{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:13:58Z","timestamp":1786979638470,"version":"build-2736575974"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Social Insurance Institution of Finland"},{"name":"Metagenics Inc."},{"name":"Kuopio, Tampere and Turku University Hospital Medical Funds","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association"},{"name":"Research Institute for Diseases in the Elderly"},{"DOI":"10.13039\/501100001717","name":"Universiteit Leiden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001717","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Netherlands Genomics Initiative"},{"name":"Municipality of Rotterdam"},{"DOI":"10.13039\/501100001828","name":"Erasmus Universiteit Rotterdam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001828","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nestec. Ltd."},{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00d6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008484","name":"Paavo Nurmen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008484","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["0730094N"],"award-info":[{"award-number":["0730094N"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004037","name":"Juho Vainion S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5K01DK082729-04"],"award-info":[{"award-number":["5K01DK082729-04"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK063491"],"award-info":[{"award-number":["DK063491"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK091718"],"award-info":[{"award-number":["DK091718"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK100383"],"award-info":[{"award-number":["DK100383"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK58845"],"award-info":[{"award-number":["DK58845"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK078616"],"award-info":[{"award-number":["R01DK078616"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006310","name":"Medicinska Forskningsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG004402"],"award-info":[{"award-number":["U01HG004402"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001069","name":"Women and Infants Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005039","name":"Leids Universitair Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Boston Area Diabetes, Endocrinology Research Center Feasibility Program","award":["P30 DK057521"],"award-info":[{"award-number":["P30 DK057521"]}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-82893"],"award-info":[{"award-number":["MOP-82893"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008700","name":"Centre International de Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG023629"],"award-info":[{"award-number":["R01AG023629"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004756","name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002999","name":"Ministerie van Volksgezondheid, Welzijn en Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SNP Health Association Resources","award":["N01-HC-95159"],"award-info":[{"award-number":["N01-HC-95159"]}]},{"name":"SNP Health Association Resources","award":["N01-HC-95160"],"award-info":[{"award-number":["N01-HC-95160"]}]},{"name":"SNP Health Association Resources","award":["N01-HC-95161"],"award-info":[{"award-number":["N01-HC-95161"]}]},{"name":"SNP Health Association Resources","award":["N01-HC-95162"],"award-info":[{"award-number":["N01-HC-95162"]}]},{"name":"SNP Health Association Resources","award":["N01-HC-95163"],"award-info":[{"award-number":["N01-HC-95163"]}]},{"name":"SNP Health Association Resources","award":["N01-HC-95164"],"award-info":[{"award-number":["N01-HC-95164"]}]},{"name":"SNP Health Association Resources","award":["N01-HC-95165"],"award-info":[{"award-number":["N01-HC-95165"]}]},{"name":"SNP Health Association Resources","award":["N01-HC-95166"],"award-info":[{"award-number":["N01-HC-95166"]}]},{"name":"SNP Health Association Resources","award":["N01-HC-95167"],"award-info":[{"award-number":["N01-HC-95167"]}]},{"name":"SNP Health Association Resources","award":["N01-HC-95168"],"award-info":[{"award-number":["N01-HC-95168"]}]},{"name":"SNP Health Association Resources","award":["N01-HC-95169"],"award-info":[{"award-number":["N01-HC-95169"]}]},{"name":"Dutch Science Organization","award":["916.14.023"],"award-info":[{"award-number":["916.14.023"]}]},{"DOI":"10.13039\/501100004325","name":"Signe ja Ane Gyllenbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003245","name":"Ministerie van Onderwijs, Cultuur en Wetenschap","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001063","name":"Raine Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000124"],"award-info":[{"award-number":["UL1TR000124"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001742","name":"United States-Israel Binational Science Foundation","doi-asserted-by":"publisher","award":["2011036"],"award-info":[{"award-number":["2011036"]}],"id":[{"id":"10.13039\/501100001742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007917","name":"USDA