{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:46:33Z","timestamp":1793321193968,"version":"4.5.0"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000774","name":"Newcastle University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000774","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00125-017-4504-z","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T09:30:37Z","timestamp":1510738237000},"page":"273-283","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Translating aetiological insight into sustainable management of type 2 diabetes"],"prefix":"10.1007","volume":"61","author":[{"given":"Roy","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison C.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"4504_CR1","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1007\/s00125-008-1116-7","volume":"51","author":"R Taylor","year":"2008","unstructured":"Taylor R (2008) Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause. Diabetologia 51:1781\u20131789","journal-title":"Diabetologia"},{"key":"4504_CR2","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1007\/s00125-011-2204-7","volume":"54","author":"EL Lim","year":"2011","unstructured":"Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R (2011) Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 54:2506\u20132514","journal-title":"Diabetologia"},{"key":"4504_CR3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2337\/dc15-0750","volume":"39","author":"S Steven","year":"2016","unstructured":"Steven S, Hollingsworth KG, Small P et al (2016) Weight loss decreases excess pancreatic triacylglycerol specifically in type 2 diabetes. Diabetes Care 39:158\u2013165","journal-title":"Diabetes Care"},{"key":"4504_CR4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/ajcn\/77.1.43","volume":"77","author":"JM Schwarz","year":"2003","unstructured":"Schwarz JM, Linfoot P, Dare D, Aghajanian K (2003) Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am J Clin Nutr 77:43\u201350","journal-title":"Am J Clin Nutr"},{"key":"4504_CR5","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00125-005-0125-z","volume":"49","author":"M Adiels","year":"2006","unstructured":"Adiels M, Taskinen MR, Packard C et al (2006) Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia 49:755\u2013765","journal-title":"Diabetologia"},{"key":"4504_CR6","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.2337\/db06-0016","volume":"55","author":"F Lalloyer","year":"2006","unstructured":"Lalloyer F, Vandewalle B, Percevault F et al (2006) Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets. Diabetes 55:1605\u20131613","journal-title":"Diabetes"},{"key":"4504_CR7","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.2337\/dc16-0619","volume":"39","author":"MG White","year":"2016","unstructured":"White MG, Shaw JAM, Taylor R (2016) Type 2 diabetes: the pathologic basis of reversible beta-cell dysfunction. Diabetes Care 39:2080\u20132088","journal-title":"Diabetes Care"},{"key":"4504_CR8","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/dc12-1805","volume":"36","author":"R Taylor","year":"2013","unstructured":"Taylor R (2013) Type 2 diabetes: etiology and reversibility. Diabetes Care 36:1047\u20131055","journal-title":"Diabetes Care"},{"key":"4504_CR9","doi-asserted-by":"crossref","first-page":"808","DOI":"10.2337\/dc15-1942","volume":"39","author":"S Steven","year":"2016","unstructured":"Steven S, Hollingsworth KG, Al-Mrabeh A et al (2016) Very low calorie diet and 6 months of weight stability in type 2 diabetes: pathophysiological changes in responders and nonresponders. Diabetes Care 39:808\u2013815","journal-title":"Diabetes Care"},{"key":"4504_CR10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1042\/CS20140553","volume":"128","author":"R Taylor","year":"2015","unstructured":"Taylor R, Holman R (2015) Normal weight individuals who develop type 2 diabetes: the personal fat threshold. Clin Sci 128:405\u2013410","journal-title":"Clin Sci"},{"key":"4504_CR11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.molmed.2015.04.004","volume":"21","author":"AL Robbins","year":"2015","unstructured":"Robbins AL, Savage DB (2015) The genetics of lipid storage and