{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:46:16Z","timestamp":1791265576756,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T00:00:00Z","timestamp":1418256000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1007\/s00125-014-3466-7","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T08:58:14Z","timestamp":1418201894000},"page":"615-624","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice"],"prefix":"10.1007","volume":"58","author":[{"given":"Isaac E.","family":"Sasson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa P.","family":"Vitins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica A.","family":"Mainigi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelle H.","family":"Moley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,12,11]]},"reference":[{"key":"3466_CR1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1056\/NEJMp048008","volume":"350","author":"WH Dietz","year":"2004","unstructured":"Dietz WH (2004) Overweight in childhood and adolescence. N Engl J Med 350:855\u2013857","journal-title":"N Engl J Med"},{"key":"3466_CR2","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1113\/jphysiol.2005.088989","volume":"567","author":"SA Bayol","year":"2005","unstructured":"Bayol SA, Simbi BH, Stickland NC (2005) A maternal cafeteria diet during gestation and lactation promotes adiposity and impairs skeletal muscle development and metabolism in rat offspring at weaning. J Physiol 567:951\u2013961","journal-title":"J Physiol"},{"key":"3466_CR3","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1210\/jc.2003-031046","volume":"88","author":"PM Catalano","year":"2003","unstructured":"Catalano PM (2003) Obesity and pregnancy\u2014the propagation of a viscous cycle? J Clin Endocrinol Metab 88:3505\u20133506","journal-title":"J Clin Endocrinol Metab"},{"key":"3466_CR4","doi-asserted-by":"crossref","first-page":"R1087","DOI":"10.1152\/ajpregu.00402.2002","volume":"283","author":"BE Levin","year":"2002","unstructured":"Levin BE, Dunn-Meynell AA (2002) Maternal obesity alters adiposity and monoamine function in genetically predisposed offspring. Am J Physiol Regul Integr Comp Physiol 283:R1087\u2013R1093","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"3466_CR5","first-page":"R1374","volume":"275","author":"BE Levin","year":"1998","unstructured":"Levin BE, Govek E (1998) Gestational obesity accentuates obesity in obesity-prone progeny. Am J Physiol 275:R1374\u2013R1379","journal-title":"Am J Physiol"},{"key":"3466_CR6","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0031-9384(94)00342-4","volume":"57","author":"F Guo","year":"1995","unstructured":"Guo F, Jen KL (1995) High-fat feeding during pregnancy and lactation affects offspring metabolism in rats. Physiol Behav 57:681\u2013686","journal-title":"Physiol Behav"},{"key":"3466_CR7","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1101\/gr.147000","volume":"10","author":"PC Reifsnyder","year":"2000","unstructured":"Reifsnyder PC, Churchill G, Leiter EH (2000) Maternal environment and genotype interact to establish diabesity in mice. Genome Res 10:1568\u20131578","journal-title":"Genome Res"},{"key":"3466_CR8","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1210\/en.2011-2161","volume":"153","author":"H Masuyama","year":"2012","unstructured":"Masuyama H, Hiramatsu Y (2012) Effects of a high-fat diet exposure in utero on the metabolic syndrome-like phenomenon in mouse offspring through epigenetic changes in adipocytokine gene expression. Endocrinology 153:2823\u20132830","journal-title":"Endocrinology"},{"key":"3466_CR9","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1210\/en.2009-0500","volume":"150","author":"GA Dunn","year":"2009","unstructured":"Dunn GA, Bale TL (2009) Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice. Endocrinology 150:4999\u20135009","journal-title":"Endocrinology"},{"key":"3466_CR10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1113\/expphysiol.2005.032854","volume":"92","author":"PD Taylor","year":"2007","unstructured":"Taylor PD, Poston L (2007) Developmental programming of obesity in mammals. Exp Physiol 92:287\u2013298","journal-title":"Exp Physiol"},{"key":"3466_CR11","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1053\/j.semperi.2008.08.004","volume":"32","author":"R Simmons","year":"2008","unstructured":"Simmons R (2008) Perinatal programming of obesity. Semin Perinatol 32:371\u2013374","journal-title":"Semin