{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T21:53:48Z","timestamp":1794434028254,"version":"4.9.1"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"VA-Merit Grant","award":["NIH R00 DK100465."],"award-info":[{"award-number":["NIH R00 DK100465."]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s00125-020-05177-6","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T16:02:45Z","timestamp":1591891365000},"page":"1464-1474","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":408,"title":["Exercise and metabolic health: beyond skeletal muscle"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7920-7466","authenticated-orcid":false,"given":"John P.","family":"Thyfault","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1266-5144","authenticated-orcid":false,"given":"Audrey","family":"Bergouignan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"issue":"2","key":"5177_CR1","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1249\/MSS.0b013e3181949333","volume":"41","author":"JE Donnelly","year":"2009","unstructured":"Donnelly JE, Blair SN, Jakicic JM, Manore MM, Rankin JW, Smith BK (2009) American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc 41(2):459\u2013471. https:\/\/doi.org\/10.1249\/MSS.0b013e3181949333","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"5177_CR2","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jhep.2016.08.023","volume":"66","author":"R Hashida","year":"2017","unstructured":"Hashida R, Kawaguchi T, Bekki M et al (2017) Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: a systematic review. J Hepatol 66(1):142\u2013152. https:\/\/doi.org\/10.1016\/j.jhep.2016.08.023","journal-title":"J Hepatol"},{"issue":"11","key":"5177_CR3","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.2337\/db10-0822","volume":"59","author":"PT Katzmarzyk","year":"2010","unstructured":"Katzmarzyk PT (2010) Physical activity, sedentary behavior, and health: paradigm paralysis or paradigm shift? Diabetes 59(11):2717\u20132725. https:\/\/doi.org\/10.2337\/db10-0822","journal-title":"Diabetes"},{"issue":"10","key":"5177_CR4","doi-asserted-by":"publisher","first-page":"R157","DOI":"10.1530\/EC-19-0350","volume":"8","author":"L Hodson","year":"2019","unstructured":"Hodson L, Karpe F (2019) Hyperinsulinemia: does it tip the balance toward intrahepatic fat accumulation? Endocr Connect 8(10):R157\u2013R168. https:\/\/doi.org\/10.1530\/EC-19-0350","journal-title":"Endocr Connect"},{"issue":"9","key":"5177_CR5","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1111\/obr.12862","volume":"20","author":"RCR Meex","year":"2019","unstructured":"Meex RCR, Blaak EE, van Loon LJC (2019) Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes. Obes Rev 20(9):1205\u20131217. https:\/\/doi.org\/10.1111\/obr.12862","journal-title":"Obes Rev"},{"issue":"3","key":"5177_CR6","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1172\/JCI134165","volume":"130","author":"GI Smith","year":"2019","unstructured":"Smith GI, Shankaran M, Yoshino M et al (2019) Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease. J Clin Invest 130(3):1453\u20131460. https:\/\/doi.org\/10.1172\/JCI134165","journal-title":"J Clin Invest"},{"issue":"5","key":"5177_CR7","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.cmet.2017.04.015","volume":"25","author":"BH Goodpaster","year":"2017","unstructured":"Goodpaster BH, Sparks LM (2017) Metabolic flexibility in health and disease. Cell Metab 25(5):1027\u20131036. https:\/\/doi.org\/10.1016\/j.cmet.2017.04.015","journal-title":"Cell Metab"},{"issue":"4","key":"5177_CR8","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","volume":"98","author":"MC Petersen","year":"2018","unstructured":"Petersen MC, Shulman GI (2018) Mechanisms of insulin action and insulin resistance. Physiol Rev 98(4):2133\u20132223. https:\/\/doi.org\/10.1152\/physrev.00063.2017","journal-title":"Physiol Rev"},{"issue":"Suppl 2","key":"5177_CR9","doi-asserted-by":"publisher","first-page":"S168","DOI":"10.2337\/dc09-S304","volume":"32","author":"P Iozzo","year":"2009","unstructured":"Iozzo P (2009) Viewpoints on the way to the consensus session: where does insulin resistance start? The adipose tissue. Diabetes Care 32(Suppl 2):S168\u2013S173. https:\/\/doi.org\/10.2337\/dc09-S304","journal-title":"Diabetes Care"},{"issue":"3","key":"5177_CR10","doi-asserted-by":"publisher","first-page":"R173","DOI":"10.1530\/JOE-16-0449","volume":"232","author":"NM Templeman","year":"2017","unstructured":"Templeman NM, Skovso S, Page MM, Lim GE, Johnson JD (2017) A causal role for hyperinsulinemia in obesity. J Endocrinol 232(3):R173\u2013R183. https:\/\/doi.org\/10.1530\/JOE-16-0449","journal-title":"J Endocrinol"},{"issue":"4","key":"5177_CR11","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1152\/japplphysiol.00478.2011","volume":"111","author":"JP Thyfault","year":"2011","unstructured":"Thyfault JP, Krogh-Madsen R (2011) Metabolic disruptions induced by reduced ambulatory activity in free-living humans. J Appl Physiol 111(4):1218\u20131224. https:\/\/doi.org\/10.1152\/japplphysiol.00478.2011","journal-title":"J Appl