{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:08:06Z","timestamp":1791205686970,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2015,6,7]],"date-time":"2015-06-07T00:00:00Z","timestamp":1433635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1007\/s00125-015-3625-5","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T06:16:20Z","timestamp":1433571380000},"page":"1814-1826","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas)"],"prefix":"10.1007","volume":"58","author":[{"given":"Rodolfo","family":"Guardado Mendoza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Perego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Finzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"La Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Capella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia M.","family":"Jimenez-Ceja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licio A.","family":"Velloso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario J. A.","family":"Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Sessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Bertuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Edward J.","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto M.","family":"Davalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Folli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,7]]},"reference":[{"key":"3625_CR1","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1242\/dev.127.13.2883","volume":"127","author":"M Gannon","year":"2000","unstructured":"Gannon M, Ray MK, van Zee K, Rausa F, Costa RH, Wright CV (2000) Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. Development 127:2883\u20132895","journal-title":"Development"},{"key":"3625_CR2","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/S0140-6736(75)92078-4","volume":"2","author":"L Orci","year":"1975","unstructured":"Orci L, Unger RH (1975) Functional subdivision of islets of Langerhans and possible role of D cells. Lancet 2:1243\u20131244","journal-title":"Lancet"},{"key":"3625_CR3","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0026-0495(90)90212-U","volume":"39","author":"E Samols","year":"1990","unstructured":"Samols E, Stagner JI (1990) Islet somatostatin\u2014microvascular, paracrine, and pulsatile regulation. Metabolism 39:55\u201360","journal-title":"Metabolism"},{"key":"3625_CR4","doi-asserted-by":"publisher","first-page":"16009","DOI":"10.1073\/pnas.1006639107","volume":"107","author":"RH Unger","year":"2010","unstructured":"Unger RH, Orci L (2010) Paracrinology of islets and the paracrinopathy of diabetes. Proc Natl Acad Sci U S A 107:16009\u201316012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3625_CR5","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1210\/er.2006-0007","volume":"28","author":"J Gromada","year":"2007","unstructured":"Gromada J, Franklin I, Wollheim CB (2007) Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 28:84\u2013116","journal-title":"Endocr Rev"},{"key":"3625_CR6","doi-asserted-by":"publisher","first-page":"883","DOI":"10.2337\/diab.31.10.883","volume":"31","author":"S Bonner-Weir","year":"1982","unstructured":"Bonner-Weir S, Orci L (1982) New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes 31:883\u2013889","journal-title":"Diabetes"},{"key":"3625_CR7","doi-asserted-by":"publisher","first-page":"241","DOI":"10.2337\/diab.26.3.241","volume":"26","author":"RH Unger","year":"1977","unstructured":"Unger RH, Orci L (1977) Possible roles of the pancreatic D-cell in the normal and diabetic states. Diabetes 26:241\u2013244","journal-title":"Diabetes"},{"key":"3625_CR8","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.2337\/db07-1842","volume":"57","author":"S Bonner-Weir","year":"2008","unstructured":"Bonner-Weir S, O\u2019Brien TD (2008) Islets in type 2 diabetes: in honor of Dr. Robert C. Turner. Diabetes 57:2899\u20132904","journal-title":"Diabetes"},{"key":"3625_CR9","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.2337\/db09-1177","volume":"59","author":"D Bosco","year":"2010","unstructured":"Bosco D, Armanet M, Morel P et al (2010) Unique arrangement of alpha- and beta-cells in human islets of Langerhans. Diabetes 59:1202\u20131210","journal-title":"Diabetes"},{"key":"3625_CR10","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1073\/pnas.0510790103","volume":"103","author":"O Cabrera","year":"2006","unstructured":"Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A (2006) The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci