{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:44:09Z","timestamp":1791258249972,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,2,2]],"date-time":"2014-02-02T00:00:00Z","timestamp":1391299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1007\/s00125-014-3170-7","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T23:14:22Z","timestamp":1391210062000},"page":"980-990","source":"Crossref","is-referenced-by-count":69,"title":["Pharmacological application of carbon monoxide ameliorates islet-directed autoimmunity in mice via anti-inflammatory and anti-apoptotic effects"],"prefix":"10.1007","volume":"57","author":[{"given":"Ivana","family":"Nikolic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Saksida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Mangano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Vujicic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Stojanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislava","family":"Stosic-Grujicic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,2]]},"reference":[{"key":"3170_CR1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pharmtox.37.1.517","volume":"37","author":"MD Maines","year":"1997","unstructured":"Maines MD (1997) The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37:517\u2013554","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"3170_CR2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/physrev.00011.2005","volume":"86","author":"SW Ryter","year":"2006","unstructured":"Ryter SW, Alam J, Choi AM (2006) Heme oxygenase-1\/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 86:583\u2013650","journal-title":"Physiol Rev"},{"key":"3170_CR3","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrd3228","volume":"9","author":"R Motterlini","year":"2010","unstructured":"Motterlini R, Otterbein LE (2010) The therapeutic potential of carbon monoxide. Nat Rev Drug Discov 9:728\u2013743","journal-title":"Nat Rev Drug Discov"},{"key":"3170_CR4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1365-2249.2010.04303.x","volume":"163","author":"P Fagone","year":"2011","unstructured":"Fagone P, Mangano K, Quattrocchi C et al (2011) Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1. Clin Exp Immunol 163:368\u2013374","journal-title":"Clin Exp Immunol"},{"key":"3170_CR5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2249.2011.04491.x","volume":"167","author":"P Fagone","year":"2012","unstructured":"Fagone P, Mangano K, Coco M et al (2012) Therapeutic potential of carbon monoxide in multiple sclerosis. Clin Exp Immunol 167:179\u2013187","journal-title":"Clin Exp Immunol"},{"key":"3170_CR6","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00134-008-1011-1","volume":"34","author":"R Foresti","year":"2008","unstructured":"Foresti R, Bani-Hani MG, Motterlini R (2008) Use of carbon monoxide as a therapeutic agent: promises and challenges. Intensive Care Med 34:649\u2013658","journal-title":"Intensive Care Med"},{"key":"3170_CR7","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.2174\/1381612033453785","volume":"9","author":"R Motterlini","year":"2003","unstructured":"Motterlini R, Mann BE, Johnson TR, Clark JE, Foresti R, Green CJ (2003) Bioactivity and pharmacological actions of carbon monoxide-releasing molecules. Curr Pharm Des 9:2525\u20132539","journal-title":"Curr Pharm Des"},{"key":"3170_CR8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1096\/fj.04-2169fje","volume":"19","author":"R Motterlini","year":"2005","unstructured":"Motterlini R, Sawle P, Hammad J et al (2005) CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule. FASEB J 19:284\u2013286","journal-title":"FASEB J"},{"key":"3170_CR9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2009.21","volume":"5","author":"DL Eizirik","year":"2009","unstructured":"Eizirik DL, Colli ML, Ortis F (2009) The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol 5:219\u2013226","journal-title":"Nat Rev Endocrinol"},{"key":"3170_CR10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nri3422","volume":"13","author":"KC Herold","year":"2013","unstructured":"Herold KC, Vignali DA, Cooke A, Bluestone JA (2013) Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol 13:243\u2013256","journal-title":"Nat Rev Immunol"},{"key":"3170_CR11","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.coi.2008.09.006","volume":"20","author":"CA Piccirillo","year":"2008","unstructured":"Piccirillo CA, d\u2019Hennezel E, Sgouroudis E, Yurchenko E (2008) CD4+Foxp3+ regulatory T cells in the control of autoimmunity: in vivo veritas. Curr Opin Immunol 20:655\u2013662","journal-title":"Curr Opin Immunol"},{"key":"3170_CR12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4161\/isl.2.4.12219","volume":"2","author":"JD Acharya","year":"2010","unstructured":"Acharya JD, Ghaskadbi SS (2010) Islets and their antioxidant defense. Islets 2:225\u2013235","journal-title":"Islets"},{"key":"3170_CR13","doi-asserted-by":"crossref","first-page":"994","DOI":"10.2337\/diabetes.51.4.994","volume":"51","author":"L G\u00fcnther","year":"2002","unstructured":"G\u00fcnther L, Berberat PO, Haga M et al (2002) Carbon monoxide protects pancreatic cells from apoptosis and improves islet function\/survival after