human lipodystrophies. Trends Mol Med 21:433\u2013438","journal-title":"Trends Mol Med"},{"key":"4504_CR12","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bbalip.2009.12.006","volume":"1801","author":"S Virtue","year":"2010","unstructured":"Virtue S, Vidal-Puig A (2010) Adipose tissue expandability, lipotoxicity and the metabolic syndrome\u2014an allostatic perspective. Biochim Biophys Acta 1801:338\u2013349","journal-title":"Biochim Biophys Acta"},{"key":"4504_CR13","doi-asserted-by":"crossref","first-page":"481","DOI":"10.7326\/0003-4819-122-7-199504010-00001","volume":"122","author":"GA Colditz","year":"1995","unstructured":"Colditz GA, Willett WC, Rotnitzky A, Manson JE (1995) Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 122:481\u2013486","journal-title":"Ann Intern Med"},{"key":"4504_CR14","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/BF00400195","volume":"34","author":"UKPDS","year":"1991","unstructured":"UKPDS (1991) UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance. Diabetologia 34:877\u2013890","journal-title":"Diabetologia"},{"key":"4504_CR15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/03014468500007621","volume":"12","author":"S Rosenbaum","year":"1985","unstructured":"Rosenbaum S, Skinner RK, Knight IB, Garrow JS (1985) A survey of heights and weights of adults in Great Britain, 1980. Ann Hum Biol 12:115\u2013127","journal-title":"Ann Hum Biol"},{"key":"4504_CR16","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/jcb.22445","volume":"109","author":"K Pinnick","year":"2010","unstructured":"Pinnick K, Neville M, Clark A, Fielding B (2010) Reversibility of metabolic and morphological changes associated with chronic exposure of pancreatic islet beta-cells to fatty acids. J Cell Biochem 109:683\u2013692","journal-title":"J Cell Biochem"},{"key":"4504_CR17","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/oby.2007.110","volume":"16","author":"KE Pinnick","year":"2008","unstructured":"Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding BA (2008) Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity 16:522\u2013530","journal-title":"Obesity"},{"key":"4504_CR18","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.cell.2012.07.029","volume":"150","author":"C Talchai","year":"2012","unstructured":"Talchai C, Xuan S, Lin HV, Sussel L, Accili D (2012) Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Cell 150:1223\u20131234","journal-title":"Cell"},{"key":"4504_CR19","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.2337\/dc13-0705","volume":"36","author":"MG White","year":"2013","unstructured":"White MG, Marshall HL, Rigby R et al (2013) Expression of mesenchymal and alpha-cell phenotypic markers in islet beta-cells in recently diagnosed diabetes. Diabetes Care 36:3818\u20133820","journal-title":"Diabetes Care"},{"key":"4504_CR20","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2337\/dc08-1274","volume":"32","author":"AM Cali","year":"2009","unstructured":"Cali AM, Man CD, Cobelli C et al (2009) Primary defects in beta-cell function further exacerbated by worsening of insulin resistance mark the development of impaired glucose tolerance in obese adolescents. Diabetes Care 32:456\u2013461","journal-title":"Diabetes Care"},{"key":"4504_CR21","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2337\/diabetes.53.1.160","volume":"53","author":"E Ferrannini","year":"2004","unstructured":"Ferrannini E, Nannipieri M, Williams K, Gonzales C, Haffner SM, Stern MP (2004) Mode of onset of type 2 diabetes from normal or impaired glucose tolerance. Diabetes 53:160\u2013165","journal-title":"Diabetes"},{"key":"4504_CR22","doi-asserted-by":"crossref","first-page":"e0126825","DOI":"10.1371\/journal.pone.0126825","volume":"10","author":"M Macauley","year":"2015","unstructured":"Macauley M, Percival K, Thelwall PE, Hollingsworth KG, Taylor R (2015) Altered volume, morphology and composition of the pancreas in type 2 diabetes. PLoS One 10:e0126825","journal-title":"PLoS One"},{"key":"4504_CR23","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1007\/s00125-016-3984-6","volume":"59","author":"A Al-Mrabeh","year":"2016","unstructured":"Al-Mrabeh A, Hollingsworth KG, Steven