Agriculture Research Service","doi-asserted-by":"crossref","award":["58-1950-0-014"],"award-info":[{"award-number":["58-1950-0-014"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["117787"],"award-info":[{"award-number":["117787"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["121584"],"award-info":[{"award-number":["121584"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["124282"],"award-info":[{"award-number":["124282"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["126925"],"award-info":[{"award-number":["126925"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["129378"],"award-info":[{"award-number":["129378"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["134309"],"award-info":[{"award-number":["134309"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["286284"],"award-info":[{"award-number":["286284"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["41071"],"award-info":[{"award-number":["41071"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268200800007C"],"award-info":[{"award-number":["HHSN268200800007C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100005C"],"award-info":[{"award-number":["HHSN268201100005C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100006C"],"award-info":[{"award-number":["HHSN268201100006C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100007C"],"award-info":[{"award-number":["HHSN268201100007C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100008C"],"award-info":[{"award-number":["HHSN268201100008C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100009C"],"award-info":[{"award-number":["HHSN268201100009C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100010C"],"award-info":[{"award-number":["HHSN268201100010C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100011C"],"award-info":[{"award-number":["HHSN268201100011C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100012C"],"award-info":[{"award-number":["HHSN268201100012C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201200036C"],"award-info":[{"award-number":["HHSN268201200036C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL034594"],"award-info":[{"award-number":["HL034594"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL071981"],"award-info":[{"award-number":["HL071981"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL105756"],"award-info":[{"award-number":["HL105756"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL126024"],"award-info":[{"award-number":["HL126024"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC25195"],"award-info":[{"award-number":["N01HC25195"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC55222"],"award-info":[{"award-number":["N01HC55222"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC85079"],"award-info":[{"award-number":["N01HC85079"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC85080"],"award-info":[{"award-number":["N01HC85080"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC85081"],"award-info":[{"award-number":["N01HC85081"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC85082"],"award-info":[{"award-number":["N01HC85082"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC85083"],"award-info":[{"award-number":["N01HC85083"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC85086"],"award-info":[{"award-number":["N01HC85086"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N02-HL-6-4278"],"award-info":[{"award-number":["N02-HL-6-4278"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N02HL64278"],"award-info":[{"award-number":["N02HL64278"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL071051"],"award-info":[{"award-number":["R01HL071051"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL071205"],"award-info":[{"award-number":["R01HL071205"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL071250"],"award-info":[{"award-number":["R01HL071250"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL071251"],"award-info":[{"award-number":["R01HL071251"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL071252"],"award-info":[{"award-number":["R01HL071252"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL071258"],"award-info":[{"award-number":["R01HL071258"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL071259"],"award-info":[{"award-number":["R01HL071259"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL086694"],"award-info":[{"award-number":["R01HL086694"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL087641"],"award-info":[{"award-number":["R01HL087641"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL087652"],"award-info":[{"award-number":["R01HL087652"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL103612"],"award-info":[{"award-number":["R01HL103612"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL105756"],"award-info":[{"award-number":["R01HL105756"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL120393"],"award-info":[{"award-number":["R01HL120393"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL130114"],"award-info":[{"award-number":["R01HL130114"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL59367"],"award-info":[{"award-number":["R01HL59367"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RR-024156"],"award-info":[{"award-number":["RR-024156"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01HL080295"],"award-info":[{"award-number":["U01HL080295"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Health