{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:44:59Z","timestamp":1790066699521,"version":"4.0.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Danish Diabetes Academy funded by the Novo Nordisk foundation","award":["NNF17SA0031406"],"award-info":[{"award-number":["NNF17SA0031406"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s00125-020-05323-0","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T13:02:49Z","timestamp":1604667769000},"page":"304-312","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Do variations in insulin sensitivity and insulin secretion in pregnancy predict differences in obstetric and neonatal outcomes?"],"prefix":"10.1007","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-9564","authenticated-orcid":false,"given":"Lene R.","family":"Madsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen S.","family":"Gibbons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C. W.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Hung","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Sacks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8819-5794","authenticated-orcid":false,"given":"H. David","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"issue":"Suppl 1","key":"5323_CR1","doi-asserted-by":"publisher","first-page":"S183","DOI":"10.2337\/dc20-S014","volume":"43","author":"American Diabetes Association","year":"2020","unstructured":"American Diabetes Association (2020) 14. Management of diabetes in pregnancy: standards of medical care in diabetes 2020. Diabetes Care 43(Suppl 1):S183\u2013s192. https:\/\/doi.org\/10.2337\/dc20-S014","journal-title":"Diabetes Care"},{"issue":"8","key":"5323_CR2","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.4239\/wjd.v6.i8.1065","volume":"6","author":"U Kampmann","year":"2015","unstructured":"Kampmann U, Madsen LR, Skajaa GO, Iversen DS, Moeller N, Ovesen P (2015) Gestational diabetes: a clinical update. World J Diabetes 6(8):1065\u20131072. https:\/\/doi.org\/10.4239\/wjd.v6.i8.1065","journal-title":"World J Diabetes"},{"issue":"1","key":"5323_CR3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41572-019-0098-8","volume":"5","author":"HD McIntyre","year":"2019","unstructured":"McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P (2019) Gestational diabetes mellitus. Nat Rev Dis Primers 5(1):47. https:\/\/doi.org\/10.1038\/s41572-019-0098-8","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"5323_CR4","doi-asserted-by":"publisher","first-page":"676","DOI":"10.2337\/dc09-1848","volume":"33","author":"BE Metzger","year":"2010","unstructured":"Metzger BE, Gabbe SG, Persson B et al (2010) International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 33(3):676\u2013682. https:\/\/doi.org\/10.2337\/dc09-1848","journal-title":"Diabetes Care"},{"issue":"Suppl 1","key":"5323_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ijgo.12926","volume":"147","author":"E Sheiner","year":"2019","unstructured":"Sheiner E, Kapur A, Retnakaran R et al (2019) FIGO (International Federation of Gynecology and Obstetrics) Postpregnancy Initiative: long-term maternal implications of pregnancy complications-follow-up considerations. Int J Gynaecol Obstet 147(Suppl 1):1\u201331. https:\/\/doi.org\/10.1002\/ijgo.12926","journal-title":"Int J Gynaecol Obstet"},{"issue":"6","key":"5323_CR6","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.2337\/dc15-2672","volume":"39","author":"CE Powe","year":"2016","unstructured":"Powe CE, Allard C, Battista MC et al (2016) Heterogeneous contribution of insulin sensitivity and secretion defects to gestational diabetes mellitus. Diabetes Care 39(6):1052\u20131055. https:\/\/doi.org\/10.2337\/dc15-2672","journal-title":"Diabetes Care"},{"issue":"11","key":"5323_CR7","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1007\/s00125-019-4961-7","volume":"62","author":"K Benhalima","year":"2019","unstructured":"Benhalima K, Van Crombrugge P, Moyson C et al (2019) Characteristics and pregnancy outcomes across gestational diabetes mellitus subtypes based on insulin resistance. Diabetologia 62(11):2118\u20132128. https:\/\/doi.org\/10.1007\/s00125-019-4961-7","journal-title":"Diabetologia"},{"key":"5323_CR8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1472-6823-13-21","volume":"13","author":"A Sokup","year":"2013","unstructured":"Sokup