{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:10:09Z","timestamp":1791587409994,"version":"4.3.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1007\/s00125-014-3213-0","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T07:43:38Z","timestamp":1395647018000},"page":"1182-1191","source":"Crossref","is-referenced-by-count":130,"title":["GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans"],"prefix":"10.1007","volume":"57","author":[{"given":"Virginia M.","family":"Stone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalinee","family":"Dhayal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy J.","family":"Brocklehurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Lenaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"S\u00f6rhede Winzell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e5rten","family":"Hammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel G.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"3213_CR1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0014-5793(03)01196-7","volume":"554","author":"R Fredriksson","year":"2003","unstructured":"Fredriksson R, Hoglund PJ, Gloriam DEI, Lagerstrom MC, Schioth HB (2003) Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett 554:381\u2013388","journal-title":"FEBS Lett"},{"key":"3213_CR2","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.bbrc.2010.05.057","volume":"396","author":"RN Burns","year":"2010","unstructured":"Burns RN, Moniri NH (2010) Agonism with the omega-3 fatty acids [alpha]-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. Biochem Biophys Res Commun 396:1030\u20131035","journal-title":"Biochem Biophys Res Commun"},{"key":"3213_CR3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1124\/mol.111.077388","volume":"81","author":"SJ Watson","year":"2012","unstructured":"Watson SJ, Brown AJ, Holliday ND (2012) Differential signaling by splice variants of the human free fatty acid receptor GPR120. Mol Pharmacol 81:631\u2013642","journal-title":"Mol Pharmacol"},{"key":"3213_CR4","doi-asserted-by":"crossref","first-page":"8376","DOI":"10.1523\/JNEUROSCI.0496-10.2010","volume":"30","author":"C Cartoni","year":"2010","unstructured":"Cartoni C, Yasumatsu K, Ohkuri T et al (2010) Taste preference for fatty acids is mediated by GPR40 and GPR120. J Neurosci 30:8376\u20138382","journal-title":"J Neurosci"},{"key":"3213_CR5","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1002\/jps.22639","volume":"100","author":"T Hara","year":"2011","unstructured":"Hara T, Hirasawa A, Ichimura A, Kimura I, Tsujimoto G (2011) Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders. J Pharm Sci 100:3594\u20133601","journal-title":"J Pharm Sci"},{"key":"3213_CR6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nm1168","volume":"11","author":"A Hirasawa","year":"2005","unstructured":"Hirasawa A, Keiko T, Awaji T et al (2005) Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med 11:90\u201394","journal-title":"Nat Med"},{"key":"3213_CR7","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.prostaglandins.2009.05.003","volume":"89","author":"A Ichimura","year":"2009","unstructured":"Ichimura A, Hirasawa A, Hara T, Tsujimoto G (2009) Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. Prostaglandins Lipid Mediat 89:82\u201388","journal-title":"Prostaglandins Lipid Mediat"},{"key":"3213_CR8","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature10798","volume":"483","author":"A Ichimura","year":"2012","unstructured":"Ichimura A, Hirasawa A, Poulain-Godefroy O et al (2012) Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 483:350\u2013354","journal-title":"Nature"},{"key":"3213_CR9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00210-008-0390-8","volume":"379","author":"S Miyauchi","year":"2009","unstructured":"Miyauchi S, Hirasawa A, Iga T et al (2009) Distribution and regulation of protein expression of the free fatty acid receptor GPR120. Naunyn Schmiedeberg\u2019s Arch Pharmacol 379:427\u2013434","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"3213_CR10","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","volume":"142","author":"DY Oh","year":"2010","unstructured":"Oh DY, Talukdar S, Bae EJ et al (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142:687\u2013698","journal-title":"Cell"},{"key":"3213_CR11","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.tips.2011.04.004","volume":"32","author":"S Talukdar","year":"2011","unstructured":"Talukdar S, Olefsky JM, Osborn O (2011) Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. Trends Pharmacol Sci 32:543\u2013550","journal-title":"Trends Pharmacol Sci"},{"key":"3213_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2011.00112","volume":"2","author":"ND Holliday","year":"2012","unstructured":"Holliday ND, Watson S-J, Brown AJH (2012) Drug discovery opportunities and challenges at G protein coupled receptors for long chain free fatty acids. Front Endocrinol 2:1\u201312","journal-title":"Front Endocrinol"},{"key":"3213_CR13","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00210-007-0200-8","volume":"377","author":"T Tanaka","year":"2007","unstructured":"Tanaka T, Katsuma S, Adachi T, Koshimizu T, Hirasawa A, Tsujimoto G (2007) Free fatty acids induce cholecystokinin secretion through GPR120. Naunyn Schmiedeberg\u2019s Arch Pharmacol 377:523\u2013527","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"3213_CR14","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00210-007-0250-y","volume":"377","author":"T