insulin biosynthesis. Some possible zinc\u2013insulin interactions in the pancreatic B-cell. Diabetologia 19:174\u2013182","journal-title":"Diabetologia"},{"key":"1733_CR10","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.1242\/jcs.03164","volume":"119","author":"F Chimienti","year":"2006","unstructured":"Chimienti F, Devergnas S, Pattou F et al (2006) In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci 119:4199\u20134206","journal-title":"J Cell Sci"},{"key":"1733_CR11","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.2337\/diabetes.53.9.2330","volume":"53","author":"F Chimienti","year":"2004","unstructured":"Chimienti F, Devergnas S, Favier A, Seve M (2004) Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 53:2330\u20132337","journal-title":"Diabetes"},{"key":"1733_CR12","doi-asserted-by":"crossref","first-page":"14872","DOI":"10.1073\/pnas.0906587106","volume":"106","author":"K Lemaire","year":"2009","unstructured":"Lemaire K, Ravier MA, Schraenen A et al (2009) Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl Acad Sci USA 106:14872\u201314877","journal-title":"Proc Natl Acad Sci USA"},{"key":"1733_CR13","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.2337\/db09-0551","volume":"58","author":"TJ Nicolson","year":"2009","unstructured":"Nicolson TJ, Bellomo EA, Wijesekara N et al (2009) Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes 58:2070\u20132083","journal-title":"Diabetes"},{"key":"1733_CR14","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1042\/BJ20090530","volume":"421","author":"LD Pound","year":"2009","unstructured":"Pound LD, Sarkar SA, Benninger RK et al (2009) Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochem J 421:371\u2013376","journal-title":"Biochem J"},{"key":"1733_CR15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2164-5-32","volume":"5","author":"M Seve","year":"2004","unstructured":"Seve M, Chimienti F, Devergnas S, Favier A (2004) In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. BMC Genomics 5:32","journal-title":"BMC Genomics"},{"key":"1733_CR16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mce.2006.10.010","volume":"264","author":"K Smidt","year":"2007","unstructured":"Smidt K, Pedersen SB, Brock B et al (2007) Zinc-transporter genes in human visceral and subcutaneous adipocytes: lean versus obese. Mol Cell Endocrinol 264:68\u201373","journal-title":"Mol Cell Endocrinol"},{"key":"1733_CR17","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1189\/jlb.0307148","volume":"83","author":"S Overbeck","year":"2008","unstructured":"Overbeck S, Uciechowski P, Ackland ML, Ford D, Rink L (2008) Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. J Leukoc Biol 83:368\u2013380","journal-title":"J Leukoc Biol"},{"key":"1733_CR18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.numecd.2008.09.004","volume":"19","author":"C Murgia","year":"2009","unstructured":"Murgia C, Devirgiliis C, Mancini E, Donadel G, Zalewski P, Perozzi G (2009) Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands. Nutr Metab Cardiovasc Dis 19:431\u2013439","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"1733_CR19","doi-asserted-by":"crossref","first-page":"10184","DOI":"10.1074\/jbc.M707005200","volume":"283","author":"AV Gyulkhandanyan","year":"2008","unstructured":"Gyulkhandanyan AV, Lu H, Lee SC et al (2008) Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells. J Biol Chem 283:10184\u201310197","journal-title":"J Biol Chem"},{"key":"1733_CR20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2174\/157339910790442655","volume":"6","author":"L Egefjord","year":"2010","unstructured":"Egefjord L, Petersen AB, Rungby J (2010) Zinc, alpha cells and glucagon secretion. Current Diabetes Reviews 6:52\u201357","journal-title":"Current Diabetes Reviews"},{"issue":"Suppl 1","key":"1733_CR21","first-page":"501","volume":"51","author":"SC Souza","year":"2009","unstructured":"Souza SC, Qiu L, Inouye KE, Roix JJ, Chen H (2009) Zinc transporter ZnT-8 regulates insulin and glucagon seretion in Min6 and aTC1-9 pancreatic cell lines. Diabetologia 51(Suppl 1):501","journal-title":"Diabetologia"},{"key":"1733_CR22","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.2337\/db06-1454","volume":"56","author":"H Zhou","year":"2007","unstructured":"Zhou H, Zhang T, Harmon JS, Bryan J, Robertson RP (2007) Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo. Diabetes 56:1107\u20131112","journal-title":"Diabetes"},{"key":"1733_CR23","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.2337\/diabetes.54.6.1808","volume":"54","author":"I Franklin","year":"2005","unstructured":"Franklin I, Gromada J, Gjinovci A, Theander S, Wollheim CB (2005) Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes 