{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:58:19Z","timestamp":1791187099876,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T00:00:00Z","timestamp":1319587200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1007\/s00125-011-2338-7","type":"journal-article","created":{"date-parts":[[2011,10,25]],"date-time":"2011-10-25T08:59:19Z","timestamp":1319533159000},"page":"166-174","source":"Crossref","is-referenced-by-count":73,"title":["cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets"],"prefix":"10.1007","volume":"55","author":[{"given":"S. L.","family":"Subramanian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. L.","family":"Hull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zraika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Aston-Mourney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Udayasankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. E.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,10,26]]},"reference":[{"key":"2338_CR1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF01219652","volume":"15","author":"P Westermark","year":"1978","unstructured":"Westermark P, Wilander E (1978) The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus. Diabetologia 15:417\u2013421","journal-title":"Diabetologia"},{"key":"2338_CR2","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1210\/jc.2004-0405","volume":"89","author":"RL Hull","year":"2004","unstructured":"Hull RL, Westermark GT, Westermark P, Kahn SE (2004) Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes. J Clin Endocrinol Metab 89:3629\u20133643","journal-title":"J Clin Endocrinol Metab"},{"key":"2338_CR3","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1016\/j.ajpath.2011.02.036","volume":"178","author":"CA Jurgens","year":"2011","unstructured":"Jurgens CA, Toukatly MN, Fligner CL et al (2011) \u00df-cell loss and \u00df-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition. Am J Pathol 178:2632\u20132640","journal-title":"Am J Pathol"},{"key":"2338_CR4","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1073\/pnas.84.11.3881","volume":"84","author":"P Westermark","year":"1987","unstructured":"Westermark P, Wernstedt C, Wilander E, Hayden DW, O\u2019Brien TD, Johnson KH (1987) Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islets. Proc Natl Acad Sci USA 84:3881\u20133885","journal-title":"Proc Natl Acad Sci USA"},{"key":"2338_CR5","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1073\/pnas.84.23.8628","volume":"84","author":"GJS Cooper","year":"1987","unstructured":"Cooper GJS, Willis AC, Clark A, Turner RC, Sim RB, Reid KBM (1987) Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 84:8628\u20138632","journal-title":"Proc Natl Acad Sci USA"},{"key":"2338_CR6","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2337\/diabetes.39.5.634","volume":"39","author":"SE Kahn","year":"1990","unstructured":"Kahn SE, D\u2019Alessio DA, Schwartz MW et al (1990) Evidence of cosecretion of islet amyloid polypeptide and insulin by \u00df-cells. Diabetes 39:634\u2013638","journal-title":"Diabetes"},{"key":"2338_CR7","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1073\/pnas.87.13.5036","volume":"87","author":"P Westermark","year":"1990","unstructured":"Westermark P, Engstrom U, Johnson KH, Westermark GT, Betsholtz C (1990) Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation. Proc Natl Acad Sci USA 87:5036\u20135040","journal-title":"Proc Natl Acad Sci USA"},{"key":"2338_CR8","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/368756a0","volume":"368","author":"A Lorenzo","year":"1994","unstructured":"Lorenzo A, Razzaboni B, Weir GC, Yankner BA (1994) Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 368:756\u2013760","journal-title":"Nature"},{"key":"2338_CR9","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1074\/jbc.271.4.1988","volume":"271","author":"TA Mirzabekov","year":"1996","unstructured":"Mirzabekov TA, Lin MC, Kagan BL (1996) Pore formation by the cytotoxic islet amyloid peptide amylin. J Biol Chem 271:1988\u20131992","journal-title":"J Biol Chem"},{"key":"2338_CR10","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1006\/bbrc.1998.9574","volume":"251","author":"S Janciauskiene","year":"1998","unstructured":"Janciauskiene S, Ahren B (1998) Different sensitivity to the cytotoxic action of IAPP fibrils in two insulin-producing cell lines, HIT-T15 and RINm5F cells. Biochem