Perinatol"},{"key":"3466_CR12","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.2337\/db10-0301","volume":"59","author":"S Sen","year":"2010","unstructured":"Sen S, Simmons RA (2010) Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats. Diabetes 59:3058\u20133065","journal-title":"Diabetes"},{"key":"3466_CR13","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1210\/en.2010-0098","volume":"151","author":"ES Jungheim","year":"2010","unstructured":"Jungheim ES, Schoeller EL, Marquard KL, Louden ED, Schaffer JE, Moley KH (2010) Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring. Endocrinology 151:4039\u20134046","journal-title":"Endocrinology"},{"key":"3466_CR14","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1210\/en.2011-1974","volume":"153","author":"SH Purcell","year":"2012","unstructured":"Purcell SH, Chi MM, Lanzendorf S, Moley KH (2012) Insulin-stimulated glucose uptake occurs in specialized cells within the cumulus oocyte complex. Endocrinology 153:2444\u20132454","journal-title":"Endocrinology"},{"key":"3466_CR15","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1095\/biolreprod.111.092148","volume":"85","author":"ES Jungheim","year":"2011","unstructured":"Jungheim ES, Louden ED, Chi MM, Frolova AI, Riley JK, Moley KH (2011) Preimplantation exposure of mouse embryos to palmitic acid results in fetal growth restriction followed by catch-up growth in the offspring. Biol Reprod 85:678\u2013683","journal-title":"Biol Reprod"},{"key":"3466_CR16","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.fertnstert.2010.10.026","volume":"95","author":"KL Marquard","year":"2011","unstructured":"Marquard KL, Stephens SM, Jungheim ES et al (2011) Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization\/intracytoplasmic sperm injection cycles. Fertil Steril 95:2146\u20132149","journal-title":"Fertil Steril"},{"key":"3466_CR17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ajog.2010.06.043","volume":"203","author":"ES Jungheim","year":"2010","unstructured":"Jungheim ES, Moley KH (2010) Current knowledge of obesity's effects in the pre- and periconceptional periods and avenues for future research. Am J Obstet Gynecol 203:525\u2013530","journal-title":"Am J Obstet Gynecol"},{"key":"3466_CR18","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.2337\/db07-0074","volume":"56","author":"GS Eng","year":"2007","unstructured":"Eng GS, Sheridan RA, Wyman A et al (2007) AMP kinase activation increases glucose uptake, decreases apoptosis, and improves pregnancy outcome in embryos exposed to high IGF-I concentrations. Diabetes 56:2228\u20132234","journal-title":"Diabetes"},{"key":"3466_CR19","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1210\/en.2010-1078","volume":"152","author":"K Shankar","year":"2011","unstructured":"Shankar K, Zhong Y, Kang P et al (2011) Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst. Endocrinology 152:4158\u20134170","journal-title":"Endocrinology"},{"key":"3466_CR20","doi-asserted-by":"crossref","first-page":"e10074","DOI":"10.1371\/journal.pone.0010074","volume":"5","author":"N Igosheva","year":"2010","unstructured":"Igosheva N, Abramov AY, Poston L et al (2010) Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PLoS One 5:e10074","journal-title":"PLoS One"},{"key":"3466_CR21","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/1440-1681.12061","volume":"40","author":"S Ojha","year":"2013","unstructured":"Ojha S, Saroha V, Symonds ME, Budge H (2013) Excess nutrient supply in early life and its later metabolic consequences. Clin Exp Pharmacol Physiol 40:817\u2013823","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"3466_CR22","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1017\/S0029665109990152","volume":"68","author":"ME Symonds","year":"2009","unstructured":"Symonds ME, Sebert SP, Budge H (2009) The impact of diet during early life and its contribution to later disease: critical checkpoints in development and their long-term consequences for metabolic health. Proc Nutr Soc 68:416\u2013421","journal-title":"Proc Nutr Soc"},{"key":"3466_CR23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1071\/RD11905","volume":"24","author":"TP Fleming","year":"2011","unstructured":"Fleming TP, Lucas ES, Watkins AJ, Eckert JJ (2011) Adaptive responses of the embryo to maternal diet and consequences for post-implantation development. Reprod Fertil Dev 24:35\u201344","journal-title":"Reprod Fertil Dev"},{"key":"3466_CR24","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/npp.2013.193","volume":"39","author":"NM