{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:13:45Z","timestamp":1793261625370,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["Grant"],"award-info":[{"award-number":["Grant"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Gouvernment and County councils","award":["ALF, Research grant"],"award-info":[{"award-number":["ALF, Research grant"]}]},{"name":"Swedish Foundation for rehabilitation and medical research","award":["Grant"],"award-info":[{"award-number":["Grant"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Aims\/hypothesis<\/jats:title>\n                <jats:p>The aim of this work was to study the incidence over time of lower extremity amputations and determine variables associated with increased risk of amputations in people with type 1 diabetes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Individuals with type 1 diabetes registered in the Swedish National Diabetes Registry with no previous amputation from 1 January 1998 and followed to 2 October 2019 were included. Time-updated Cox regression and gradient of risk per SD were used to evaluate the impact of risk factors on the incidence of amputation. Age- and sex-adjusted incidences were estimated over time.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of 46,088 people with type 1 diabetes with no previous amputation (mean age 32.5\u00a0years [SD 14.5], 25,354 [55%] male sex), 1519 (3.3%) underwent amputation. Median follow-up was 12.4\u00a0years. The standardised incidence for any amputation in 1998\u20132001 was 2.84 (95% CI 2.32, 3.36) per 1000 person-years and decreased to 1.64 (95% CI 1.38, 1.90) per 1000 person-years in 2017\u20132019. The incidence for minor and major amputations showed a similar pattern. Hyperglycaemia and renal dysfunction were the strongest risk factors for amputation, followed by older age, male sex, cardiovascular comorbidities, smoking and hypertension. Glycaemic control and age- and sex-adjusted renal function improved during the corresponding time period as amputations decreased.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions\/interpretation<\/jats:title>\n                <jats:p>The incidence of amputation and of the most prominent risk factors for amputation, including renal dysfunction and hyperglycaemia, has improved considerably during recent years for people with type 1 diabetes. This finding has important implications for quality of life, health economics and prognosis regarding CVD, indicating a trend shift in the treatment of type 1 diabetes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00125-021-05550-z","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T23:04:46Z","timestamp":1631055886000},"page":"2751-2761","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Risk factors and incidence over time for lower extremity amputations in people with type 1 diabetes: an observational cohort study of 46,088 patients from the Swedish National Diabetes Registry"],"prefix":"10.1007","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1119-5267","authenticated-orcid":false,"given":"Sara","family":"Hallstr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8121-2045","authenticated-orcid":false,"given":"Ann-Marie","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2224-3236","authenticated-orcid":false,"given":"Aldina","family":"Pivodic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2083-2512","authenticated-orcid":false,"given":"Arnd\u00eds F.","family":"\u00d3lafsd\u00f3ttir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-3920","authenticated-orcid":false,"given":"Magnus","family":"L\u00f6ndahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7571-0021","authenticated-orcid":false,"given":"Hans","family":"Wedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3796-9283","authenticated-orcid":false,"given":"Marcus","family":"Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"5550_CR1","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1016\/S1078-5884(11)60012-9","volume":"42","author":"M Lep\u00e4ntalo","year":"2011","unstructured":"Lep\u00e4ntalo M, Apelqvist J, Setacci C et al (2011) Chapter V: Diabetic Foot. Eur J Vasc Endovasc Surg 42:S60\u2013S74. https:\/\/doi.org\/10.1016\/S1078-5884(11)60012-9","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"4","key":"5550_CR2","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/dme.12647","volume":"32","author":"ML Alva","year":"2015","unstructured":"Alva ML, Gray A, Mihaylova B, Leal J, Holman RR (2015) The impact of diabetes-related complications