{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:05:08Z","timestamp":1792717508593,"version":"4.5.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK017047 ,DK088082, DK109584"],"award-info":[{"award-number":["DK017047 ,DK088082, DK109584"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s00125-017-4272-9","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T11:06:21Z","timestamp":1491822381000},"page":"952-959","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["The islet endothelial cell: a novel contributor to beta cell secretory dysfunction in diabetes"],"prefix":"10.1007","volume":"60","author":[{"given":"Meghan F.","family":"Hogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Hull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"key":"4272_CR1","first-page":"759","volume-title":"The pancreas: biology, pathobiology, and disease","author":"S Bonner-Weir","year":"1993","unstructured":"Bonner-Weir S (1993) The microvasculature of the pancreas, with emphasis on that of the islets of Langerhans. In: Go VLW, DiMagno ER, Gardner JD, Lebenthal FP, Reber HA, Scheele GA (eds) The pancreas: biology, pathobiology, and disease. Raven Press, New York, pp 759\u2013768"},{"key":"4272_CR2","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.biocel.2005.06.021","volume":"38","author":"R Olsson","year":"2006","unstructured":"Olsson R, Carlsson PO (2006) The pancreatic islet endothelial cell: emerging roles in islet function and disease. Int J Biochem Cell Biol 38:492\u2013497","journal-title":"Int J Biochem Cell Biol"},{"key":"4272_CR3","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1210\/er.2009-0035","volume":"31","author":"OC Richards","year":"2010","unstructured":"Richards OC, Raines SM, Attie AD (2010) The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action. Endocr Rev 31:343\u2013363","journal-title":"Endocr Rev"},{"key":"4272_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2337\/db13-0617","volume":"63","author":"H Peiris","year":"2014","unstructured":"Peiris H, Bonder CS, Coates PT, Keating DJ, Jessup CF (2014) The beta-cell\/EC axis: how do islet cells talk to each other? Diabetes 63:3\u201311","journal-title":"Diabetes"},{"key":"4272_CR5","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/BF00251896","volume":"25","author":"L Jansson","year":"1983","unstructured":"Jansson L, Hellerstrom C (1983) Stimulation by glucose of the blood flow to the pancreatic islets of the rat. Diabetologia 25:45\u201350","journal-title":"Diabetologia"},{"key":"4272_CR6","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/978-90-481-3271-3_10","volume":"654","author":"M Kragl","year":"2010","unstructured":"Kragl M, Lammert E (2010) Basement membrane in pancreatic islet function. Adv Exp Med Biol 654:217\u2013234","journal-title":"Adv Exp Med Biol"},{"key":"4272_CR7","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1369\/0022155415573324","volume":"63","author":"M Brissova","year":"2015","unstructured":"Brissova M, Shostak A, Fligner CL et al (2015) Human islets have fewer blood vessels than mouse islets and the density of islet vascular structures is increased in type 2 diabetes. J Histochem Cytochem 63:637\u2013645","journal-title":"J Histochem Cytochem"},{"key":"4272_CR8","doi-asserted-by":"publisher","first-page":"5418","DOI":"10.1210\/jc.2002-020728","volume":"87","author":"PO Carlsson","year":"2002","unstructured":"Carlsson PO, Palm F, Mattsson G (2002) Low revascularization of experimentally transplanted human pancreatic islets. J Clin Endocrinol Metab 87:5418\u20135423","journal-title":"J Clin Endocrinol Metab"},{"key":"4272_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.cmet.2011.05.008","volume":"14","author":"R Rodriguez-Diaz","year":"2011","unstructured":"Rodriguez-Diaz R, Abdulreda MH, Formoso AL et al (2011) Innervation patterns of autonomic axons in the human endocrine pancreas. Cell Metab 14:45\u201354","journal-title":"Cell Metab"},{"key":"4272_CR10","doi-asserted-by":"publisher","first-page":"442","DOI":"10.2353\/ajpath.2008.080238","volume":"173","author":"E Favaro","year":"2008","unstructured":"Favaro E, Miceli I, Bussolati B et al (2008) Hyperglycemia induces apoptosis of human pancreatic islet endothelial cells: effects of pravastatin on the Akt survival