{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:27:04Z","timestamp":1787970424777,"version":"build-2784847793"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s00125-015-3771-9","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T18:03:55Z","timestamp":1444327435000},"page":"2885-2898","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Role of the renal sympathetic nerve in renal glucose metabolism during the development of type 2 diabetes in rats"],"prefix":"10.1007","volume":"58","author":[{"given":"Kazi","family":"Rafiq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamshad J.","family":"Sherajee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asadur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu","family":"Sufiun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kobori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Koepsell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Mogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatsugu","family":"Horiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,8]]},"reference":[{"key":"3771_CR1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/01.HYP.0000242642.42177.49","volume":"48","author":"M Esler","year":"2006","unstructured":"Esler M, Straznicky N, Eikelis N, Masuo K, Lambert G, Lambert E (2006) Mechanisms of sympathetic activation in obesity-related hypertension. Hypertension 48:787\u2013796","journal-title":"Hypertension"},{"key":"3771_CR2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.pharmthera.2010.02.002","volume":"126","author":"GW Lambert","year":"2010","unstructured":"Lambert GW, Straznicky NE, Lambert EA, Dixon JB, Schlaich MP (2010) Sympathetic nervous activation in obesity and the metabolic syndrome\u2014causes, consequences and therapeutic implications. Pharmacol Ther 126:159\u2013172","journal-title":"Pharmacol Ther"},{"key":"3771_CR3","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1161\/01.CIR.96.11.4104","volume":"96","author":"U Scherrer","year":"1997","unstructured":"Scherrer U, Sartori C (1997) Insulin as a vascular and sympathoexcitatory hormone: implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity. Circulation 96:4104\u20134113","journal-title":"Circulation"},{"key":"3771_CR4","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1097\/HJH.0b013e328048d004","volume":"25","author":"G Mancia","year":"2007","unstructured":"Mancia G, Bousquet P, Elghozi JL et al (2007) The sympathetic nervous system and the metabolic syndrome. J Hypertens 25:909\u2013920","journal-title":"J Hypertens"},{"key":"3771_CR5","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/ajh\/hpu123","volume":"28","author":"D Linz","year":"2015","unstructured":"Linz D, Hohl M, Schutze J et al (2015) Progression of kidney injury and cardiac remodeling in obese spontaneously hypertensive rats: the role of renal sympathetic innervation. Am J Hypertens 28:256\u2013265","journal-title":"Am J Hypertens"},{"key":"3771_CR6","doi-asserted-by":"crossref","first-page":"R633","DOI":"10.1152\/ajpregu.00258.2005","volume":"289","author":"GF DiBona","year":"2005","unstructured":"DiBona GF (2005) Physiology in perspective: the wisdom of the body. Neural control of the kidney. Am J Physiol Regul Integr Com Physiol 289:R633\u2013R641","journal-title":"Am J Physiol Regul Integr Com Physiol"},{"key":"3771_CR7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1152\/japplphysiol.00832.2009","volume":"108","author":"M Esler","year":"2010","unstructured":"Esler M (2010) The 2009 Carl Ludwig lecture: pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management. J Appl Physiol (1985) 108:227\u2013237","journal-title":"J Appl Physiol (1985)"},{"key":"3771_CR8","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1161\/01.CIR.0000103123.66264.FE","volume":"108","author":"RJ Huggett","year":"2003","unstructured":"Huggett RJ, Scott EM, Gilbey SG, Stoker JB, Mackintosh AF, Mary DA (2003) Impact of type 2 diabetes mellitus on sympathetic neural mechanisms in hypertension. Circulation 108:3097\u20133101","journal-title":"Circulation"},{"key":"3771_CR9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1172\/JCI116542","volume":"92","author":"P Vollenweider","year":"1993","unstructured":"Vollenweider P, Tappy L, Randin D et al (1993) Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans. J Clin Invest 92:147\u2013154","journal-title":"J Clin Invest"},{"key":"3771_CR10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/01.CIR.73.4.615","volume":"73","author":"GJ Hasking","year":"1986","unstructured":"Hasking GJ, Esler MD, Jennings GL, Burton D, Johns JA, Korner PI (1986) Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation 73:615\u2013621","journal-title":"Circulation"},{"key":"3771_CR11","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1161\/CIRCULATIONAHA.112.130880","volume":"126","author":"MD Esler","year":"2012","unstructured":"Esler MD, Krum H, Schlaich M, Schmieder RE, Bohm M, Sobotka PA (2012) Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial. Circulation 126:2976\u20132982","journal-title":"Circulation"},{"key":"3771_CR12","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(10)62039-9","volume":"376","author":"MD Esler","year":"2010","unstructured":"Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M (2010) Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 376:1903\u20131909","journal-title":"Lancet"},{"key":"3771_CR13","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0140-6736(09)60566-3","volume":"373","author":"H Krum","year":"2009","unstructured":"Krum H, Schlaich M, Whitbourn R et al (2009) Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 373:1275\u20131281","journal-title":"Lancet"},{"key":"3771_CR14","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jacc.2011.11.034","volume":"59","author":"MC Brandt","year":"2012","unstructured":"Brandt MC, Mahfoud F, Reda S et al (2012) Renal sympathetic denervation reduces left ventricular hypertrophy and improves cardiac function in patients with resistant hypertension. J Am Coll Cardiol 59:901\u2013909","journal-title":"J Am Coll Cardiol"},{"key":"3771_CR15","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1161\/CIRCULATIONAHA.111.064097","volume":"125","author":"K Rafiq","year":"2012","unstructured":"Rafiq K, Noma T, Fujisawa Y et al (2012) Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation. Circulation 125:1402\u20131413","journal-title":"Circulation"},{"key":"3771_CR16","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJMoa1402670","volume":"370","author":"DL Bhatt","year":"2014","unstructured":"Bhatt DL, Kandzari DE, O'Neill WW et al (2014) A controlled trial of renal denervation for resistant hypertension. N Engl J Med 370:1393\u20131401","journal-title":"N Engl J Med"},{"key":"3771_CR17","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1161\/CIRCULATIONAHA.110.991869","volume":"123","author":"F Mahfoud","year":"2011","unstructured":"Mahfoud F, Schlaich M, Kindermann I et al (2011) Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: a pilot study. Circulation 123:1940\u20131946","journal-title":"Circulation"},{"key":"3771_CR18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1161\/HYPERTENSIONAHA.111.173799","volume":"58","author":"A Witkowski","year":"2011","unstructured":"Witkowski A, Prejbisz A, Florczak E et al (2011) Effects of renal sympathetic denervation on blood pressure, sleep apnea course, and glycemic control in patients with resistant hypertension and sleep apnea. Hypertension 58:559\u2013565","journal-title":"Hypertension"},{"key":"3771_CR19","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1097\/HJH.0b013e328344db3a","volume":"29","author":"MP Schlaich","year":"2011","unstructured":"Schlaich MP, Straznicky N, Grima M et al (2011) Renal denervation: a potential new treatment modality for polycystic ovary syndrome? J Hypertens 29:991\u2013996","journal-title":"J Hypertens"},{"key":"3771_CR20","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.2337\/diab.41.11.1422","volume":"41","author":"K Kawano","year":"1992","unstructured":"Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M, Natori T (1992) Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41:1422\u20131428","journal-title":"Diabetes"},{"key":"3771_CR21","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1161\/01.HYP.29.3.728","volume":"29","author":"K Yagi","year":"1997","unstructured":"Yagi K, Kim S, Wanibuchi H, Yamashita T, Yamamura Y, Iwao H (1997) Characteristics of diabetes, blood pressure, and cardiac and renal complications in Otsuka Long-Evans Tokushima Fatty rats. Hypertension 29:728\u2013735","journal-title":"Hypertension"},{"key":"3771_CR22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0165-1838(82)90046-7","volume":"6","author":"G Recordati","year":"1982","unstructured":"Recordati G, Genovesi S, Cerati D (1982) Renorenal reflexes in the rat elicited upon stimulation of renal chemoreceptors. J Auton Nerv Syst 