{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:12:45Z","timestamp":1776730365730,"version":"3.51.2"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s00125-015-3538-3","type":"journal-article","created":{"date-parts":[[2015,2,28]],"date-time":"2015-02-28T12:17:52Z","timestamp":1425125872000},"page":"1175-1182","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Upper gastrointestinal motility and symptoms in individuals with diabetes, prediabetes and normal glucose tolerance"],"prefix":"10.1007","volume":"58","author":[{"given":"Georgios C.","family":"Boronikolos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn A.","family":"Menge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Schenker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G. K.","family":"Breuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Michel","family":"Otte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha","family":"Heckermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freimut","family":"Schliess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juris J.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"key":"3538_CR1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ncpgasthep1054","volume":"5","author":"JH Sellin","year":"2008","unstructured":"Sellin JH, Chang EB (2008) Therapy insight: gastrointestinal complications of diabetes\u2014pathophysiology and management. Nat Clin Pract Gastroenterol Hepatol 5:162\u2013171","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"3538_CR2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1046\/j.1464-5491.2002.00658.x","volume":"19","author":"M Horowitz","year":"2002","unstructured":"Horowitz M, O'Donovan D, Jones KL, Feinle C, Rayner CK, Samsom M (2002) Gastric emptying in diabetes: clinical significance and treatment. Diabet Med 19:177\u2013194","journal-title":"Diabet Med"},{"key":"3538_CR3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/BF00403371","volume":"37","author":"M Horowitz","year":"1994","unstructured":"Horowitz M, Fraser R (1994) Disordered gastric motor function in diabetes mellitus. Diabetologia 37:543\u2013551","journal-title":"Diabetologia"},{"key":"3538_CR4","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/BF00400362","volume":"36","author":"M Horowitz","year":"1993","unstructured":"Horowitz M, Edelbroek MA, Wishart JM, Straathof JW (1993) Relationship between oral glucose tolerance and gastric emptying in normal healthy subjects. Diabetologia 36:857\u2013862","journal-title":"Diabetologia"},{"issue":"Suppl 5","key":"3538_CR5","first-page":"S34","volume":"13","author":"C Moyses","year":"1996","unstructured":"Moyses C, Young A, Kolterman O (1996) Modulation of gastric emptying as a therapeutic approach to glycaemic control. Diabet Med J Br Diabet Assoc 13(Suppl 5):S34\u2013S38","journal-title":"Diabet Med J Br Diabet Assoc"},{"key":"3538_CR6","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.2337\/diacare.18.8.1179","volume":"18","author":"OG Kolterman","year":"1995","unstructured":"Kolterman OG, Gottlieb A, Moyses C, Colburn W (1995) Reduction of postprandial hyperglycemia in subjects with IDDM by intravenous infusion of AC137, a human amylin analogue. Diabetes Care 18:1179\u20131182","journal-title":"Diabetes Care"},{"key":"3538_CR7","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1210\/jc.2003-030049","volume":"88","author":"JJ Meier","year":"2003","unstructured":"Meier JJ, Gallwitz B, Salmen S et al (2003) Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes. J Clin Endocrinol Metab 88:2719\u20132725","journal-title":"J Clin Endocrinol Metab"},{"key":"3538_CR8","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.2337\/diabetes.54.7.2212","volume":"54","author":"JJ Meier","year":"2005","unstructured":"Meier JJ, Kemmeries G, Holst JJ, Nauck MA (2005) Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects. Diabetes 