{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:07:59Z","timestamp":1792642079786,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T00:00:00Z","timestamp":1330473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1007\/s00125-012-2495-3","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T06:59:28Z","timestamp":1330412368000},"page":"1544-1553","source":"Crossref","is-referenced-by-count":143,"title":["Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db\/db mouse model of type 2 diabetes"],"prefix":"10.1007","volume":"55","author":[{"given":"K.","family":"Huynh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kiriazis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.-J.","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Love","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"Jandeleit-Dahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"McMullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. H.","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,2,29]]},"reference":[{"issue":"1","key":"2495_CR1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","volume":"87","author":"JE Shaw","year":"2010","unstructured":"Shaw JE, Sicree RA, Zimmet PZ (2010) Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 87(1):4\u201314","journal-title":"Diabetes Res Clin Pract"},{"key":"2495_CR2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1210\/er.2003-0012","volume":"25","author":"ZY Fang","year":"2004","unstructured":"Fang ZY, Prins JB, Marwick TH (2004) Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications. Endocr Rev 25:543\u2013567","journal-title":"Endocr Rev"},{"key":"2495_CR3","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0002-9149(72)90595-4","volume":"30","author":"S Rubler","year":"1972","unstructured":"Rubler S, Yuceoglu YZ, Kumral T, Grishman A, Branwood AW, Dlugash J (1972) New type of cardiomyopathy associated with diabetic glomerulosclerosis. Am J Cardiol 30:595\u2013602","journal-title":"Am J Cardiol"},{"key":"2495_CR4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000064682","volume":"98","author":"CM Schannwell","year":"2002","unstructured":"Schannwell CM, Schneppenheim M, Perings S, Plehn G, Strauer BE (2002) Left ventricular diastolic dysfunction as an early manifestation of diabetic cardiomyopathy. Cardiology 98:33\u201339","journal-title":"Cardiology"},{"key":"2495_CR5","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jacc.2005.09.050","volume":"47","author":"J Asbun","year":"2006","unstructured":"Asbun J, Villarreal FJ (2006) The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy. J Am Coll Cardiol 47:693\u2013700","journal-title":"J Am Coll Cardiol"},{"key":"2495_CR6","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/er.2001-0039","volume":"23","author":"JL Evans","year":"2002","unstructured":"Evans JL, Goldfine ID, Maddux BA, Grodsky GM (2002) Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23:599\u2013622","journal-title":"Endocr Rev"},{"key":"2495_CR7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2174\/157016106777698469","volume":"4","author":"MA Haidara","year":"2006","unstructured":"Haidara MA, Yaseen HZ, Rateb M, Ammar H, Zorkani MA (2006) Role of oxidative stress in development of cardiovascular complications in diabetes mellitus. Curr Vasc Pharmacol 4:215\u2013227","journal-title":"Curr Vasc Pharmacol"},{"key":"2495_CR8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jbt.10058","volume":"17","author":"AC Maritim","year":"2003","unstructured":"Maritim AC, Sanders RA, Watkins JB (2003) Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 17:24\u201338","journal-title":"J Biochem Mol Toxicol"},{"key":"2495_CR9","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.yjmcc.2004.07.008","volume":"37","author":"F Fiordaliso","year":"2004","unstructured":"Fiordaliso F, Bianchi R, Staszewsky L et al (2004) Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats. J Mol Cell Cardiol 37:959\u2013968","journal-title":"J Mol Cell Cardiol"},{"key":"2495_CR10","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.yjmcc.2007.03.900","volume":"42","author":"RH Ritchie","year":"2007","unstructured":"Ritchie RH, Quinn JM, Cao AH et al (2007) The antioxidant tempol inhibits cardiac hypertrophy in the insulin-resistant GLUT4-deficient mouse in vivo. J Mol Cell Cardiol 42:1119\u20131128","journal-title":"J Mol Cell Cardiol"},{"key":"2495_CR11","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.freeradbiomed.2006.06.007","volume":"41","author":"L Cai","year":"2006","unstructured":"Cai L (2006) Suppression of nitrative damage by metallothionein in diabetic heart contributes to the prevention of cardiomyopathy. Free Radic Biol Med 41:851\u2013861","journal-title":"Free Radic Biol Med"},{"key":"2495_CR12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/1099-0461(2001)15:1<41::AID-JBT5>3.0.CO;2-Z","volume":"15","author":"FM