transplantation. Diabetes 51:994\u2013999","journal-title":"Diabetes"},{"key":"3170_CR14","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.2337\/db06-0495","volume":"56","author":"CM Hu","year":"2007","unstructured":"Hu CM, Lin HH, Chiang MT, Chang PF, Chau LY (2007) Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in NOD mice. Diabetes 56:1240\u20131247","journal-title":"Diabetes"},{"key":"3170_CR15","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1007\/s00125-010-1858-x","volume":"53","author":"SH Huang","year":"2010","unstructured":"Huang SH, Chu CH, Yu JC et al (2010) Transgenic expression of haem oxygenase-1 in pancreatic beta cells protects non-obese mice used as a model of diabetes from autoimmune destruction and prolongs graft survival following islet transplantation. Diabetologia 53:2389\u20132400","journal-title":"Diabetologia"},{"key":"3170_CR16","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1165\/rcmb.2008-0458OC","volume":"41","author":"M Althaus","year":"2009","unstructured":"Althaus M, Fronius M, Buckhackert Y et al (2009) Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels. Am J Respir Cell Mol Biol 41:639\u2013650","journal-title":"Am J Respir Cell Mol Biol"},{"key":"3170_CR17","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1210\/en.2004-1393","volume":"146","author":"I Cvetkovic","year":"2005","unstructured":"Cvetkovic I, Al-Abed Y, Miljkovic D et al (2005) Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Endocrinology 146:2942\u20132951","journal-title":"Endocrinology"},{"key":"3170_CR18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/jaut.2000.0456","volume":"16","author":"S Stosic-Grujicic","year":"2001","unstructured":"Stosic-Grujicic S, Maksimovic D, Badovinac V et al (2001) Antidiabetogenic effect of pentoxifylline is associated with systemic and target tissue modulation of cytokines and nitric oxide production. J Autoimmun 16:47\u201358","journal-title":"J Autoimmun"},{"key":"3170_CR19","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1017\/S0007114509993394","volume":"103","author":"T Cvjeticanin","year":"2010","unstructured":"Cvjeticanin T, Miljkovic D, Stojanovic I, Dekanski D, Stosic-Grujicic S (2010) Dried leaf extract of Olea europaea ameliorates islet-directed autoimmunity in mice. Br J Nutr 103:1413\u20131424","journal-title":"Br J Nutr"},{"key":"3170_CR20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.trsl.2012.10.005","volume":"161","author":"N Zdravkovic","year":"2013","unstructured":"Zdravkovic N, Pavlovic S, Zdravkovic V, Pejnovic N, Arsenijevic N, Lukic ML (2013) ST2 gene-deletion reveals a role of Foxp3+ regulatory T cells in diabetes modulation in BALB\/c mice. Transl Res 161:118\u2013129","journal-title":"Transl Res"},{"key":"3170_CR21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1365-2249.2012.04607.x","volume":"169","author":"I Stojanovic","year":"2012","unstructured":"Stojanovic I, Saksida T, Nikolic I, Nicoletti F, Stosic-Grujicic S (2012) Macrophage migration inhibitory factor deficiency protects pancreatic islets from cytokine-induced apoptosis in vitro. Clin Exp Immunol 169:156\u2013163","journal-title":"Clin Exp Immunol"},{"key":"3170_CR22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jlb.50.4.373","volume":"50","author":"JC Monboisse","year":"1991","unstructured":"Monboisse JC, Garnotel R, Randoux A, Dufer J, Borel JP (1991) Adhesion of human neutrophils to and activation by type-I collagen involving a \u03b22 integrin. J Leukoc Biol 50:373\u2013380","journal-title":"J Leukoc Biol"},{"key":"3170_CR23","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/icb.2011.89","volume":"90","author":"T Saksida","year":"2012","unstructured":"Saksida T, Stosic-Grujicic S, Timotijevic G, Sandler S, Stojanovic I (2012) Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis. Immunol Cell Biol 90:688\u2013698","journal-title":"Immunol Cell Biol"},{"key":"3170_CR24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1210\/endo-127-1-126","volume":"127","author":"J Miyazaki","year":"1990","unstructured":"Miyazaki J, Araki K, Yamato E et al (1990) Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127:126\u2013132","journal-title":"Endocrinology"},{"key":"3170_CR25","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1530\/eje.0.1470543","volume":"147","author":"T Rydgren","year":"2002","unstructured":"Rydgren T, Sandler S (2002) Efficacy of 1400 W, a novel inhibitor of inducible nitric oxide synthase, in preventing interleukin-1beta-induced suppression of pancreatic islet function in vitro and multiple low-dose streptozotocin-induced diabetes in vivo. Eur J Endocrinol 147:543\u2013551","journal-title":"Eur J Endocrinol"},{"key":"3170_CR26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1155\/1998\/92198","volume":"6","author":"ML Lukic","year":"1998","unstructured":"Lukic ML, Stosic-Grujicic S, Shahin A (1998) Effector mechanisms in low-dose streptozotocin-induced diabetes. Dev Immunol 6:119\u2013128","journal-title":"Dev Immunol"},{"key":"3170_CR27","first-page":"591","volume-title":"Diabetes mellitus: a fundamental and clinical text","author":"JP Mordes","year":"2004","unstructured":"Mordes JP, Serreze DV, Greiner DL, Rossini AA (2004) Animal