54:1808\u20131815","journal-title":"Diabetes"},{"key":"1733_CR24","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ncb951","volume":"5","author":"H Ishihara","year":"2003","unstructured":"Ishihara H, Maechler P, Gjinovci A, Herrera PL, Wollheim CB (2003) Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol 5:330\u2013335","journal-title":"Nat Cell Biol"},{"key":"1733_CR25","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.2337\/diabetes.54.6.1789","volume":"54","author":"MA Ravier","year":"2005","unstructured":"Ravier MA, Rutter GA (2005) Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells. Diabetes 54:1789\u20131797","journal-title":"Diabetes"},{"key":"1733_CR26","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1128\/MCB.00238-06","volume":"26","author":"KT Nguyen","year":"2006","unstructured":"Nguyen KT, Tajmir P, Lin CH et al (2006) Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo. Mol Cell Biol 26:4511\u20134518","journal-title":"Mol Cell Biol"},{"key":"1733_CR27","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1016\/j.febslet.2007.07.068","volume":"581","author":"N Quoix","year":"2007","unstructured":"Quoix N, Cheng-Xue R, Guiot Y, Herrera PL, Henquin JC, Gilon P (2007) The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells. FEBS Lett 581:4235\u20134240","journal-title":"FEBS Lett"},{"key":"1733_CR28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1677\/JOE-09-0117","volume":"203","author":"SC Lee","year":"2009","unstructured":"Lee SC, Robson-Doucette CA, Wheeler MB (2009) Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin. J Endocrinol 203:33\u201343","journal-title":"J Endocrinol"},{"key":"1733_CR29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/01.tp.0000172216.47547.d5","volume":"80","author":"D O'Gorman","year":"2005","unstructured":"O'Gorman D, Kin T, Murdoch T et al (2005) The standardization of pancreatic donors for islet isolations. Transplantation 80:801\u2013806","journal-title":"Transplantation"},{"key":"1733_CR30","doi-asserted-by":"crossref","first-page":"30441","DOI":"10.1074\/jbc.M109.040659","volume":"284","author":"AB Hardy","year":"2009","unstructured":"Hardy AB, Fox JE, Giglou PR et al (2009) Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets. J Biol Chem 284:30441\u201330452","journal-title":"J Biol Chem"},{"key":"1733_CR31","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/jcp.21456","volume":"216","author":"P Tam","year":"2008","unstructured":"Tam P, Mahfoud R, Nutikka A et al (2008) Differential intracellular transport and binding of verotoxin 1 and verotoxin 2 to globotriaosylceramide-containing lipid assemblies. J Cell Physiol 216:750\u2013763","journal-title":"J Cell Physiol"},{"key":"1733_CR32","doi-asserted-by":"crossref","first-page":"16531","DOI":"10.1016\/S0021-9258(18)49288-5","volume":"262","author":"J Michael","year":"1987","unstructured":"Michael J, Carroll R, Swift HH, Steiner DF (1987) Studies on the molecular organization of rat insulin secretory granules. J Biol Chem 262:16531\u201316535","journal-title":"J Biol Chem"},{"key":"1733_CR33","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1074\/jbc.M508542200","volume":"281","author":"AV Gyulkhandanyan","year":"2006","unstructured":"Gyulkhandanyan AV, Lee SC, Bikopoulos G, Dai F, Wheeler MB (2006) The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channel. J Biol Chem 281:9361\u20139372","journal-title":"J Biol Chem"},{"key":"1733_CR34","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4161\/isl.1.2.9433","volume":"1","author":"M Tamaki","year":"2009","unstructured":"Tamaki M, Fujitani Y, Uchida T, Hirose T, Kawamori R, Watada H (2009) Downregulation of ZnT8 expression in pancreatic b-cells of diabetic mice. Islets 1:124\u2013128","journal-title":"Islets"},{"key":"1733_CR35","doi-asserted-by":"crossref","first-page":"e5679","DOI":"10.1371\/journal.pone.0005679","volume":"4","author":"Y Fu","year":"2009","unstructured":"Fu Y, Tian W, Pratt EB et al (2009) Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion. PLoS One 4:e5679","journal-title":"PLoS One"},{"key":"1733_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/isl.2.1.10259","volume":"2","author":"GA Rutter","year":"2010","unstructured":"Rutter GA (2010) Think zinc: new roles for zinc in the control of insulin secretion. Islets 2:1\u20132","journal-title":"Islets"},{"key":"1733_CR37","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1172\/JCI10842","volume":"106","author":"BB Kahn","year":"2000","unstructured":"Kahn BB, Flier JS (2000) Obesity and insulin resistance. J Clin Invest 106:473\u2013481","journal-title":"J Clin Invest"},{"key":"1733_CR38","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev.ph.37.030175.001333","volume":"37","author":"K Leung","year":"1975","unstructured":"Leung