54:2212\u20132218","journal-title":"Diabetes"},{"key":"3538_CR9","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1023\/A:1022528414264","volume":"48","author":"S Gonlachanvit","year":"2003","unstructured":"Gonlachanvit S, Hsu CW, Boden GH et al (2003) Effect of altering gastric emptying on postprandial plasma glucose concentrations following a physiologic meal in type-II diabetic patients. Dig Dis Sci 48:488\u2013497","journal-title":"Dig Dis Sci"},{"issue":"Suppl 3","key":"3538_CR10","doi-asserted-by":"crossref","first-page":"S220","DOI":"10.2337\/diabetes.53.suppl_3.S220","volume":"53","author":"JJ Meier","year":"2004","unstructured":"Meier JJ, Gallwitz B, Kask B et al (2004) Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. Diabetes 53(Suppl 3):S220\u2013S224","journal-title":"Diabetes"},{"key":"3538_CR11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2165\/00063030-200317020-00002","volume":"17","author":"JJ Meier","year":"2003","unstructured":"Meier JJ, Gallwitz B, Nauck MA (2003) Glucagon-like peptide 1 and gastric inhibitory polypeptide: potential applications in type 2 diabetes mellitus. BioDrugs 17:93\u2013102","journal-title":"BioDrugs"},{"key":"3538_CR12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF01225454","volume":"16","author":"W Creutzfeldt","year":"1979","unstructured":"Creutzfeldt W (1979) The incretin concept today. Diabetologia 16:75\u201385","journal-title":"Diabetologia"},{"issue":"Suppl 3","key":"3538_CR13","doi-asserted-by":"crossref","first-page":"S190","DOI":"10.2337\/diabetes.53.suppl_3.S190","volume":"53","author":"MA Nauck","year":"2004","unstructured":"Nauck MA, Baller B, Meier JJ (2004) Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes. Diabetes 53(Suppl 3):S190\u2013S196","journal-title":"Diabetes"},{"key":"3538_CR14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0016-5085(97)70080-5","volume":"113","author":"E Schvarcz","year":"1997","unstructured":"Schvarcz E, Palmer M, Aman J, Horowitz M, Stridsberg M, Berne C (1997) Physiological hyperglycemia slows gastric emptying in normal subjects and patients with insulin-dependent diabetes mellitus. Gastroenterology 113:60\u201366","journal-title":"Gastroenterology"},{"key":"3538_CR15","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1210\/jc.2008-2197","volume":"94","author":"K Vollmer","year":"2009","unstructured":"Vollmer K, Gardiwal H, Menge BA et al (2009) Hyperglycemia acutely lowers the postprandial excursions of glucagon-like peptide-1 and gastric inhibitory polypeptide in humans. J Clin Endocrinol Metab 94:1379\u20131385","journal-title":"J Clin Endocrinol Metab"},{"key":"3538_CR16","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.2337\/dc13-1813","volume":"37","author":"MP Plummer","year":"2014","unstructured":"Plummer MP, Jones KL, Annink CE et al (2014) Glucagon-like peptide 1 attenuates the acceleration of gastric emptying induced by hypoglycemia in healthy subjects. Diabetes Care 37:1509\u20131515","journal-title":"Diabetes Care"},{"key":"3538_CR17","doi-asserted-by":"crossref","first-page":"468","DOI":"10.2337\/diacare.19.5.468","volume":"19","author":"JG Schwartz","year":"1996","unstructured":"Schwartz JG, Green GM, Guan D, McMahan CA, Phillips WT (1996) Rapid gastric emptying of a solid pancake meal in type II diabetic patients. Diabetes Care 19:468\u2013471","journal-title":"Diabetes Care"},{"key":"3538_CR18","doi-asserted-by":"crossref","unstructured":"Ziegler D, Schadewaldt P, Pour Mirza A et al (1996) [13C]Octanoic acid breath test for non-invasive assessment of gastric emptying in diabetic patients: validation and relationship to gastric symptoms and cardiovascular autonomic function. Diabetologia 39:823\u2013830","DOI":"10.1007\/s001250050516"},{"key":"3538_CR19","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.2337\/diacare.19.10.1075","volume":"19","author":"R Lehmann","year":"1996","unstructured":"Lehmann R, Borovicka J, Kunz P et al (1996) Evaluation of delayed gastric emptying