Biophys Res Commun 251:888\u2013893","journal-title":"Biochem Biophys Res Commun"},{"key":"2338_CR11","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2337\/diabetes.48.3.491","volume":"48","author":"J Janson","year":"1999","unstructured":"Janson J, Ashley RH, Harrison D, McIntyre S, Butler PC (1999) The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes 48:491\u2013498","journal-title":"Diabetes"},{"key":"2338_CR12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0014-5793(99)00894-7","volume":"455","author":"S Zhang","year":"1999","unstructured":"Zhang S, Liu J, Saafi EL, Cooper GJ (1999) Induction of apoptosis by human amylin in RINm5F islet beta cells is associated with enhanced expression of p53 and p21WAF1\/CIP1. FEBS Lett 455:315\u2013320","journal-title":"FEBS Lett"},{"key":"2338_CR13","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0014-5793(01)02972-6","volume":"507","author":"TA Harroun","year":"2001","unstructured":"Harroun TA, Bradshaw JP, Ashley RH (2001) Inhibitors can arrest the membrane activity of human islet amyloid polypeptide independently of amyloid formation. FEBS Lett 507:200\u2013204","journal-title":"FEBS Lett"},{"key":"2338_CR14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s125-002-8248-z","volume":"45","author":"H Sakuraba","year":"2002","unstructured":"Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S (2002) Reduced beta cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients. Diabetologia 45:85\u201396","journal-title":"Diabetologia"},{"key":"2338_CR15","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s00125-008-1255-x","volume":"52","author":"S Zraika","year":"2009","unstructured":"Zraika S, Hull RL, Udayasankar J et al (2009) Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis. Diabetologia 52:626\u2013635","journal-title":"Diabetologia"},{"key":"2338_CR16","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s00125-006-0590-z","volume":"50","author":"DR Laybutt","year":"2007","unstructured":"Laybutt DR, Preston AM, Akerfeldt MC et al (2007) Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 50:752\u2013763","journal-title":"Diabetologia"},{"key":"2338_CR17","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1007\/s00125-009-1329-4","volume":"52","author":"RL Hull","year":"2009","unstructured":"Hull RL, Zraika S, Udayasankar J, Aston-Mourney K, Subramanian SL, Kahn SE (2009) Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress. Diabetologia 52:1102\u20131111","journal-title":"Diabetologia"},{"key":"2338_CR18","doi-asserted-by":"crossref","first-page":"E1656","DOI":"10.1152\/ajpendo.00318.2007","volume":"293","author":"CJ Huang","year":"2007","unstructured":"Huang CJ, Haataja L, Gurlo T et al (2007) Induction of endoplasmic reticulum stress-induced beta cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. Am J Physiol Endocrinol Metab 293:E1656\u2013E1662","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2338_CR19","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.2337\/db07-0197","volume":"56","author":"CJ Huang","year":"2007","unstructured":"Huang CJ, Lin CY, Haataja L et al (2007) High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes. Diabetes 56:2016\u20132027","journal-title":"Diabetes"},{"key":"2338_CR20","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1096\/fj.07-101824","volume":"22","author":"K Maedler","year":"2008","unstructured":"Maedler K, Schulthess FT, Bielman C et al (2008) Glucose and leptin induce apoptosis in human beta cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases. FASEB J 22:1905\u20131913","journal-title":"FASEB J"},{"key":"2338_CR21","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1242\/jcs.026062","volume":"121","author":"DA Cunha","year":"2008","unstructured":"Cunha DA, Hekerman P, Ladriere L et al (2008) Initiation and execution of lipotoxic ER stress in pancreatic beta cells. J Cell Sci 121:2308\u20132318","journal-title":"J Cell Sci"},{"key":"2338_CR22","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.2337\/diabetes.49.9.1468","volume":"49","author":"A Ammendrup","year":"2000","unstructured":"Ammendrup A, Maillard A, Nielsen K et al (2000) The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta cells. Diabetes 49:1468\u20131476","journal-title":"Diabetes"},{"key":"2338_CR23","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.2337\/diabetes.50.12.2721","volume":"50","author":"CD