K, Munck A (1975) Peripheral actions of glucocorticoids. Annu Rev Physiol 37:245\u2013272","journal-title":"Annu Rev Physiol"},{"key":"1733_CR39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1210\/er.2006-0007","volume":"28","author":"J Gromada","year":"2007","unstructured":"Gromada J, Franklin I, Wollheim CB (2007) Alpha-cells of the endocrine pancreas: 35\u00a0years of research but the enigma remains. Endocr Rev 28:84\u2013116","journal-title":"Endocr Rev"},{"key":"1733_CR40","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0959-440X(98)80037-7","volume":"8","author":"G Dodson","year":"1998","unstructured":"Dodson G, Steiner D (1998) The role of assembly in insulin's biosynthesis. Curr Opin Struct Biol 8:189\u2013194","journal-title":"Curr Opin Struct Biol"},{"key":"1733_CR41","doi-asserted-by":"crossref","first-page":"49903","DOI":"10.1074\/jbc.M206796200","volume":"277","author":"K Kataoka","year":"2002","unstructured":"Kataoka K, Han SI, Shioda S, Hirai M, Nishizawa M, Handa H (2002) MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem 277:49903\u201349910","journal-title":"J Biol Chem"},{"key":"1733_CR42","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1002\/j.1460-2075.1993.tb06109.x","volume":"12","author":"H Ohlsson","year":"1993","unstructured":"Ohlsson H, Karlsson K, Edlund T (1993) IPF1, a homeodomain-containing transactivator of the insulin gene. Embo J 12:4251\u20134259","journal-title":"Embo J"},{"key":"1733_CR43","doi-asserted-by":"crossref","first-page":"19049","DOI":"10.1074\/jbc.M200910200","volume":"277","author":"T Kambe","year":"2002","unstructured":"Kambe T, Narita H, Yamaguchi-Iwai Y et al (2002) Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. J Biol Chem 277:19049\u201319055","journal-title":"J Biol Chem"},{"key":"1733_CR44","first-page":"94","volume":"22","author":"DF Steiner","year":"1996","unstructured":"Steiner DF, Rouille Y, Gong Q, Martin S, Carroll R, Chan SJ (1996) The role of prohormone convertases in insulin biosynthesis: evidence for inherited defects in their action in man and experimental animals. Diabetes Metab 22:94\u2013104","journal-title":"Diabetes Metab"},{"key":"1733_CR45","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/scdb.2000.0172","volume":"11","author":"KA Goodge","year":"2000","unstructured":"Goodge KA, Hutton JC (2000) Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell. Semin Cell Dev Biol 11:235\u2013242","journal-title":"Semin Cell Dev Biol"},{"key":"1733_CR46","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1074\/jbc.273.6.3431","volume":"273","author":"M Furuta","year":"1998","unstructured":"Furuta M, Carroll R, Martin S et al (1998) Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31, 32 proinsulin intermediates in islets of mice lacking active PC2. J Biol Chem 273:3431\u20133437","journal-title":"J Biol Chem"},{"key":"1733_CR47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ng0695-135","volume":"10","author":"JK Naggert","year":"1995","unstructured":"Naggert JK, Fricker LD, Varlamov O et al (1995) Hyperproinsulinaemia in obese fat\/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat Genet 10:135\u2013142","journal-title":"Nat Genet"},{"key":"1733_CR48","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1093\/nar\/gkp122","volume":"37","author":"Y Yang","year":"2009","unstructured":"Yang Y, Chang BH, Samson SL, Li MV, Chan L (2009) The Kruppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic Acids Res 37:2529\u20132538","journal-title":"Nucleic Acids Res"},{"key":"1733_CR49","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1210\/en.2005-1336","volume":"147","author":"K Eto","year":"2006","unstructured":"Eto K, Kaur V, Thomas MK (2006) Regulation of insulin gene transcription by the immediate-early growth response gene Egr-1. Endocrinology 147:2923\u20132935","journal-title":"Endocrinology"},{"key":"1733_CR50","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00125-008-0926-y","volume":"51","author":"K Kirchhoff","year":"2008","unstructured":"Kirchhoff K, Machicao F, Haupt A et al (2008) Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 51:597\u2013601","journal-title":"Diabetologia"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-010-1733-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-010-1733-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-010-1733-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T19:56:30Z","timestamp":1635278190000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-010-1733-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,28]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["1733"],"URL":"https:\/\/doi.org\/10.1007\/s00125-010-1733-9","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,28]]}}}