pathway. Am J Pathol 173:442\u2013450","journal-title":"Am J Pathol"},{"key":"4272_CR11","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jcyt.2016.10.005","volume":"19","author":"V Sordi","year":"2017","unstructured":"Sordi V, Ferri A, Ceserani V et al (2017) Establishment, characterization and long-term culture of human endocrine pancreas-derived microvascular endothelial cells. Cytotherapy 19:141\u2013152","journal-title":"Cytotherapy"},{"key":"4272_CR12","doi-asserted-by":"crossref","unstructured":"Brissova M, Shostak A, Shiota M et al (2006) Pancreatic islet production of vascular endothelial growth factor-a is essential for islet vascularization, revascularization, and function. Diabetes 55:2974\u20132985","DOI":"10.2337\/db06-0690"},{"key":"4272_CR13","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1210\/en.2005-0997","volume":"147","author":"M Johansson","year":"2006","unstructured":"Johansson M, Mattsson G, Andersson A, Jansson L, Carlsson PO (2006) Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats. Endocrinology 147:2315\u20132324","journal-title":"Endocrinology"},{"key":"4272_CR14","doi-asserted-by":"publisher","first-page":"E564","DOI":"10.1152\/ajpendo.00194.2016","volume":"311","author":"RC Pasek","year":"2016","unstructured":"Pasek RC, Dunn JC, Elsakr JM, Aramandla M, Matta AR, Gannon M (2016) Connective tissue growth factor is critical for proper beta-cell function and pregnancy-induced beta-cell hyperplasia in adult mice. Am J Physiol Endocrinol Metab 311:E564\u2013E574","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"4272_CR15","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.2337\/db10-0277","volume":"60","author":"J Olerud","year":"2011","unstructured":"Olerud J, Mokhtari D, Johansson M et al (2011) Thrombospondin-1: an islet endothelial cell signal of importance for beta-cell function. Diabetes 60:1946\u20131954","journal-title":"Diabetes"},{"key":"4272_CR16","doi-asserted-by":"publisher","first-page":"e47451","DOI":"10.1371\/journal.pone.0047451","volume":"7","author":"CJ Drott","year":"2012","unstructured":"Drott CJ, Olerud J, Emanuelsson H, Christoffersson G, Carlsson PO (2012) Sustained beta-cell dysfunction but normalized islet mass in aged thrombospondin-1 deficient mice. PLoS One 7:e47451","journal-title":"PLoS One"},{"key":"4272_CR17","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1007\/BF00400650","volume":"39","author":"S Gregersen","year":"1996","unstructured":"Gregersen S, Thomsen JL, Brock B, Hermansen K (1996) Endothelin-1 stimulates insulin secretion by direct action on the islets of Langerhans in mice. Diabetologia 39:1030\u20131035","journal-title":"Diabetologia"},{"key":"4272_CR18","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1007\/s001250051442","volume":"42","author":"B Brock","year":"1999","unstructured":"Brock B, Gregersen S, Kristensen K et al (1999) The insulinotropic effect of endothelin-1 is mediated by glucagon release from the islet alpha cells. Diabetologia 42:1302\u20131307","journal-title":"Diabetologia"},{"key":"4272_CR19","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1007\/s00125-009-1485-6","volume":"52","author":"A Johansson","year":"2009","unstructured":"Johansson A, Lau J, Sandberg M, Borg LA, Magnusson PU, Carlsson PO (2009) Endothelial cell signalling supports pancreatic beta cell function in the rat. Diabetologia 52:2385\u20132394","journal-title":"Diabetologia"},{"key":"4272_CR20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/en.2016-1393","volume":"158","author":"MF Hogan","year":"2017","unstructured":"Hogan MF, Liu AW, Peters MJ et al (2017) Markers of islet endothelial dysfunction occur in male db\/db mice and may contribute to reduced insulin release. Endocrinology 158:293\u2013303","journal-title":"Endocrinology"},{"key":"4272_CR21","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1177\/002215540205001206","volume":"50","author":"FX Jiang","year":"2002","unstructured":"Jiang FX, Naselli G, Harrison LC (2002) Distinct distribution of laminin and its integrin receptors in the pancreas. J Histochem Cytochem 50:1625\u20131632","journal-title":"J Histochem Cytochem"},{"key":"4272_CR22","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.devcel.2006.01.015","volume":"10","author":"G