on healthcare costs: new results from the UKPDS (UKPDS 84). Diabet Med 32(4):459\u2013466. https:\/\/doi.org\/10.1111\/dme.12647","journal-title":"Diabet Med"},{"issue":"5","key":"5550_CR3","doi-asserted-by":"publisher","first-page":"964","DOI":"10.2337\/dc19-1614","volume":"43","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Lazzarini PA, McPhail SM, van Netten JJ, Armstrong DG, Pacella RE (2020) Global Disability Burdens of Diabetes-Related Lower-Extremity Complications in 1990 and 2016. Diabetes Care 43(5):964\u2013974. https:\/\/doi.org\/10.2337\/dc19-1614","journal-title":"Diabetes Care"},{"issue":"5","key":"5550_CR4","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1111\/wrr.12593","volume":"25","author":"FK Barg","year":"2017","unstructured":"Barg FK, Cronholm PF, Easley EE et al (2017) A qualitative study of the experience of lower extremity wounds and amputations among people with diabetes in Philadelphia. Wound Repair Regen 25(5):864\u2013870. https:\/\/doi.org\/10.1111\/wrr.12593","journal-title":"Wound Repair Regen"},{"issue":"1","key":"5550_CR5","doi-asserted-by":"publisher","first-page":"e000602","DOI":"10.1136\/bmjdrc-2018-000602","volume":"7","author":"AF Olafsdottir","year":"2019","unstructured":"Olafsdottir AF, Svensson AM, Pivodic A et al (2019) Excess risk of lower extremity amputations in people with type 1 diabetes compared with the general population: amputations and type 1 diabetes. BMJ Open Diabetes Res Care 7(1):e000602. https:\/\/doi.org\/10.1136\/bmjdrc-2018-000602","journal-title":"BMJ Open Diabetes Res Care"},{"issue":"17","key":"5550_CR6","first-page":"30322","volume":"S1537-1891","author":"R Madonna","year":"2018","unstructured":"Madonna R, Pieragostino D, Balistreri CR et al (2018) Diabetic macroangiopathy: Pathogenetic insights and novel therapeutic approaches with focus on high glucose-mediated vascular damage. Vasc Pharmacol S1537-1891(17):30322\u201330321","journal-title":"Vasc Pharmacol"},{"key":"5550_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vph.2017.01.004","volume":"90","author":"R Madonna","year":"2017","unstructured":"Madonna R, Balistreri CR, Geng YJ, De Caterina R (2017) Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches. Vasc Pharmacol 90:1\u20137. https:\/\/doi.org\/10.1016\/j.vph.2017.01.004","journal-title":"Vasc Pharmacol"},{"issue":"2","key":"5550_CR8","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1001\/jama.293.2.217","volume":"293","author":"N Singh","year":"2005","unstructured":"Singh N, Armstrong DG, Lipsky BA (2005) Preventing Foot Ulcers in Patients With Diabetes. Jama. 293(2):217\u2013228. https:\/\/doi.org\/10.1001\/jama.293.2.217","journal-title":"Jama."},{"issue":"6","key":"5550_CR9","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/j.jvs.2011.02.006","volume":"53","author":"J Apelqvist","year":"2011","unstructured":"Apelqvist J, Elgzyri T, Larsson J, L\u00f6ndahl M, Nyberg P, Th\u00f6rne J (2011) Factors related to outcome of neuroischemic\/ischemic foot ulcer in diabetic patients. J Vasc Surg 53(6):1582\u20138.e2. https:\/\/doi.org\/10.1016\/j.jvs.2011.02.006","journal-title":"J Vasc Surg"},{"issue":"4","key":"5550_CR10","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/j.jvs.2019.08.244","volume":"71","author":"J Musuuza","year":"2020","unstructured":"Musuuza J, Sutherland BL, Kurter S, Balasubramanian P, Bartels CM, Brennan MB (2020) A systematic review of multidisciplinary teams to reduce major amputations for patients with diabetic foot ulcers. J Vasc Surg 71(4):1433\u201346. e3. https:\/\/doi.org\/10.1016\/j.jvs.2019.08.244","journal-title":"J Vasc Surg"},{"issue":"5","key":"5550_CR11","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1007\/s00125-009-1638-7","volume":"53","author":"AI Adler","year":"2010","unstructured":"Adler AI, Erqou S, Lima TA, Robinson AH (2010) Association between glycated haemoglobin and the risk of lower extremity amputation in patients with diabetes mellitus-review and meta-analysis. Diabetologia. 53(5):840\u2013849. https:\/\/doi.org\/10.1007\/s00125-009-1638-7","journal-title":"Diabetologia."