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HTM, AMD, JH and GH researched data and revised the manuscript critically. GH was involved in data analysis and discussions. He also critically read the manuscript. RNK supervised the experiments pertaining to pancreatic cell areas, analysed data, and reviewed critically the manuscript. SMN was responsible for study design, conceptualisation, data analysis and results interpretation, and reviewing the manuscript. SMN had full access to all the data of the study and takes responsibility for the integrity and accuracy of data analysis and the decision to submit and publish the manuscript. All authors have given final approval of this version to be published.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}