Physiol"},{"issue":"4","key":"5177_CR12","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1152\/japplphysiol.00698.2011","volume":"111","author":"A Bergouignan","year":"2011","unstructured":"Bergouignan A, Rudwill F, Simon C, Blanc S (2011) Physical inactivity as the culprit of metabolic inflexibility: evidence from bed-rest studies. J Appl Physiol 111(4):1201\u20131210. https:\/\/doi.org\/10.1152\/japplphysiol.00698.2011","journal-title":"J Appl Physiol"},{"issue":"1","key":"5177_CR13","doi-asserted-by":"publisher","first-page":"158","DOI":"10.2337\/diabetes.54.1.158","volume":"54","author":"DE Laaksonen","year":"2005","unstructured":"Laaksonen DE, Lindstrom J, Lakka TA et al (2005) Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study. Diabetes 54(1):158\u2013165. https:\/\/doi.org\/10.2337\/diabetes.54.1.158","journal-title":"Diabetes"},{"issue":"8","key":"5177_CR14","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.2337\/dc11-2321","volume":"35","author":"AM Fretts","year":"2012","unstructured":"Fretts AM, Howard BV, McKnight B et al (2012) Modest levels of physical activity are associated with a lower incidence of diabetes in a population with a high rate of obesity: the strong heart family study. Diabetes Care 35(8):1743\u20131745. https:\/\/doi.org\/10.2337\/dc11-2321","journal-title":"Diabetes Care"},{"key":"5177_CR15","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3389\/fendo.2012.00142","volume":"3","author":"C Tudor-Locke","year":"2012","unstructured":"Tudor-Locke C, Schuna JM Jr (2012) Steps to preventing type 2 diabetes: exercise, walk more, or sit less? Front Endocrinol (Lausanne) 3:142. https:\/\/doi.org\/10.3389\/fendo.2012.00142","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"11","key":"5177_CR16","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.2337\/dc07-1189","volume":"30","author":"PT Williams","year":"2007","unstructured":"Williams PT (2007) Changes in vigorous physical activity and incident diabetes in male runners. Diabetes Care 30(11):2838\u20132842. https:\/\/doi.org\/10.2337\/dc07-1189","journal-title":"Diabetes Care"},{"issue":"10","key":"5177_CR17","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/j.amjmed.2019.04.035","volume":"132","author":"Y Wang","year":"2019","unstructured":"Wang Y, Lee DC, Brellenthin AG et al (2019) Leisure-time running reduces the risk of incident type 2 diabetes. Am J Med 132(10):1225\u20131232. https:\/\/doi.org\/10.1016\/j.amjmed.2019.04.035","journal-title":"Am J Med"},{"issue":"2","key":"5177_CR18","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2337\/dc08-1377","volume":"32","author":"DC Lee","year":"2009","unstructured":"Lee DC, Sui X, Church TS, Lee IM, Blair SN (2009) Associations of cardiorespiratory fitness and obesity with risks of impaired fasting glucose and type 2 diabetes in men. Diabetes Care 32(2):257\u2013262. https:\/\/doi.org\/10.2337\/dc08-1377","journal-title":"Diabetes Care"},{"issue":"4","key":"5177_CR19","doi-asserted-by":"publisher","first-page":"517","DOI":"10.2337\/dbi18-0043","volume":"69","author":"JP Thyfault","year":"2020","unstructured":"Thyfault JP, Rector RS (2020) Exercise combats hepatic steatosis: potential mechanisms and clinical implications. Diabetes 69(4):517\u2013524. https:\/\/doi.org\/10.2337\/dbi18-0043","journal-title":"Diabetes"},{"issue":"7","key":"5177_CR20","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1053\/j.gastro.2006.03.019","volume":"130","author":"TS Church","year":"2006","unstructured":"Church TS, Kuk JL, Ross R, Priest EL, Biltoft E, Blair SN (2006) Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease. Gastroenterology 130(7):2023\u20132030. https:\/\/doi.org\/10.1053\/j.gastro.2006.03.019","journal-title":"Gastroenterology"},{"issue":"9","key":"5177_CR21","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1249\/MSS.0000000000001288","volume":"49","author":"KS Palve","year":"2017","unstructured":"Palve KS, Pahkala K, Suomela E et al (2017) Cardiorespiratory fitness and risk of fatty liver: the Young Finns Study. Med Sci Sports Exerc 49(9):1834\u20131841. https:\/\/doi.org\/10.1249\/MSS.0000000000001288","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"5177_CR22","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1152\/physrev.00019.2016","volume":"97","author":"FW Booth","year":"2017","unstructured":"Booth FW, Roberts CK, Thyfault JP, Ruegsegger GN, Toedebusch RG (2017) Role of inactivity in chronic diseases: evolutionary insight and pathophysiological mechanisms. Physiol Rev 97(4):1351\u20131402. https:\/\/doi.org\/10.1152\/physrev.00019.2016","journal-title":"Physiol Rev"},{"issue":"11","key":"5177_CR23","doi-asserted-by":"publisher","first-page":"4885","DOI":"10.1021\/acs.jproteome.5b00720","volume":"14","author":"AS Deshmukh","year":"2015","unstructured":"Deshmukh AS, Cox J, Jensen LJ, Meissner F, Mann M (2015) Secretome analysis of lipid-induced insulin resistance in skeletal muscle cells by a combined experimental and bioinformatics workflow. J Proteome Res 14(11):4885\u20134895. https:\/\/doi.org\/10.1021\/acs.jproteome.5b00720","journal-title":"J Proteome Res"},{"issue":"6","key":"5177_CR24","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.cmet.2015.09.023","volume":"22","author":"RC