S, Taylor R (2016) Morphology of the pancreas in type 2 diabetes: effect of weight loss with or without normalisation of insulin secretory capacity. Diabetologia 59:1753\u20131759","journal-title":"Diabetologia"},{"key":"4504_CR24","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.2337\/dc16-0074","volume":"39","author":"H Yamazaki","year":"2016","unstructured":"Yamazaki H, Tsuboya T, Katanuma A et al (2016) Lack of independent associationbetween fatty pancreas and incidence of type 2 diabetes: 5-year Japanese cohort study. Diabetes Care 39:1677\u20131683","journal-title":"Diabetes Care"},{"key":"4504_CR25","doi-asserted-by":"crossref","unstructured":"van der Zijl NJ, Goossens GH, Moors CC et al (2011) Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on beta-cell function in individuals with impaired glucose metabolism. J Clin Endocrinol Metab 96:459\u2013467","DOI":"10.1210\/jc.2010-1722"},{"key":"4504_CR26","doi-asserted-by":"crossref","unstructured":"Kuhn JP, Berthold F, Mayerle J et al (2015) Pancreatic steatosis demonstrated at MR imaging in the general population: clinical relevance. Radiology 276:129\u2013136","DOI":"10.1148\/radiol.15140446"},{"key":"4504_CR27","doi-asserted-by":"crossref","first-page":"e0174660","DOI":"10.1371\/journal.pone.0174660","volume":"12","author":"A Al-Mrabeh","year":"2017","unstructured":"Al-Mrabeh A, Hollingsworth KG, Steven S, Tiniakos D, Taylor R (2017) Quantification of intrapancreatic fat in type 2 diabetes. PLoS One 12:e0174660","journal-title":"PLoS One"},{"key":"4504_CR28","doi-asserted-by":"crossref","unstructured":"Skyler JS, Bakris GL, Bonifacio E et al (2017) Differentiation of diabetes by pathophysiology, natural history, and prognosis. diabetes 66:241\u2013255","DOI":"10.2337\/db16-0806"},{"key":"4504_CR29","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/S0140-6736(13)62219-9","volume":"383","author":"T Tuomi","year":"2014","unstructured":"Tuomi T, Santoro N, Caprio S, Cai M, Weng J, Groop L (2014) The many faces of diabetes: a disease with increasing heterogeneity. Lancet 383:1084\u20131094","journal-title":"Lancet"},{"key":"4504_CR30","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/ajh.2009.192","volume":"22","author":"PC Rijn-Bikker van","year":"2009","unstructured":"van Rijn-Bikker PC, Mairuhu G, van Montfrans GA et al (2009) Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population. Am J Hypertens 22:1295\u20131302","journal-title":"Am J Hypertens"},{"key":"4504_CR31","first-page":"346","volume":"f1515","author":"M Franco","year":"2013","unstructured":"Franco M, Bilal U, Ordunez P et al (2013) Population-wide weight loss and regain in relation to diabetes burden and cardiovascular mortality in Cuba 1980-2010: repeated cross sectional surveys and ecological comparison of secular trends. BMJ f1515:346","journal-title":"BMJ"},{"key":"4504_CR32","first-page":"323","volume":"42","author":"HP Himsworth","year":"1949","unstructured":"Himsworth HP (1949) Diet in the aetiology of human diabetes. Proc R Soc Med 42:323\u2013326","journal-title":"Proc R Soc Med"},{"key":"4504_CR33","volume-title":"Physiological and medical observations amongs the Indians of southwestern United States and north Mexico","author":"A Hrdli\u010dka","year":"1908","unstructured":"Hrdli\u010dka A (1908) Physiological and medical observations amongs the Indians of southwestern United States and north Mexico. Washington Government Printing Office, Washington DC"},{"key":"4504_CR34","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1001\/jama.1940.02810500001001","volume":"115","author":"EP Joslin","year":"1940","unstructured":"Joslin EP (1940) The universality of diabetes: a survey of diabetes mortality in Arizona. JAMA 115:2033\u20132038","journal-title":"JAMA"},{"key":"4504_CR35","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/oxfordjournals.aje.a112648","volume":"108","author":"WC Knowler","year":"1978","unstructured":"Knowler WC, Bennett PH, Hamman RF, Miller M (1978) Diabetes incidence and prevalence in Pima Indians: a 19 fold greater incidence than in Rochester Minnesota. Am J Epidemiol 108:497\u2013505","journal-title":"Am J