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Barri Private Foundation (PV12142S to MM); the Medical Research Council (G0701446 to SS); and National Institutes of Health Grant (GM028140 to GMC). CIBER de Diabetes y Enfermedades Metab\u00f3licas asociadas (CB07708\/0012) is an initiative of the ISCIII. MM acknowledges support from the \u2018Miguel Servet\u2019 tenure track programme (CP11\/00021), from the Fondo de Investigaci\u00f3n Sanitaria (FIS) co-financed by the European Regional Development Fund (ERDF), and supported by a Salvador de Madariaga Mobility fellowship from the Spanish Ministry of Education (PR2011-0584). AT is the recipient of a FI-DGR fellowship (9015-97318\/2012) from the Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca (AGAUR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that there is no duality of interest associated with this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Duality of interest"}},{"value":"SS, AZ and MM were the main contributors in the conception, design and interpretation of the data, and in writing the manuscript. AT, HS, G-SH, DS, JC, CM and MM performed the experiments and data analysis, and revised the manuscript. JG, MW, CR, OY and GMC were responsible for acquisition of data and analysis, and revised the manuscript. All authors had final approval of the submitted and published versions. MM is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}