Nikolova","year":"2006","unstructured":"Nikolova G, Jabs N, Konstantinova I et al (2006) The vascular basement membrane: a niche for insulin gene expression and beta cell proliferation. Dev Cell 10:397\u2013405","journal-title":"Dev Cell"},{"key":"4272_CR23","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.2337\/db05-1388","volume":"55","author":"G Parnaud","year":"2006","unstructured":"Parnaud G, Hammar E, Rouiller DG, Armanet M, Halban PA, Bosco D (2006) Blockade of beta1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix. Diabetes 55:1413\u20131420","journal-title":"Diabetes"},{"key":"4272_CR24","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1074\/jbc.M111.279885","volume":"287","author":"D Rondas","year":"2012","unstructured":"Rondas D, Tomas A, Soto-Ribeiro M, Wehrle-Haller B, Halban PA (2012) Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion. J Biol Chem 287:2423\u20132436","journal-title":"J Biol Chem"},{"key":"4272_CR25","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.2337\/db06-0120","volume":"55","author":"T Kaido","year":"2006","unstructured":"Kaido T, Yebra M, Cirulli V, Rhodes C, Diaferia G, Montgomery AM (2006) Impact of defined matrix interactions on insulin production by cultured human beta-cells: effect on insulin content, secretion, and gene transcription. Diabetes 55:2723\u20132729","journal-title":"Diabetes"},{"key":"4272_CR26","doi-asserted-by":"publisher","first-page":"e0161834","DOI":"10.1371\/journal.pone.0161834","volume":"11","author":"P Shah","year":"2016","unstructured":"Shah P, Lueschen N, Ardestani A et al (2016) Angiopoetin-2 signals do not mediate the hypervascularization of islets in type 2 diabetes. PLoS One 11:e0161834","journal-title":"PLoS One"},{"key":"4272_CR27","doi-asserted-by":"publisher","first-page":"e6963","DOI":"10.1371\/journal.pone.0006963","volume":"4","author":"G Lacraz","year":"2009","unstructured":"Lacraz G, Giroix MH, Kassis N et al (2009) Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat. PLoS One 4:e6963","journal-title":"PLoS One"},{"key":"4272_CR28","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0168-8227(95)01155-2","volume":"30","author":"M Nakamura","year":"1995","unstructured":"Nakamura M, Kitamura H, Konishi S et al (1995) The endocrine pancreas of spontaneously diabetic db\/db mice: microangiopathy as revealed by transmission electron microscopy. Diabetes Res Clin Pract 30:89\u2013100","journal-title":"Diabetes Res Clin Pract"},{"key":"4272_CR29","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.2337\/db06-0733","volume":"55","author":"X Li","year":"2006","unstructured":"Li X, Zhang L, Meshinchi S et al (2006) Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes. Diabetes 55:2965\u20132973","journal-title":"Diabetes"},{"key":"4272_CR30","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0026-0495(99)90107-5","volume":"48","author":"A Mizuno","year":"1999","unstructured":"Mizuno A, Noma Y, Kuwajima M, Murakami T, Zhu M, Shima K (1999) Changes in islet capillary angioarchitecture coincide with impaired B cell function but not with insulin resistance in male Otsuka-Long-Evans-Tokushima fatty rats: dimorphism of the diabetic phenotype at an advanced age. Metabolism 48:477\u2013483","journal-title":"Metabolism"},{"key":"4272_CR31","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1016\/j.bbrc.2006.04.011","volume":"344","author":"J Shao","year":"2006","unstructured":"Shao J, Iwashita N, Ikeda F et al (2006) Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db\/db mice. Biochem Biophys Res Commun 344:1224\u20131233","journal-title":"Biochem Biophys Res Commun"},{"key":"4272_CR32","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.bbrc.2003.12.180","volume":"314","author":"T Masuyama","year":"2004","unstructured":"Masuyama T, Komeda K, Hara A et al (2004) Chronological characterization of diabetes development in male Spontaneously Diabetic Torii rats. Biochem Biophys Res Commun 314:870\u2013877","journal-title":"Biochem Biophys Res Commun"},{"key":"4272_CR33","doi-asserted-by":"publisher","first-page":"989","DOI":"10.2337\/diabetes.53.4.989","volume":"53","author":"C Tikellis","year":"2004","unstructured":"Tikellis C, Wookey PJ, Candido R, Andrikopoulos S, Thomas MC, Cooper ME (2004) Improved islet morphology