{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:09:58Z","timestamp":1793747398851,"version":"4.6.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470499"],"award-info":[{"award-number":["81470499"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s00125-019-4828-y","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T13:21:52Z","timestamp":1550496112000},"page":"860-872","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Selective deletion of endothelial cell calpain in mice reduces diabetic cardiomyopathy by improving angiogenesis"],"prefix":"10.1007","volume":"62","author":[{"given":"Xiaomei","family":"Teng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiting","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidong","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Chang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Greer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenya","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,18]]},"reference":[{"issue":"11","key":"4828_CR1","doi-asserted-by":"publisher","first-page":"e442","DOI":"10.1371\/journal.pmed.0030442","volume":"3","author":"CD Mathers","year":"2006","unstructured":"Mathers CD, Loncar D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3(11):e442. https:\/\/doi.org\/10.1371\/journal.pmed.0030442","journal-title":"PLoS Med"},{"issue":"3","key":"4828_CR2","doi-asserted-by":"publisher","first-page":"699","DOI":"10.2337\/diacare.27.3.699","volume":"27","author":"AG Bertoni","year":"2004","unstructured":"Bertoni AG, Hundley WG, Massing MW, Bonds DE, Burke GL, Goff DC Jr (2004) Heart failure prevalence, incidence, and mortality in the elderly with diabetes. Diabetes Care 27(3):699\u2013703. https:\/\/doi.org\/10.2337\/diacare.27.3.699","journal-title":"Diabetes Care"},{"issue":"25","key":"4828_CR3","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1161\/CIRCULATIONAHA.106.679597","volume":"115","author":"S Boudina","year":"2007","unstructured":"Boudina S, Abel ED (2007) Diabetic cardiomyopathy revisited. Circulation 115(25):3213\u20133223. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.679597","journal-title":"Circulation"},{"issue":"3","key":"4828_CR4","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1152\/physrev.00029.2002","volume":"83","author":"DE Goll","year":"2003","unstructured":"Goll DE, Thompson VF, Li H, Wei W, Cong J (2003) The calpain system. Physiol Rev 83(3):731\u2013801. https:\/\/doi.org\/10.1152\/physrev.00029.2002","journal-title":"Physiol Rev"},{"issue":"2","key":"4828_CR5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/(SICI)1097-4644(19970801)66:2<197::AID-JCB7>3.0.CO;2-L","volume":"66","author":"K Fujitani","year":"1997","unstructured":"Fujitani K, Kambayashi J, Sakon M et al (1997) Identification of mu-, m-calpains and calpastatin and capture of mu-calpain activation in endothelial cells. J Cell Biochem 66(2):197\u2013209. https:\/\/doi.org\/10.1002\/(SICI)1097-4644(19970801)66:2<197::AID-JCB7>3.0.CO;2-L","journal-title":"J Cell Biochem"},{"issue":"6","key":"4828_CR6","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/dvg.20216","volume":"44","author":"Y Tan","year":"2006","unstructured":"Tan Y, Dourdin N, Wu C, De Veyra T, Elce JS, Greer PA (2006) Conditional disruption of ubiquitous calpains in the mouse. Genesis 44(6):297\u2013303. https:\/\/doi.org\/10.1002\/dvg.20216","journal-title":"Genesis"},{"issue":"11","key":"4828_CR7","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.2337\/db10-1333","volume":"60","author":"Y Li","year":"2011","unstructured":"Li Y, Ma J, Zhu H et al (2011) Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes. Diabetes 60(11):2985\u20132994. https:\/\/doi.org\/10.2337\/db10-1333","journal-title":"Diabetes"},{"issue":"11","key":"4828_CR8","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/j.bbadis.2016.08.005","volume":"1862","author":"S Li","year":"2016","unstructured":"Li S, Zhang L, Ni R et al (2016) Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress. Biochim Biophys Acta 1862(11):2023\u20132033. https:\/\/doi.org\/10.1016\/j.bbadis.2016.08.005","journal-title":"Biochim Biophys Acta"},{"key":"4828_CR9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2337\/db15-0963","volume":"65","author":"R Ni","year":"2016","unstructured":"Ni R, Zheng D, Xiong S et al (2016) Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type 