and Medical Research Council Of Australia","award":["003209"],"award-info":[{"award-number":["003209"]}]},{"name":"National Health and Medical Research Council Of Australia","award":["403981"],"award-info":[{"award-number":["403981"]}]},{"DOI":"10.13039\/501100006738","name":"Medicinska Fakulteten, Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011025","name":"Government of Western Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011025","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Australian Goverment"},{"name":"National Health and Medical Research Council of Australia National Enabling Facility"},{"name":"Telethon Institute for Child Health Research"},{"name":"University of Western Australia Faculty of Medicine, Dentistry, and Health Sciences"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 HL112845"],"award-info":[{"award-number":["K08 HL112845"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24DK080140"],"award-info":[{"award-number":["K24DK080140"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR001109"],"award-info":[{"award-number":["KL2TR001109"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA49449"],"award-info":[{"award-number":["R01 CA49449"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DK100425"],"award-info":[{"award-number":["R01-DK100425"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01DK078616"],"award-info":[{"award-number":["U01DK078616"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1RR025005"],"award-info":[{"award-number":["UL1RR025005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA186107"],"award-info":[{"award-number":["UM1 CA186107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Boston Obesity Nutrition Research Center","award":["DK46200"],"award-info":[{"award-number":["DK46200"]}]},{"name":"City of Malm\u00f6"},{"name":"P\u00e5hlsson Foundation and the Swedish Heart and Lung Foundation"},{"name":"Centre National de G\u00e9notypage"},{"DOI":"10.13039\/100010114","name":"Yrj\u00f6 Jahnssonin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003061","name":"Erasmus Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00125-017-4475-0","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T20:45:04Z","timestamp":1509655504000},"page":"317-330","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis"],"prefix":"10.1007","volume":"61","author":[{"given":"Nicola M.","family":"McKeown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan S.","family":"Dashti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle E.","family":"Haslam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica C.","family":"Kiefte-de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caren E.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariaelisa","family":"Graff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozenn N.","family":"Lemaitre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Rybin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Sonestedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis C.","family":"Frazier-Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis O.","family":"Mook-Kanamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth T. M.","family":"Leermakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Mikkil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Mukamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Adrienne","family":"Cupples","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina-Alexandra","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-An","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Li-Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy H.","family":"Oddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Raitakari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Meigs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrika","family":"Ericson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn M.","family":"Steffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits R.","family":"Rosendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hofman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"K\u00e4h\u00f6nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Psaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Brunkwall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre G.","family":"Uitterlinden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma","family":"Viikari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Siscovick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Sepp\u00e4l\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari E.","family":"North","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariush","family":"Mozaffarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9e","family":"Dupuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marju","family":"Orho-Melander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen S.","family":"Rich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e","family":"de Mutsert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig E.","family":"Pennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar H.","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terho","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Herman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,2]]},"reference":[{"key":"4475_CR1","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1161\/CIRCULATIONAHA.115.018704","volume":"133","author":"J Ma","year":"2016","unstructured":"Ma J, McKeown NM, Hwang S-J et al (2016) Sugar-sweetened beverage consumption is associated with change of visceral adipose tissue over 6 years of follow-up. Circulation 133:370\u2013377","journal-title":"Circulation"},{"key":"4475_CR2","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.2337\/dc10-1079","volume":"33","author":"VS Malik","year":"2010","unstructured":"Malik VS, Popkin BM, Bray GA et al (2010) Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care 33:2477\u20132483","journal-title":"Diabetes Care"},{"key":"4475_CR3","doi-asserted-by":"publisher","unstructured":"Imamura F, O\u2019Connor L, Ye Z et al (2015) Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction. BMJ. https:\/\/doi.org\/10.1136\/bmj.h3576","DOI":"10.1136\/bmj.h3576"},{"key":"4475_CR4","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1161\/CIRCULATIONAHA.110.972166","volume":"123","author":"JA Welsh","year":"2011","unstructured":"Welsh JA, Sharma A, Cunningham SA, Vos MB (2011) Consumption of added sugars and indicators of cardiovascular disease risk among US adolescents. Circulation 123:249\u2013257","journal-title":"Circulation"},{"key":"4475_CR5","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1172\/JCI37385","volume":"119","author":"KL Stanhope","year":"2009","unstructured":"Stanhope KL, Schwarz JM, Keim NL et al (2009) Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight\/obese humans. J Clin Invest 119:1322\u20131334","journal-title":"J Clin Invest"},{"key":"4475_CR6","doi-asserted-by":"publisher","first-page":"150","DOI":"10.2337\/dc12-0540","volume":"36","author":"I Aeberli","year":"2013","unstructured":"Aeberli I, Hochuli M, Gerber PA et al (2013) Moderate amounts of fructose consumption impair insulin sensitivity in healthy young men. Diabetes Care 36:150\u2013156","journal-title":"Diabetes Care"},{"key":"4475_CR7","doi-asserted-by":"publisher","first-page":"306","DOI":"10.3945\/ajcn.115.129650","volume":"104","author":"JN Kuzma","year":"2016","unstructured":"Kuzma JN, Cromer G, Hagman DK et al (2016) No differential effect of beverages sweetened with fructose, high-fructose corn syrup, or glucose on systemic or adipose tissue inflammation in normal-weight to obese adults: a randomized controlled trial. Am J Clin Nutr 104:306\u2013314","journal-title":"Am J Clin Nutr"},{"key":"4475_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/ejcn.2013.228","volume":"68","author":"G Silbernagel","year":"2014","unstructured":"Silbernagel G, Machann J, H\u00e4ring H-U et al (2014) Plasminogen activator inhibitor-1, monocyte chemoattractant protein-1, e-selectin and C-reactive protein levels in response to 4-week very-high-fructose or -glucose diets. Eur J Clin Nutr 68:97\u2013100","journal-title":"Eur J Clin Nutr"},{"key":"4475_CR9","unstructured":"Centers for Disease Control 2017. Centers for Disease Control National Diabetes Statistics Report. www.cdc.gov\/diabetes\/data\/statistics\/statistics-report.html . Accessed 17 October 2017"},{"key":"4475_CR10","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.3945\/jn.114.195230","volume":"144","author":"A Lana","year":"2014","unstructured":"Lana A, Rodr\u00edguez-Artalejo F, Lopez-Garcia E (2014) Consumption of sugar-sweetened beverages is positively related to insulin resistance and higher plasma leptin concentrations in men and nonoverweight women. J Nutr 144:1099\u20131105","journal-title":"J Nutr"},{"key":"4475_CR11","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1093\/jn\/137.9.2121","volume":"137","author":"M Yoshida","year":"2007","unstructured":"Yoshida M, McKeown NM, Rogers G et al (2007) Surrogate markers of insulin resistance are associated with consumption of sugar-sweetened drinks and fruit juice in middle and older-aged adults. J Nutr 137:2121\u20132127","journal-title":"J Nutr"},{"key":"4475_CR12","doi-asserted-by":"publisher","first-page":"7432","DOI":"10.1073\/pnas.0701600104","volume":"104","author":"Y Ogawa","year":"2007","unstructured":"Ogawa Y, Kurosu H, Yamamoto M