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JEV and NWZ were each supported by an Australian Postgraduate Award. NLL is a Sylvia and Charles Viertel Senior Medical Research Fellow and is supported by funding from the NHMRC (1071916). STG is an ARC Future Fellow and an NHMRC Research Fellow (569825). The authors have no conflicting financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that there is no duality of interest associated with this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Duality of interest"}},{"value":"JEV and SNW conducted and analysed islet and skin transplant and histological studies. MS and SIA conducted and analysed heart transplant studies. JEV conducted and analysed in vitro T cells assays, cell signalling studies and T cell polarisation studies. NWZ and EKM established and analysed inhibitor and signalling studies. KAW and NLL designed, conducted, analysed and interpreted viral immunity experiments. RB generated critical genetic tools for the study. JEV and STG interpreted all findings and co-wrote the manuscript. All authors were involved in revising the article critically for important intellectual content and gave final approval of the version to be published. STG designed and led the study and, as guarantor, takes responsibility for the contents of the article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}