after blockade of the renin-angiotensin system in the ZDF rat. Diabetes 53:989\u2013997","journal-title":"Diabetes"},{"key":"4272_CR34","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.1559-4572.2008.00024.x","volume":"3","author":"MR Hayden","year":"2008","unstructured":"Hayden MR, Patel K, Habibi J et al (2008) Attenuation of endocrine-exocrine pancreatic communication in type 2 diabetes: pancreatic extracellular matrix ultrastructural abnormalities. J Cardiometab Syndr 3:234\u2013243","journal-title":"J Cardiometab Syndr"},{"key":"4272_CR35","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1002\/dmr.5610100405","volume":"10","author":"L Jansson","year":"1994","unstructured":"Jansson L (1994) The regulation of pancreatic islet blood flow. Diabetes Metab Rev 10:407\u2013416","journal-title":"Diabetes Metab Rev"},{"key":"4272_CR36","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s001250050880","volume":"41","author":"PO Carlsson","year":"1998","unstructured":"Carlsson PO, Berne C, Jansson L (1998) Angiotensin II and the endocrine pancreas: effects on islet blood flow and insulin secretion in rats. Diabetologia 41:127\u2013133","journal-title":"Diabetologia"},{"key":"4272_CR37","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2337\/db06-0623","volume":"56","author":"EY Lai","year":"2007","unstructured":"Lai EY, Jansson L, Patzak A, Persson AE (2007) Vascular reactivity in arterioles from normal and alloxan-diabetic mice: studies on single perfused islets. Diabetes 56:107\u2013112","journal-title":"Diabetes"},{"key":"4272_CR38","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/j.1748-1716.1985.tb07655.x","volume":"124","author":"L Jansson","year":"1985","unstructured":"Jansson L (1985) Dissociation between pancreatic islet blood flow and insulin release in the rat. Acta Physiol Scand 124:223\u2013228","journal-title":"Acta Physiol Scand"},{"key":"4272_CR39","first-page":"S54","volume":"32 Suppl 3","author":"F Cosentino","year":"1998","unstructured":"Cosentino F, Luscher TF (1998) Endothelial dysfunction in diabetes mellitus. J Cardiovasc Pharmacol 32 Suppl 3:S54\u2013S61","journal-title":"J Cardiovasc Pharmacol"},{"key":"4272_CR40","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.diabres.2007.09.005","volume":"79","author":"G De Mattia","year":"2008","unstructured":"De Mattia G, Bravi MC, Laurenti O et al (2008) Endothelial dysfunction and oxidative stress in type 1 and type 2 diabetic patients without clinical macrovascular complications. Diabetes Res Clin Pract 79:337\u2013342","journal-title":"Diabetes Res Clin Pract"},{"key":"4272_CR41","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1056\/NEJM199309303291401","volume":"329","author":"The Diabetes Control and Complications Trial Research Group","year":"1993","unstructured":"The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977\u2013986","journal-title":"N Engl J Med"},{"key":"4272_CR42","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.2337\/diacare.25.6.1055","volume":"25","author":"KC Tan","year":"2002","unstructured":"Tan KC, Chow WS, Ai VH, Metz C, Bucala R, Lam KS (2002) Advanced glycation end products and endothelial dysfunction in type 2 diabetes. Diabetes Care 25:1055\u20131059","journal-title":"Diabetes Care"},{"key":"4272_CR43","doi-asserted-by":"publisher","first-page":"e0124418","DOI":"10.1371\/journal.pone.0124418","volume":"10","author":"KC Lan","year":"2015","unstructured":"Lan KC, Chiu CY, Kao CW et al (2015) Advanced glycation end-products induce apoptosis in pancreatic islet endothelial cells via NF-kappaB-activated cyclooxygenase-2\/prostaglandin E2 up-regulation. PLoS One 10:e0124418","journal-title":"PLoS One"},{"key":"4272_CR44","doi-asserted-by":"publisher","first-page":"2879","DOI":"10.2337\/db12-1281","volume":"62","author":"X Wan","year":"2013","unstructured":"Wan X, Guloglu FB, Vanmorlan AM et al (2013) Recovery from overt type 1 diabetes ensues when immune tolerance and beta-cell formation are coupled with regeneration of endothelial cells in the pancreatic islets. Diabetes 62:2879\u20132889","journal-title":"Diabetes"},{"key":"4272_CR45","first-page":"685","volume":"145","author":"C Suschek","year":"1994","unstructured":"Suschek C, Fehsel K, Kroncke KD, Sommer A, Kolb-Bachofen V (1994) Primary cultures of rat islet capillary endothelial cells. Constitutive and cytokine-inducible macrophagelike nitric oxide synthases are expressed and activities regulated by glucose concentration. Am J Pathol 145:685\u2013695","journal-title":"Am J Pathol"},{"key":"4272_CR46","first-page":"E594","volume":"275","author":"PO Carlsson","year":"1998","unstructured":"Carlsson PO, Andersson A, Jansson L (1998) Influence of age, hyperglycemia, leptin, and NPY on islet blood flow in obese-hyperglycemic mice. Am J Phys 275:E594\u2013E601","journal-title":"Am J Phys"},{"key":"4272_CR47","first-page":"931","volume":"36","author":"L Yuan","year":"2013","unstructured":"Yuan L, Li Y, Li G, Song Y, Gong X (2013) Ang(1-7) treatment attenuates beta-cell dysfunction by improving pancreatic microcirculation in a rat model of type 2 diabetes. J Endocrinol Investig 36:931\u2013937","journal-title":"J Endocrinol Investig"},{"key":"4272_CR48","first-page":"391476","volume":"2014","author":"L Yuan","year":"2014","unstructured":"Yuan L, Lu CL, Wang Y, Li Y, Li XY (2014) Ang (1-7) protects islet endothelial cells from palmitate-induced apoptosis by AKT, eNOS, p38 MAPK, and JNK pathways. J Diabetes Res 2014:391476","journal-title":"J Diabetes Res"},{"key":"4272_CR49","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.3892\/ijmm.2016.2711","volume":"38","author":"Z Zhang","year":"2016","unstructured":"Zhang Z, Yang L, Lei L, Chen R, Chen H, Zhang H (2016) Glucagon-like peptide-1 attenuates advanced oxidation protein product-mediated damage in islet microvascular endothelial cells partly through the RAGE pathway. Int J Mol Med 38:1161\u20131169","journal-title":"Int J Mol Med"},{"key":"4272_CR50","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.2337\/db12-0134","volume":"61","author":"J Agudo","year":"2012","unstructured":"Agudo J, Ayuso E, Jimenez V et al (2012) Vascular endothelial growth factor-mediated islet hypervascularization and inflammation contribute to progressive reduction of beta-cell mass. Diabetes 61:2851\u20132861","journal-title":"Diabetes"},{"key":"4272_CR51","doi-asserted-by":"publisher","first-page":"3852","DOI":"10.2337\/db15-0054","volume":"64","author":"ZC Feng","year":"2015","unstructured":"Feng ZC, Popell A, Li J et al (2015) c-Kit receptor signaling regulates islet vasculature, beta-cell survival, and function in vivo. Diabetes 64:3852\u20133866","journal-title":"Diabetes"},{"key":"4272_CR52","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.cmet.2014.02.001","volume":"19","author":"M Brissova","year":"2014","unstructured":"Brissova M, Aamodt K, Brahmachary P et al (2014) Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes beta cell regeneration. Cell Metab 19:498\u2013511","journal-title":"Cell Metab"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-017-4272-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-017-4272-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-017-4272-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T06:58:51Z","timestamp":1601881131000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-017-4272-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,10]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["4272"],"URL":"https:\/\/doi.org\/10.1007\/s00125-017-4272-9","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,10]]},"assertion":[{"value":"3 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors\u2019 work in this area is supported by the Department of Veterans Affairs, VA Puget Sound Health Care System (Seattle, WA, USA), Seattle Institute for Biomedical and Clinical Research (Seattle, WA, USA) and National Institutes of Health grants R01 DK088082 (RLH), F32 DK109584 (MFH) and P30 DK017047 (University of Washington Diabetes Research Center).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that there is no duality of interest associated with this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Duality of interest"}},{"value":"RLH conceived the outline for this review. All authors reviewed and discussed the relevant literature, and were responsible for drafting the article and revising it critically for important intellectual content. All authors approved the version to be published.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}