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For approved ancillary studies and sub-studies, the Look AHEAD coordinating centre provides a cleaned data set of approved data relevant to the ancillary study. When the coordinating centre ceases to function as an analytic resource it will release all Look AHEAD data to the clinical centres and NIH. Two years subsequent to this release, the full data set will be made public. Data from the active intervention phase of the study, which ended in 2012, is available with permission through the NIH data archives (), including data from screening, baseline and follow-up for approximately 10 years.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"This work was funded by the National Institutes of Health through cooperative agreements with the National Institute of Diabetes and Digestive and Kidney Diseases: 5U01DK57136, 5U01DK57149, 5U01DK56990, 5U01DK57177, 5U01DK57171, 5U01DK57151, 5U01DK57182, 5U01DK57131, 5U01DK57002, 5U01DK57078, 5U01DK57154, 5U01DK57178, 5U01DK57219, 5U01DK57008, 5U01DK57135 and 5U01DK56992. Additional funding was provided by the National Heart, Lung, and Blood Institute, National Institute of Nursing Research, National Center on Minority Health and Health Disparities, NIH Office of Research on Women\u2019s Health and the Centers for Disease Control and Prevention. This research was supported in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. The Indian Health Service (IHS) provided personnel, medical oversight, and use of facilities. The opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the IHS or other funding sources.Additional support was received from the following institutions: The Johns Hopkins Medical Institutions Bayview General Clinical Research Center (M01RR02719); the Massachusetts General Hospital Mallinckrodt General Clinical Research Center and the Massachusetts Institute of Technology General Clinical Research Center (M01RR01066); the Harvard Clinical and Translational Science Center (RR025758-04); the University of Colorado Health Sciences Center General Clinical Research Center (M01RR00051) and Clinical Nutrition Research Unit (P30 DK48520); the University of Tennessee at Memphis General Clinical Research Center (M01RR0021140); the University of Pittsburgh General Clinical Research Center (GCRC) (M01RR000056), the Clinical Translational Research Center (CTRC) funded by the Clinical & Translational Science Award (UL1 RR 024153) and NIH grant (DK 046204); the VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs and the Frederic C. Bartter General Clinical Research Center (M01RR01346).The following organisations have committed to make major contributions to Look AHEAD: FedEx Corporation; Health Management Resources; LifeScan, Inc., a Johnson & Johnson Company; OPTIFAST of Nestle HealthCare Nutrition, Inc.; Hoffmann-La Roche Inc.; Abbott Nutrition; and Slim-Fast Brand of Unilever North America.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that there is no duality of interest associated with this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Duality of interest"}},{"value":"All members of the writing group (see Appendix) were involved in the conception and design of the study, in the acquisition and analyses of the data and in the preparation of the manuscript. All those listed as authors (see Appendix) were involved in the conception, design and conduct of the study and in the review and final approval of the manuscript for the Look AHEAD Study Group. Edward S. Horton is the guarantor of this work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}}]}}