Epidemiol"},{"key":"4504_CR36","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12875-016-0406-2","volume":"17","author":"WS Leslie","year":"2016","unstructured":"Leslie WS, Ford I, Sattar N et al (2016) The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial. BMC Fam Pract 17:20","journal-title":"BMC Fam Pract"},{"key":"4504_CR37","doi-asserted-by":"publisher","unstructured":"Rehackova L, Ara\u00fajo-Soares V, Adamson AJ, Stevens S, Taylor R, Sniehotta FF (2017) Acceptability of a Very Low Energy Diet in Type 2 Diabetes: Patient Experiences and Behaviour Regulation. Diabet Med. https:\/\/doi.org\/10.1111\/dme.13426","DOI":"10.1111\/dme.13426"},{"key":"4504_CR38","doi-asserted-by":"crossref","unstructured":"Leslie WS, Taylor R, Harris L, Lean ME (2017) Weight losses with low-energy formula diets in obese patients with and without type 2 diabetes: systematic review and meta-analysis. Int J Obes 41:96\u2013101","DOI":"10.1038\/ijo.2016.175"},{"key":"4504_CR39","doi-asserted-by":"crossref","unstructured":"Taylor R (2011) Reversing type 2 diabetes. Available from http:\/\/www.ncl.ac.uk\/magres\/research\/diabetes\/reversal\/#publicinformation . Accessed 19 May 2017","DOI":"10.1002\/pdi.1639"},{"key":"4504_CR40","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.1111\/dme.12116","volume":"30","author":"S Steven","year":"2013","unstructured":"Steven S, Lim E, Taylor R (2013) Population response to information on reversibility of type 2 diabetes. Diabet Med 30:e135\u2013e138","journal-title":"Diabet Med"},{"key":"4504_CR41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3945\/ajcn.113.070052","volume":"99","author":"K Johansson","year":"2014","unstructured":"Johansson K, Neovius M, Hemmingsson E (2014) Effects of anti-obesity drugs, diet, and exercise on weight-loss maintenance after a very-low-calorie diet or low-calorie diet: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 99:14\u201323","journal-title":"Am J Clin Nutr"},{"key":"4504_CR42","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1017\/S0007114509991474","volume":"103","author":"L Gripeteg","year":"2010","unstructured":"Gripeteg L, Torgerson J, Karlsson J, Lindroos AK (2010) Prolonged refeeding improves weight maintenance after weight loss with very-low-energy diets. Br J Nutr 103:141\u2013148","journal-title":"Br J Nutr"},{"key":"4504_CR43","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/ajcn\/51.2.241","volume":"51","author":"MD Mifflin","year":"1990","unstructured":"Mifflin MD, St Jeor ST, Hill LA, Scott BJ, Daugherty SA, Koh YO (1990) A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr 51:241\u2013247","journal-title":"Am J Clin Nutr"},{"key":"4504_CR44","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.orcp.2016.01.004","volume":"10","author":"C Shieh","year":"2016","unstructured":"Shieh C, Knisely MR, Clark D, Carpenter JS (2016) Self-weighing in weight management interventions: A systematic review of literature. Obes Res Clin Pract 10:493\u2013519","journal-title":"Obes Res Clin Pract"},{"key":"4504_CR45","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1467-789X.2011.00972.x","volume":"13","author":"KMR Middleton","year":"2012","unstructured":"Middleton KMR, Patidar SM, Perri MG (2012) The impact of extended care on the long-term maintenance of weight loss: a systematic review and meta-analysis. Obes Rev 13:509\u2013517","journal-title":"Obes Rev"},{"key":"4504_CR46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/oby.20967","volume":"23","author":"PS MacLean","year":"2015","unstructured":"MacLean PS, Wing RR, Davidson T et al (2015) NIH Working Group Report: innovative research to improve maintenance of weight loss. Obesity 23:7\u201315","journal-title":"Obesity"},{"key":"4504_CR47","doi-asserted-by":"crossref","unstructured":"Lean M, Brosnahan N, McLoone P et al (2013) Feasibility and indicative results from a 12-month low-energy liquid diet treatment and maintenance programme for severe obesity. Br J Gen Pract 63:e115\u2013e124","DOI":"10.3399\/bjgp13X663073"},{"key":"4504_CR48","first-page":"118","volume":"20","author":"A Keys","year":"1953","unstructured":"Keys A (1953) Atherosclerosis: a problem in newer public health. J Mt Sinai Hosp N Y 20:118\u2013139","journal-title":"J