},{"issue":"2","key":"5550_CR12","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.jvs.2015.02.051","volume":"62","author":"J Otte","year":"2015","unstructured":"Otte J, van Netten JJ, Woittiez A-JJ (2015) The association of chronic kidney disease and dialysis treatment with foot ulceration and major amputation. J Vasc Surg 62(2):406\u2013411. https:\/\/doi.org\/10.1016\/j.jvs.2015.02.051","journal-title":"J Vasc Surg"},{"issue":"4","key":"5550_CR13","doi-asserted-by":"publisher","first-page":"891","DOI":"10.2337\/dc17-2210","volume":"41","author":"EJ Boyko","year":"2018","unstructured":"Boyko EJ, Seelig AD, Ahroni JH (2018) Limb- and Person-Level Risk Factors for Lower-Limb Amputation in the Prospective Seattle Diabetic Foot Study. Diabetes Care 41(4):891\u2013898. https:\/\/doi.org\/10.2337\/dc17-2210","journal-title":"Diabetes Care"},{"issue":"7258","key":"5550_CR14","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","volume":"321","author":"IM Stratton","year":"2000","unstructured":"Stratton IM, Adler AI, Neil HA et al (2000) Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ (Clin Res Ed) 321(7258):405\u2013412. https:\/\/doi.org\/10.1136\/bmj.321.7258.405","journal-title":"BMJ (Clin Res Ed)"},{"issue":"2","key":"5550_CR15","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1177\/1534734615593190","volume":"14","author":"Z-Y Zhou","year":"2015","unstructured":"Zhou Z-Y, Liu Y-K, Chen H-L, Yang H-L, Liu F (2015) HbA1c and Lower Extremity Amputation Risk in Patients With Diabetes:A Meta-Analysis. Int J Low Extrem Wounds 14(2):168\u2013177. https:\/\/doi.org\/10.1177\/1534734615593190","journal-title":"Int J Low Extrem Wounds"},{"issue":"3","key":"5550_CR16","doi-asserted-by":"publisher","first-page":"649","DOI":"10.2337\/dc10-1712","volume":"34","author":"K Sahakyan","year":"2011","unstructured":"Sahakyan K, Klein BE, Lee KE, Myers CE, Klein R (2011) The 25-year cumulative incidence of lower extremity amputations in people with type 1 diabetes. Diabetes Care 34(3):649\u2013651. https:\/\/doi.org\/10.2337\/dc10-1712","journal-title":"Diabetes Care"},{"issue":"9786","key":"5550_CR17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/S0140-6736(11)60471-6","volume":"378","author":"M Lind","year":"2011","unstructured":"Lind M, Bounias I, Olsson M, Gudbj\u00f6rnsdottir S, Svensson AM, Rosengren A (2011) Glycaemic control and incidence of heart failure in 20,985 patients with type 1 diabetes: an observational study. Lancet (London, England) 378(9786):140\u2013146","journal-title":"Lancet (London, England)"},{"issue":"7","key":"5550_CR18","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.2337\/dc10-0398","volume":"33","author":"K Eeg-Olofsson","year":"2010","unstructured":"Eeg-Olofsson K, Cederholm J, Nilsson PM et al (2010) Glycemic control and cardiovascular disease in 7,454 patients with type 1 diabetes: an observational study from the Swedish National Diabetes Register (NDR). Diabetes Care 33(7):1640\u20131646. https:\/\/doi.org\/10.2337\/dc10-0398","journal-title":"Diabetes Care"},{"issue":"6","key":"5550_CR19","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1111\/j.1523-1755.2005.00365.x","volume":"67","author":"AS Levey","year":"2005","unstructured":"Levey AS, Eckardt KU, Tsukamoto Y et al (2005) Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 67(6):2089\u20132100. https:\/\/doi.org\/10.1111\/j.1523-1755.2005.00365.x","journal-title":"Kidney Int"},{"issue":"2","key":"5550_CR20","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/oby.2011.301","volume":"20","author":"MW Sohn","year":"2012","unstructured":"Sohn MW, Budiman-Mak E, Oh EH et al (2012) Obesity paradox in amputation risk among nonelderly diabetic men. Obesity (Silver Spring, Md) 20(2):460\u2013462. https:\/\/doi.org\/10.1038\/oby.2011.301","journal-title":"Obesity (Silver Spring, Md)"},{"issue":"3","key":"5550_CR21","doi-asserted-by":"publisher","first-page":"635","DOI":"10.2337\/dc10-0878","volume":"34","author":"BC Callaghan","year":"2011","unstructured":"Callaghan BC, Feldman E, Liu J et al (2011) Triglycerides and amputation risk in patients with diabetes: ten-year follow-up in the DISTANCE study. Diabetes Care 34(3):635\u2013640. https:\/\/doi.org\/10.2337\/dc10-0878","journal-title":"Diabetes Care"},{"issue":"1","key":"5550_CR22","first-page":"24","volume":"22","author":"M Zubair","year":"2012","unstructured":"Zubair M, Malik A, Ahmad J (2012) Incidence, risk factors for amputation among patients with diabetic foot ulcer in a North Indian tertiary care hospital. Foot (Edinburgh, Scotland) 22(1):24\u201330","journal-title":"Foot (Edinburgh, Scotland)"},{"issue":"7","key":"5550_CR23","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.2337\/dc07-2145","volume":"31","author":"E Ghanassia","year":"2008","unstructured":"Ghanassia E, Villon L, Thuan dit Dieudonn\u00e9 J-F, Boegner C, Avignon A, Sultan A (2008) Long-Term Outcome and Disability of Diabetic Patients Hospitalized for Diabetic Foot