6:127\u2013142","journal-title":"J Auton Nerv Syst"},{"issue":"Suppl 6","key":"3771_CR23","doi-asserted-by":"crossref","first-page":"S323","DOI":"10.1042\/cs059323s","volume":"59","author":"G Recordati","year":"1980","unstructured":"Recordati G, Genovesi S, Cerati D, di Cintio R (1980) Reno-renal and reno-adrenal reflexes in the rat. Clin Sci (Lond) 59(Suppl 6):S323\u2013S325","journal-title":"Clin Sci (Lond)"},{"key":"3771_CR24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000188995","volume":"73","author":"A Nakashima","year":"1996","unstructured":"Nakashima A, Matsuoka H, Yasukawa H et al (1996) Renal denervation prevents intraglomerular platelet aggregation and glomerular injury induced by chronic inhibition of nitric oxide synthesis. Nephron 73:34\u201340","journal-title":"Nephron"},{"key":"3771_CR25","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/ndt\/gfg584","volume":"19","author":"G Luippold","year":"2004","unstructured":"Luippold G, Beilharz M, Muhlbauer B (2004) Chronic renal denervation prevents glomerular hyperfiltration in diabetic rats. Nephrol Dial Transplant 19:342\u2013347","journal-title":"Nephrol Dial Transplant"},{"key":"3771_CR26","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/hy1101.092970","volume":"38","author":"EJ Henriksen","year":"2001","unstructured":"Henriksen EJ, Jacob S, Kinnick TR, Teachey MK, Krekler M (2001) Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats. Hypertension 38:884\u2013890","journal-title":"Hypertension"},{"key":"3771_CR27","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.2741\/238","volume":"3","author":"K Rafiq","year":"2011","unstructured":"Rafiq K, Hitomi H, Nakano D, Ichihara A, Nishiyama A (2011) Possible involvement of the (pro)renin receptor-dependent system in the development of insulin resistance. Front Biosci (Schol Ed) 3:1478\u20131485","journal-title":"Front Biosci (Schol Ed)"},{"key":"3771_CR28","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1152\/ajpcell.1983.245.1.C1","volume":"245","author":"EW Kraegen","year":"1983","unstructured":"Kraegen EW, James DE, Bennett SP, Chisholm DJ (1983) In vivo insulin sensitivity in the rat determined by euglycemic clamp. Am J Physiol 245:E1\u2013E7","journal-title":"Am J Physiol"},{"key":"3771_CR29","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1161\/01.HYP.0000040262.48405.A8","volume":"40","author":"T Ogihara","year":"2002","unstructured":"Ogihara T, Asano T, Ando K et al (2002) Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling. Hypertension 40:872\u2013879","journal-title":"Hypertension"},{"key":"3771_CR30","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nm.2603","volume":"18","author":"O Prysyazhna","year":"2012","unstructured":"Prysyazhna O, Rudyk O, Eaton P (2012) Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension. Nat Med 18:286\u2013290","journal-title":"Nat Med"},{"key":"3771_CR31","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1161\/01.CIR.101.6.682","volume":"101","author":"YC Zhang","year":"2000","unstructured":"Zhang YC, Bui JD, Shen L, Phillips MI (2000) Antisense inhibition of beta(1)-adrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats. Circulation 101:682\u2013688","journal-title":"Circulation"},{"key":"3771_CR32","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1161\/01.HYP.0000125142.41703.64","volume":"43","author":"T Shiuchi","year":"2004","unstructured":"Shiuchi T, Iwai M, Li HS et al (2004) Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice. Hypertension 43:1003\u20131010","journal-title":"Hypertension"},{"key":"3771_CR33","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1210\/endo.142.2.7964","volume":"142","author":"T Shiuchi","year":"2001","unstructured":"Shiuchi T, Nakagami H, Iwai M et al (2001) Involvement of bradykinin and nitric oxide in leptin-mediated glucose uptake in skeletal muscle. Endocrinology 142:608\u2013612","journal-title":"Endocrinology"},{"key":"3771_CR34","first-page":"E298","volume":"261","author":"M Sudo","year":"1991","unstructured":"Sudo M, Minokoshi Y, Shimazu T (1991) Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats. Am J Physiol 261:E298\u2013E303","journal-title":"Am J Physiol"},{"key":"3771_CR35","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/HJH.0b013e32834103a9","volume":"29","author":"K Rafiq","year":"2011","unstructured":"Rafiq K, Nakano D, Ihara G et al (2011) Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats. J Hypertens 