1 diabetic hearts: a novel mechanism contributing to diabetic cardiomyopathy. Diabetes 65:255\u2013268","journal-title":"Diabetes"},{"issue":"3","key":"4828_CR10","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.ccl.2014.04.001","volume":"32","author":"D Aronson","year":"2014","unstructured":"Aronson D, Edelman ER (2014) Coronary artery disease and diabetes mellitus. Cardiol Clin 32(3):439\u2013455. https:\/\/doi.org\/10.1016\/j.ccl.2014.04.001","journal-title":"Cardiol Clin"},{"issue":"31","key":"4828_CR11","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1093\/eurheartj\/eht142","volume":"34","author":"JA Beckman","year":"2013","unstructured":"Beckman JA, Paneni F, Cosentino F, Creager MA (2013) Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part II. Eur Heart J 34(31):2444\u20132452. https:\/\/doi.org\/10.1093\/eurheartj\/eht142","journal-title":"Eur Heart J"},{"issue":"2","key":"4828_CR12","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jacc.2016.10.058","volume":"69","author":"R Hinkel","year":"2017","unstructured":"Hinkel R, Hoewe A, Renner S et al (2017) Diabetes mellitus-induced microvascular destabilization in the myocardium. J Am Coll Cardiol 69(2):131\u2013143. https:\/\/doi.org\/10.1016\/j.jacc.2016.10.058","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"4828_CR13","doi-asserted-by":"publisher","first-page":"3082","DOI":"10.1161\/ATVBAHA.112.300291","volume":"32","author":"DM Muris","year":"2012","unstructured":"Muris DM, Houben AJ, Schram MT, Stehouwer CD (2012) Microvascular dysfunction is associated with a higher incidence of type 2 diabetes mellitus: a systematic review and meta-analysis. Arterioscler Thromb Vasc Biol 32(12):3082\u20133094. https:\/\/doi.org\/10.1161\/ATVBAHA.112.300291","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"11","key":"4828_CR14","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1007\/s00125-015-3717-2","volume":"58","author":"C Sabanayagam","year":"2015","unstructured":"Sabanayagam C, Lye WK, Klein R et al (2015) Retinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis. Diabetologia 58(11):2476\u20132485. https:\/\/doi.org\/10.1007\/s00125-015-3717-2","journal-title":"Diabetologia"},{"issue":"4","key":"4828_CR15","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.2337\/diabetes.54.4.1132","volume":"54","author":"TJ Stalker","year":"2005","unstructured":"Stalker TJ, Gong Y, Scalia R (2005) The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes. Diabetes 54(4):1132\u20131140. https:\/\/doi.org\/10.2337\/diabetes.54.4.1132","journal-title":"Diabetes"},{"issue":"7","key":"4828_CR16","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.2337\/db06-1198","volume":"56","author":"R Scalia","year":"2007","unstructured":"Scalia R, Gong Y, Berzins B, Zhao LJ, Sharma K (2007) Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation: the role of mu-calpain. Diabetes 56(7):1842\u20131849. https:\/\/doi.org\/10.2337\/db06-1198","journal-title":"Diabetes"},{"issue":"2","key":"4828_CR17","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1161\/ATVBAHA.110.217901","volume":"31","author":"AR Smolock","year":"2011","unstructured":"Smolock AR, Mishra G, Eguchi K, Eguchi S, Scalia R (2011) Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpain. Arterioscler Thromb Vasc Biol 31(2):289\u2013296. https:\/\/doi.org\/10.1161\/ATVBAHA.110.217901","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"4828_CR18","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1475-2840-13-88","volume":"13","author":"B Chen","year":"2014","unstructured":"Chen B, Zhao Q, Ni R et al (2014) Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes. Cardiovasc Diabetol 13(1):88. https:\/\/doi.org\/10.1186\/1475-2840-13-88","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"4828_CR19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s00395-016-0596-8","volume":"112","author":"V Randriamboavonjy","year":"2017","unstructured":"Randriamboavonjy V, Kyselova A, Elgheznawy A, Zukunft S, Wittig I, Fleming I (2017) Calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice. Basic Res Cardiol 112(1):10. https:\/\/doi.org\/10.1007\/s00395-016-0596-8","journal-title":"Basic Res Cardiol"},{"issue":"6","key":"4828_CR20","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1242\/dmm.028530","volume":"10","author":"LM Hinder","year":"2017","unstructured":"Hinder