et al (2007) \u03b2-Klotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci 104:7432\u20137437","journal-title":"Proc Natl Acad Sci"},{"key":"4475_CR13","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.cmet.2006.06.008","volume":"4","author":"K Uyeda","year":"2006","unstructured":"Uyeda K, Repa JJ (2006) Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab 4:107\u2013110","journal-title":"Cell Metab"},{"key":"4475_CR14","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1016\/j.febslet.2009.07.053","volume":"583","author":"K Iizuka","year":"2009","unstructured":"Iizuka K, Takeda J, Horikawa Y (2009) Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes. FEBS Lett 583:2882\u20132886","journal-title":"FEBS Lett"},{"key":"4475_CR15","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.bbrc.2009.09.109","volume":"390","author":"H-Y Koo","year":"2009","unstructured":"Koo H-Y, Miyashita M, Simon Cho BH, Nakamura MT (2009) Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus. Biochem Biophys Res Commun 390:285\u2013289","journal-title":"Biochem Biophys Res Commun"},{"key":"4475_CR16","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1210\/en.2012-1725","volume":"154","author":"DM Erion","year":"2013","unstructured":"Erion DM, Popov V, Hsiao JJ et al (2013) The role of the carbohydrate response element-binding protein in male fructose-fed rats. Endocrinology 154:36\u201344","journal-title":"Endocrinology"},{"key":"4475_CR17","doi-asserted-by":"publisher","first-page":"4372","DOI":"10.1172\/JCI81993","volume":"126","author":"M-S Kim","year":"2016","unstructured":"Kim M-S, Krawczyk SA, Doridot L et al (2016) ChREBP regulates fructose-induced glucose production independently of insulin signaling. J Clin Invest 126:4372\u20134386","journal-title":"J Clin Invest"},{"key":"4475_CR18","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/ng.2007.61","volume":"40","author":"JS Kooner","year":"2008","unstructured":"Kooner JS, Chambers JC, Aguilar-Salinas CA et al (2008) Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet 40:149\u2013151","journal-title":"Nat Genet"},{"key":"4475_CR19","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/ng.75","volume":"40","author":"S Kathiresan","year":"2008","unstructured":"Kathiresan S, Melander O, Guiducci C et al (2008) Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 40:189\u2013197","journal-title":"Nat Genet"},{"key":"4475_CR20","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.molmet.2014.09.008","volume":"4","author":"JR Dushay","year":"2015","unstructured":"Dushay JR, Toschi E, Mitten EK et al (2015) Fructose ingestion acutely stimulates circulating FGF21 levels in humans. Mol Metab 4:51\u201357","journal-title":"Mol Metab"},{"key":"4475_CR21","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.molmet.2016.11.008","volume":"6","author":"FM Fisher","year":"2017","unstructured":"Fisher FM, Kim M, Doridot L et al (2017) A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism. Mol Metab 6:14\u201321","journal-title":"Mol Metab"},{"key":"4475_CR22","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1172\/JCI67353","volume":"124","author":"B Emanuelli","year":"2014","unstructured":"Emanuelli B, Vienberg SG, Smyth G et al (2014) Interplay between FGF21 and insulin action in the liver regulates metabolism. J Clin Invest 124:515\u2013527","journal-title":"J Clin Invest"},{"key":"4475_CR23","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.tem.2014.03.001","volume":"25","author":"RE Gimeno","year":"2014","unstructured":"Gimeno RE, Moller DE (2014) FGF21-based pharmacotherapy\u2014potential utility for metabolic disorders. Trends Endocrinol Metab 25:303\u2013311","journal-title":"Trends Endocrinol Metab"},{"key":"4475_CR24","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.3945\/ajcn.112.052183","volume":"97","author":"T Tanaka","year":"2013","unstructured":"Tanaka T, Ngwa JS, van Rooij FJ et al (2013) Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. Am J Clin Nutr 97:1395\u20131402","journal-title":"Am J Clin Nutr"},{"key":"4475_CR25","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1093\/hmg\/ddt032","volume":"22","author":"AY Chu","year":"2013","unstructured":"Chu AY, Workalemahu T, Paynter NP et al (2013) Novel locus including FGF21 is associated with dietary macronutrient intake. Hum Mol Genet 22:1895\u20131902","journal-title":"Hum Mol Genet"},{"key":"4475_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0002-9149(99)00211-8","volume":"83","author":"SM Grundy","year":"1999","unstructured":"Grundy SM (1999) Hypertriglyceridemia, insulin resistance, and the metabolic syndrome. Am J Cardiol 83:25\u201329","journal-title":"Am J Cardiol"},{"key":"4475_CR27","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/0002-9343(74)90006-0","volume":"57","author":"JM Olefsky","year":"1974","unstructured":"Olefsky JM, Farquhar JW, Reaven GM (1974) Reappraisal of the role of insulin in hypertriglyceridemia. Am J Med 57:551\u2013560","journal-title":"Am