Grissom","year":"2014","unstructured":"Grissom NM, Lyde R, Christ L et al (2014) Obesity at conception programs the opioid system in the offspring brain. Neuropsychopharmacology 39:801\u2013810","journal-title":"Neuropsychopharmacology"},{"key":"3466_CR25","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1095\/biolreprod.106.053603","volume":"75","author":"A Dokras","year":"2006","unstructured":"Dokras A, Hoffmann DS, Eastvold JS et al (2006) Severe feto-placental abnormalities precede the onset of hypertension and proteinuria in a mouse model of preeclampsia. Biol Reprod 75:899\u2013907","journal-title":"Biol Reprod"},{"key":"3466_CR26","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1095\/biolreprod.104.030890","volume":"71","author":"CS Rosenfeld","year":"2004","unstructured":"Rosenfeld CS, Roberts RM (2004) Maternal diet and other factors affecting offspring sex ratio: a review. Biol Reprod 71:1063\u20131070","journal-title":"Biol Reprod"},{"key":"3466_CR27","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1073\/pnas.0800221105","volume":"105","author":"GL Drevenstedt","year":"2008","unstructured":"Drevenstedt GL, Crimmins EM, Vasunilashorn S, Finch CE (2008) The rise and fall of excess male infant mortality. Proc Natl Acad Sci 105:5016\u20135021","journal-title":"Proc Natl Acad Sci"},{"key":"3466_CR28","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1053\/plac.2001.0630","volume":"22","author":"S Heinonen","year":"2001","unstructured":"Heinonen S, Taipale P, Saarikoski S (2001) Weights of placentae from small-for-gestational age infants revisited. Placenta 22:399\u2013404","journal-title":"Placenta"},{"key":"3466_CR29","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1210\/jc.2010-2504","volume":"96","author":"JC Escobar","year":"2011","unstructured":"Escobar JC, Patel SS, Beshay VE et al (2011) The human placenta expresses CYP17 and generates androgens de novo. J Clin Endocrinol Metab 96:1385\u20131392","journal-title":"J Clin Endocrinol Metab"},{"key":"3466_CR30","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.4238\/2012.May.22.1","volume":"11","author":"H Yan","year":"2012","unstructured":"Yan H, Guo Y, Yang TL, Zhao LJ, Deng HW (2012) A family-based association study identified CYP17 as a candidate gene for obesity susceptibility in Caucasians. Genet Mol Res 11:1967\u20131974","journal-title":"Genet Mol Res"},{"key":"3466_CR31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1471-0528.1983.tb08899.x","volume":"90","author":"GM Masson","year":"1983","unstructured":"Masson GM, Anthony F, Wilson M (1983) Value of Schwan-gerschaftsprotein 1 (SP1) and pregnancy-associated plasma protein-A (PAPP-A) in the clinical management of threatened abortion. Br J Obstet Gynaecol 90:146\u2013149","journal-title":"Br J Obstet Gynaecol"},{"key":"3466_CR32","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0143-4004(05)80211-5","volume":"14","author":"RM Silver","year":"1993","unstructured":"Silver RM, Heyborne KD, Leslie KK (1993) Pregnancy specific beta 1 glycoprotein (SP-1) in maternal serum and amniotic fluid; pre-eclampsia, small for gestational age fetus and fetal distress. Placenta 14:583\u2013589","journal-title":"Placenta"},{"key":"3466_CR33","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tcb.2011.09.003","volume":"22","author":"M Maceyka","year":"2012","unstructured":"Maceyka M, Harikumar KB, Milstien S, Spiegel S (2012) Sphingosine-1-phosphate signaling and its role in disease. Trends Cell Biol 22:50\u201360","journal-title":"Trends Cell Biol"},{"key":"3466_CR34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cmet.2013.11.016","volume":"19","author":"V Kameswaran","year":"2014","unstructured":"Kameswaran V, Bramswig NC, McKenna LB et al (2014) Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets. Cell Metab 19:135\u2013145","journal-title":"Cell Metab"},{"key":"3466_CR35","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1194\/jlr.R046458","volume":"55","author":"YC Yung","year":"2014","unstructured":"Yung YC, Stoddard NC, Chun J (2014) LPA receptor signaling: pharmacology, physiology, and pathophysiology. J Lipid Res 55:1192\u20131214","journal-title":"J Lipid Res"},{"key":"3466_CR36","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1186\/1471-2164-14-386","volume":"14","author":"A Dogan","year":"2013","unstructured":"Dogan A, Lasch P, Neuschl C et al (2013) ATR-FTIR spectroscopy reveals genomic loci regulating the tissue response in high fat diet fed