Mt Sinai Hosp N Y"},{"key":"4504_CR49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nut.2014.06.011","volume":"31","author":"RD Feinman","year":"2015","unstructured":"Feinman RD, Pogozelski WK, Astrup A et al (2015) Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition 31:1\u201313","journal-title":"Nutrition"},{"key":"4504_CR50","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1111\/j.1464-5491.2011.03371.x","volume":"28","author":"PA Dyson","year":"2011","unstructured":"Dyson PA, Kelly T, Deakin T et al (2011) Diabetes UK evidence-based nutrition guidelines for the prevention and management of diabetes. Diabet Med 28:1282\u20131288","journal-title":"Diabet Med"},{"key":"4504_CR51","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/nbu.12219","volume":"41","author":"A Spiro","year":"2016","unstructured":"Spiro A, Stanner S (2016) The National Obesity Forum report is an opinion piece not a scientific review. Nutr Bull 41:257\u2013269","journal-title":"Nutr Bull"},{"key":"4504_CR52","doi-asserted-by":"crossref","unstructured":"van Wyk HJ, Davis RE, Davies JS (2016) A critical review of low-carbohydrate diets in people with type 2 diabetes. Diabet Med 33:148\u2013157","DOI":"10.1111\/dme.12964"},{"key":"4504_CR53","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3945\/ajcn.111.026328","volume":"95","author":"RJ Souza de","year":"2012","unstructured":"de Souza RJ, Bray GA, Carey VJ et al (2012) Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial. Am J Clin Nutr 95:614\u2013625","journal-title":"Am J Clin Nutr"},{"key":"4504_CR54","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/jhn.12436","volume":"30","author":"PD McArdle","year":"2017","unstructured":"McArdle PD, Greenfield SM, Avery A, Adams GG, Gill PS (2017) Dietitians\u2019 practice in giving carbohydrate advice in the management of type 2 diabetes: a mixed methods study. J Hum Nutr Diet 30:385\u2013393","journal-title":"J Hum Nutr Diet"},{"key":"4504_CR55","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s13300-015-0136-9","volume":"6","author":"P Dyson","year":"2015","unstructured":"Dyson P (2015) Low carbohydrate diets and type 2 diabetes: what is the latest Evidence? Diabetes Ther 6:411\u2013424","journal-title":"Diabetes Ther"},{"key":"4504_CR56","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S2213-8587(16)30085-7","volume":"4","author":"R Estruch","year":"2016","unstructured":"Estruch R, Martinez-Gonzalez MA, Corella D et al (2016) Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial. Lancet Diabetes Endocrinol 4:666\u2013676","journal-title":"Lancet Diabetes Endocrinol"},{"key":"4504_CR57","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.3390\/nu6093474","volume":"6","author":"E Garcia-Fernandez","year":"2014","unstructured":"Garcia-Fernandez E, Rico-Cabanas L, Rosgaard N, Estruch R, Bach-Faig A (2014) Mediterranean diet and cardiodiabesity: a review. Nutrients 6:3474\u20133500","journal-title":"Nutrients"},{"key":"4504_CR58","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/MCO.0000000000000316","volume":"19","author":"MA Martinez-Gonzalez","year":"2016","unstructured":"Martinez-Gonzalez MA, Martin-Calvo N (2016) Mediterranean diet and life expectancy; beyond olive oil, fruits, and vegetables. Curr Opin Clin Nutr Metab Care 19:401\u2013407","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"4504_CR59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2337\/dc10-1288","volume":"34","author":"J Salas-Salvado","year":"2011","unstructured":"Salas-Salvado J, Bullo M, Babio N et al (2011) Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial. Diabetes Care 34:14\u201319","journal-title":"Diabetes Care"},{"key":"4504_CR60","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.2337\/dc13-2899","volume":"37","author":"K Esposito","year":"2014","unstructured":"Esposito K, Maiorino MI, Petrizzo M, Bellastella G, Giugliano D (2014) The effects of a Mediterranean diet on the need for diabetes drugs and remission of newly diagnosed type 2 diabetes: follow-up of a randomized trial. Diabetes Care 37:1824\u20131830","journal-title":"Diabetes Care"},{"key":"4504_CR61","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/ejcn.2015.195","volume":"70","author":"CS