LM, O\u2019Brien PD, Hayes JM et al (2017) Dietary reversal of neuropathy in a murine model of prediabetes and metabolic syndrome. Dis Model Mech 10(6):717\u2013725. https:\/\/doi.org\/10.1242\/dmm.028530","journal-title":"Dis Model Mech"},{"issue":"4","key":"4828_CR21","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s00125-009-1258-2","volume":"52","author":"T Kusakabe","year":"2009","unstructured":"Kusakabe T, Tanioka H, Ebihara K et al (2009) Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet. Diabetologia 52(4):675\u2013683. https:\/\/doi.org\/10.1007\/s00125-009-1258-2","journal-title":"Diabetologia"},{"issue":"1","key":"4828_CR22","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1093\/cvr\/cvp189","volume":"84","author":"Y Li","year":"2009","unstructured":"Li Y, Li Y, Feng Q, Arnold M, Peng T (2009) Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes. Cardiovasc Res 84(1):100\u2013110. https:\/\/doi.org\/10.1093\/cvr\/cvp189","journal-title":"Cardiovasc Res"},{"issue":"1","key":"4828_CR23","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nprot.2011.435","volume":"7","author":"M Baker","year":"2011","unstructured":"Baker M, Robinson SD, Lechertier T et al (2011) Use of the mouse aortic ring assay to study angiogenesis. Nat Protoc 7(1):89\u2013104. https:\/\/doi.org\/10.1038\/nprot.2011.435","journal-title":"Nat Protoc"},{"issue":"3","key":"4828_CR24","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/ni.3659","volume":"18","author":"E Dror","year":"2017","unstructured":"Dror E, Dalmas E, Meier DT et al (2017) Postprandial macrophage-derived IL-1beta stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat Immunol 18(3):283\u2013292. https:\/\/doi.org\/10.1038\/ni.3659","journal-title":"Nat Immunol"},{"issue":"8","key":"4828_CR25","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1007\/s00125-015-3622-8","volume":"58","author":"D Zheng","year":"2015","unstructured":"Zheng D, Ma J, Yu Y et al (2015) Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL\/6 mice. Diabetologia 58(8):1949\u20131958. https:\/\/doi.org\/10.1007\/s00125-015-3622-8","journal-title":"Diabetologia"},{"issue":"2","key":"4828_CR26","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nprot.2007.30","volume":"2","author":"CC Liang","year":"2007","unstructured":"Liang CC, Park AY, Guan JL (2007) In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2(2):329\u2013333. https:\/\/doi.org\/10.1038\/nprot.2007.30","journal-title":"Nat Protoc"},{"issue":"3","key":"4828_CR27","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1172\/JCI0213595","volume":"109","author":"D Graesser","year":"2002","unstructured":"Graesser D, Solowiej A, Bruckner M et al (2002) Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. J Clin Invest 109(3):383\u2013392. https:\/\/doi.org\/10.1172\/JCI0213595","journal-title":"J Clin Invest"},{"key":"4828_CR28","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1651-2227.2004.tb00235.x","volume":"93","author":"G Oskarsson","year":"2004","unstructured":"Oskarsson G (2004) Coronary flow and flow reserve in children. Acta Paediatr Suppl 93:20\u201325","journal-title":"Acta Paediatr Suppl"},{"issue":"1","key":"4828_CR29","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2174\/1573399052952550","volume":"1","author":"H Nakagami","year":"2005","unstructured":"Nakagami H, Kaneda Y, Ogihara T, Morishita R (2005) Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis. Curr Diabetes Rev 1(1):59\u201363. https:\/\/doi.org\/10.2174\/1573399052952550","journal-title":"Curr Diabetes Rev"},{"issue":"4-5","key":"4828_CR30","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1080\/13813450701783513","volume":"113","author":"G Cohen","year":"2007","unstructured":"Cohen G, Riahi Y, Alpert E, Gruzman A, Sasson S (2007) The roles of hyperglycaemia and oxidative stress in the rise and collapse of the natural protective mechanism against vascular endothelial cell dysfunction in diabetes. Arch Physiol Biochem 113(4-5):259\u2013267. https:\/\/doi.org\/10.1080\/13813450701783513","journal-title":"Arch Physiol Biochem"},{"issue":"4","key":"4828_CR31","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.yjmcc.2011.01.007","volume":"50","author":"LC Heather","year":"2011","unstructured":"Heather LC, Clarke K (2011) Metabolism, hypoxia and the diabetic heart. J Mol Cell Cardiol 