J Med"},{"key":"4475_CR28","doi-asserted-by":"crossref","unstructured":"Santer R, Rischewski J, von Weihe M et al (2005) The spectrum of aldolase B (ALDOB) mutations and the prevalence of hereditary fructose intolerance in Central Europe. Hum Mutat 25:594","DOI":"10.1002\/humu.9343"},{"key":"4475_CR29","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/j.1432-1033.1989.tb14538.x","volume":"179","author":"E van Schaftingen","year":"1989","unstructured":"van Schaftingen E (1989) A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phosphate and fructose 1-phosphate. Eur J Biochem 179:179\u2013184","journal-title":"Eur J Biochem"},{"key":"4475_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20080595","volume":"414","author":"L Agius","year":"2008","unstructured":"Agius L (2008) Glucokinase and molecular aspects of liver glycogen metabolism. Biochem J 414:1\u201318","journal-title":"Biochem J"},{"key":"4475_CR31","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1042\/bj3500149","volume":"350","author":"PA Helliwell","year":"2000","unstructured":"Helliwell PA, Richardson M, Affleck J, Kellett GL (2000) Stimulation of fructose transport across the intestinal brush-border membrane by PMA is mediated by GLUT2 and dynamically regulated by protein kinase C. Biochem J 350:149\u2013154","journal-title":"Biochem J"},{"key":"4475_CR32","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1093\/hmg\/3.9.1627","volume":"3","author":"DT Bonthron","year":"1994","unstructured":"Bonthron DT, Brady N, Donaldson IA, Steinmann B (1994) Molecular basis of essential fructosuria: molecular cloning and mutational analysis of human ketohexokinase (fructokinase). Hum Mol Genet 3:1627\u20131631","journal-title":"Hum Mol Genet"},{"key":"4475_CR33","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s004240050124","volume":"432","author":"CP Corpe","year":"1996","unstructured":"Corpe CP, Basaleh MM, Affleck J et al (1996) The regulation of GLUT5 and GLUT2 activity in the adaptation of intestinal brush-border fructose transport in diabetes. Pflugers Arch 432:192\u2013201","journal-title":"Pflugers Arch"},{"key":"4475_CR34","doi-asserted-by":"crossref","first-page":"14523","DOI":"10.1016\/S0021-9258(18)42067-4","volume":"267","author":"CF Burant","year":"1992","unstructured":"Burant CF, Takeda J, Brot-Laroche E et al (1992) Fructose transporter in human spermatozoa and small intestine is GLUT5. J Biol Chem 267:14523\u201314526","journal-title":"J Biol Chem"},{"key":"4475_CR35","doi-asserted-by":"publisher","first-page":"20314","DOI":"10.1074\/jbc.M312475200","volume":"279","author":"R Dentin","year":"2004","unstructured":"Dentin R, P\u00e9gorier J-P, Benhamed F et al (2004) Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem 279:20314\u201320326","journal-title":"J Biol Chem"},{"key":"4475_CR36","doi-asserted-by":"publisher","first-page":"7281","DOI":"10.1073\/pnas.0401516101","volume":"101","author":"K Iizuka","year":"2004","unstructured":"Iizuka K, Bruick RK, Liang G et al (2004) Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci U S A 101:7281\u20137286","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4475_CR37","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1172\/JCI25256","volume":"115","author":"R Dentin","year":"2005","unstructured":"Dentin R, Benhamed F, P\u00e9gorier J-P et al (2005) Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J Clin Invest 115:2843\u20132854","journal-title":"J Clin Invest"},{"key":"4475_CR38","doi-asserted-by":"publisher","first-page":"e1000338","DOI":"10.1371\/journal.pgen.1000338","volume":"5","author":"T Tanaka","year":"2009","unstructured":"Tanaka T, Shen J, Abecasis GR et al (2009) Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI study. PLoS Genet 5:e1000338","journal-title":"PLoS Genet"},{"key":"4475_CR39","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/ng.970","volume":"43","author":"JC Chambers","year":"2011","unstructured":"Chambers JC, Zhang W, Sehmi J et al (2011) Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet 43:1131\u20131138","journal-title":"Nat Genet"},{"key":"4475_CR40","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1530\/JME-13-0243","volume":"52","author":"Y Ishizuka","year":"2014","unstructured":"Ishizuka Y, Nakayama K, Ogawa A et al (2014) TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions. J Mol Endocrinol 52:145\u2013158","journal-title":"J Mol Endocrinol"},{"key":"4475_CR41","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1097\/MCO.0b013e328342991c","volume":"14","author":"DB Jump","year":"2011","unstructured":"Jump DB (2011) Fatty acid regulation of hepatic lipid metabolism. Curr Opin Clin Nutr Metab Care 14:115\u2013120","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"4475_CR42","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cmet.2015.12.008","volume":"23","author":"S Talukdar","year":"2016","unstructured":"Talukdar S, Owen BM, Song P et al (2016) FGF21 regulates sweet and alcohol preference. Cell