Rauscher","year":"2001","unstructured":"Rauscher FM, Sanders RA, Watkins JB (2001) Effects of coenzyme Q10 treatment on antioxidant pathways in normal and streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 15:41\u201346","journal-title":"J Biochem Mol Toxicol"},{"key":"2495_CR13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/jbt.10035","volume":"16","author":"AD Coldiron","year":"2002","unstructured":"Coldiron AD, Sanders RA, Watkins JB (2002) Effects of combined quercetin and coenzyme Q(10) treatment on oxidative stress in normal and diabetic rats. J Biochem Mol Toxicol 16:197\u2013202","journal-title":"J Biochem Mol Toxicol"},{"key":"2495_CR14","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1016\/S0098-2997(97)00006-X","volume":"18","author":"PH Langsjoen","year":"1997","unstructured":"Langsjoen PH, Langsjoen A, Willis R, Folkers K (1997) Treatment of hypertrophic cardiomyopathy with coenzyme Q(10). Mol Asp Med 18:S145\u2013S151","journal-title":"Mol Asp Med"},{"key":"2495_CR15","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.amjcard.2004.07.121","volume":"94","author":"MA Silver","year":"2004","unstructured":"Silver MA, Langsjoen PH, Szabo S, Patil H, Zelinger A (2004) Effect of atorvastatin on left ventricular, diastolic function and ability of coenzyme Q(10) to reverse that dysfunction. Am J Cardiol 94:1306\u20131310","journal-title":"Am J Cardiol"},{"key":"2495_CR16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.cardfail.2006.03.007","volume":"12","author":"S Sander","year":"2006","unstructured":"Sander S, Coleman CI, Patel AA, Kluger J, White CM (2006) The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. J Card Fail 12:464\u2013472","journal-title":"J Card Fail"},{"key":"2495_CR17","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.freeradbiomed.2011.11.017","volume":"52","author":"KC Sourris","year":"2012","unstructured":"Sourris KC, Harcourt BE, Tang PH et al (2012) Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes. Free Radic Biol Med 52:716\u2013723","journal-title":"Free Radic Biol Med"},{"key":"2495_CR18","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1111\/j.1523-1755.2004.00600.x","volume":"65","author":"SR Dunn","year":"2004","unstructured":"Dunn SR, Qi ZH, Bottinger EP, Breyer MD, Sharma K (2004) Utility of endogenous creatinine clearance as a measure of renal function in mice. Kidney Int 65:1959\u20131967","journal-title":"Kidney Int"},{"key":"2495_CR19","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.2337\/db09-1456","volume":"59","author":"K Huynh","year":"2010","unstructured":"Huynh K, McMullen JR, Julius T et al (2010) Cardiac-specific insulin-like growth factor 1 receptor transgenic expression protects against cardiac fibrosis and diastolic dysfunction in a mouse model of diabetic cardiomyopathy. Diabetes 59:1512\u20131520","journal-title":"Diabetes"},{"key":"2495_CR20","doi-asserted-by":"crossref","first-page":"H2313","DOI":"10.1152\/ajpheart.2001.280.5.H2313","volume":"280","author":"ZY Chen","year":"2001","unstructured":"Chen ZY, Chua CC, Ho YS, Hamdy RC, Chua BHL (2001) Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I\/R injury in transgenic mice. Am J Physiol-Heart Circul Physiol 280:H2313\u2013H2320","journal-title":"Am J Physiol-Heart Circul Physiol"},{"key":"2495_CR21","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.2337\/diabetes.52.9.2389","volume":"52","author":"AC Rosenkranz","year":"2003","unstructured":"Rosenkranz AC, Hood SG, Woods RL, Dusting GJ, Ritchie RH (2003) B-type natriuretic peptide prevents acute hypertrophic responses in the diabetic rat heart\u2014importance of cyclic GMP. Diabetes 52:2389\u20132395","journal-title":"Diabetes"},{"key":"2495_CR22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cardiores.2006.07.006","volume":"72","author":"A Laskowski","year":"2006","unstructured":"Laskowski A, Woodman OL, Cao AH et al (2006) Antioxidant actions contribute to the antihypertrophic effects of atrial natriuretic peptide in neonatal rat cardiomyocytes. Cardiovasc Res 72:112\u2013123","journal-title":"Cardiovasc Res"},{"key":"2495_CR23","doi-asserted-by":"crossref","first-page":"12355","DOI":"10.1073\/pnas.1934654100","volume":"100","author":"JR McMullen","year":"2003","unstructured":"McMullen JR, Shioi T, Zhang L et al (2003) Phosphoinositide 3-kinase(p110 alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc Natl Acad Sci USA 100:12355\u201312360","journal-title":"Proc Natl Acad Sci USA"},{"key":"2495_CR24","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1161\/01.CIR.101.19.2271","volume":"101","author":"RB Devereux","year":"2000","unstructured":"Devereux RB, Roman MJ, Paranicas M et al (2000) Impact of diabetes on cardiac structure and function. The strong heart study. Circulation 