{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:18:19Z","timestamp":1790900299062,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T00:00:00Z","timestamp":1321574400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1007\/s00125-011-2366-3","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T11:42:10Z","timestamp":1321530130000},"page":"1469-1481","source":"Crossref","is-referenced-by-count":87,"title":["Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob\/ob mice"],"prefix":"10.1007","volume":"55","author":[{"given":"S.-L.","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.-T.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-L.","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-H.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-D.","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,11,18]]},"reference":[{"key":"2366_CR1","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.2337\/diab.30.12.1000","volume":"30","author":"RA DeFronzo","year":"1981","unstructured":"DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP (1981) The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30:1000\u20131007","journal-title":"Diabetes"},{"key":"2366_CR2","doi-asserted-by":"crossref","first-page":"16113","DOI":"10.1016\/S0021-9258(19)85395-4","volume":"268","author":"JM Ren","year":"1993","unstructured":"Ren JM, Marshall BA, Gulve EA et al (1993) Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle. J Biol Chem 268:16113\u201316115","journal-title":"J Biol Chem"},{"key":"2366_CR3","doi-asserted-by":"crossref","first-page":"5413","DOI":"10.1182\/blood-2010-11-317115","volume":"117","author":"CA Hansell","year":"2011","unstructured":"Hansell CA, Schiering C, Kinstrie R et al (2011) Universal expression and dual function of the atypical chemokine receptor D6 on innate-like B cells in mice. Blood 117:5413\u20135424","journal-title":"Blood"},{"key":"2366_CR4","doi-asserted-by":"crossref","first-page":"E1130","DOI":"10.1152\/ajpcell.1999.277.6.C1130","volume":"277","author":"DE Kelley","year":"1999","unstructured":"Kelley DE, Goodpaster B, Wing RR, Simoneau JA (1999) Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol 277:E1130\u2013E1141","journal-title":"Am J Physiol"},{"key":"2366_CR5","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.2337\/diabetes.53.6.1436","volume":"53","author":"Y Leng","year":"2004","unstructured":"Leng Y, Steiler TL, Zierath JR (2004) Effects of insulin, contraction, and phorbol esters on mitogen-activated protein kinase signaling in skeletal muscle from lean and ob\/ob mice. Diabetes 53:1436\u20131444","journal-title":"Diabetes"},{"key":"2366_CR6","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s001250051457","volume":"43","author":"JR Zierath","year":"2000","unstructured":"Zierath JR, Krook A, Wallberg-Henriksson H (2000) Insulin action and insulin resistance in human skeletal muscle. Diabetologia 43:821\u2013835","journal-title":"Diabetologia"},{"key":"2366_CR7","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI29044","volume":"116","author":"YC Long","year":"2006","unstructured":"Long YC, Zierath JR (2006) AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116:1776\u20131783","journal-title":"J Clin Invest"},{"key":"2366_CR8","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1152\/jappl.2001.91.3.1017","volume":"91","author":"WW Winder","year":"2001","unstructured":"Winder WW (2001) Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle. J Appl Physiol 91:1017\u20131028","journal-title":"J Appl Physiol"},{"key":"2366_CR9","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2337\/diabetes.52.5.1066","volume":"52","author":"HA Koistinen","year":"2003","unstructured":"Koistinen HA, Galuska D, Chibalin AV et al (2003) 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes 52:1066\u20131072","journal-title":"Diabetes"},{"key":"2366_CR10","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1073\/pnas.0308061100","volume":"101","author":"RJ Shaw","year":"2004","unstructured":"Shaw RJ, Kosmatka M, Bardeesy N et al (2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A 101:3329\u20133335","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2366_CR11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cmet.2005.06.005","volume":"2","author":"A Woods","year":"2005","unstructured":"Woods A, Dickerson K, Heath R et al (2005) Ca2+\/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab 2:21\u201333","journal-title":"Cell Metab"},{"key":"2366_CR12","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/01.RES.0000256090.42690.05","volume":"100","author":"MC Towler","year":"2007","unstructured":"Towler MC, Hardie DG (2007) AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 100:328\u2013341","journal-title":"Circ Res"},{"key":"2366_CR13","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.2741\/3460","volume":"14","author":"B Viollet","year":"2009","unstructured":"Viollet B, Lantier L, Devin-Leclerc J et al (2009) Targeting the AMPK pathway for the treatment of type 2 diabetes. Front Biosci 14:3380\u20133400","journal-title":"Front Biosci"},{"key":"2366_CR14","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.2337\/diabetes.51.7.2074","volume":"51","author":"N Musi","year":"2002","unstructured":"Musi N, Hirshman MF, Nygren J et al (2002) Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes 51:2074\u20132081","journal-title":"Diabetes"},{"key":"2366_CR15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cmet.2006.05.005","volume":"3","author":"B Cool","year":"2006","unstructured":"Cool B, Zinker B, Chiou