{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:20:28Z","timestamp":1793330428720,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T00:00:00Z","timestamp":1425513600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1007\/s00125-015-3544-5","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T12:00:02Z","timestamp":1425470402000},"page":"1646-1655","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans"],"prefix":"10.1007","volume":"58","author":[{"given":"Paul","family":"Begovatz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysi","family":"Koliaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Strassburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Nowotny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nowotny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"M\u00fcssig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Bunke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pacini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Szendr\u00f6di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Roden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,3,5]]},"reference":[{"key":"3544_CR1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","volume":"52","author":"AE Butler","year":"2003","unstructured":"Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102\u2013110","journal-title":"Diabetes"},{"key":"3544_CR2","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/nature05482","volume":"444","author":"SE Kahn","year":"2006","unstructured":"Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840\u2013846","journal-title":"Nature"},{"key":"3544_CR3","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.2337\/diabetes.50.6.1290","volume":"50","author":"M Federici","year":"2001","unstructured":"Federici M, Hribal M, Perego L et al (2001) High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes 50:1290\u20131301","journal-title":"Diabetes"},{"key":"3544_CR4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00281991","volume":"28","author":"RH Unger","year":"1985","unstructured":"Unger RH, Grundy S (1985) Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia 28:119\u2013121","journal-title":"Diabetologia"},{"issue":"Suppl 1","key":"3544_CR5","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.2337\/diabetes.53.2007.S119","volume":"53","author":"RP Robertson","year":"2004","unstructured":"Robertson RP, Harmon J, Tran PO, Poitout V (2004) Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 53(Suppl 1):S119\u2013S124","journal-title":"Diabetes"},{"key":"3544_CR6","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1172\/JCI29103","volume":"116","author":"M Prentki","year":"2006","unstructured":"Prentki M, Nolan CJ (2006) Islet beta cell failure in type 2 diabetes. J Clin Invest 116:1802\u20131812","journal-title":"J Clin Invest"},{"key":"3544_CR7","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1016\/j.ejrad.2009.03.062","volume":"74","author":"M Krssak","year":"2010","unstructured":"Krssak M, Hofer H, Wrba F et al (2010) Non-invasive assessment of hepatic fat accumulation in chronic hepatitis C by 1H magnetic resonance spectroscopy. Eur J Radiol 74:e60\u2013e66","journal-title":"Eur J Radiol"},{"key":"3544_CR8","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.2337\/diabetes.48.8.1600","volume":"48","author":"G Perseghin","year":"1999","unstructured":"Perseghin G, Scifo P, De Cobelli F et al (1999) Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 48:1600\u20131606","journal-title":"Diabetes"},{"key":"3544_CR9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s001250051123","volume":"42","author":"M Krssak","year":"1999","unstructured":"Krssak M, Falk Petersen K, Dresner A et al (1999) Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42:113\u2013116","journal-title":"Diabetologia"},{"key":"3544_CR10","first-page":"E977","volume":"276","author":"LS Szczepaniak","year":"1999","unstructured":"Szczepaniak LS, Babcock EE, Schick F et al (1999) Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol 276:E977\u2013E989","journal-title":"Am J Physiol"},{"key":"3544_CR11","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/oby.2007.110","volume":"16","author":"KE Pinnick","year":"2008","unstructured":"Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding BA (2008) Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity (Silver Spring) 16:522\u2013530","journal-title":"Obesity (Silver Spring)"},{"key":"3544_CR12","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/ijo.2009.245","volume":"34","author":"Y Lee","year":"2010","unstructured":"Lee Y, Lingvay I, Szczepaniak LS, Ravazzola M, Orci L, Unger RH (2010) Pancreatic steatosis: harbinger of type 2 diabetes in obese rodents. Int J Obes (Lond) 34:396\u2013400","journal-title":"Int J Obes (Lond)"},{"key":"3544_CR13","doi-asserted-by":"crossref","first-page":"10878","DOI":"10.1073\/pnas.91.23.10878","volume":"91","author":"Y Lee","year":"1994","unstructured":"Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH (1994) Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A 91:10878\u201310882","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3544_CR14","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/ca.20543","volume":"20","author":"Y Saisho","year":"2007","unstructured":"Saisho Y, Butler AE, Meier JJ et al (2007) Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes. Clin Anat 20:933\u2013942","journal-title":"Clin Anat"},{"key":"3544_CR15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0046-8177(84)80294-4","volume":"15","author":"BH Stamm","year":"1984","unstructured":"Stamm BH (1984) Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: a systematic study of 112 autopsies in patients without known pancreatic disease. Hum Pathol 15:677\u2013683","journal-title":"Hum Pathol"},{"key":"3544_CR16","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/apt.12237","volume":"37","author":"NS Patel","year":"2013","unstructured":"Patel NS, Peterson MR, Brenner DA, Heba E, Sirlin C, Loomba R (2013) Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Aliment Pharmacol Ther 37:630\u2013639","journal-title":"Aliment Pharmacol Ther"},{"key":"3544_CR17","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1210\/jc.2009-0584","volume":"94","author":"I Lingvay","year":"2009","unstructured":"Lingvay I, Esser V, Legendre JL et al (2009) Noninvasive quantification of pancreatic fat in humans. J Clin Endocrinol Metab 94:4070\u20134076","journal-title":"J Clin Endocrinol Metab"},{"key":"3544_CR18","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/dmrr.1073","volume":"26","author":"M Heni","year":"2010","unstructured":"Heni M, Machann J, Staiger H et al (2010) Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and\/or impaired glucose tolerance: a nuclear magnetic resonance study. Diabetes Metab Res Rev 26:200\u2013205","journal-title":"Diabetes Metab Res Rev"},{"key":"3544_CR19","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.2337\/dc07-0326","volume":"30","author":"ME Tushuizen","year":"2007","unstructured":"Tushuizen ME, Bunck MC, Pouwels PJ (2007) Pancreatic fat content and beta-cell function in men with and without type 2 diabetes. Diabetes Care 30:2916\u20132921","journal-title":"Diabetes Care"},{"key":"3544_CR20","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.2337\/dc12-0701","volume":"35","author":"LS Szczepaniak","year":"2012","unstructured":"Szczepaniak LS, Victor RG, Mathur R et al (2012) Pancreatic steatosis and its relationship to beta-cell dysfunction in humans: racial and ethnic variations. Diabetes Care 35:2377\u20132383","journal-title":"Diabetes Care"},{"key":"3544_CR21","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2337\/dc10-0760","volume":"34","author":"KA Le","year":"2011","unstructured":"Le KA, Ventura EE, Fisher JQ et al (2011) Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers. Diabetes Care 34:485\u2013490","journal-title":"Diabetes Care"},{"key":"3544_CR22","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/RLI.0b013e31816a88c6","volume":"43","author":"NF Schwenzer","year":"2008","unstructured":"Schwenzer NF, Machann J, Martirosian P et al (2008) Quantification of pancreatic lipomatosis and liver steatosis by MRI: comparison of in\/opposed-phase and spectral-spatial excitation techniques. Investig Radiol 43:330\u2013337","journal-title":"Investig Radiol"},{"key":"3544_CR23","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/oby.2009.352","volume":"18","author":"HH Hu","year":"2010","unstructured":"Hu HH, Kim HW, Nayak KS, Goran MI (2010) Comparison of fat-water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans. Obesity (Silver Spring) 18:841\u2013847","journal-title":"Obesity (Silver Spring)"},{"key":"3544_CR24","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1210\/jc.2010-1722","volume":"96","author":"NJ Zijl van der","year":"2011","unstructured":"van der Zijl NJ, Goossens GH, Moors CC et al (2011) Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on beta-cell function in individuals with impaired glucose metabolism. J Clin Endocrinol Metab 96:459\u2013467","journal-title":"J Clin Endocrinol Metab"},{"key":"3544_CR25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s125-002-8248-z","volume":"45","author":"H Sakuraba","year":"2002","unstructured":"Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S (2002) Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia 45:85\u201396","journal-title":"Diabetologia"},{"key":"3544_CR26","doi-asserted-by":"crossref","first-page":"32487","DOI":"10.1074\/jbc.273.49.32487","volume":"273","author":"M Shimabukuro","year":"1998","unstructured":"Shimabukuro M, Higa M, Zhou YT, Wang MY, Newgard CB, Unger RH (1998) Lipoapoptosis in beta-cells of obese prediabetic fa\/fa rats. Role of serine palmitoyltransferase overexpression. J Biol Chem 273:32487\u201332490","journal-title":"J Biol Chem"},{"key":"3544_CR27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrgastro.2011.4","volume":"8","author":"MM Smits","year":"2011","unstructured":"Smits MM, van Geenen EJ (2011) The clinical significance of pancreatic steatosis. Nat Rev Gastroenterol Hepatol 8:169\u2013177","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"3544_CR28","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/mrm.22578","volume":"65","author":"H Eggers","year":"2011","unstructured":"Eggers H, Brendel B, Duijndam A, Herigault G (2011) Dual-echo Dixon imaging with flexible choice of echo times. Magn Reson Med 65:96\u2013107","journal-title":"Magn Reson Med"},{"key":"3544_CR29","unstructured":"Begovatz P, Koliaki C, Szendroedi J, Giani G, Bunke J, Roden M (2014) Pancreas fat via dual-echo mDIXON imaging shows that intracellular fat does not accumulate within the pancreas of healthy and T2DM subjects. Proc Intl Soc Magn Reson 23:3608 (Abstract)"},{"key":"3544_CR30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1521-690X(03)00042-3","volume":"17","author":"G Pacini","year":"2003","unstructured":"Pacini G, Mari A (2003) Methods for clinical assessment of insulin sensitivity and beta-cell function. Best Pract Res Clin Endocrinol Metab 17:305\u2013322","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"3544_CR31","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2337\/dc08-1123","volume":"32","author":"J Szendroedi","year":"2009","unstructured":"Szendroedi J, Anderwald C, Krssak M et al (2009) Effects of high-dose simvastatin therapy on glucose metabolism and ectopic lipid deposition in nonobese type 2 diabetic patients. Diabetes Care 32:209\u2013214","journal-title":"Diabetes Care"},{"key":"3544_CR32","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2337\/diacare.24.3.539","volume":"24","author":"A Mari","year":"2001","unstructured":"Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ (2001) A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 24:539\u2013548","journal-title":"Diabetes Care"},{"key":"3544_CR33","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1530\/eje.0.1500097","volume":"150","author":"B Ahren","year":"2004","unstructured":"Ahren B, Pacini G (2004) Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess beta cell function in clinical studies. Eur J Endocrinol 150:97\u2013104","journal-title":"Eur J Endocrinol"},{"key":"3544_CR34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.2337\/diabetes.52.2.244","volume":"52","author":"A Kautzky-Willer","year":"2003","unstructured":"Kautzky-Willer A, Krssak M, Winzer C et al (2003) Increased intramyocellular lipid concentration identifies impaired glucose metabolism in women with previous gestational diabetes. Diabetes 52:244\u2013251","journal-title":"Diabetes"},{"key":"3544_CR35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2337\/dc08-1478","volume":"32","author":"KM Utzschneider","year":"2009","unstructured":"Utzschneider KM, Prigeon RL, Faulenbach MV et al (2009) Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels. Diabetes Care 32:335\u2013341","journal-title":"Diabetes Care"},{"key":"3544_CR36","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.diabres.2005.10.005","volume":"72","author":"A Tura","year":"2006","unstructured":"Tura A, Kautzky-Willer A, Pacini G (2006) Insulinogenic indices from insulin and C-peptide: comparison of beta-cell function from OGTT and IVGTT. Diabetes Res Clin Pract 72:298\u2013301","journal-title":"Diabetes Res Clin Pract"},{"key":"3544_CR37","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1007\/s00125-007-0819-5","volume":"50","author":"KM Utzschneider","year":"2007","unstructured":"Utzschneider KM, Prigeon RL, Tong J et al (2007) Within-subject variability of measures of beta cell function derived from a 2 h OGTT: implications for research studies. Diabetologia 50:2516\u20132525","journal-title":"Diabetologia"},{"key":"3544_CR38","doi-asserted-by":"crossref","unstructured":"Livingstone RS, Begovatz P, Kahl S, et al. (2014) Initial clinical application of modified Dixon with flexible echo times: hepatic and