Meex","year":"2015","unstructured":"Meex RC, Hoy AJ, Morris A et al (2015) Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism. Cell Metab 22(6):1078\u20131089. https:\/\/doi.org\/10.1016\/j.cmet.2015.09.023","journal-title":"Cell Metab"},{"issue":"1","key":"5177_CR25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.cmet.2009.06.001","volume":"10","author":"S Crowe","year":"2009","unstructured":"Crowe S, Wu LE, Economou C et al (2009) Pigment epithelium-derived factor contributes to insulin resistance in obesity. Cell Metab 10(1):40\u201347. https:\/\/doi.org\/10.1016\/j.cmet.2009.06.001","journal-title":"Cell Metab"},{"key":"5177_CR26","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fphys.2020.00091","volume":"11","author":"C Laurens","year":"2020","unstructured":"Laurens C, Bergouignan A, Moro C (2020) Exercise-released myokines in the control of energy metabolism. Front Physiol 11:91. https:\/\/doi.org\/10.3389\/fphys.2020.00091","journal-title":"Front Physiol"},{"issue":"2","key":"5177_CR27","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.cmet.2012.12.012","volume":"17","author":"B Egan","year":"2013","unstructured":"Egan B, Zierath JR (2013) Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab 17(2):162\u2013184. https:\/\/doi.org\/10.1016\/j.cmet.2012.12.012","journal-title":"Cell Metab"},{"issue":"1","key":"5177_CR28","doi-asserted-by":"publisher","first-page":"32044","DOI":"10.1038\/srep32044","volume":"6","author":"A Bergouignan","year":"2016","unstructured":"Bergouignan A, Latouche C, Heywood S et al (2016) Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: ancillary analysis from randomized clinical trials. Sci Rep 6(1):32044. https:\/\/doi.org\/10.1038\/srep32044","journal-title":"Sci Rep"},{"issue":"4","key":"5177_CR29","doi-asserted-by":"publisher","first-page":"R1103","DOI":"10.1152\/ajpregu.00542.2007","volume":"294","author":"JP Thyfault","year":"2008","unstructured":"Thyfault JP (2008) Setting the stage: possible mechanisms by which acute contraction restores insulin sensitivity in muscle. Am J Physiol Regul Integr Comp Physiol 294(4):R1103\u2013R1110. https:\/\/doi.org\/10.1152\/ajpregu.00542.2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"5177_CR30","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1152\/japplphysiol.00993.2010","volume":"110","author":"Z Yan","year":"2011","unstructured":"Yan Z, Okutsu M, Akhtar YN, Lira VA (2011) Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol (1985) 110(1):264\u2013274. https:\/\/doi.org\/10.1152\/japplphysiol.00993.2010","journal-title":"J Appl Physiol (1985)"},{"key":"5177_CR31","doi-asserted-by":"publisher","first-page":"3165396","DOI":"10.1155\/2017\/3165396","volume":"2017","author":"Y Kim","year":"2017","unstructured":"Kim Y, Triolo M, Hood DA (2017) Impact of aging and exercise on mitochondrial quality control in skeletal muscle. Oxidative Med Cell Longev 2017:3165396\u20133165316. https:\/\/doi.org\/10.1155\/2017\/3165396","journal-title":"Oxidative Med Cell Longev"},{"issue":"11","key":"5177_CR32","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1080\/15548627.2018.1491488","volume":"14","author":"A Parousis","year":"2018","unstructured":"Parousis A, Carter HN, Tran C et al (2018) Contractile activity attenuates autophagy suppression and reverses mitochondrial defects in skeletal muscle cells. Autophagy 14(11):1886\u20131897. https:\/\/doi.org\/10.1080\/15548627.2018.1491488","journal-title":"Autophagy"},{"issue":"12","key":"5177_CR33","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1038\/ijo.2017.151","volume":"41","author":"E Lefai","year":"2017","unstructured":"Lefai E, Blanc S, Momken I et al (2017) Exercise training improves fat metabolism independent of total energy expenditure in sedentary overweight men, but does not restore lean metabolic phenotype. Int J Obes 41(12):1728\u20131736. https:\/\/doi.org\/10.1038\/ijo.2017.151","journal-title":"Int J Obes"},{"issue":"12","key":"5177_CR34","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.tem.2013.08.001","volume":"24","author":"PM Badin","year":"2013","unstructured":"Badin PM, Langin D, Moro C (2013) Dynamics of skeletal muscle lipid pools. Trends Endocrinol Metab 24(12):607\u2013615. https:\/\/doi.org\/10.1016\/j.tem.2013.08.001","journal-title":"Trends Endocrinol Metab"},{"issue":"8","key":"5177_CR35","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrendo.2012.49","volume":"8","author":"BK Pedersen","year":"2012","unstructured":"Pedersen BK, Febbraio MA (2012) Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 8(8):457\u2013465. https:\/\/doi.org\/10.1038\/nrendo.2012.49","journal-title":"Nat Rev Endocrinol"},{"key":"5177_CR36","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3389\/fphys.2019.00042","volume":"10","author":"JH Lee","year":"2019","unstructured":"Lee JH, Jun HS (2019) Role of myokines in regulating skeletal muscle mass and function. Front Physiol 10:42. https:\/\/doi.org\/10.3389\/fphys.2019.00042","journal-title":"Front Physiol"},{"key":"5177_CR37","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3389\/fphys.2019.00287","volume":"10","author":"R