U S A 103:2334\u20132339","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3625_CR11","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1530\/JOE-12-0070","volume":"214","author":"AR Quinn","year":"2012","unstructured":"Quinn AR, Blanco CL, Perego C et al (2012) The ontogeny of the endocrine pancreas in the fetal\/newborn baboon. J Endocrinol 214:289\u2013299","journal-title":"J Endocrinol"},{"key":"3625_CR12","doi-asserted-by":"publisher","first-page":"538","DOI":"10.2337\/diab.31.6.538","volume":"31","author":"L Orci","year":"1982","unstructured":"Orci L (1982) Macro- and micro-domains in the endocrine pancreas. Diabetes 31:538\u2013565","journal-title":"Diabetes"},{"key":"3625_CR13","first-page":"151","volume":"9","author":"A Clark","year":"1988","unstructured":"Clark A, Wells CA, Buley ID et al (1988) Islet amyloid, increased A-cells, reduced B cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res 9:151\u2013159","journal-title":"Diabetes Res"},{"key":"3625_CR14","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1210\/jc.2002-020735","volume":"88","author":"KH Yoon","year":"2003","unstructured":"Yoon KH, Ko SH, Cho JH et al (2003) Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab 88:2300\u20132308","journal-title":"J Clin Endocrinol Metab"},{"key":"3625_CR15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s125-002-8248-z","volume":"45","author":"H Sakuraba","year":"2002","unstructured":"Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S (2002) Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients. Diabetologia 45:85\u201396","journal-title":"Diabetologia"},{"key":"3625_CR16","doi-asserted-by":"publisher","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","volume":"52","author":"AE Butler","year":"2003","unstructured":"Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102\u2013110","journal-title":"Diabetes"},{"key":"3625_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028050","volume":"6","author":"F Folli","year":"2011","unstructured":"Folli F, Okada T, Perego C et al (2011) Altered insulin receptor signalling and beta-cell cycle dynamics in type 2 diabetes mellitus. PLoS One 6, e28050","journal-title":"PLoS One"},{"key":"3625_CR18","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1210\/er.2006-0026","volume":"28","author":"BE Dunning","year":"2007","unstructured":"Dunning BE, Gerich JE (2007) The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications. Endocr Rev 28:253\u2013283","journal-title":"Endocr Rev"},{"key":"3625_CR19","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1369\/jhc.6A7024.2006","volume":"55","author":"K Iki","year":"2007","unstructured":"Iki K, Pour PM (2007) Distribution of pancreatic endocrine cells including IAPP-expressing cells in non-diabetic and type 2 diabetic cases. J Histochem Cytochem 55:111\u2013118","journal-title":"J Histochem Cytochem"},{"key":"3625_CR20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1146\/annurev.ph.40.030178.001515","volume":"40","author":"RH Unger","year":"1978","unstructured":"Unger RH, Dobbs RE, Orci L (1978) Insulin, glucagon, and somatostatin secretion in the regulation of metabolism. Annu Rev Physiol 40:307\u2013343","journal-title":"Annu Rev Physiol"},{"key":"3625_CR21","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1177\/002215540405200310","volume":"52","author":"E Ludvigsen","year":"2004","unstructured":"Ludvigsen E, Olsson R, Stridsberg M, Janson ET, Sandler S (2004) Expression and distribution of somatostatin receptor subtypes in the pancreatic islets of mice and rats. J Histochem Cytochem 52:391\u2013400","journal-title":"J Histochem Cytochem"},{"key":"3625_CR22","doi-asserted-by":"publisher","first-page":"403","DOI":"10.2337\/db08-0792","volume":"58","author":"AC Hauge-Evans","year":"2009","unstructured":"Hauge-Evans AC, King AJ, Carmignac D et al (2009) Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function. Diabetes 58:403\u2013411","journal-title":"Diabetes"},{"key":"3625_CR23","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1172\/JCI111823","volume":"75","author":"YC Patel","year":"1985","unstructured":"Patel YC, Pierzchala I, Amherdt M, Orci L (1985) Effects of cysteamine and antibody to somatostatin on islet cell function in vitro. Evidence that intracellular somatostatin deficiency augments insulin and glucagon secretion. J Clin Invest 75:1249\u20131255","journal-title":"J Clin Invest"},{"key":"3625_CR24","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.2337\/diab.38.12.1534","volume":"38","author":"DA