BXD recombinant inbred mouse strains. BMC Genomics 14:386","journal-title":"BMC Genomics"},{"key":"3466_CR37","doi-asserted-by":"crossref","first-page":"e68991","DOI":"10.1371\/journal.pone.0068991","volume":"8","author":"CE Kleinrouweler","year":"2013","unstructured":"Kleinrouweler CE, van Uitert M, Moerland PD, Ris-Stalpers C, van der Post JA, Afink GB (2013) Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis. PLoS One 8:e68991","journal-title":"PLoS One"},{"key":"3466_CR38","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.mce.2013.09.008","volume":"382","author":"E Zambrano","year":"2014","unstructured":"Zambrano E, Guzm\u00e1n C, Rodr\u00edguez-Gonz\u00e1lez GL, Durand-Carbajal M, Nathanielsz PW (2014) Fetal programming of sexual development and reproductive function. Mol Cell Endocrinol 382:538\u2013549","journal-title":"Mol Cell Endocrinol"},{"key":"3466_CR39","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0092-8674(93)90680-O","volume":"75","author":"J Baker","year":"1993","unstructured":"Baker J, Liu JP, Robertson EJ, Efstratiadis A (1993) Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75:73\u201382","journal-title":"Cell"},{"key":"3466_CR40","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1055\/s-0031-1275521","volume":"29","author":"JS Dyer","year":"2011","unstructured":"Dyer JS, Rosenfeld CR (2011) Metabolic imprinting by prenatal, perinatal, and postnatal overnutrition: a review. Semin Reprod Med 29:266\u2013276","journal-title":"Semin Reprod Med"},{"key":"3466_CR41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1203\/PDR.0b013e3182055ede","volume":"69","author":"L Poston","year":"2011","unstructured":"Poston L, Harthoorn LF, van Der Beek EM (2011) Obesity in pregnancy: implications for the mother and lifelong health of the child. A consensus statement. Pediatr Res 69:175\u2013180","journal-title":"Pediatr Res"},{"key":"3466_CR42","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1210\/en.2010-0505","volume":"151","author":"Z Vucetic","year":"2010","unstructured":"Vucetic Z, Kimmel J, Totoki K, Hollenbeck E, Reyes TM (2010) Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes. Endocrinology 151:4756\u20134764","journal-title":"Endocrinology"},{"key":"3466_CR43","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1017\/S0007114507812037","volume":"98","author":"SA Bayol","year":"2007","unstructured":"Bayol SA, Farrington SJ, Stickland NC (2007) A maternal junk food diet in pregnancy and lactation promotes an exacerbated taste for junk food and a greater propensity for obesity in rat offspring. Br J Nutr 98:843\u2013851","journal-title":"Br J Nutr"},{"key":"3466_CR44","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/oby.2006.71","volume":"14","author":"T Rankinen","year":"2006","unstructured":"Rankinen T, Zuberi A, Chagnon YC et al (2006) The human obesity gene map: the 2005 update. Obesity 14:529\u2013644","journal-title":"Obesity"},{"key":"3466_CR45","doi-asserted-by":"crossref","first-page":"322.e1","DOI":"10.1016\/j.ajog.2006.11.027","volume":"196","author":"E Oken","year":"2007","unstructured":"Oken E, Taveras EM, Kleinman KP, Rich-Edwards JW, Gillman MW (2007) Gestational weight gain and child adiposity at age 3 years. Am J Obstet Gynecol 196:322.e1\u20138","journal-title":"Am J Obstet Gynecol"},{"issue":"Suppl 3","key":"3466_CR46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000091500","volume":"65","author":"PD Gluckman","year":"2006","unstructured":"Gluckman PD, Hanson MA (2006) The consequences of being born small-an adaptive perspective. Horm Res 65(Suppl 3):5\u201314","journal-title":"Horm Res"},{"key":"3466_CR47","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2337\/diacare.26.2.539","volume":"26","author":"G Reaven","year":"2003","unstructured":"Reaven G (2003) Age and glucose intolerance: effect of fitness and fatness. Diabetes Care 26:539\u2013540","journal-title":"Diabetes Care"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-014-3466-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-014-3466-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-014-3466-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T07:53:52Z","timestamp":1558598032000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-014-3466-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,11]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["3466"],"URL":"https:\/\/doi.org\/10.1007\/s00125-014-3466-7","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,11]]}}}