Piccirillo","year":"2019","unstructured":"Piccirillo R (2019) Exercise-induced myokines with therapeutic potential for muscle wasting. Front Physiol 10:287. https:\/\/doi.org\/10.3389\/fphys.2019.00287","journal-title":"Front Physiol"},{"issue":"2\u20133","key":"5177_CR38","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1023\/A:1026070911202","volume":"24","author":"BK Pedersen","year":"2003","unstructured":"Pedersen BK, Steensberg A, Fischer C et al (2003) Searching for the exercise factor: is IL-6 a candidate? J Muscle Res Cell Motil 24(2\u20133):113\u2013119. https:\/\/doi.org\/10.1023\/A:1026070911202","journal-title":"J Muscle Res Cell Motil"},{"key":"5177_CR39","first-page":"6","volume":"8","author":"K Suzuki","year":"2002","unstructured":"Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, Sugawara K (2002) Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exerc Immunol Rev 8:6\u201348","journal-title":"Exerc Immunol Rev"},{"issue":"14","key":"5177_CR40","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1096\/fj.01-0507fje","volume":"15","author":"C Keller","year":"2001","unstructured":"Keller C, Steensberg A, Pilegaard H et al (2001) Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content. FASEB J 15(14):2748\u20132750. https:\/\/doi.org\/10.1096\/fj.01-0507fje","journal-title":"FASEB J"},{"issue":"Pt 2","key":"5177_CR41","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1113\/jphysiol.2003.042374","volume":"549","author":"MA Febbraio","year":"2003","unstructured":"Febbraio MA, Steensberg A, Keller C et al (2003) Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans. J Physiol 549(Pt 2):607\u2013612. https:\/\/doi.org\/10.1113\/jphysiol.2003.042374","journal-title":"J Physiol"},{"issue":"5","key":"5177_CR42","doi-asserted-by":"publisher","first-page":"E832","DOI":"10.1152\/ajpendo.00328.2010","volume":"299","author":"E Wolsk","year":"2010","unstructured":"Wolsk E, Mygind H, Grondahl TS, Pedersen BK, van Hall G (2010) IL-6 selectively stimulates fat metabolism in human skeletal muscle. Am J Physiol Endocrinol Metab 299(5):E832\u2013E840. https:\/\/doi.org\/10.1152\/ajpendo.00328.2010","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"10","key":"5177_CR43","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.2337\/db05-1404","volume":"55","author":"AL Carey","year":"2006","unstructured":"Carey AL, Steinberg GR, Macaulay SL et al (2006) Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 55(10):2688\u20132697. https:\/\/doi.org\/10.2337\/db05-1404","journal-title":"Diabetes"},{"issue":"1","key":"5177_CR44","doi-asserted-by":"publisher","first-page":"E11","DOI":"10.1152\/ajpendo.90563.2008","volume":"296","author":"DH Wasserman","year":"2009","unstructured":"Wasserman DH (2009) Four grams of glucose. Am J Physiol Endocrinol Metab 296(1):E11\u2013E21. https:\/\/doi.org\/10.1152\/ajpendo.90563.2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"5177_CR45","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/bs.pmbts.2015.07.010","volume":"135","author":"E Trefts","year":"2015","unstructured":"Trefts E, Williams AS, Wasserman DH (2015) Exercise and the regulation of hepatic metabolism. Prog Mol Biol Transl Sci 135:203\u2013225. https:\/\/doi.org\/10.1016\/bs.pmbts.2015.07.010","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"4","key":"5177_CR46","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1210\/clinem\/dgz266","volume":"105","author":"C Hu","year":"2019","unstructured":"Hu C, Hoene M, Plomgaard P et al (2019) Muscle-liver substrate fluxes in exercising humans and potential effects on hepatic metabolism. J Clin Endocrinol Metab 105(4):1196\u20131209. https:\/\/doi.org\/10.1210\/clinem\/dgz266","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"5177_CR47","doi-asserted-by":"publisher","first-page":"G619","DOI":"10.1152\/ajpgi.00428.2007","volume":"294","author":"RS Rector","year":"2008","unstructured":"Rector RS, Thyfault JP, Morris RT et al (2008) Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats. Am J Physiol Gastrointest Liver Physiol 294(3):G619\u2013G626. https:\/\/doi.org\/10.1152\/ajpgi.00428.2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"5177_CR48","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1249\/MSS.0000000000000430","volume":"47","author":"MA Linden","year":"2015","unstructured":"Linden MA, Fletcher JA, Morris EM et al (2015) Treating NAFLD in OLETF rats with vigorous-intensity interval exercise training. Med Sci Sports Exerc 47(3):556\u2013567. https:\/\/doi.org\/10.1249\/MSS.0000000000000430","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"5177_CR49","doi-asserted-by":"publisher","first-page":"G874","DOI":"10.1152\/ajpgi.00510.2010","volume":"300","author":"RS Rector","year":"2011","unstructured":"Rector RS, Uptergrove GM, Morris EM et al (2011) Daily exercise vs. caloric restriction for prevention of nonalcoholic fatty liver disease in the OLETF rat model. Am J Physiol Gastrointest Liver Physiol 300(5):G874\u2013G883. https:\/\/doi.org\/10.1152\/ajpgi.00510.2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"2","key":"5177_CR50","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","volume":"25","author":"P