Metab 23:344\u2013349","journal-title":"Cell Metab"},{"key":"4475_CR43","doi-asserted-by":"publisher","first-page":"e49977","DOI":"10.1371\/journal.pone.0049977","volume":"7","author":"AC Adams","year":"2012","unstructured":"Adams AC, Cheng CC, Coskun T, Kharitonenkov A (2012) FGF21 requires \u03b2klotho to act in vivo. PLoS One 7:e49977","journal-title":"PLoS One"},{"key":"4475_CR44","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1038\/ng.2797","volume":"45","author":"Global Lipids Genetics Consortium","year":"2013","unstructured":"Global Lipids Genetics Consortium (2013) Discovery and refinement of loci associated with lipid levels. Nat Genet 45:1274\u20131283","journal-title":"Nat Genet"},{"key":"4475_CR45","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.appet.2010.05.046","volume":"55","author":"DV Ranawana","year":"2010","unstructured":"Ranawana DV, Henry CJK (2010) Are caloric beverages compensated for in the short-term by young adults? An investigation with particular focus on gender differences. Appetite 55:137\u2013146","journal-title":"Appetite"},{"key":"4475_CR46","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.appet.2012.05.065","volume":"59","author":"NS Gadah","year":"2012","unstructured":"Gadah NS, Kyle LA, Rogers PJ (2012) Gender differences in the satiety effects of sugar-containing drinks. Appetite 59:626","journal-title":"Appetite"},{"key":"4475_CR47","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/ng.520","volume":"42","author":"J Dupuis","year":"2010","unstructured":"Dupuis J, Langenberg C, Prokopenko I et al (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42:105\u2013116","journal-title":"Nat Genet"},{"key":"4475_CR48","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/ng.521","volume":"42","author":"R Saxena","year":"2010","unstructured":"Saxena R, Hivert M-F, Langenberg C et al (2010) Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 42:142\u2013148","journal-title":"Nat Genet"},{"key":"4475_CR49","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3945\/jn.113.182519","volume":"144","author":"J Wang","year":"2014","unstructured":"Wang J, Light K, Henderson M et al (2014) Consumption of added sugars from liquid but not solid sources predicts impaired glucose homeostasis and insulin resistance among youth at risk of obesity. J Nutr 144:81\u201386","journal-title":"J Nutr"},{"key":"4475_CR50","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/ejcn.2013.84","volume":"67","author":"S Bel-Serrat","year":"2013","unstructured":"Bel-Serrat S, Mouratidou T, Santaliestra-Pas\u00edas AM et al (2013) Clustering of multiple lifestyle behaviours and its association to cardiovascular risk factors in children: the IDEFICS study. Eur J Clin Nutr 67:848\u2013854","journal-title":"Eur J Clin Nutr"},{"key":"4475_CR51","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1001\/archpediatrics.2009.21","volume":"163","author":"AA Bremer","year":"2009","unstructured":"Bremer AA, Auinger P, Byrd RS (2009) Relationship between insulin resistance-associated metabolic parameters and anthropometric measurements with sugar-sweetened beverage intake and physical activity levels in US adolescents: findings from the 1999\u20132004 National Health and Nutrition Examination Survey. Arch Pediatr Adolesc Med 163:328\u2013335","journal-title":"Arch Pediatr Adolesc Med"},{"key":"4475_CR52","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1002\/oby.20437","volume":"21","author":"R Rezvani","year":"2013","unstructured":"Rezvani R, Cianflone K, McGahan JP et al (2013) Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin and adiponectin: relationships with metabolic outcomes. Obesity 21:2471\u20132480","journal-title":"Obesity"},{"key":"4475_CR53","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3390\/nu8040179","volume":"8","author":"TJ Angelopoulos","year":"2016","unstructured":"Angelopoulos TJ, Lowndes J, Sinnett S, Rippe JM (2016) Fructose containing sugars at normal levels of consumption do not effect adversely components of the metabolic syndrome and risk factors for cardiovascular disease. Nutrients 8:179","journal-title":"Nutrients"},{"key":"4475_CR54","doi-asserted-by":"publisher","first-page":"3566","DOI":"10.2337\/db06-0220","volume":"55","author":"RNA Black","year":"2006","unstructured":"Black RNA, Spence M, McMahon RO et al (2006) Effect of eucaloric high- and low-sucrose diets with identical macronutrient profile on insulin resistance and vascular risk. Diabetes 55:3566\u20133572","journal-title":"Diabetes"},{"key":"4475_CR55","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/jdi.12309","volume":"6","author":"M Wang","year":"2015","unstructured":"Wang M, Yu M, Fang L, Hu R-Y (2015) Association between sugar-sweetened beverages and type 2 diabetes: a meta-analysis. J Diabetes Investig 6:360\u2013366","journal-title":"J Diabetes Investig"},{"key":"4475_CR56","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1056\/NEJMoa1203039","volume":"367","author":"Q