A, Ruszkowska-Ciastek B, Goralczyk K, Walentowicz M, Szymanski M, Rosc D (2013) Insulin resistance as estimated by the homeostatic method at diagnosis of gestational diabetes: estimation of disease severity and therapeutic needs in a population-based study. BMC Endocr Disord 13:21. https:\/\/doi.org\/10.1186\/1472-6823-13-21","journal-title":"BMC Endocr Disord"},{"issue":"19","key":"5323_CR9","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1056\/NEJMoa0707943","volume":"358","author":"BE Metzger","year":"2008","unstructured":"Metzger BE, Lowe LP, Dyer AR et al (2008) Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 358(19):1991\u20132002. https:\/\/doi.org\/10.1056\/NEJMoa0707943","journal-title":"N Engl J Med"},{"issue":"1","key":"5323_CR10","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/s0020-7292(02)00092-9","volume":"78","author":"HAPO Study Cooperative Research Group","year":"2002","unstructured":"HAPO Study Cooperative Research Group (2002) The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. Int J Gynaecol Obstet 78(1):69\u201377. https:\/\/doi.org\/10.1016\/s0020-7292(02)00092-9","journal-title":"Int J Gynaecol Obstet"},{"key":"5323_CR11","doi-asserted-by":"publisher","unstructured":"HAPO Study Cooperative Research Group (2010) Hyperglycaemia and Adverse Pregnancy Outcome (HAPO) Study: associations with maternal body mass index. BJOG 117(5):575\u2013584. https:\/\/doi.org\/10.1111\/j.1471-0528.2009.02486.x","DOI":"10.1111\/j.1471-0528.2009.02486.x"},{"issue":"4","key":"5323_CR12","doi-asserted-by":"publisher","first-page":"780","DOI":"10.2337\/dc11-1790","volume":"35","author":"PM Catalano","year":"2012","unstructured":"Catalano PM, McIntyre HD, Cruickshank JK et al (2012) The hyperglycemia and adverse pregnancy outcome study: associations of GDM and obesity with pregnancy outcomes. Diabetes Care 35(4):780\u2013786. https:\/\/doi.org\/10.2337\/dc11-1790","journal-title":"Diabetes Care"},{"issue":"7","key":"5323_CR13","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1002\/oby.20742","volume":"22","author":"SE Badon","year":"2014","unstructured":"Badon SE, Dyer AR, Josefson JL (2014) Gestational weight gain and neonatal adiposity in the Hyperglycemia and Adverse Pregnancy Outcome study-North American region. Obesity (Silver Spring) 22(7):1731\u20131738. https:\/\/doi.org\/10.1002\/oby.20742","journal-title":"Obesity (Silver Spring)"},{"issue":"4","key":"5323_CR14","doi-asserted-by":"publisher","first-page":"796","DOI":"10.2337\/diacare.24.4.796","volume":"24","author":"M Stumvoll","year":"2001","unstructured":"Stumvoll M, Van Haeften T, Fritsche A, Gerich J (2001) Oral glucose tolerance test indexes for insulin sensitivity and secretion based on various availabilities of sampling times. Diabetes Care 24(4):796\u2013797. https:\/\/doi.org\/10.2337\/diacare.24.4.796","journal-title":"Diabetes Care"},{"issue":"9","key":"5323_CR15","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","volume":"22","author":"M Matsuda","year":"1999","unstructured":"Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22(9):1462\u20131470. https:\/\/doi.org\/10.2337\/diacare.22.9.1462","journal-title":"Diabetes Care"},{"issue":"7\u20138","key":"5323_CR16","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.clinbiochem.2016.12.004","volume":"50","author":"PB Larsen","year":"2017","unstructured":"Larsen PB, Linneberg A, Hansen T, Friis-Hansen L (2017) Reference intervals for C-peptide and insulin derived from a general adult Danish population. Clin Biochem 50(7\u20138):408\u2013413. https:\/\/doi.org\/10.1016\/j.clinbiochem.2016.12.004","journal-title":"Clin Biochem"},{"issue":"3","key":"5323_CR17","doi-asserted-by":"publisher","first-page":"490","DOI":"10.2337\/dc09-1463","volume":"33","author":"T Radaelli","year":"2010","unstructured":"Radaelli T, Farrell KA, Huston-Presley L et al (2010) Estimates of insulin sensitivity using glucose and C-peptide from the hyperglycemia and adverse pregnancy outcome glucose tolerance test. Diabetes Care 33(3):490\u2013494. https:\/\/doi.org\/10.2337\/dc09-1463","journal-title":"Diabetes Care"},{"issue":"3","key":"5323_CR18","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2307\/2531595","volume":"44","author":"ER