Puchalska","year":"2017","unstructured":"Puchalska P, Crawford PA (2017) Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics. Cell Metab 25(2):262\u2013284. https:\/\/doi.org\/10.1016\/j.cmet.2016.12.022","journal-title":"Cell Metab"},{"issue":"4","key":"5177_CR51","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1097\/MCO.0000000000000283","volume":"19","author":"K Karstoft","year":"2016","unstructured":"Karstoft K, Pedersen BK (2016) Skeletal muscle as a gene regulatory endocrine organ. Curr Opin Clin Nutr Metab Care 19(4):270\u2013275. https:\/\/doi.org\/10.1097\/MCO.0000000000000283","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"15","key":"5177_CR52","doi-asserted-by":"publisher","first-page":"11968","DOI":"10.1074\/jbc.M111.336834","volume":"287","author":"MM Seldin","year":"2012","unstructured":"Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW (2012) Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem 287(15):11968\u201311980. https:\/\/doi.org\/10.1074\/jbc.M111.336834","journal-title":"J Biol Chem"},{"issue":"10","key":"5177_CR53","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.molmet.2017.06.018","volume":"6","author":"B Ingerslev","year":"2017","unstructured":"Ingerslev B, Hansen JS, Hoffmann C et al (2017) Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP. Mol Metab 6(10):1286\u20131295. https:\/\/doi.org\/10.1016\/j.molmet.2017.06.018","journal-title":"Mol Metab"},{"issue":"8","key":"5177_CR54","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/S1043-2760(03)00143-7","volume":"14","author":"JF Horowitz","year":"2003","unstructured":"Horowitz JF (2003) Fatty acid mobilization from adipose tissue during exercise. Trends Endocrinol Metab 14(8):386\u2013392. https:\/\/doi.org\/10.1016\/S1043-2760(03)00143-7","journal-title":"Trends Endocrinol Metab"},{"issue":"Suppl 4","key":"5177_CR55","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1038\/sj.ijo.0801505","volume":"24","author":"M Lafontan","year":"2000","unstructured":"Lafontan M, Sengenes C, Galitzky J et al (2000) Recent developments on lipolysis regulation in humans and discovery of a new lipolytic pathway. Int J Obes Relat Metab Disord 24(Suppl 4):S47\u2013S52. https:\/\/doi.org\/10.1038\/sj.ijo.0801505","journal-title":"Int J Obes Relat Metab Disord"},{"issue":"2","key":"5177_CR56","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/21623945.2016.1191307","volume":"5","author":"KI Stanford","year":"2016","unstructured":"Stanford KI, Goodyear LJ (2016) Exercise regulation of adipose tissue. Adipocyte 5(2):153\u2013162. https:\/\/doi.org\/10.1080\/21623945.2016.1191307","journal-title":"Adipocyte"},{"issue":"9","key":"5177_CR57","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1038\/oby.2007.267","volume":"15","author":"C Moro","year":"2007","unstructured":"Moro C, Pillard F, de Glisezinski I et al (2007) Sex differences in lipolysis-regulating mechanisms in overweight subjects: effect of exercise intensity. Obesity (Silver Spring) 15(9):2245\u20132255. https:\/\/doi.org\/10.1038\/oby.2007.267","journal-title":"Obesity (Silver Spring)"},{"issue":"3","key":"5177_CR58","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1210\/jc.2003-031001","volume":"89","author":"B Richterova","year":"2004","unstructured":"Richterova B, Stich V, Moro C et al (2004) Effect of endurance training on adrenergic control of lipolysis in adipose tissue of obese women. J Clin Endocrinol Metab 89(3):1325\u20131331. https:\/\/doi.org\/10.1210\/jc.2003-031001","journal-title":"J Clin Endocrinol Metab"},{"issue":"Pt 7","key":"5177_CR59","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1113\/jphysiol.2008.165464","volume":"587","author":"LN Sutherland","year":"2009","unstructured":"Sutherland LN, Bomhof MR, Capozzi LC, Basaraba SA, Wright DC (2009) Exercise and adrenaline increase PGC-1\u03b1 mRNA expression in rat adipose tissue. J Physiol 587(Pt 7):1607\u20131617. https:\/\/doi.org\/10.1113\/jphysiol.2008.165464","journal-title":"J Physiol"},{"issue":"8","key":"5177_CR60","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.2337\/db13-1234","volume":"63","author":"E Trevellin","year":"2014","unstructured":"Trevellin E, Scorzeto M, Olivieri M et al (2014) Exercise training induces mitochondrial biogenesis and glucose uptake in subcutaneous adipose tissue through eNOS-dependent mechanisms. Diabetes 63(8):2800\u20132811. https:\/\/doi.org\/10.2337\/db13-1234","journal-title":"Diabetes"},{"issue":"2","key":"5177_CR61","doi-asserted-by":"publisher","first-page":"E505","DOI":"10.1152\/ajpendo.90227.2008","volume":"295","author":"C Moro","year":"2008","unstructured":"Moro C, Pillard F, de Glisezinski I et al (2008) Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men. Am J Physiol Endocrinol Metab 295(2):E505\u2013E513. https:\/\/doi.org\/10.1152\/ajpendo.90227.2008","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"5177_CR62","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/oby.2004.31","volume":"12","author":"L Perreault","year":"2004","unstructured":"Perreault L, Lavely JM, Kittelson JM, Horton TJ (2004) Gender