Davis","year":"2016","unstructured":"Davis CS, Clarke RE, Coulter SN et al (2016) Intermittent energy restriction and weight loss: a systematic review. Eur J Clin Nutr 70:292\u2013299","journal-title":"Eur J Clin Nutr"},{"key":"4504_CR62","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1017\/S0007114513000792","volume":"110","author":"M Harvie","year":"2013","unstructured":"Harvie M, Wright C, Pegington M et al (2013) The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women. Br J Nutr 110:1534\u20131547","journal-title":"Br J Nutr"},{"key":"4504_CR63","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.diabres.2016.10.010","volume":"122","author":"S Carter","year":"2016","unstructured":"Carter S, Clifton PM, Keogh JB (2016) The effects of intermittent compared to continuous energy restriction on glycaemic control in type 2 diabetes; a pragmatic pilot trial. Diabetes Res Clin Pract 122:106\u2013112","journal-title":"Diabetes Res Clin Pract"},{"key":"4504_CR64","doi-asserted-by":"crossref","unstructured":"Harvie MN, Howell T (2016) Could intermittent energy restriction and intermittent fasting reduce rates of cancer in obese, overweight, and normal-weight subjects? A summary of evidence. Advances in Nutrition 7:690\u2013705","DOI":"10.3945\/an.115.011767"},{"key":"4504_CR65","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3945\/ajcn.113.064410","volume":"98","author":"AW Brown","year":"2013","unstructured":"Brown AW, Bohan Brown MM, Allison DB (2013) Belief beyond the evidence: using the proposed effect of breakfast on obesity to show 2 practices that distort scientific evidence. Am J Clin Nutr 98:1298\u20131308","journal-title":"Am J Clin Nutr"},{"key":"4504_CR66","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.nut.2015.06.013","volume":"32","author":"DJ Clayton","year":"2016","unstructured":"Clayton DJ, Stensel DJ, James LJ (2016) Effect of breakfast omission on subjective appetite, metabolism, acylated ghrelin and GLP-17-36 during rest and exercise. Nutrition 32:179\u2013185","journal-title":"Nutrition"},{"key":"4504_CR67","unstructured":"Kealey T (2016) Breakfast is a dangerous meal. 4th Estate, London"},{"key":"4504_CR68","doi-asserted-by":"crossref","first-page":"222S","DOI":"10.1093\/ajcn\/82.1.222S","volume":"82","author":"RR Wing","year":"2005","unstructured":"Wing RR, Phelan S (2005) Long-term weight loss maintenance. Am J Clin Nutr 82:222S\u2013225S","journal-title":"Am J Clin Nutr"},{"key":"4504_CR69","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.physbeh.2009.02.002","volume":"97","author":"G Finlayson","year":"2009","unstructured":"Finlayson G, Bryant E, Blundell JE, King NA (2009) Acute compensatory eating following exercise is associated with implicit hedonic wanting for food. Physiol Behav 97:62\u201367","journal-title":"Physiol Behav"},{"key":"4504_CR70","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1136\/bjsports-2012-091721","volume":"48","author":"M Hopkins","year":"2014","unstructured":"Hopkins M, Blundell JE, King NA (2014) Individual variability in compensatory eating following acute exercise in overweight and obese women. Br J Sports Med 48:1472\u20131476","journal-title":"Br J Sports Med"},{"key":"4504_CR71","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/bjsm.2010.082495","volume":"46","author":"NA King","year":"2012","unstructured":"King NA, Horner K, Hills AP et al (2012) Exercise, appetite and weight management: understanding the compensatory responses in eating behaviour and how they contribute to variability in exercise-induced weight loss. Br J Sports Med 46:315\u2013322","journal-title":"Br J Sports Med"},{"key":"4504_CR72","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/oby.20662","volume":"22","author":"LookAhead","year":"2014","unstructured":"LookAhead (2014) Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study. Obesity 22:5\u201313","journal-title":"Obesity"},{"key":"4504_CR73","doi-asserted-by":"crossref","unstructured":"Sheth H, Sheth J, Sheth F, Burn J (2016) The poor patient with diabetes \u2018should live like a saint\u2019. Diabet Med 