Major","year":"2001","unstructured":"Major CD, Wolf BA (2001) Interleukin-1beta stimulation of c-Jun NH(2)-terminal kinase activity in insulin-secreting cells: evidence for cytoplasmic restriction. Diabetes 50:2721\u20132728","journal-title":"Diabetes"},{"key":"2338_CR24","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00109-005-0640-x","volume":"83","author":"H Kaneto","year":"2005","unstructured":"Kaneto H, Matsuoka TA, Nakatani Y et al (2005) Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes. J Mol Med (Berl) 83:429\u2013439","journal-title":"J Mol Med (Berl)"},{"key":"2338_CR25","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0022-2836(02)01044-6","volume":"324","author":"S Zhang","year":"2002","unstructured":"Zhang S, Liu J, MacGibbon G, Dragunow M, Cooper GJ (2002) Increased expression and activation of c-Jun contributes to human amylin-induced apoptosis in pancreatic islet beta cells. J Mol Biol 324:271\u2013285","journal-title":"J Mol Biol"},{"key":"2338_CR26","doi-asserted-by":"crossref","first-page":"52810","DOI":"10.1074\/jbc.M308244200","volume":"278","author":"S Zhang","year":"2003","unstructured":"Zhang S, Liu J, Dragunow M, Cooper GJ (2003) Fibrillogenic amylin evokes islet \u00df-cell apoptosis through linked activation of a caspase cascade and JNK1. J Biol Chem 278:52810\u201352819","journal-title":"J Biol Chem"},{"key":"2338_CR27","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.biocel.2009.01.002","volume":"41","author":"XL Li","year":"2009","unstructured":"Li XL, Xu G, Chen T et al (2009) Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways. Int J Biochem Cell Biol 41:1526\u20131535","journal-title":"Int J Biochem Cell Biol"},{"key":"2338_CR28","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2337\/db07-0849","volume":"57","author":"S Zhang","year":"2008","unstructured":"Zhang S, Liu H, Yu H, Cooper GJ (2008) Fas-associated death receptor signaling evoked by human amylin in islet beta cells. Diabetes 57:348\u2013356","journal-title":"Diabetes"},{"key":"2338_CR29","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.2337\/db09-0732","volume":"58","author":"HE Thomas","year":"2009","unstructured":"Thomas HE, Biden TJ (2009) Bad news for beta cell apoptosis. Diabetes 58:1725\u20131727","journal-title":"Diabetes"},{"key":"2338_CR30","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00125-009-1431-7","volume":"52","author":"S Abdelli","year":"2009","unstructured":"Abdelli S, Puyal J, Bielmann C et al (2009) JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis. Diabetologia 52:1871\u20131880","journal-title":"Diabetologia"},{"key":"2338_CR31","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.2337\/diabetes.43.12.1457","volume":"43","author":"DA D\u2019Alessio","year":"1994","unstructured":"D\u2019Alessio DA, Verchere CB, Kahn SE et al (1994) Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse. Diabetes 43:1457\u20131461","journal-title":"Diabetes"},{"key":"2338_CR32","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.2337\/diabetes.49.12.2056","volume":"49","author":"S Andrikopoulos","year":"2000","unstructured":"Andrikopoulos S, Verchere CB, Terauchi K, Kadowaki T, Kahn SE (2000) \u00df-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes. Diabetes 49:2056\u20132062","journal-title":"Diabetes"},{"key":"2338_CR33","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bbrc.2006.12.187","volume":"354","author":"S Zraika","year":"2007","unstructured":"Zraika S, Hull RL, Udayasankar J et al (2007) Glucose- and time-dependence of islet amyloid formation in vitro. Biochem Biophys Res Commun 354:234\u2013239","journal-title":"Biochem Biophys Res Commun"},{"key":"2338_CR34","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2337\/diabetes.50.1.77","volume":"50","author":"C Bonny","year":"2001","unstructured":"Bonny C, Oberson A, Negri S, Sauser C, Schorderet DF (2001) Cell-permeable peptide inhibitors of JNK: novel blockers of beta cell death. Diabetes 50:77\u201382","journal-title":"Diabetes"},{"key":"2338_CR35","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1172\/JCI200215318","volume":"110","author":"K Maedler","year":"2002","unstructured":"Maedler K, Sergeev P, Ris F et al (2002) Glucose-induced \u00df cell production of IL-1\u00df contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110:851\u2013860","journal-title":"J Clin