Ulcers. Diabetes Care 31(7):1288. https:\/\/doi.org\/10.2337\/dc07-2145","journal-title":"Diabetes Care"},{"issue":"21","key":"5550_CR24","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1136\/heartjnl-2016-311050","volume":"103","author":"V Matuleviciene-Anangen","year":"2017","unstructured":"Matuleviciene-Anangen V, Rosengren A, Svensson AM et al (2017) Glycaemic control and excess risk of major coronary events in persons with type 1 diabetes. Heart 103(21):1687\u20131695. https:\/\/doi.org\/10.1136\/heartjnl-2016-311050","journal-title":"Heart"},{"issue":"8","key":"5550_CR25","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.2337\/dc18-2457","volume":"42","author":"S Hallstrom","year":"2019","unstructured":"Hallstrom S, Pivodic A, Rosengren A, Olafsdottir AF, Svensson AM, Lind M (2019) Risk Factors for Atrial Fibrillation in People With Type 1 Diabetes: An Observational Cohort Study of 36,258 Patients From the Swedish National Diabetes Registry. Diabetes Care 42(8):1530\u20131538. https:\/\/doi.org\/10.2337\/dc18-2457","journal-title":"Diabetes Care"},{"issue":"1","key":"5550_CR26","doi-asserted-by":"publisher","first-page":"e000727","DOI":"10.1136\/openhrt-2017-000727","volume":"5","author":"D Vestberg","year":"2018","unstructured":"Vestberg D, Rosengren A, Eeg-Olofsson K et al (2018) Body mass index as a risk factor for coronary events and mortality in patients with type 1 diabetes. Open Heart 5(1):e000727. https:\/\/doi.org\/10.1136\/openhrt-2017-000727","journal-title":"Open Heart"},{"issue":"2","key":"5550_CR27","doi-asserted-by":"publisher","first-page":"73","DOI":"10.12861\/jrip.2013.24","volume":"2","author":"H Shahbazian","year":"2013","unstructured":"Shahbazian H, Rezaii I (2013) Diabetic kidney disease; review of the current knowledge. J Renal Inj Prev 2(2):73. https:\/\/doi.org\/10.12861\/jrip.2013.24","journal-title":"J Renal Inj Prev"},{"issue":"1","key":"5550_CR28","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jval.2015.10.010","volume":"19","author":"A Hayes","year":"2016","unstructured":"Hayes A, Arima H, Woodward M et al (2016) Changes in Quality of Life Associated with Complications of Diabetes: Results from the ADVANCE Study. Value Health 19(1):36\u201341. https:\/\/doi.org\/10.1016\/j.jval.2015.10.010","journal-title":"Value Health"},{"issue":"9","key":"5550_CR29","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1080\/09638280110105213","volume":"24","author":"AS Whyte","year":"2002","unstructured":"Whyte AS, Carroll LJ (2002) A preliminary examination of the relationship between employment, pain and disability in an amputee population. Disabil Rehabil 24(9):462\u2013470","journal-title":"Disabil Rehabil"},{"key":"5550_CR30","doi-asserted-by":"publisher","unstructured":"Lind M, Polonsky W, Hirsch IB et al (2017) Continuous Glucose Monitoring vs Conventional Therapy for Glycemic Control in Adults With Type 1 Diabetes Treated With Multiple Daily Insulin Injections: The GOLD Randomized Clinical Trial. JAMA 317(4):379\u2013387. https:\/\/doi.org\/10.1001\/jama.2016.19976","DOI":"10.1001\/jama.2016.19976"},{"key":"5550_CR31","doi-asserted-by":"publisher","unstructured":"Karges B, Schwandt A, Heidtmann B et al (2017) Association of Insulin Pump Therapy vs Insulin Injection Therapy With Severe Hypoglycemia, Ketoacidosis, and Glycemic Control Among Children, Adolescents, and Young Adults With Type 1 Diabetes. .Jama. JAMA 318(14):1358\u20131366. https:\/\/doi.org\/10.1001\/jama.2017.13994","DOI":"10.1001\/jama.2017.13994"},{"issue":"2","key":"5550_CR32","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1210\/jc.2008-1824","volume":"94","author":"A Ceriello","year":"2009","unstructured":"Ceriello A, Ihnat MA, Thorpe JE (2009) The \u201cMetabolic Memory\u201d: Is More Than Just Tight Glucose Control Necessary to Prevent Diabetic Complications? J Clin Endocrinol Metab 94(2):410\u2013415. https:\/\/doi.org\/10.1210\/jc.2008-1824","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-021-05550-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00125-021-05550-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-021-05550-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T08:08:23Z","timestamp":1635840503000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00125-021-05550-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["5550"],"URL":"https:\/\/doi.org\/10.1007\/s00125-021-05550-z","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,8]]},"assertion":[{"value":"6 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}