models of autoimmune diabetes mellitus. In: LeRoith D, Taylor SI, Olefsky JM (eds) Diabetes mellitus: a fundamental and clinical text. Lippincott Williams and Wilkins, Philadelphia, pp 591\u2013610"},{"key":"3170_CR28","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1084\/jem.20042398","volume":"201","author":"SM Pop","year":"2005","unstructured":"Pop SM, Wong CP, Culton DA, Clarke SH, Tisch R (2005) Single cell analysis shows decreasing FoxP3 and TGF coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med 201:1333\u20131346","journal-title":"J Exp Med"},{"key":"3170_CR29","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.4049\/jimmunol.1203045","volume":"190","author":"R Rodeghero","year":"2013","unstructured":"Rodeghero R, Cao Y, Olalekan SA, Iwakua Y, Glant TT, Finnegan A (2013) Location of CD4+ T cell priming regulates the differentiation of Th1 and Th17 cells and their contribution to arthritis. J Immunol 190:5423\u20135435","journal-title":"J Immunol"},{"key":"3170_CR30","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI28844","volume":"117","author":"AA Chora","year":"2007","unstructured":"Chora AA, Fontoura P, Cunha A et al (2007) Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation. J Clin Invest 117:438\u2013447","journal-title":"J Clin Invest"},{"key":"3170_CR31","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.4049\/jimmunol.149.12.4096","volume":"149","author":"C K\u00fcrschner","year":"1992","unstructured":"K\u00fcrschner C, Ozmen L, Garotta G, Dembic Z (1992) IFN-gamma receptor-Ig fusion proteins. Half-life, immunogenicity, and in vivo activity. J Immunol 149:4096\u20134100","journal-title":"J Immunol"},{"key":"3170_CR32","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/382174a0","volume":"382","author":"MH Kaplan","year":"1996","unstructured":"Kaplan MH, Sun YL, Hoey T, Grusby MJ (1996) Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174\u2013177","journal-title":"Nature"},{"key":"3170_CR33","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1182\/blood-2005-02-0494","volume":"106","author":"C Chauveau","year":"2005","unstructured":"Chauveau C, Remy S, Royer PJ et al (2005) Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression. Blood 106:1694\u20131702","journal-title":"Blood"},{"key":"3170_CR34","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0002-9440(10)63365-2","volume":"165","author":"MH Kapturczak","year":"2004","unstructured":"Kapturczak MH, Wasserfall C, Brusko T et al (2004) Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse. Am J Pathol 165:1045\u20131053","journal-title":"Am J Pathol"},{"key":"3170_CR35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/eji.201242684","volume":"43","author":"T Simon","year":"2013","unstructured":"Simon T, Pogy S, Tardif V et al (2013) Carbon monoxide-treated dendritic cells decrease \u03b21-integrin induction on CD8+ T cells and protect from type 1 diabetes. Eur J Immunol 43:209\u2013218","journal-title":"Eur J Immunol"},{"key":"3170_CR36","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ni1289","volume":"7","author":"Q Tang","year":"2006","unstructured":"Tang Q, Adams JY, Tooley AJ et al (2006) Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol 7:83\u201392","journal-title":"Nat Immunol"},{"key":"3170_CR37","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1084\/jem.179.2.493","volume":"179","author":"R Bacchetta","year":"1994","unstructured":"Bacchetta R, Bigler M, Touraine JL et al (1994) High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J Exp Med 179:493\u2013502","journal-title":"J Exp Med"},{"key":"3170_CR38","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/cmi.2012.47","volume":"9","author":"X Hu","year":"2012","unstructured":"Hu X, Liu G, Hou Y et al (2012) Induction of M2-like macrophages in recipient NOD-scid mice by allogeneic donor CD4+CD25+ regulatory T cells. Cell Mol Immunol 9:464\u2013472","journal-title":"Cell Mol Immunol"},{"key":"3170_CR39","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ceb.2010.08.002","volume":"22","author":"C Bogner","year":"2010","unstructured":"Bogner C, Leber B, Andrews DW (2010) Apoptosis: embedded in membranes. Curr Opin Cell Biol 22:845\u2013851","journal-title":"Curr Opin Cell Biol"},{"key":"3170_CR40","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1089\/ars.2007.1568","volume":"9","author":"M Li","year":"2007","unstructured":"Li M, Peterson S, Husney D et al (2007) Interdiction of the diabetic state in NOD mice by sustained induction of heme oxygenase: possible role of carbon monoxide and bilirubin. Antioxid Redox Signal 9:855\u2013863","journal-title":"Antioxid Redox Signal"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-014-3170-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-014-3170-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-014-3170-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T05:28:13Z","timestamp":1688966893000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-014-3170-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,2]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["3170"],"URL":"https:\/\/doi.org\/10.1007\/s00125-014-3170-7","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,2]]}}}