differences in lipoprotein lipase activity after acute exercise. Obes Res 12(2):241\u2013249. https:\/\/doi.org\/10.1038\/oby.2004.31","journal-title":"Obes Res"},{"issue":"3","key":"5177_CR63","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1152\/jappl.1984.57.3.698","volume":"57","author":"H Lithell","year":"1984","unstructured":"Lithell H, Schele R, Vessby B, Jacobs I (1984) Lipoproteins, lipoprotein lipase, and glycogen after prolonged physical activity. J Appl Physiol Respir Environ Exerc Physiol 57(3):698\u2013702. https:\/\/doi.org\/10.1152\/jappl.1984.57.3.698","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"issue":"5","key":"5177_CR64","doi-asserted-by":"publisher","first-page":"E1020","DOI":"10.1152\/ajpendo.2000.279.5.E1020","volume":"279","author":"D Malkova","year":"2000","unstructured":"Malkova D, Evans RD, Frayn KN, Humphreys SM, Jones PR, Hardman AE (2000) Prior exercise and postprandial substrate extraction across the human leg. Am J Physiol Endocrinol Metab 279(5):E1020\u2013E1028. https:\/\/doi.org\/10.1152\/ajpendo.2000.279.5.E1020","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"5177_CR65","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1093\/ajcn\/70.3.346","volume":"70","author":"JH Wilmore","year":"1999","unstructured":"Wilmore JH, Despres JP, Stanforth PR et al (1999) Alterations in body weight and composition consequent to 20 wk of endurance training: the HERITAGE Family Study. Am J Clin Nutr 70(3):346\u2013352. https:\/\/doi.org\/10.1093\/ajcn\/70.3.346","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"5177_CR66","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/j.1365-2362.1987.tb02395.x","volume":"17","author":"P Mauriege","year":"1987","unstructured":"Mauriege P, Galitzky J, Berlan M, Lafontan M (1987) Heterogeneous distribution of beta and alpha-2 adrenoceptor binding sites in human fat cells from various fat deposits: functional consequences. Eur J Clin Investig 17(2):156\u2013165. https:\/\/doi.org\/10.1111\/j.1365-2362.1987.tb02395.x","journal-title":"Eur J Clin Investig"},{"issue":"12","key":"5177_CR67","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1038\/sj.ijo.0803683","volume":"31","author":"K Ohkawara","year":"2007","unstructured":"Ohkawara K, Tanaka S, Miyachi M, Ishikawa-Takata K, Tabata I (2007) A dose-response relation between aerobic exercise and visceral fat reduction: systematic review of clinical trials. Int J Obes 31(12):1786\u20131797. https:\/\/doi.org\/10.1038\/sj.ijo.0803683","journal-title":"Int J Obes"},{"issue":"5","key":"5177_CR68","doi-asserted-by":"publisher","first-page":"E1164","DOI":"10.1152\/ajpendo.00054.2009","volume":"296","author":"VJ Vieira","year":"2009","unstructured":"Vieira VJ, Valentine RJ, Wilund KR, Antao N, Baynard T, Woods JA (2009) Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice. Am J Physiol Endocrinol Metab 296(5):E1164\u2013E1171. https:\/\/doi.org\/10.1152\/ajpendo.00054.2009","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"6","key":"5177_CR69","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/oby.2010.310","volume":"19","author":"G Fisher","year":"2011","unstructured":"Fisher G, Hyatt TC, Hunter GR, Oster RA, Desmond RA, Gower BA (2011) Effect of diet with and without exercise training on markers of inflammation and fat distribution in overweight women. Obesity (Silver Spring) 19(6):1131\u20131136. https:\/\/doi.org\/10.1038\/oby.2010.310","journal-title":"Obesity (Silver Spring)"},{"issue":"4","key":"5177_CR70","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.cmet.2018.12.007","volume":"29","author":"AS Wedell-Neergaard","year":"2019","unstructured":"Wedell-Neergaard AS, Lang Lehrskov L, Christensen RH et al (2019) Exercise-induced changes in visceral adipose tissue mass are regulated by il-6 signaling: a randomized controlled trial. Cell Metab 29(4):844\u2013855 e843. https:\/\/doi.org\/10.1016\/j.cmet.2018.12.007","journal-title":"Cell Metab"},{"key":"5177_CR71","doi-asserted-by":"publisher","unstructured":"Laurens C, Parmar A, Murphy E et al (2020) Growth and differentiation factor 15 is secreted by skeletal muscle during exercise and promotes lipolysis in humans. JCI Insight 5(6). https:\/\/doi.org\/10.1172\/jci.insight.131870","DOI":"10.1172\/jci.insight.131870"},{"issue":"2","key":"5177_CR72","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s42255-018-0030-7","volume":"1","author":"H Takahashi","year":"2019","unstructured":"Takahashi H, Alves CRR, Stanford KI et al (2019) TGF-beta2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism. Nat Metab 1(2):291\u2013303. https:\/\/doi.org\/10.1038\/s42255-018-0030-7","journal-title":"Nat Metab"},{"issue":"4","key":"5177_CR73","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1113\/EP088220","volume":"105","author":"M Curran","year":"2020","unstructured":"Curran M, Drayson MT, Andrews RC et al (2020) The benefits of physical exercise for the health of the pancreatic beta-cell: a review of the evidence. Exp Physiol 105(4):579\u2013589. https:\/\/doi.org\/10.1113\/EP088220","journal-title":"Exp Physiol"},{"issue":"2","key":"5177_CR74","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1152\/jappl.1983.55.2.512","volume":"55","author":"GW