50(4):598\u2013605. https:\/\/doi.org\/10.1016\/j.yjmcc.2011.01.007","journal-title":"J Mol Cell Cardiol"},{"issue":"22","key":"4828_CR32","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.lfs.2013.04.001","volume":"92","author":"PZ Costa","year":"2013","unstructured":"Costa PZ, Soares R (2013) Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox. Life Sci 92(22):1037\u20131045. https:\/\/doi.org\/10.1016\/j.lfs.2013.04.001","journal-title":"Life Sci"},{"issue":"23","key":"4828_CR33","doi-asserted-by":"publisher","first-page":"22070","DOI":"10.1074\/jbc.M501810200","volume":"280","author":"R Benetti","year":"2005","unstructured":"Benetti R, Copetti T, Dell\u2019Orso S et al (2005) The calpain system is involved in the constitutive regulation of beta-catenin signaling functions. J Biol Chem 280(23):22070\u201322080. https:\/\/doi.org\/10.1074\/jbc.M501810200","journal-title":"J Biol Chem"},{"issue":"8","key":"4828_CR34","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1161\/CIRCRESAHA.115.307853","volume":"118","author":"Y Shen","year":"2016","unstructured":"Shen Y, Zuo S, Wang Y et al (2016) Thromboxane governs the differentiation of adipose-derived stromal cells toward endothelial cells in vitro and in vivo. Circ Res 118(8):1194\u20131207. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.307853","journal-title":"Circ Res"},{"issue":"8","key":"4828_CR35","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1016\/j.jacc.2006.07.033","volume":"48","author":"M Galderisi","year":"2006","unstructured":"Galderisi M (2006) Diastolic dysfunction and diabetic cardiomyopathy: evaluation by Doppler echocardiography. J Am Coll Cardiol 48(8):1548\u20131551. https:\/\/doi.org\/10.1016\/j.jacc.2006.07.033","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"4828_CR36","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1093\/cvr\/27.8.1387","volume":"27","author":"C Ganote","year":"1993","unstructured":"Ganote C, Armstrong S (1993) Ischaemia and the myocyte cytoskeleton: review and speculation. Cardiovasc Res 27(8):1387\u20131403. https:\/\/doi.org\/10.1093\/cvr\/27.8.1387","journal-title":"Cardiovasc Res"},{"issue":"2","key":"4828_CR37","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s10741-016-9532-0","volume":"21","author":"GW Moe","year":"2016","unstructured":"Moe GW, Marin-Garcia J (2016) Role of cell death in the progression of heart failure. Heart Fail Rev 21(2):157\u2013167. https:\/\/doi.org\/10.1007\/s10741-016-9532-0","journal-title":"Heart Fail Rev"},{"issue":"17","key":"4828_CR38","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1093\/eurheartj\/eht513","volume":"35","author":"F Crea","year":"2014","unstructured":"Crea F, Camici PG, Bairey Merz CN (2014) Coronary microvascular dysfunction: an update. Eur Heart J 35(17):1101\u20131111. https:\/\/doi.org\/10.1093\/eurheartj\/eht513","journal-title":"Eur Heart J"},{"issue":"11","key":"4828_CR39","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1096\/fj.02-1213fje","volume":"17","author":"TJ Stalker","year":"2003","unstructured":"Stalker TJ, Skvarka CB, Scalia R (2003) A novel role for calpains in the endothelial dysfunction of hyperglycemia. FASEB J 17(11):1511\u20131513. https:\/\/doi.org\/10.1096\/fj.02-1213fje","journal-title":"FASEB J"},{"issue":"12","key":"4828_CR40","doi-asserted-by":"publisher","first-page":"2818","DOI":"10.1161\/ATVBAHA.113.302012","volume":"33","author":"RJ Bodnar","year":"2013","unstructured":"Bodnar RJ, Rodgers ME, Chen WC, Wells A (2013) Pericyte regulation of vascular remodeling through the CXC receptor 3. Arterioscler Thromb Vasc Biol 33(12):2818\u20132829. https:\/\/doi.org\/10.1161\/ATVBAHA.113.302012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"4828_CR41","doi-asserted-by":"publisher","first-page":"H1667","DOI":"10.1152\/ajpheart.00810.2014","volume":"309","author":"C Yildirim","year":"2015","unstructured":"Yildirim C, Favre J, Weijers EM et al (2015) IFN-\u03b2 affects the angiogenic potential of circulating angiogenic cells by activating calpain 1. Am J Physiol Heart Circ Physiol 309(10):H1667\u2013H1678. https:\/\/doi.org\/10.1152\/ajpheart.00810.2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"9","key":"4828_CR42","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1096\/fj.05-5354com","volume":"20","author":"Y Su","year":"2006","unstructured":"Su Y, Cui Z, Li Z, Block ER (2006) Calpain-2 regulation of VEGF-mediated