DeLong","year":"1988","unstructured":"DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44(3):837\u2013845. https:\/\/doi.org\/10.2307\/2531595","journal-title":"Biometrics"},{"issue":"3","key":"5323_CR19","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1210\/jcem.86.3.7339","volume":"86","author":"TA Buchanan","year":"2001","unstructured":"Buchanan TA (2001) Pancreatic B-cell defects in gestational diabetes: implications for the pathogenesis and prevention of type 2 diabetes. J Clin Endocrinol Metab 86(3):989\u2013993. https:\/\/doi.org\/10.1210\/jcem.86.3.7339","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"5323_CR20","doi-asserted-by":"publisher","first-page":"526","DOI":"10.2337\/dc11-1641","volume":"35","author":"DA Sacks","year":"2012","unstructured":"Sacks DA, Hadden DR, Maresh M et al (2012) Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG consensus panel-recommended criteria: the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. Diabetes Care 35(3):526\u2013528. https:\/\/doi.org\/10.2337\/dc11-1641","journal-title":"Diabetes Care"},{"issue":"2","key":"5323_CR21","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1159\/000052903","volume":"51","author":"H Yamada","year":"2001","unstructured":"Yamada H, Hirayama Kato E, Tsuruga R et al (2001) Insulin response patterns contribute to different perinatal risks in gestational diabetes. Gynecol Obstet Investig 51(2):103\u2013109. https:\/\/doi.org\/10.1159\/000052903","journal-title":"Gynecol Obstet Investig"},{"issue":"6","key":"5323_CR22","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/1753-0407.13013","volume":"12","author":"YY Sun","year":"2020","unstructured":"Sun YY, Juan J, Xu QQ, Su RN, Hirst JE, Yang HX (2020) Increasing insulin resistance predicts adverse pregnancy outcomes in women with gestational diabetes mellitus. J Diabetes 12(6):438\u2013446. https:\/\/doi.org\/10.1111\/1753-0407.13013","journal-title":"J Diabetes"},{"issue":"1","key":"5323_CR23","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12967-018-1666-5","volume":"16","author":"Y Liu","year":"2018","unstructured":"Liu Y, Hou W, Meng X et al (2018) Heterogeneity of insulin resistance and beta cell dysfunction in gestational diabetes mellitus: a prospective cohort study of perinatal outcomes. J Transl Med 16(1):289","journal-title":"J Transl Med"},{"issue":"11","key":"5323_CR24","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1507\/endocrj.k10e-231","volume":"57","author":"Y Saisho","year":"2010","unstructured":"Saisho Y, Miyakoshi K, Tanaka M et al (2010) Beta cell dysfunction and its clinical significance in gestational diabetes. Endocr J 57(11):973\u2013980. https:\/\/doi.org\/10.1507\/endocrj.k10e-231","journal-title":"Endocr J"},{"key":"5323_CR25","doi-asserted-by":"publisher","unstructured":"Powe CE, Locascio JJ, Catalano P (2020) Changes in OGTT-based measures of insulin secretory response across pregnancy. Diabetes 69(Suppl 1). https:\/\/doi.org\/10.2337\/db20-1384-P","DOI":"10.2337\/db20-1384-P"},{"key":"5323_CR26","doi-asserted-by":"publisher","unstructured":"Powe CE, Gordesky LH, Catalano PM (2020) OR08-02 Do OGTT-based insulin secretory response measures approximate 1(st) phase insulin response in pregnant women? J Endocr Soc 4(Suppl 1):OR08-02. https:\/\/doi.org\/10.1210\/jendso\/bvaa046.245","DOI":"10.1210\/jendso\/bvaa046.245"},{"key":"5323_CR27","doi-asserted-by":"publisher","unstructured":"McIntyre HD, Gibbons KS, Lowe J, Oats JJN Development of a risk engine relating maternal glycemia and body mass index to pregnancy outcomes. Diabetes Res Clin Pract 139:331\u2013338. https:\/\/doi.org\/10.1016\/j.diabres.2018.02.036","DOI":"10.1016\/j.diabres.2018.02.036"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-020-05323-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00125-020-05323-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-020-05323-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T01:02:21Z","timestamp":1636160541000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00125-020-05323-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,6]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["5323"],"URL":"https:\/\/doi.org\/10.1007\/s00125-020-05323-0","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,6]]},"assertion":[{"value":"28 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}