Heath","year":"1983","unstructured":"Heath GW, Gavin JR 3rd, Hinderliter JM, Hagberg JM, Bloomfield SA, Holloszy JO (1983) Effects of exercise and lack of exercise on glucose tolerance and insulin sensitivity. J Appl Physiol 55(2):512\u2013517. https:\/\/doi.org\/10.1152\/jappl.1983.55.2.512","journal-title":"J Appl Physiol"},{"issue":"11","key":"5177_CR75","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.2337\/diab.42.11.1663","volume":"42","author":"SE Kahn","year":"1993","unstructured":"Kahn SE, Prigeon RL, McCulloch DK et al (1993) Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 42(11):1663\u20131672. https:\/\/doi.org\/10.2337\/diab.42.11.1663","journal-title":"Diabetes"},{"issue":"6","key":"5177_CR76","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1172\/JCI110398","volume":"68","author":"RN Bergman","year":"1981","unstructured":"Bergman RN, Phillips LS, Cobelli C (1981) Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 68(6):1456\u20131467. https:\/\/doi.org\/10.1172\/JCI110398","journal-title":"J Clin Invest"},{"issue":"7","key":"5177_CR77","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.2337\/dc09-2021","volume":"33","author":"TP Solomon","year":"2010","unstructured":"Solomon TP, Haus JM, Kelly KR, Rocco M, Kashyap SR, Kirwan JP (2010) Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide. Diabetes Care 33(7):1561\u20131566. https:\/\/doi.org\/10.2337\/dc09-2021","journal-title":"Diabetes Care"},{"issue":"10","key":"5177_CR78","doi-asserted-by":"publisher","first-page":"4176","DOI":"10.1210\/jc.2013-2232","volume":"98","author":"TP Solomon","year":"2013","unstructured":"Solomon TP, Malin SK, Karstoft K, Kashyap SR, Haus JM, Kirwan JP (2013) Pancreatic beta-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity. J Clin Endocrinol Metab 98(10):4176\u20134186. https:\/\/doi.org\/10.1210\/jc.2013-2232","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"5177_CR79","doi-asserted-by":"publisher","first-page":"E1289","DOI":"10.1210\/jc.2014-4506","volume":"100","author":"CS Christensen","year":"2015","unstructured":"Christensen CS, Christensen DP, Lundh M et al (2015) Skeletal muscle to pancreatic beta-cell cross-talk: the effect of humoral mediators liberated by muscle contraction and acute exercise on beta-cell apoptosis. J Clin Endocrinol Metab 100(10):E1289\u2013E1298. https:\/\/doi.org\/10.1210\/jc.2014-4506","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"5177_CR80","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.2337\/db17-0002","volume":"66","author":"A Natalicchio","year":"2017","unstructured":"Natalicchio A, Marrano N, Biondi G et al (2017) The myokine irisin is released in response to saturated fatty acids and promotes pancreatic beta-cell survival and insulin secretion. Diabetes 66(11):2849\u20132856. https:\/\/doi.org\/10.2337\/db17-0002","journal-title":"Diabetes"},{"issue":"8","key":"5177_CR81","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1113\/jphysiol.2014.284513","volume":"594","author":"AJ Wagenmakers","year":"2016","unstructured":"Wagenmakers AJ, Strauss JA, Shepherd SO, Keske MA, Cocks M (2016) Increased muscle blood supply and transendothelial nutrient and insulin transport induced by food intake and exercise: effect of obesity and ageing. J Physiol 594(8):2207\u20132222. https:\/\/doi.org\/10.1113\/jphysiol.2014.284513","journal-title":"J Physiol"},{"key":"5177_CR82","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/bs.pmbts.2015.07.017","volume":"135","author":"TD Olver","year":"2015","unstructured":"Olver TD, Ferguson BS, Laughlin MH (2015) Molecular mechanisms for exercise training-induced changes in vascular structure and function: skeletal muscle, cardiac muscle, and the brain. Prog Mol Biol Transl Sci 135:227\u2013257. https:\/\/doi.org\/10.1016\/bs.pmbts.2015.07.017","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"10","key":"5177_CR83","doi-asserted-by":"publisher","first-page":"4556","DOI":"10.1210\/jc.2003-031431","volume":"88","author":"RN Bergman","year":"2003","unstructured":"Bergman RN (2003) Insulin action and distribution of tissue blood flow. J Clin Endocrinol Metab 88(10):4556\u20134558. https:\/\/doi.org\/10.1210\/jc.2003-031431","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"5177_CR84","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/S0008-6363(02)00593-X","volume":"56","author":"EC Eringa","year":"2002","unstructured":"Eringa EC, Stehouwer CD, Merlijn T, Westerhof N, Sipkema P (2002) Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles. Cardiovasc Res 56(3):464\u2013471. https:\/\/doi.org\/10.1016\/S0008-6363(02)00593-X","journal-title":"Cardiovasc Res"},{"issue":"1","key":"5177_CR85","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1152\/japplphysiol.00286.2016","volume":"122","author":"LJ Reynolds","year":"2017","unstructured":"Reynolds LJ, Credeur DP, Manrique C, Padilla J, Fadel PJ, Thyfault JP (2017) Obesity, type 2 diabetes, and impaired insulin-stimulated blood flow: role of skeletal muscle NO synthase and endothelin-1. J Appl Physiol (1985) 