W et al (2006) Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab 3:403\u2013416","journal-title":"Cell Metab"},{"key":"2366_CR16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1021\/np068054v","volume":"70","author":"DJ Newman","year":"2007","unstructured":"Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25\u00a0years. J Nat Prod 70:461\u2013477","journal-title":"J Nat Prod"},{"key":"2366_CR17","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.2337\/db06-0006","volume":"55","author":"YS Lee","year":"2006","unstructured":"Lee YS, Kim WS, Kim KH et al (2006) Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 55:2256\u20132264","journal-title":"Diabetes"},{"key":"2366_CR18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature05354","volume":"444","author":"JA Baur","year":"2006","unstructured":"Baur JA, Pearson KJ, Price NL et al (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337\u2013342","journal-title":"Nature"},{"key":"2366_CR19","doi-asserted-by":"crossref","first-page":"30143","DOI":"10.1074\/jbc.M702390200","volume":"282","author":"QF Collins","year":"2007","unstructured":"Collins QF, Liu HY, Pi J, Liu Z, Quon MJ, Cao W (2007) Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5\u2032-AMP-activated protein kinase. J Biol Chem 282:30143\u201330149","journal-title":"J Biol Chem"},{"key":"2366_CR20","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nbt1387","volume":"26","author":"BK Wagner","year":"2008","unstructured":"Wagner BK, Kitami T, Gilbert TJ et al (2008) Large-scale chemical dissection of mitochondrial function. Nat Biotechnol 26:343\u2013351","journal-title":"Nat Biotechnol"},{"key":"2366_CR21","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/db07-1552","volume":"57","author":"N Turner","year":"2008","unstructured":"Turner N, Li JY, Gosby A et al (2008) Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes 57:1414\u20131418","journal-title":"Diabetes"},{"key":"2366_CR22","doi-asserted-by":"crossref","first-page":"43940","DOI":"10.1074\/jbc.M404421200","volume":"279","author":"MH Zou","year":"2004","unstructured":"Zou MH, Kirkpatrick SS, Davis BJ et al (2004) Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species. J Biol Chem 279:43940\u201343951","journal-title":"J Biol Chem"},{"key":"2366_CR23","doi-asserted-by":"crossref","first-page":"25226","DOI":"10.1074\/jbc.M202489200","volume":"277","author":"LG Fryer","year":"2002","unstructured":"Fryer LG, Parbu-Patel A, Carling D (2002) The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 277:25226\u201325232","journal-title":"J Biol Chem"},{"key":"2366_CR24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jep.2009.01.038","volume":"122","author":"F Zhao","year":"2009","unstructured":"Zhao F, Wang L, Liu K (2009) In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway. J Ethnopharmacol 122:457\u2013462","journal-title":"J Ethnopharmacol"},{"key":"2366_CR25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-0030-1250179","volume":"77","author":"S Sun","year":"2011","unstructured":"Sun S, Wang X, Wang C et al (2011) Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells. Planta Med 77:141\u2013145","journal-title":"Planta Med"},{"key":"2366_CR26","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","volume":"140","author":"GS Hotamisligil","year":"2010","unstructured":"Hotamisligil GS (2010) Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140:900\u2013917","journal-title":"Cell"},{"key":"2366_CR27","doi-asserted-by":"crossref","first-page":"E695","DOI":"10.1152\/ajpendo.00038.2010","volume":"299","author":"L Deldicque","year":"2010","unstructured":"Deldicque L, Cani PD, Philp A et al (2010) The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis. Am J Physiol Endocrinol Metab 299:E695\u2013E705","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2366_CR28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2337\/db09-0755","volume":"59","author":"R Ye","year":"2010","unstructured":"Ye R, Jung DY, Jun JY et al (2010) Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes 59:6\u201316","journal-title":"Diabetes"},{"key":"2366_CR29","doi-asserted-by":"crossref","first-page":"E938","DOI":"10.1152\/ajpcell.1999.276.4.C938","volume":"276","author":"R Bergeron","year":"1999","unstructured":"Bergeron R, Russell RR 3rd, Young LH et al (1999) Effect of AMPK activation on muscle glucose metabolism in conscious rats. Am J Physiol 276:E938\u2013E944","journal-title":"Am J Physiol"},{"key":"2366_CR30","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.1210\/en.2003-0982","volume":"144","author":"DG Hardie","year":"2003","unstructured":"Hardie DG (2003) Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 144:5179\u20135183","journal-title":"Endocrinology"},{"key":"2366_CR31","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0026-0495(89)90129-7","volume":"38","author":"RA DeFronzo","year":"1989","unstructured":"DeFronzo RA, Ferrannini E, Simonson DC (1989) Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism 38:387\u2013395","journal-title":"Metabolism"},{"key":"2366_CR32","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature03047","volume":"432","author":"C Wolfrum","year":"2004","unstructured":"Wolfrum C, Asilmaz E, Luca E, Friedman JM, Stoffel M (2004) Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature 432:1027\u20131032","journal-title":"Nature"},{"key":"2366_CR33","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","volume":"108","author":"G Zhou","year":"2001","unstructured":"Zhou G, Myers R, Li Y et al (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167\u20131174","journal-title":"J Clin Invest"},{"key":"2366_CR34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1042\/BJ20061520","volume":"403","author":"MJ Sanders","year":"2007","unstructured":"Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D (2007) Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J 403:139\u2013148","journal-title":"Biochem J"},{"key":"2366_CR35","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1007\/s00125-010-1729-5","volume":"53","author":"Y Fujita","year":"2010","unstructured":"Fujita Y, Hosokawa M, Fujimoto S et al (2010) Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice. Diabetologia 53:1472\u20131481","journal-title":"Diabetologia"},{"key":"2366_CR36","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2337\/diabetes.49.4.527","volume":"49","author":"T Hayashi","year":"2000","unstructured":"Hayashi T, Hirshman MF, Fujii N, Habinowski SA, Witters LA, Goodyear LJ (2000) Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism. Diabetes 49:527\u2013531","journal-title":"Diabetes"},{"key":"2366_CR37","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1021\/ac0484631","volume":"77","author":"T Kosaka","year":"2005","unstructured":"Kosaka T, Okuyama R, Sun W et al (2005) Identification of molecular target of AMP-activated protein kinase activator by affinity purification and mass spectrometry. Anal Chem 77:2050\u20132055","journal-title":"Anal Chem"},{"key":"2366_CR38","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1007\/s00125-005-1713-7","volume":"48","author":"D Konrad","year":"2005","unstructured":"Konrad D, Rudich A, Bilan PJ et al (2005) Troglitazone causes acute mitochondrial membrane depolarisation and an AMPK-mediated increase in glucose phosphorylation in muscle cells. Diabetologia 48:954\u2013966","journal-title":"Diabetologia"},{"key":"2366_CR39","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.cellsig.2007.02.006","volume":"19","author":"DS Hutchinson","year":"2007","unstructured":"Hutchinson DS, Csikasz RI, Yamamoto DL et al (2007) Diphenylene iodonium stimulates glucose uptake in skeletal muscle cells through mitochondrial complex I inhibition and activation of AMP-activated protein kinase. Cell Signal 19:1610\u20131620","journal-title":"Cell Signal"},{"key":"2366_CR40","doi-asserted-by":"crossref","first-page":"14681","DOI":"10.1073\/pnas.95.25.14681","volume":"95","author":"M Narita","year":"1998","unstructured":"Narita M, Shimizu S, Ito T et al (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci U S A 95:14681\u201314686","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2366_CR41","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1467-789X.2001.00043.x","volume":"2","author":"JA Harper","year":"2001","unstructured":"Harper JA, Dickinson K, Brand MD (2001) Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obes Rev 2:255\u2013265","journal-title":"Obes Rev"},{"key":"2366_CR42","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.2337\/diabetes.53.4.1052","volume":"53","author":"B Brunmair","year":"2004","unstructured":"Brunmair B, Staniek K, Gras F et al (2004) Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? Diabetes 53:1052\u20131059","journal-title":"Diabetes"},{"key":"2366_CR43","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1042\/0264-6021:3480607","volume":"348","author":"MR Owen","year":"2000","unstructured":"Owen MR, Doran E, Halestrap AP (2000) Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 348:607\u2013614","journal-title":"Biochem J"},{"key":"2366_CR44","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cell.2008.06.051","volume":"134","author":"VA Narkar","year":"2008","unstructured":"Narkar VA, Downes M, Yu RT et al (2008) AMPK and PPARdelta agonists are exercise mimetics. Cell 134:405\u2013415","journal-title":"Cell"},{"key":"2366_CR45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1748-1716.2009.01970.x","volume":"196","author":"B Viollet","year":"2009","unstructured":"Viollet B, Guigas B, Leclerc J et al (2009) AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol (Oxf) 196:81\u201398","journal-title":"Acta Physiol (Oxf)"},{"key":"2366_CR46","first-page":"E299","volume":"270","author":"WW Winder","year":"1996","unstructured":"Winder WW, Hardie DG (1996) Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am J Physiol 270:E299\u2013E304","journal-title":"Am J Physiol"},{"key":"2366_CR47","doi-asserted-by":"crossref","first-page":"983","DOI":"10.2337\/diabetes.46.6.983","volume":"46","author":"DA Pan","year":"1997","unstructured":"Pan DA, Lillioja S, Kriketos AD et al (1997) Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46:983\u2013988","journal-title":"Diabetes"},{"key":"2366_CR48","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.2337\/diabetes.46.12.2022","volume":"46","author":"ND Oakes","year":"1997","unstructured":"Oakes ND, Bell KS, Furler SM et al (1997) Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA. Diabetes 46:2022\u20132028","journal-title":"Diabetes"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-011-2366-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-011-2366-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-011-2366-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T19:30:58Z","timestamp":1639683058000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-011-2366-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,18]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["2366"],"URL":"https:\/\/doi.org\/10.1007\/s00125-011-2366-3","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,18]]}}}