33:134\u2013135","DOI":"10.1111\/dme.12826"},{"key":"4504_CR74","unstructured":"Bouchardat A (1875) De la glycosurie ou diab\u00e8te sucr\u00e9. Librarie G. Bailli\u00e8re, Paris [document in French]"},{"key":"4504_CR75","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1001\/jama.1914.02570110041011","volume":"63","author":"FM Allen","year":"1914","unstructured":"Allen FM (1914) Studies concerning diabetes. J Am Med Assoc 63:939\u2013943","journal-title":"J Am Med Assoc"},{"key":"4504_CR76","first-page":"201","volume":"100","author":"MN Friedman","year":"1955","unstructured":"Friedman MN, Sancetta AJ, Magovern GJ (1955) The amelioration of diabetes mellitus following subtotal gastrectomy. Surg Gynecol Obstet 100:201\u2013204","journal-title":"Surg Gynecol Obstet"},{"key":"4504_CR77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.metabol.2007.05.008","volume":"57","author":"C Lara-Castro","year":"2008","unstructured":"Lara-Castro C, Newcomer BR, Rowell J et al (2008) Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects. Metab Clin Exp 57:1\u20138","journal-title":"Metab Clin Exp"},{"key":"4504_CR78","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1001\/archinte.1991.00400070100012","volume":"151","author":"RR Wing","year":"1991","unstructured":"Wing RR, Marcus MD, Salata R, Epstein LH, Miaskiewicz S, Blair EH (1991) Effects of a very-low-calorie diet on long-term glycemic control in obese type 2 diabetic subjects. Arch Intern Med 151:1334\u20131340","journal-title":"Arch Intern Med"},{"key":"4504_CR79","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1046\/j.1365-277X.2002.00342.x","volume":"15","author":"RB Paisey","year":"2002","unstructured":"Paisey RB, Frost J, Harvey P et al (2002) Five year results of a prospective very low calorie diet or conventional weight loss programme in type 2 diabetes. J Hum Nutr Diet 15:121\u2013127","journal-title":"J Hum Nutr Diet"},{"key":"4504_CR80","doi-asserted-by":"crossref","first-page":"990","DOI":"10.2337\/diab.35.9.990","volume":"35","author":"RR Henry","year":"1986","unstructured":"Henry RR, Wallace P, Olefsky JM (1986) Effects of weight loss on mechanisms of hyperglycaemia in obese non-insulin dependent diabetes mellitus. Diabetes 35:990\u2013998","journal-title":"Diabetes"},{"key":"4504_CR81","first-page":"837","volume":"352","author":"UKPDS","year":"1999","unstructured":"UKPDS (1999) Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352:837\u2013853","journal-title":"Lancet"},{"key":"4504_CR82","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1056\/NEJMoa0806470","volume":"359","author":"RR Holman","year":"2008","unstructured":"Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA (2008) 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 359:1577\u20131589","journal-title":"N Engl J Med"},{"key":"4504_CR83","doi-asserted-by":"crossref","unstructured":"UKPDS (1995) UK prospective diabetes study 16. Overview of 6 years\u2019 therapy of type II diabetes: a progressive disease. Diabetes 44:1249\u20131258","DOI":"10.2337\/diab.44.11.1249"},{"key":"4504_CR84","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0140-6736(98)07037-8","volume":"352","author":"UKPDS","year":"1998","unstructured":"UKPDS (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352:854\u2013865","journal-title":"Lancet"},{"key":"4504_CR85","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/17446651.2016.1239525","volume":"11","author":"R Taylor","year":"2016","unstructured":"Taylor R (2016) Calorie restriction and reversal of type 2 diabetes. Expert Rev Endocrinol Metab 11:521\u2013528","journal-title":"Expert Rev Endocrinol Metab"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-017-4504-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-017-4504-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-017-4504-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T17:16:30Z","timestamp":1719594990000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-017-4504-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,15]]},"references-count":85,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["4504"],"URL":"https:\/\/doi.org\/10.1007\/s00125-017-4504-z","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,15]]}}}