D\u2019Alessio","year":"1989","unstructured":"D\u2019Alessio DA, Fujimoto WY, Ensinck JW (1989) Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures. Diabetes 38:1534\u20131538","journal-title":"Diabetes"},{"key":"3625_CR25","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1097\/00006676-200101000-00010","volume":"22","author":"A Guenifi","year":"2001","unstructured":"Guenifi A, Ahren B, Abdel-Halim SM (2001) Differential effects of glucagon-like peptide-1 (7-36)amide versus cholecystokinin on arginine-induced islet hormone release in vivo and in vitro. Pancreas 22:58\u201364","journal-title":"Pancreas"},{"key":"3625_CR26","first-page":"G852","volume":"269","author":"RS Heller","year":"1995","unstructured":"Heller RS, Aponte GW (1995) Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7\u201336) amide. Am J Physiol 269:G852\u2013G860","journal-title":"Am J Physiol"},{"key":"3625_CR27","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0014-2999(03)01692-3","volume":"469","author":"RA Silvestre","year":"2003","unstructured":"Silvestre RA, Rodriguez-Gallardo J, Egido EM, Marco J (2003) Interrelationship among insulin, glucagon and somatostatin secretory responses to exendin-4 in the perfused rat pancreas. Eur J Pharmacol 469:195\u2013200","journal-title":"Eur J Pharmacol"},{"key":"3625_CR28","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1007\/s00125-006-0511-1","volume":"50","author":"E Vieira","year":"2007","unstructured":"Vieira E, Salehi A, Gylfe E (2007) Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells. Diabetologia 50:370\u2013379","journal-title":"Diabetologia"},{"key":"3625_CR29","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1475-2840-8-22","volume":"8","author":"AO Chavez","year":"2009","unstructured":"Chavez AO, Gastaldelli A, Guardado-Mendoza R et al (2009) Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons. Cardiovasc Diabetol 8:22","journal-title":"Cardiovasc Diabetol"},{"key":"3625_CR30","doi-asserted-by":"publisher","first-page":"899","DOI":"10.2337\/db07-0790","volume":"57","author":"AO Chavez","year":"2008","unstructured":"Chavez AO, Lopez-Alvarenga JC, Tejero ME et al (2008) Physiological and molecular determinants of insulin action in the baboon. Diabetes 57:899\u2013908","journal-title":"Diabetes"},{"key":"3625_CR31","doi-asserted-by":"publisher","first-page":"13992","DOI":"10.1073\/pnas.0906471106","volume":"106","author":"R Guardado-Mendoza","year":"2009","unstructured":"Guardado-Mendoza R, Davalli AM, Chavez AO et al (2009) Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons. Proc Natl Acad Sci U S A 106:13992\u201313997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3625_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027617","volume":"6","author":"S Kamath","year":"2011","unstructured":"Kamath S, Chavez AO, Gastaldelli A et al (2011) Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates. PLoS One 6, e27617","journal-title":"PLoS One"},{"key":"3625_CR33","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/ijo.2012.205","volume":"37","author":"R Guardado-Mendoza","year":"2013","unstructured":"Guardado-Mendoza R, Jimenez-Ceja L, Majluf-Cruz A et al (2013) Impact of obesity severity and duration on pancreatic beta- and alpha-cell dynamics in normoglycemic non-human primates. Int J Obes (Lond) 37:1071\u20131078","journal-title":"Int J Obes (Lond)"},{"key":"3625_CR34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1365-2818.1967.tb04489.x","volume":"87","author":"RH Freere","year":"1967","unstructured":"Freere RH, Weibel ER (1967) Stereologic techniques in microscopy. J R Microsc Soc 87:25\u201334","journal-title":"J R Microsc Soc"},{"key":"3625_CR35","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1590\/S0001-37652003000400006","volume":"75","author":"CA Mandarim-de-Lacerda","year":"2003","unstructured":"Mandarim-de-Lacerda CA (2003) Stereological tools in biomedical research. An Acad Bras Cienc 75:469\u2013486","journal-title":"An Acad Bras Cienc"},{"key":"3625_CR36","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412\u2013419","journal-title":"Diabetologia"},{"issue":"Suppl 2","key":"3625_CR37","doi-asserted-by":"publisher","first-page":"S56","DOI":"10.1016\/S1262-3636(08)73396-2","volume":"34","author":"R Lupi","year":"2008","unstructured":"Lupi R, del Prato S (2008) Beta-cell apoptosis in type 2 diabetes: quantitative and functional consequences. Diabetes Metab 34(Suppl 2):S56\u2013S64","journal-title":"Diabetes