pancreatic fat assessments in comparison with 1H MRS. MAGMA 27:397\u2013405","DOI":"10.1007\/s10334-013-0421-4"},{"key":"3544_CR39","doi-asserted-by":"crossref","unstructured":"Hamilton G, Yokoo T, Bydder M et al (2011) In vivo characterization of the liver fat 1H MR spectrum. NMR Biomed 24:784\u2013790","DOI":"10.1002\/nbm.1622"},{"key":"3544_CR40","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1073\/pnas.95.5.2498","volume":"95","author":"M Shimabukuro","year":"1998","unstructured":"Shimabukuro M, Zhou YT, Levi M, Unger RH (1998) Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A 95:2498\u20132502","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3544_CR41","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.transproceed.2004.04.032","volume":"36","author":"DD Nghiem","year":"2004","unstructured":"Nghiem DD, Olson PR, Ormond D (2004) The \"fatty pancreas allograft\": anatomopathologic findings and clinical experience. Transplant Proc 36:1045\u20131047","journal-title":"Transplant Proc"},{"key":"3544_CR42","doi-asserted-by":"crossref","first-page":"107ra110","DOI":"10.1126\/scitranslmed.3002573","volume":"3","author":"S Navina","year":"2011","unstructured":"Navina S, Acharya C, DeLany JP et al (2011) Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity. Sci Transl Med 3:107ra110","journal-title":"Sci Transl Med"},{"key":"3544_CR43","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00592-014-0581-3","volume":"51","author":"S Lim","year":"2014","unstructured":"Lim S, Bae JH, Chun EJ et al (2014) Differences in pancreatic volume, fat content, and fat density measured by multidetector-row computed tomography according to the duration of diabetes. Acta Diabetol 51:739\u2013748","journal-title":"Acta Diabetol"},{"key":"3544_CR44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/mrm.10372","volume":"49","author":"LS Szczepaniak","year":"2003","unstructured":"Szczepaniak LS, Dobbins RL, Metzger GJ et al (2003) Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging. Magn Reson Med 49:417\u2013423","journal-title":"Magn Reson Med"},{"key":"3544_CR45","doi-asserted-by":"crossref","unstructured":"Reeder SB, Cruite I, Hamilton G, Sirlin CB (2011) Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. J Magn Reson Imaging 34:729\u2013749","DOI":"10.1002\/jmri.22580"},{"key":"3544_CR46","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.3748\/wjg.v16.i16.1993","volume":"16","author":"PE Sijens","year":"2010","unstructured":"Sijens PE, Edens MA, Bakker SJ, Stolk RP (2010) MRI-determined fat content of human liver, pancreas and kidney. World J Gastroenterol 16:1993\u20131998","journal-title":"World J Gastroenterol"},{"key":"3544_CR47","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.2337\/dc08-0044","volume":"31","author":"Y Saisho","year":"2008","unstructured":"Saisho Y, Butler AE, Butler PC (2008) Pancreatic fat content and beta-cell function in men with and without type 2 diabetes: response to Tushuizen et al. Diabetes Care 31:e38, author reply e39","journal-title":"Diabetes Care"},{"key":"3544_CR48","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/path.1700920232","volume":"92","author":"MN Walters","year":"1966","unstructured":"Walters MN (1966) Adipose atrophy of the exocrine pancreas. J Pathol Bacteriol 92:547\u2013557","journal-title":"J Pathol Bacteriol"},{"issue":"Suppl 4","key":"3544_CR49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1463-1326.2008.00969.x","volume":"10","author":"J Rahier","year":"2008","unstructured":"Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC (2008) Pancreatic beta-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab 10(Suppl 4):32\u201342","journal-title":"Diabetes Obes Metab"},{"key":"3544_CR50","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/MCO.0b013e32833aa1ef","volume":"13","author":"DH Raalte van","year":"2010","unstructured":"van Raalte DH, van der Zijl NJ, Diamant M (2010) Pancreatic steatosis in humans: cause or marker of lipotoxicity? Curr Opin Clin Nutr Metab Care 13:478\u2013485","journal-title":"Curr Opin Clin Nutr Metab Care"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-015-3544-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-015-3544-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-015-3544-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T11:53:54Z","timestamp":1558612434000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-015-3544-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,5]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["3544"],"URL":"https:\/\/doi.org\/10.1007\/s00125-015-3544-5","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,5]]}}}