29:290\u2013298","journal-title":"J Hypertens"},{"key":"3771_CR36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1161\/ATVBAHA.111.240697","volume":"32","author":"SJ Sherajee","year":"2012","unstructured":"Sherajee SJ, Fujita Y, Rafiq K et al (2012) Aldosterone induces vascular insulin resistance by increasing insulin-like growth factor-1 receptor and hybrid receptor. Arterioscler Thromb Vasc Biol 32:257\u2013263","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3771_CR37","doi-asserted-by":"crossref","first-page":"C1174","DOI":"10.1152\/ajpcell.00450.2011","volume":"302","author":"I Sabolic","year":"2012","unstructured":"Sabolic I, Vrhovac I, Eror DB et al (2012) Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences. Am J Physiol Cell Physiol 302:C1174\u2013C1188","journal-title":"Am J Physiol Cell Physiol"},{"key":"3771_CR38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0895-7061(96)00303-2","volume":"10","author":"K Masuo","year":"1997","unstructured":"Masuo K, Mikami H, Ogihara T, Tuck ML (1997) Sympathetic nerve hyperactivity precedes hyperinsulinemia and blood pressure elevation in a young, nonobese Japanese population. Am J Hypertens 10:77\u201383","journal-title":"Am J Hypertens"},{"key":"3771_CR39","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s00125-005-1798-z","volume":"48","author":"G Grassi","year":"2005","unstructured":"Grassi G, Dell'Oro R, Quarti-Trevano F et al (2005) Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome. Diabetologia 48:1359\u20131365","journal-title":"Diabetologia"},{"key":"3771_CR40","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/01.HYP.21.5.618","volume":"21","author":"KA Jamerson","year":"1993","unstructured":"Jamerson KA, Julius S, Gudbrandsson T, Andersson O, Brant DO (1993) Reflex sympathetic activation induces acute insulin resistance in the human forearm. Hypertension 21:618\u2013623","journal-title":"Hypertension"},{"key":"3771_CR41","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1097\/00004872-200412000-00019","volume":"22","author":"G Grassi","year":"2004","unstructured":"Grassi G, Dell'Oro R, Facchini A, Quarti Trevano F, Bolla GB, Mancia G (2004) Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives. J Hypertens 22:2363\u20132369","journal-title":"J Hypertens"},{"key":"3771_CR42","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/01.HYP.32.6.1022","volume":"32","author":"RR Wenzel","year":"1998","unstructured":"Wenzel RR, Spieker L, Qui S, Shaw S, Luscher TF, Noll G (1998) I1-imidazoline agonist moxonidine decreases sympathetic nerve activity and blood pressure in hypertensives. Hypertension 32:1022\u20131027","journal-title":"Hypertension"},{"key":"3771_CR43","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.2337\/diabetes.48.5.1093","volume":"48","author":"FE Yakubu-Madus","year":"1999","unstructured":"Yakubu-Madus FE, Johnson WT, Zimmerman KM, Dananberg J, Steinberg MI (1999) Metabolic and hemodynamic effects of moxonidine in the Zucker diabetic fatty rat model of type 2 diabetes. Diabetes 48:1093\u20131100","journal-title":"Diabetes"},{"key":"3771_CR44","first-page":"541","volume":"57","author":"J Krupicka","year":"2011","unstructured":"Krupicka J, Soucek M, Chroust K (2011) The efficacy and safety of moxonidine in patients with metabolic syndrome (the O.B.E.Z.I.T.A. trial). Vnitr Lek 57:541\u2013545","journal-title":"Vnitr Lek"},{"key":"3771_CR45","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/080370502760050403","volume":"11","author":"BN Prichard","year":"2002","unstructured":"Prichard BN, Jager BA, Luszick JH et al (2002) Placebo-controlled comparison of the efficacy and tolerability of once-daily moxonidine and enalapril in mild to moderate essential hypertension. Blood Press 11:166\u2013172","journal-title":"Blood Press"},{"key":"3771_CR46","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/0002-9343(84)90990-2","volume":"76","author":"A Helgeland","year":"1984","unstructured":"Helgeland A, Leren P, Foss OP, Hjermann I, Holme I, Lund-Larsen PG (1984) Serum glucose levels during long-term observation of treated and untreated men with mild hypertension. The Oslo study. Am J Med 76:802\u2013805","journal-title":"Am J Med"},{"key":"3771_CR47","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.0954-6820.1979.tb06031.x","volume":"205","author":"T William-Olsson","year":"1979","unstructured":"William-Olsson T, Fellenius E, Bjorntorp P, Smith U (1979) Differences in metabolic responses to beta-adrenergic