Tanaka","year":"2008","unstructured":"Tanaka T, Yano T, Adachi T, Koshimizu TA, Hirasawa A, Tsujimoto G (2008) Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells. Naunyn Schmiedeberg\u2019s Arch Pharmacol 377:515\u2013522","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"3213_CR15","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.bbrc.2007.01.028","volume":"354","author":"C Gotoh","year":"2007","unstructured":"Gotoh C, Hong YH, Iga T et al (2007) The regulation of adipogenesis through GPR120. Biochem Biophys Res Commun 354:591\u2013597","journal-title":"Biochem Biophys Res Commun"},{"key":"3213_CR16","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.neulet.2008.11.056","volume":"450","author":"S Matsumura","year":"2009","unstructured":"Matsumura S, Eguchi A, Mizushige T et al (2009) Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice. Neurosci Lett 450:186\u2013190","journal-title":"Neurosci Lett"},{"key":"3213_CR17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2220\/biomedres.28.49","volume":"28","author":"S Matsumura","year":"2007","unstructured":"Matsumura S, Mizushige T, Yoneda T et al (2007) GPR expression in the rat taste bud relating to fatty acid sensing. Biomed Res 28:49\u201355","journal-title":"Biomed Res"},{"key":"3213_CR18","doi-asserted-by":"crossref","first-page":"e30571","DOI":"10.1371\/journal.pone.0030571","volume":"7","author":"DE Cintra","year":"2012","unstructured":"Cintra DE, Ropelle ER, Moraes JC et al (2012) Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLoS ONE 7:e30571","journal-title":"PLoS ONE"},{"key":"3213_CR19","doi-asserted-by":"crossref","first-page":"16269","DOI":"10.1074\/jbc.R800014200","volume":"238","author":"S Costanzi","year":"2008","unstructured":"Costanzi S, Neumannm S, Gershengorn MC (2008) Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic and drug discovery aspects. J Biol Chem 238:16269\u201316273","journal-title":"J Biol Chem"},{"issue":"Suppl 4","key":"3213_CR20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1463-1326.2009.01114.x","volume":"11","author":"MA Kebede","year":"2009","unstructured":"Kebede MA, Alquier T, Latour MG, Poitout V (2009) Lipid receptors and islet function: therapeutic implications? Diabetes Obes Metab 11(Suppl 4):10\u201320","journal-title":"Diabetes Obes Metab"},{"key":"3213_CR21","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.bcp.2009.07.020","volume":"78","author":"NG Morgan","year":"2009","unstructured":"Morgan NG, Dhayal S (2009) G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell. Biochem Pharmacol 78:1419\u20131427","journal-title":"Biochem Pharmacol"},{"key":"3213_CR22","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cmet.2012.06.006","volume":"16","author":"J Taneera","year":"2012","unstructured":"Taneera J, Lang S, Sharma A et al (2012) A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets. Cell Metab 16:122\u2013134","journal-title":"Cell Metab"},{"issue":"Suppl 4","key":"3213_CR23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2527\/jas.53792","volume":"90","author":"M Fredborg","year":"2012","unstructured":"Fredborg M, Theil PK, Jensen BB, Purup S (2012) G protein-coupled receptor120 (GPR120) transcription in intestinal epithelial cells is significantly affected by bacteria belonging to the Bacteroides, Proteobacteria, and Firmicutes phyla. J Anim Sci 90(Suppl 4):10\u201312","journal-title":"J Anim Sci"},{"key":"3213_CR24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00210-009-0425-9","volume":"380","author":"T Hara","year":"2009","unstructured":"Hara T, Hirasawa A, Sun Q et al (2009) Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedeberg\u2019s Arch Pharmacol 380:247\u2013255","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"3213_CR25","doi-asserted-by":"crossref","first-page":"E651","DOI":"10.1152\/ajpendo.00471.2012","volume":"304","author":"Y Li","year":"2013","unstructured":"Li Y, Kokrashvili Z, Mosinger B, Margolskee RF (2013) Gustducin couples fatty acid receptors to GLP-1 release in colon. Am J Physiol Endocrinol Metab 304:E651\u2013E660","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"3213_CR26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1042\/bj2260571","volume":"226","author":"NG Morgan","year":"1985","unstructured":"Morgan NG, Montague W (1985) Studies on the mechanism of inhibition of glucose-stimulated insulin secretion by noradrenaline in rat islets of Langerhans. Biochem J 226:571\u2013576","journal-title":"Biochem J"},{"key":"3213_CR27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1530\/JOE-11-0094","volume":"211","author":"NM Whalley","year":"2011","unstructured":"Whalley NM, Pritchard LE, Smith DM, White A (2011) Processing of proglucagon to GLP-1 in pancreatic alpha-cells: is this a paracrine mechanism enabling GLP-1 to act on beta-cells? J Endocrinol 211:99\u2013106","journal-title":"J Endocrinol"},{"key":"3213_CR28","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.2337\/diabetes.53.7.1743","volume":"53","author":"A Muroyama","year":"2004","unstructured":"Muroyama A, Uehara S, Yatsushiro S et al (2004) A novel variant of ionotropic glutamate receptor regulates somatostatin secretion from delta-cells of islets of Langerhans. Diabetes 53:1743\u20131753","journal-title":"Diabetes"},{"key":"3213_CR29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mce.2008.02.007","volume":"286","author":"MZ Strowski","year":"2008","unstructured":"Strowski MZ, Blake AD (2008) Function and expression of somatostatin receptors of the endocrine pancreas. Mol Cell Endocrinol 286:169\u2013179","journal-title":"Mol Cell Endocrinol"},{"key":"3213_CR30","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1007\/s00125-009-1382-z","volume":"52","author":"M Braun","year":"2009","unstructured":"Braun M, Ramracheya R, Amisten S et al (2009) Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells. Diabetologia 52:1566\u20131578","journal-title":"Diabetologia"},{"key":"3213_CR31","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1007\/s00125-008-1149-y","volume":"51","author":"J Heer de","year":"2008","unstructured":"de Heer J, Rasmussen C, Coy DH, Holst JJ (2008) Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas. Diabetologia 51:2263\u20132270","journal-title":"Diabetologia"},{"key":"3213_CR32","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1055\/s-2004-825921","volume":"36","author":"EM Egido","year":"2004","unstructured":"Egido EM, Silvestre RA, Hernandez R, Marco J (2004) Exendin-4 dose-dependently stimulates somatostatin and insulin secretion in perfused rat pancreas. Horm Metab Res 36:595\u2013600","journal-title":"Horm Metab Res"},{"key":"3213_CR33","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1007\/s00125-012-2546-9","volume":"55","author":"AC Hauge-Evans","year":"2012","unstructured":"Hauge-Evans AC, Anderson RL, Persaud SJ, Jones PM (2012) Delta cell secretory responses to insulin secretagogues are not mediated indirectly by insulin. Diabetologia 55:1995\u20132004","journal-title":"Diabetologia"},{"key":"3213_CR34","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2337\/db08-0792","volume":"58","author":"AC Hauge-Evans","year":"2009","unstructured":"Hauge-Evans AC, King AJ, Carmignac D et al (2009) Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function. Diabetes 58:403\u2013411","journal-title":"Diabetes"},{"key":"3213_CR35","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.bbrc.2011.12.113","volume":"417","author":"B Hellman","year":"2012","unstructured":"Hellman B, Salehi A, Grapengiesser E, Gylfe E (2012) Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon. Biochem Biophys Res Commun 417:1219\u20131223","journal-title":"Biochem Biophys Res Commun"},{"key":"3213_CR36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.regpep.2004.04.017","volume":"121","author":"S Julien","year":"2004","unstructured":"Julien S, Laine J, Morisset J (2004) The rat pancreatic islets: a reliable tool to study islet responses to cholecystokinin receptor occupation. Regul Pept 121:73\u201381","journal-title":"Regul Pept"},{"key":"3213_CR37","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbrc.2010.07.036","volume":"399","author":"C Kelly","year":"2010","unstructured":"Kelly C, Flatt PR, McClenaghan NH (2010) Cell-to-cell communication and cellular environment alter the somatostatin status of delta cells. Biochem Biophys Res Commun 399:162\u2013166","journal-title":"Biochem Biophys Res Commun"},{"key":"3213_CR38","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/dmrr.1111","volume":"26","author":"C Kelly","year":"2010","unstructured":"Kelly C, Parke HG, McCluskey JT, Flatt PR, McClenaghan NH (2010) The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets. Diabetes Metab Res Rev 26:525\u2013533","journal-title":"Diabetes Metab Res Rev"},{"key":"3213_CR39","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2005.06.028","volume":"519","author":"RA Silvestre","year":"2005","unstructured":"Silvestre RA, Egido EM, Hernandez R, Marco J (2005) Tungstate stimulates insulin release and inhibits somatostatin output in the perfused rat pancreas. Eur J Pharmacol 519:127\u2013134","journal-title":"Eur J Pharmacol"},{"key":"3213_CR40","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.2337\/diabetes.53.11.2836","volume":"53","author":"CS Olofsson","year":"2004","unstructured":"Olofsson CS, Salehi A, G\u00f6pel SO, Holm C, Rorsman P (2004) Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of l-type calcium channels and elevation of cytoplasmic calcium. Diabetes 53:2836\u20132843","journal-title":"Diabetes"},{"key":"3213_CR41","doi-asserted-by":"crossref","first-page":"19507","DOI":"10.1074\/jbc.M412385200","volume":"280","author":"S Katsuma","year":"2005","unstructured":"Katsuma S, Hatae N, Yano T et al (2005) Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1. J Biol Chem 280:19507\u201319515","journal-title":"J Biol Chem"},{"key":"3213_CR42","doi-asserted-by":"crossref","first-page":"C1687","DOI":"10.1152\/ajpcell.00282.2011","volume":"302","author":"SG Straub","year":"2012","unstructured":"Straub SG, Sharp GWG (2012) Evolving insights regarding mechanisms for inhibition of insulin secretion by norepinephrine and heterotrimeric G-proteins. Am J Physiol Cell Physiol 302:C1687\u2013C1698","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-014-3213-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-014-3213-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-014-3213-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T14:11:58Z","timestamp":1551190318000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-014-3213-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,25]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["3213"],"URL":"https:\/\/doi.org\/10.1007\/s00125-014-3213-0","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,25]]}}}