Qi","year":"2012","unstructured":"Qi Q, Chu AY, Kang JH et al (2012) Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med 367:1387\u20131396","journal-title":"N Engl J Med"},{"key":"4475_CR57","doi-asserted-by":"publisher","first-page":"809","DOI":"10.3945\/ajcn.115.126052","volume":"104","author":"L Brunkwall","year":"2016","unstructured":"Brunkwall L, Chen Y, Hindy G et al (2016) Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts. Am J Clin Nutr 104:809\u2013815","journal-title":"Am J Clin Nutr"},{"key":"4475_CR58","doi-asserted-by":"publisher","first-page":"816","DOI":"10.3945\/ajcn.115.122820","volume":"104","author":"NJ Olsen","year":"2016","unstructured":"Olsen NJ, \u00c4ngquist L, Larsen SC et al (2016) Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference. Am J Clin Nutr 104:816\u2013826","journal-title":"Am J Clin Nutr"},{"key":"4475_CR59","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.3945\/ajcn.115.107177","volume":"103","author":"Y Zheng","year":"2016","unstructured":"Zheng Y, Li Y, Huang T et al (2016) Sugar-sweetened beverage intake, chromosome 9p21 variants, and risk of myocardial infarction in Hispanics. Am J Clin Nutr 103:1179\u20131184","journal-title":"Am J Clin Nutr"},{"key":"4475_CR60","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.3945\/ajcn.2010.30185","volume":"92","author":"JN Davis","year":"2010","unstructured":"Davis JN, L\u00ea K-A, Walker RW et al (2010) Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption. Am J Clin Nutr 92:1522\u20131527","journal-title":"Am J Clin Nutr"},{"key":"4475_CR61","first-page":"R1571","volume":"272","author":"TJ Horton","year":"1997","unstructured":"Horton TJ, Gayles EC, Prach PA et al (1997) Female rats do not develop sucrose-induced insulin resistance. Am J Phys 272:R1571\u2013R1576","journal-title":"Am J Phys"},{"key":"4475_CR62","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","volume":"37","author":"GM Reaven","year":"1988","unstructured":"Reaven GM (1988) Role of insulin resistance in human disease. Diabetes 37:1595\u20131607","journal-title":"Diabetes"},{"key":"4475_CR63","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1001\/jama.1990.03440210043030","volume":"263","author":"SM Haffner","year":"1990","unstructured":"Haffner SM, Stern MP, Hazuda HP et al (1990) Cardiovascular risk factors in confirmed prediabetic individuals: does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 263:2893\u20132898","journal-title":"JAMA"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-017-4475-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-017-4475-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-017-4475-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T02:09:43Z","timestamp":1659751783000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-017-4475-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,2]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["4475"],"URL":"https:\/\/doi.org\/10.1007\/s00125-017-4475-0","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,2]]},"assertion":[{"value":"4 November 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The datasets generated during and\/or analysed during the current study are available from the corresponding author on reasonable request.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"NMM received funding from the Boston Area Diabetes, Endocrinology Research Center Feasibility Program (P30 DK057521) to support part of this research, and she was funded in part by the US Department of Agriculture, under agreement No. 58-1950-0-014. MAH is supported by R01 DK100425. CES is supported by K08 HL112845. JBM is supported by K24DK080140 and U01DK078616. KLY is supported by KL2TR001109.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"BP serves on the Data and Safety Monitoring Board of a clinical trial funded by the manufacturer (Zoll LifeCor) and on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. All other authors declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Duality of interest"}},{"value":"The authors\u2019 responsibilities were as follows: NMM, HSD, JM and MAH: designed the study; NMM, HSD, JM, DEH, JCK-dJ, CES, TT, MG, RNL, DR, ES, ACF-W, DOM-K, YL, CAW, ETML, VM, KLY, KJM, LAC, C-AS, T-AC, RL-G, TH, WHO, OR, KR, JBM, UE, LMS, FRR, AH, MK, BMP, LB, AGU, JV, DSS, IS, KEN, DM, JD, MO-M, SSR, RdM, LQ, CEP, OHF, TL and MAH: played a role in acquisition of the data and critical revision of the manuscript for important intellectual content; NMM, HSD, JM, DEH, JCK-dJ, CES, TT, MG, RNL, DR, ES, ACF-W, DOM-K, YL, CAW, ETML, VM and MAH: contributed to statistical analyses; NMM, HSD, JM, DEH, JCK-dJ, CES, TT and MAH: interpreted data; NMM, HSD, JM, DEH, JCK-dJ, CES, TT, MG, RNL, DR, ES, ACF-W, DOM-K, YL, CAW, ETML, VM, JBM and MAH: contributed to writing of the manuscript; all authors read and approved the final version of the manuscript. NMM and HSD (joint co-first authors) are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}