stimulation after propranolol or metoprolol administration. Acta Med Scand 205:201\u2013206","journal-title":"Acta Med Scand"},{"key":"3771_CR48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1365-2362.1997.670617.x","volume":"27","author":"S Gudbjornsdottir","year":"1997","unstructured":"Gudbjornsdottir S, Fowelin J, Elam M et al (1997) The effect of metoprolol treatment on insulin sensitivity and diurnal plasma hormone levels in hypertensive subjects. Euro J Clin Investig 27:29\u201335","journal-title":"Euro J Clin Investig"},{"key":"3771_CR49","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1136\/bmj.298.6681.1152","volume":"298","author":"T Pollare","year":"1989","unstructured":"Pollare T, Lithell H, Selinus I, Berne C (1989) Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients. Br Med J 298:1152\u20131157","journal-title":"Br Med J"},{"key":"3771_CR50","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0026-0495(75)90090-6","volume":"24","author":"JL Day","year":"1975","unstructured":"Day JL (1975) The metabolic consequences of adrenergic blockade: a review. Metab Clin Exp 24:987\u2013996","journal-title":"Metab Clin Exp"},{"key":"3771_CR51","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0140-6736(79)90821-3","volume":"1","author":"I Lager","year":"1979","unstructured":"Lager I, Blohme G, Smith U (1979) Effect of cardioselective and non-selective beta-blockade on the hypoglycaemic response in insulin-dependent diabetics. Lancet 1:458\u2013462","journal-title":"Lancet"},{"key":"3771_CR52","first-page":"E756","volume":"272","author":"E Cersosimo","year":"1997","unstructured":"Cersosimo E, Ajmal M, Naukam RJ, Molina PE, Abumrad NN (1997) Role of the kidney in plasma glucose regulation during hyperglycemia. Am J Physiol 272:E756\u2013E761","journal-title":"Am J Physiol"},{"key":"3771_CR53","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1681\/ASN.V55s29","volume":"5","author":"JH Dominguez","year":"1994","unstructured":"Dominguez JH, Song B, Maianu L, Garvey WT, Qulali M (1994) Gene expression of epithelial glucose transporters: the role of diabetes mellitus. J Am Soc Nephrol 5:S29\u2013S36","journal-title":"J Am Soc Nephrol"},{"key":"3771_CR54","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1681\/ASN.2010030246","volume":"22","author":"V Vallon","year":"2011","unstructured":"Vallon V, Platt KA, Cunard R et al (2011) SGLT2 mediates glucose reabsorption in the early proximal tubule. J Am Soc Nephrol 22:104\u2013112","journal-title":"J Am Soc Nephrol"},{"key":"3771_CR55","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1152\/physrev.00055.2009","volume":"91","author":"EM Wright","year":"2011","unstructured":"Wright EM, Loo DD, Hirayama BA (2011) Biology of human sodium glucose transporters. Physiol Rev 91:733\u2013794","journal-title":"Physiol Rev"},{"key":"3771_CR56","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1172\/JCI116972","volume":"93","author":"Y Kanai","year":"1994","unstructured":"Kanai Y, Lee WS, You G, Brown D, Hediger MA (1994) The human kidney low affinity Na+\/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. J Clin Investig 93:397\u2013404","journal-title":"J Clin Investig"},{"key":"3771_CR57","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0005-2736(92)90241-D","volume":"1106","author":"AM Pajor","year":"1992","unstructured":"Pajor AM, Hirayama BA, Wright EM (1992) Molecular evidence for two renal Na+\/glucose cotransporters. Biochim Biophys Acta 1106:216\u2013220","journal-title":"Biochim Biophys Acta"},{"key":"3771_CR58","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000375","volume":"2","author":"T Nakagawa","year":"2013","unstructured":"Nakagawa T, Hasegawa Y, Uekawa K et al (2013) Renal denervation prevents stroke and brain injury via attenuation of oxidative stress in hypertensive rats. J Am Heart Assoc 2:e000375","journal-title":"J Am Heart Assoc"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-015-3771-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-015-3771-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-015-3771-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T21:58:50Z","timestamp":1653256730000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-015-3771-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,8]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["3771"],"URL":"https:\/\/doi.org\/10.1007\/s00125-015-3771-9","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,8]]}}}