122(1):38\u201347. https:\/\/doi.org\/10.1152\/japplphysiol.00286.2016","journal-title":"J Appl Physiol (1985)"},{"issue":"5","key":"5177_CR86","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1210\/jc.2010-2069","volume":"96","author":"TP Solomon","year":"2011","unstructured":"Solomon TP, Haus JM, Li Y, Kirwan JP (2011) Progressive hyperglycemia across the glucose tolerance continuum in older obese adults is related to skeletal muscle capillarization and nitric oxide bioavailability. J Clin Endocrinol Metab 96(5):1377\u20131384. https:\/\/doi.org\/10.1210\/jc.2010-2069","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"5177_CR87","doi-asserted-by":"publisher","first-page":"R307","DOI":"10.1152\/ajpregu.00114.2005","volume":"289","author":"JC Frisbee","year":"2005","unstructured":"Frisbee JC (2005) Reduced nitric oxide bioavailability contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome. Am J Physiol Regul Integr Comp Physiol 289(2):R307\u2013R316. https:\/\/doi.org\/10.1152\/ajpregu.00114.2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"7","key":"5177_CR88","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1113\/EP085107","volume":"100","author":"J Padilla","year":"2015","unstructured":"Padilla J, Olver TD, Thyfault JP, Fadel PJ (2015) Role of habitual physical activity in modulating vascular actions of insulin. Exp Physiol 100(7):759\u2013771. https:\/\/doi.org\/10.1113\/EP085107","journal-title":"Exp Physiol"},{"issue":"6","key":"5177_CR89","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.2337\/db16-1327","volume":"66","author":"KA Sjoberg","year":"2017","unstructured":"Sjoberg KA, Frosig C, Kjobsted R et al (2017) Exercise increases human skeletal muscle insulin sensitivity via coordinated increases in microvascular perfusion and molecular signaling. Diabetes 66(6):1501\u20131510. https:\/\/doi.org\/10.2337\/db16-1327","journal-title":"Diabetes"},{"issue":"2","key":"5177_CR90","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1113\/JP278600","volume":"598","author":"GK McConell","year":"2020","unstructured":"McConell GK, Sjoberg KA, Ceutz F et al (2020) Insulin-induced membrane permeability to glucose in human muscles at rest and following exercise. J Physiol 598(2):303\u2013315. https:\/\/doi.org\/10.1113\/JP278600","journal-title":"J Physiol"},{"key":"5177_CR91","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3389\/fphar.2017.00517","volume":"8","author":"RM Rapoport","year":"2017","unstructured":"Rapoport RM, Merkus D (2017) Endothelin-1 regulation of exercise-induced changes in flow: dynamic regulation of vascular tone. Front Pharmacol 8:517. https:\/\/doi.org\/10.3389\/fphar.2017.00517","journal-title":"Front Pharmacol"},{"issue":"7290","key":"5177_CR92","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nature08945","volume":"464","author":"CE Hagberg","year":"2010","unstructured":"Hagberg CE, Falkevall A, Wang X et al (2010) Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature 464(7290):917\u2013921. https:\/\/doi.org\/10.1038\/nature08945","journal-title":"Nature"},{"issue":"8","key":"5177_CR93","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1152\/japplphysiol.00823.2012","volume":"113","author":"JS Martin","year":"2012","unstructured":"Martin JS, Padilla J, Jenkins NT et al (2012) Functional adaptations in the skeletal muscle microvasculature to endurance and interval sprint training in the type 2 diabetic OLETF rat. J Appl Physiol (1985) 113(8):1223\u20131232. https:\/\/doi.org\/10.1152\/japplphysiol.00823.2012","journal-title":"J Appl Physiol (1985)"},{"issue":"4","key":"5177_CR94","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1152\/japplphysiol.00064.2010","volume":"109","author":"CR Mikus","year":"2010","unstructured":"Mikus CR, Rector RS, Arce-Esquivel AA et al (2010) Daily physical activity enhances reactivity to insulin in skeletal muscle arterioles of hyperphagic Otsuka Long-Evans Tokushima Fatty rats. J Appl Physiol 109(4):1203\u20131210. https:\/\/doi.org\/10.1152\/japplphysiol.00064.2010","journal-title":"J Appl Physiol"},{"key":"5177_CR95","doi-asserted-by":"publisher","first-page":"101285","DOI":"10.1016\/j.redox.2019.101285","volume":"26","author":"E DeVallance","year":"2019","unstructured":"DeVallance E, Branyan KW, Lemaster KC et al (2019) Exercise training prevents the perivascular adipose tissue-induced aortic dysfunction with metabolic syndrome. Redox Biol 26:101285. https:\/\/doi.org\/10.1016\/j.redox.2019.101285","journal-title":"Redox Biol"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-020-05177-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00125-020-05177-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-020-05177-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T20:04:14Z","timestamp":1623355454000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00125-020-05177-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,11]]},"references-count":95,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["5177"],"URL":"https:\/\/doi.org\/10.1007\/s00125-020-05177-6","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,11]]},"assertion":[{"value":"23 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}