101:2271\u20132276","journal-title":"Circulation"},{"key":"2495_CR25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijcard.2004.03.009","volume":"101","author":"F Gonzalez-Vilchez","year":"2005","unstructured":"Gonzalez-Vilchez F, Ayuela J, Ares M, Pi J, Castillo L, Martin-Duran R (2005) Oxidative stress and fibrosis in incipient myocardial dysfunction in type 2 diabetic patients. Int J Cardiol 101:53\u201358","journal-title":"Int J Cardiol"},{"key":"2495_CR26","first-page":"163","volume":"26","author":"D Bonnefont-Rousselot","year":"2000","unstructured":"Bonnefont-Rousselot D, Bastard JP, Jaudon MC, Delattre J (2000) Consequences of the diabetic status on the oxidant\/antioxidant balance. Diabetes Metab 26:163\u2013176","journal-title":"Diabetes Metab"},{"key":"2495_CR27","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.2337\/dc08-0118","volume":"31","author":"GT Chew","year":"2008","unstructured":"Chew GT, Watts GF, Davis TME et al (2008) Hemodynamic effects of fenofibrate and coenzyme Q(10) in type 2 diabetic subjects with left ventricular diastolic dysfunction. Diabetes Care 31:1502\u20131509","journal-title":"Diabetes Care"},{"key":"2495_CR28","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0735-1097(03)00625-9","volume":"42","author":"M Diamant","year":"2003","unstructured":"Diamant M, Lamb HJ, Groeneveld Y et al (2003) Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus. J Am Coll Cardiol 42:328\u2013335","journal-title":"J Am Coll Cardiol"},{"key":"2495_CR29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/jcp.46.1.32","volume":"46","author":"M Shimizu","year":"1993","unstructured":"Shimizu M, Umeda K, Sugihara N et al (1993) Collagen remodelling in myocardia of patients with diabetes. J Clin Path 46:32\u201336","journal-title":"J Clin Path"},{"key":"2495_CR30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.pharmthera.2009.07.003","volume":"124","author":"A Kumar","year":"2009","unstructured":"Kumar A, Kaur H, Devi P, Mohan V (2009) Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Pharmacol Ther 124:259\u2013268","journal-title":"Pharmacol Ther"},{"key":"2495_CR31","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.2337\/diabetes.53.12.3201","volume":"53","author":"DD Belke","year":"2004","unstructured":"Belke DD, Swanson EA, Dillmann WH (2004) Decreased sarcoplasmic reticulum activity and contractility in diabetic db\/db mouse heart. Diabetes 53:3201\u20133208","journal-title":"Diabetes"},{"key":"2495_CR32","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","volume":"322","author":"D Levy","year":"1990","unstructured":"Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP (1990) Prognostic implications of echocardiographically determined left-ventricular mass in the Framingham Heart Study. New Engl J Med 322:1561\u20131566","journal-title":"New Engl J Med"},{"key":"2495_CR33","first-page":"S145","volume-title":"Treatment of hypertrophic cardiomyopathy with coenzyme Q(10)","author":"PH Langsjoen","year":"1996","unstructured":"Langsjoen PH, Langsjoen A, Willis R, Folkers K (1996) Treatment of hypertrophic cardiomyopathy with coenzyme Q(10). Pergamon, Ancona, Italy, pp S145\u2013S151"},{"key":"2495_CR34","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/01.RES.87.12.1123","volume":"87","author":"A Frustaci","year":"2000","unstructured":"Frustaci A, Kajstura J, Chimenti C et al (2000) Myocardial cell death in human diabetes. Circ Res 87:1123\u20131132","journal-title":"Circ Res"},{"key":"2495_CR35","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/labinvest.3780057","volume":"80","author":"F Fiordaliso","year":"2000","unstructured":"Fiordaliso F, Li BS, Latini R et al (2000) Myocyte death in streptozotocin-induced diabetes in rats is angiotensin II-dependent. Lab Invest 80:513\u2013527","journal-title":"Lab Invest"},{"key":"2495_CR36","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1464-5491.2006.01996.x","volume":"23","author":"SC Lim","year":"2006","unstructured":"Lim SC, Tan HH, Goh SK et al (2006) Oxidative burden in prediabetic and diabetic individuals: evidence from plasma coenzyme Q(10). Diabet Med 23:1344\u20131349","journal-title":"Diabet Med"},{"key":"2495_CR37","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.mito.2007.02.006","volume":"7","author":"M Bentinger","year":"2007","unstructured":"Bentinger M, Brismar K, Dallner G (2007) The antioxidant role of coenzyme Q. Mitochondrion 7:S41\u2013S50","journal-title":"Mitochondrion"},{"key":"2495_CR38","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/sj.ejcn.1601464","volume":"56","author":"JM Hodgson","year":"2002","unstructured":"Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD (2002) Coenzyme Q(10) improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 56:1137\u20131142","journal-title":"Eur J Clin