in diabetic patients with autonomic neuropathy by a new magnetic resonance imaging technique and radio-opaque markers. Diabetes Care 19:1075\u20131082","journal-title":"Diabetes Care"},{"key":"3538_CR20","first-page":"357","volume":"27","author":"E Bertin","year":"2001","unstructured":"Bertin E, Schneider N, Abdelli N et al (2001) Gastric emptying is accelerated in obese type 2 diabetic patients without autonomic neuropathy. Diabetes Metab 27:357\u2013364","journal-title":"Diabetes Metab"},{"key":"3538_CR21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/(SICI)1096-9136(199602)13:2<112::AID-DIA37>3.0.CO;2-H","volume":"13","author":"MF Kong","year":"1996","unstructured":"Kong MF, Macdonald IA, Tattersall RB (1996) Gastric emptying in diabetes. Diabet Med J Br Diabet Assoc 13:112\u2013119","journal-title":"Diabet Med J Br Diabet Assoc"},{"key":"3538_CR22","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/j.1464-5491.2007.02236.x","volume":"24","author":"J Faraj","year":"2007","unstructured":"Faraj J, Melander O, Sundkvist G et al (2007) Oesophageal dysmotility, delayed gastric emptying and gastrointestinal symptoms in patients with diabetes mellitus. Diabet Med J Br Diabet Assoc 24:1235\u20131239","journal-title":"Diabet Med J Br Diabet Assoc"},{"key":"3538_CR23","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1056\/NEJMcp062614","volume":"356","author":"M Camilleri","year":"2007","unstructured":"Camilleri M (2007) Clinical practice. Diabetic gastroparesis. N Engl J Med 356:820\u2013829","journal-title":"N Engl J Med"},{"key":"3538_CR24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00004836-199909000-00014","volume":"29","author":"V Annese","year":"1999","unstructured":"Annese V, Bassotti G, Caruso N et al (1999) Gastrointestinal motor dysfunction, symptoms, and neuropathy in noninsulin-dependent (type 2) diabetes mellitus. J Clin Gastroenterol 29:171\u2013177","journal-title":"J Clin Gastroenterol"},{"key":"3538_CR25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.diabres.2012.01.036","volume":"97","author":"JX Jorge","year":"2012","unstructured":"Jorge JX, Panao EA, Simoes MA et al (2012) Esophageal body motility in people with diabetes: comparison with non-diabetic healthy individuals. Diabetes Res Clin Pract 97:77\u201381","journal-title":"Diabetes Res Clin Pract"},{"key":"3538_CR26","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1007\/s00125-006-0354-9","volume":"49","author":"B Ohlsson","year":"2006","unstructured":"Ohlsson B, Melander O, Thorsson O, Olsson R, Ekberg O, Sundkvist G (2006) Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis. Diabetologia 49:2010\u20132014","journal-title":"Diabetologia"},{"key":"3538_CR27","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.2337\/diacare.26.12.3331","volume":"26","author":"S Genuth","year":"2003","unstructured":"Genuth S, Alberti KGMM, Bennett P et al (2003) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26:3160\u20133167","journal-title":"Diabetes Care"},{"key":"3538_CR28","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1046\/j.1365-2036.2003.01553.x","volume":"17","author":"C Quan","year":"2003","unstructured":"Quan C, Talley NJ, Cross S et al (2003) Development and validation of the Diabetes Bowel Symptom Questionnaire. Aliment Pharmacol Ther 17:1179\u20131187","journal-title":"Aliment Pharmacol Ther"},{"key":"3538_CR29","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1023\/B:QURE.0000021689.86296.e4","volume":"13","author":"DA Revicki","year":"2004","unstructured":"Revicki DA, Rentz AM, Dubois D et al (2004) Gastroparesis Cardinal Symptom Index (GCSI): development and validation of a patient reported assessment of severity of gastroparesis symptoms. Qual Life Res Int J Qual Life Asp Treat Care Rehab 13:833\u2013844","journal-title":"Qual Life Res Int J Qual Life Asp Treat Care Rehab"},{"issue":"Suppl 1","key":"3538_CR30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1440-1746.2010.06573.x","volume":"26","author":"J Chang","year":"2011","unstructured":"Chang J, Rayner CK, Jones KL, Horowitz M (2011) Diabetic gastroparesis\u2014backwards and forwards. J Gastroenterol Hepatol 26(Suppl 1):46\u201357","journal-title":"J Gastroenterol Hepatol"},{"key":"3538_CR31","first-page":"1108","volume":"11","author":"PG Iyer","year":"2013","unstructured":"Iyer PG, Borah BJ, Heien HC, Das A, Cooper GS, Chak A (2013) Association of Barrett's esophagus with type II diabetes mellitus: results from a large population-based case\u2013control study. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 11:1108\u20131114","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"key":"3538_CR32","first-page":"840","volume":"82","author":"FE Murray","year":"1987","unstructured":"Murray FE, Lombard MG, Ashe J et al (1987) Esophageal function in diabetes mellitus with special reference to acid studies and relationship to peripheral neuropathy. Am J Gastroenterol 82:840\u2013843","journal-title":"Am J Gastroenterol"},{"key":"3538_CR33","doi-asserted-by":"crossref","first-page":"G797","DOI":"10.1152\/ajpgi.00383.2003","volume":"286","author":"Q Zhang","year":"2004","unstructured":"Zhang Q, Horowitz M, Rigda R, Rayner C, Worynski A, Holloway RH (2004) Effect of hyperglycemia on triggering of transient lower esophageal sphincter relaxations. Am J Physiol Gastrointest Liver Physiol 286:G797\u2013G803","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3538_CR34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1046\/j.1365-2982.1997.d01-64.x","volume":"9","author":"GE Boeckxstaens","year":"1997","unstructured":"Boeckxstaens GE, Horowitz M, Bermingham H, Holloway RH (1997) Physiological variations in blood glucose concentration affect oesophageal motility and sensation in normal subjects. Neurogastroenterol Motil 9:239\u2013246","journal-title":"Neurogastroenterol Motil"},{"key":"3538_CR35","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1097\/MEG.0b013e3282f5f734","volume":"20","author":"C Quan","year":"2008","unstructured":"Quan C, Talley NJ, Jones MP, Howell S, Horowitz M (2008) Gastrointestinal symptoms and glycemic control in diabetes mellitus: a longitudinal population study. Eur J Gastroenterol Hepatol 20:888\u2013897","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"3538_CR36","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1111\/j.1572-0241.2008.01943.x","volume":"103","author":"C Quan","year":"2008","unstructured":"Quan C, Talley NJ, Jones MP, Spies J, Horowitz M (2008) Gain and loss of gastrointestinal symptoms in diabetes mellitus: associations with psychiatric disease, glycemic control, and autonomic neuropathy over 2\u00a0years of follow-up. Am J Gastroenterol 103:2023\u20132030","journal-title":"Am J Gastroenterol"},{"key":"3538_CR37","doi-asserted-by":"crossref","unstructured":"Ali MK, Bullard KM, Saaddine JB, Cowie CC, Imperatore G, Gregg EW (2013) Achievement of goals in U.S. diabetes care, 1999\u20132010. N Engl J Med 368:1613\u20131624","DOI":"10.1056\/NEJMsa1213829"},{"key":"3538_CR38","doi-asserted-by":"crossref","unstructured":"Saaddine JB, Cadwell B, Gregg EW et al (2006) Improvements in diabetes processes of care and intermediate outcomes: United States, 1988\u20132002. Ann Intern Med 144:465\u2013474","DOI":"10.7326\/0003-4819-144-7-200604040-00005"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-015-3538-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-015-3538-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-015-3538-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T11:53:54Z","timestamp":1558612434000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-015-3538-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,1]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["3538"],"URL":"https:\/\/doi.org\/10.1007\/s00125-015-3538-3","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,1]]}}}