angiogenesis. FASEB J 20(9):1443\u20131451. https:\/\/doi.org\/10.1096\/fj.05-5354com","journal-title":"FASEB J"},{"issue":"3","key":"4828_CR43","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1093\/cvr\/cvp311","volume":"85","author":"T Miyazaki","year":"2010","unstructured":"Miyazaki T, Honda K, Ohata H (2010) m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions. Cardiovasc Res 85(3):530\u2013541. https:\/\/doi.org\/10.1093\/cvr\/cvp311","journal-title":"Cardiovasc Res"},{"issue":"2","key":"4828_CR44","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1074\/jbc.M116.766832","volume":"292","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Li Q, Youn JY, Cai H (2017) Protein phosphotyrosine phosphatase 1B (PTP1B) in calpain-dependent feedback regulation of vascular endothelial growth factor receptor (VEGFR2) in endothelial cells: implications in VEGF-dependent angiogenesis and diabetic wound healing. J Biol Chem 292(2):407\u2013416. https:\/\/doi.org\/10.1074\/jbc.M116.766832","journal-title":"J Biol Chem"},{"issue":"20","key":"4828_CR45","doi-asserted-by":"publisher","first-page":"13254","DOI":"10.1073\/pnas.202355799","volume":"99","author":"G Li","year":"2002","unstructured":"Li G, Iyengar R (2002) Calpain as an effector of the Gq signaling pathway for inhibition of Wnt\/beta -catenin-regulated cell proliferation. Proc Natl Acad Sci U S A 99(20):13254\u201313259. https:\/\/doi.org\/10.1073\/pnas.202355799","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"20","key":"4828_CR46","doi-asserted-by":"publisher","first-page":"7237","DOI":"10.1158\/0008-5472.CAN-04-1048","volume":"64","author":"J Rios-Doria","year":"2004","unstructured":"Rios-Doria J, Kuefer R, Ethier SP, Day ML (2004) Cleavage of beta-catenin by calpain in prostate and mammary tumor cells. Cancer Res 64(20):7237\u20137240. https:\/\/doi.org\/10.1158\/0008-5472.CAN-04-1048","journal-title":"Cancer Res"},{"issue":"3","key":"4828_CR47","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.carpath.2014.12.002","volume":"24","author":"XH Xi","year":"2015","unstructured":"Xi XH, Wang Y, Li J, Wang FW, Tian GH, Yin MS, Mu YL, Chong ZZ (2015) Activation of Wnt\/beta-catenin\/GSK3beta signaling during the development of diabetic cardiomyopathy. Cardiovasc Pathol 24(3):179\u2013186. https:\/\/doi.org\/10.1016\/j.carpath.2014.12.002","journal-title":"Cardiovasc Pathol"},{"issue":"3","key":"4828_CR48","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1530\/JME-15-0155","volume":"55","author":"Y Ying","year":"2015","unstructured":"Ying Y, Zhu H, Liang Z, Ma X, Li S (2015) GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt\/GSK3b\/b-catenin pathway. J Mol Endocrinol 55(3):245\u2013262. https:\/\/doi.org\/10.1530\/JME-15-0155","journal-title":"J Mol Endocrinol"},{"issue":"1","key":"4828_CR49","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1074\/jbc.M109.024190","volume":"285","author":"CJ Huang","year":"2010","unstructured":"Huang CJ, Gurlo T, Haataja L et al (2010) Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. J Biol Chem 285(1):339\u2013348. https:\/\/doi.org\/10.1074\/jbc.M109.024190","journal-title":"J Biol Chem"},{"issue":"3","key":"4828_CR50","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.nbd.2012.07.025","volume":"48","author":"AY Shanab","year":"2012","unstructured":"Shanab AY, Nakazawa T, Ryu M et al (2012) Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the therapeutic impact of calpain inhibitor. Neurobiol Dis 48(3):556\u2013567. https:\/\/doi.org\/10.1016\/j.nbd.2012.07.025","journal-title":"Neurobiol Dis"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-019-4828-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-019-4828-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-019-4828-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T01:24:03Z","timestamp":1662945843000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-019-4828-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,18]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["4828"],"URL":"https:\/\/doi.org\/10.1007\/s00125-019-4828-y","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,18]]},"assertion":[{"value":"18 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there is no duality of interest associated with this manuscript.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Duality of interest"}}]}}