Invest"},{"key":"2338_CR36","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ni.1935","volume":"11","author":"SL Masters","year":"2010","unstructured":"Masters SL, Dunne A, Subramanian SL et al (2010) Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat Immunol 11:897\u2013904","journal-title":"Nat Immunol"},{"key":"2338_CR37","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.2337\/diabetes.53.11.2815","volume":"53","author":"S Abdelli","year":"2004","unstructured":"Abdelli S, Ansite J, Roduit R et al (2004) Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure. Diabetes 53:2815\u20132823","journal-title":"Diabetes"},{"key":"2338_CR38","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s00125-010-1717-9","volume":"53","author":"E Law","year":"2010","unstructured":"Law E, Lu S, Kieffer TJ et al (2010) Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3. Diabetologia 53:1415\u20131427","journal-title":"Diabetologia"},{"key":"2338_CR39","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrn1477","volume":"5","author":"SC Benn","year":"2004","unstructured":"Benn SC, Woolf CJ (2004) Adult neuron survival strategies\u2014slamming on the brakes. Nat Rev Neurosci 5:686\u2013700","journal-title":"Nat Rev Neurosci"},{"key":"2338_CR40","doi-asserted-by":"crossref","first-page":"644","DOI":"10.2337\/db09-1151","volume":"59","author":"MD McKenzie","year":"2010","unstructured":"McKenzie MD, Jamieson E, Jansen ES et al (2010) Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes 59:644\u2013652","journal-title":"Diabetes"},{"key":"2338_CR41","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s10495-009-0339-5","volume":"14","author":"HE Thomas","year":"2009","unstructured":"Thomas HE, McKenzie MD, Angstetra E, Campbell PD, Kay TW (2009) Beta cell apoptosis in diabetes. Apoptosis 14:1389\u20131404","journal-title":"Apoptosis"},{"key":"2338_CR42","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.mce.2010.09.017","volume":"332","author":"I Mehmeti","year":"2010","unstructured":"Mehmeti I, Lenzen S, Lortz S (2010) Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status. Mol Cell Endocrinol 332:88\u201396","journal-title":"Mol Cell Endocrinol"},{"key":"2338_CR43","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.biocel.2010.12.008","volume":"43","author":"XL Li","year":"2011","unstructured":"Li XL, Chen T, Wong YS et al (2011) Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: an effect attenuated by phycocyanin. Int J Biochem Cell Biol 43:525\u2013534","journal-title":"Int J Biochem Cell Biol"},{"key":"2338_CR44","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1007\/s00125-009-1331-x","volume":"52","author":"SA Sarkar","year":"2009","unstructured":"Sarkar SA, Kutlu B, Velmurugan K et al (2009) Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line. Diabetologia 52:1092\u20131101","journal-title":"Diabetologia"},{"key":"2338_CR45","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3727\/096368908786991524","volume":"17","author":"S Rodriguez-Mulero","year":"2008","unstructured":"Rodriguez-Mulero S, Montanya E (2008) Islet graft response to transplantation injury includes upregulation of protective as well as apoptotic genes. Cell Transplant 17:1025\u20131034","journal-title":"Cell Transplant"},{"key":"2338_CR46","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/sj.cr.7290262","volume":"15","author":"J Liu","year":"2005","unstructured":"Liu J, Lin A (2005) Role of JNK activation in apoptosis: a double-edged sword. Cell Res 15:36\u201342","journal-title":"Cell Res"},{"key":"2338_CR47","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature09873","volume":"472","author":"S Alavez","year":"2011","unstructured":"Alavez S, Vantipalli MC, Zucker DJ, Klang IM, Lithgow GJ (2011) Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature 472:226\u2013229","journal-title":"Nature"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-011-2338-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-011-2338-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-011-2338-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T11:49:35Z","timestamp":1558612175000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-011-2338-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,26]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["2338"],"URL":"https:\/\/doi.org\/10.1007\/s00125-011-2338-7","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,26]]}}}