Metab"},{"key":"3625_CR38","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1016\/j.ajpath.2011.02.036","volume":"178","author":"CA Jurgens","year":"2011","unstructured":"Jurgens CA, Toukatly MN, Fligner CL et al (2011) Beta-cell loss and beta-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition. Am J Pathol 178:2632\u20132640","journal-title":"Am J Pathol"},{"key":"3625_CR39","doi-asserted-by":"publisher","first-page":"330","DOI":"10.2174\/13892037113149990050","volume":"14","author":"GT Westermark","year":"2013","unstructured":"Westermark GT, Westermark P (2013) Islet amyloid polypeptide and diabetes. Curr Protein Pept Sci 14:330\u2013337","journal-title":"Curr Protein Pept Sci"},{"key":"3625_CR40","doi-asserted-by":"publisher","first-page":"14007","DOI":"10.1074\/jbc.M110.183517","volume":"286","author":"ES Cairano Di","year":"2011","unstructured":"Di Cairano ES, Davalli AM, Perego L et al (2011) The glial glutamate transporter 1 (GLT1) is expressed by pancreatic beta-cells and prevents glutamate-induced beta-cell death. J Biol Chem 286:14007\u201314018","journal-title":"J Biol Chem"},{"key":"3625_CR41","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.2337\/diabetes.50.6.1290","volume":"50","author":"M Federici","year":"2001","unstructured":"Federici M, Hribal M, Perego L et al (2001) High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes 50:1290\u20131301","journal-title":"Diabetes"},{"key":"3625_CR42","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1007\/s00125-010-1850-5","volume":"53","author":"G Fontes","year":"2010","unstructured":"Fontes G, Zarrouki B, Hagman DK et al (2010) Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass. Diabetologia 53:2369\u20132379","journal-title":"Diabetologia"},{"key":"3625_CR43","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3109\/15513818609025923","volume":"6","author":"K Soejima","year":"1986","unstructured":"Soejima K, Landing BH (1986) Pancreatic islets in older patients with cystic fibrosis with and without diabetes mellitus: morphometric and immunocytologic studies. Pediatr Pathol 6:25\u201346","journal-title":"Pediatr Pathol"},{"key":"3625_CR44","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.2337\/db11-0251","volume":"60","author":"BA Menge","year":"2011","unstructured":"Menge BA, Gruber L, Jorgensen SM et al (2011) Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes. Diabetes 60:2160\u20132168","journal-title":"Diabetes"},{"key":"3625_CR45","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.cell.2012.07.029","volume":"150","author":"C Talchai","year":"2012","unstructured":"Talchai C, Xuan S, Lin HV, Sussel L, Accili D (2012) Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Cell 150:1223\u20131234","journal-title":"Cell"},{"key":"3625_CR46","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.2337\/db12-1001","volume":"62","author":"HS Spijker","year":"2013","unstructured":"Spijker HS, Ravelli RB, Mommaas-Kienhuis AM et al (2013) Conversion of mature human beta-cells into glucagon-producing alpha-cells. Diabetes 62:2471\u20132480","journal-title":"Diabetes"},{"key":"3625_CR47","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1073\/pnas.73.4.1338","volume":"73","author":"L Orci","year":"1976","unstructured":"Orci L, Baetens D, Rufener C et al (1976) Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes. Proc Natl Acad Sci U S A 73:1338\u20131342","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3625_CR48","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1007\/s00125-008-1082-0","volume":"51","author":"SC Collins","year":"2008","unstructured":"Collins SC, Salehi A, Eliasson L, Olofsson CS, Rorsman P (2008) Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon. Diabetologia 51:1689\u20131693","journal-title":"Diabetologia"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-015-3625-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-015-3625-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-015-3625-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-015-3625-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T17:12:34Z","timestamp":1652289154000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-015-3625-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,7]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["3625"],"URL":"https:\/\/doi.org\/10.1007\/s00125-015-3625-5","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,7]]},"assertion":[{"value":"5 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}