Nutr"},{"key":"2495_CR39","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2170\/physiolsci.RP012808","volume":"58","author":"W Liang","year":"2008","unstructured":"Liang W, Tan CYR, Ang L et al (2008) Ramipril improves oxidative stress-related vascular endothelial dysfunction in db\/db mice. J Physiol Sci 58:405\u2013411","journal-title":"J Physiol Sci"},{"key":"2495_CR40","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/01.fjc.0000238587.68239.52","volume":"48","author":"A Otto","year":"2006","unstructured":"Otto A, Fontaine J, Berkenboom G (2006) Ramipril treatment protects against nitrate-induced oxidative stress in eNOS(\u2212\/\u2212) mice: an implication of the NADPH oxidase pathway. J Cardiovasc Pharmacol 48:842\u2013849","journal-title":"J Cardiovasc Pharmacol"},{"key":"2495_CR41","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1210\/en.2007-0877","volume":"149","author":"M Aragno","year":"2008","unstructured":"Aragno M, Mastrocola R, Alloatti G et al (2008) Oxidative stress triggers cardiac fibrosis in the heart of diabetic rats. Endocrinology 149:380\u2013388","journal-title":"Endocrinology"},{"key":"2495_CR42","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/hc0302.103712","volume":"105","author":"JK Bendall","year":"2002","unstructured":"Bendall JK, Cave AC, Heymes C, Gall N, Shah AM (2002) Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice. Circulation 105:293\u2013296","journal-title":"Circulation"},{"key":"2495_CR43","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0022-2828(03)00145-7","volume":"35","author":"H Nakagami","year":"2003","unstructured":"Nakagami H, Takemoto M, Liao JK (2003) NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy. J Mol Cell Cardiol 35:851\u2013859","journal-title":"J Mol Cell Cardiol"},{"key":"2495_CR44","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1074\/jbc.M310405200","volume":"279","author":"JR McMullen","year":"2004","unstructured":"McMullen JR, Shioi T, Huang WY et al (2004) The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110 alpha) pathway. J Biol Chem 279:4782\u20134793","journal-title":"J Biol Chem"},{"key":"2495_CR45","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1023\/B:REMD.0000032410.75638.da","volume":"5","author":"SN Stas","year":"2004","unstructured":"Stas SN, El-Atat FA, Sowers JR (2004) Pathogenesis of hypertension in diabetes. Rev Endocr Metab Disord 5:221\u2013225","journal-title":"Rev Endocr Metab Disord"},{"key":"2495_CR46","doi-asserted-by":"crossref","first-page":"H1634","DOI":"10.1152\/ajpheart.00257.2008","volume":"295","author":"W Su","year":"2008","unstructured":"Su W, Guo ZH, Randall DC, Cassis L, Brown DR, Gong MC (2008) Hypertension and disrupted blood pressure circadian rhythm in type 2 diabetic db\/db mice. Am J Physiol-Heart Circ Physiol 295:H1634\u2013H1641","journal-title":"Am J Physiol-Heart Circ Physiol"},{"key":"2495_CR47","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/sj.jhh.1000778","volume":"13","author":"RB Singh","year":"1999","unstructured":"Singh RB, Niaz MA, Rastogi SS, Shukla PK, Thakur AS (1999) Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 13:203\u2013208","journal-title":"J Hum Hypertens"},{"key":"2495_CR48","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/sj.jhh.1002138","volume":"21","author":"FL Rosenfeldt","year":"2007","unstructured":"Rosenfeldt FL, Haas SJ, Krum H et al (2007) Coenzyme Q(10) in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens 21:297\u2013306","journal-title":"J Hum Hypertens"},{"key":"2495_CR49","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1097\/HJH.0b013e3282ff8864","volume":"26","author":"S Luders","year":"2008","unstructured":"Luders S, Schrader J, Berger J et al (2008) The PHARAO study: prevention of hypertension with the angiotensin-converting enzyme inhibitor ramipril in patients with high-normal blood pressure\u2014a prospective, randomised, controlled prevention trial of the German Hypertension League. J Hypertens 26:1487\u20131496","journal-title":"J Hypertens"},{"key":"2495_CR50","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1242\/dmm.001941","volume":"2","author":"H Bugger","year":"2009","unstructured":"Bugger H, Abel ED (2009) Rodent models of diabetic cardiomyopathy. Dis Model Mech 2:454\u2013466","journal-title":"Dis Model Mech"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-012-2495-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-012-2495-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-012-2495-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T13:11:45Z","timestamp":1561381905000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-012-2495-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,29]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["2495"],"URL":"https:\/\/doi.org\/10.1007\/s00125-012-2495-3","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,29]]}}}