{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:13:54Z","timestamp":1792782834744,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Arla Foods amba","id":[{"id":"https:\/\/ror.org\/01hgxez56","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008442","name":"The Danish Dairy Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008442","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Copenhagen University Hospital Bispebjerg Frederiksberg","id":[{"id":"https:\/\/ror.org\/05bpbnx46","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s00125-021-05628-8","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T23:26:47Z","timestamp":1641511607000},"page":"506-517","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Dietary carbohydrate restriction augments weight loss-induced improvements in glycaemic control and liver fat in individuals with type 2 diabetes: a randomised controlled trial"],"prefix":"10.1007","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3821-320X","authenticated-orcid":false,"given":"Mads N.","family":"Thomsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6607-2064","authenticated-orcid":false,"given":"Mads J.","family":"Skytte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2742-3893","authenticated-orcid":false,"given":"Amirsalar","family":"Samkani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin H.","family":"Carl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8968-8996","authenticated-orcid":false,"given":"Arne","family":"Astrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta","family":"Chabanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8952-8394","authenticated-orcid":false,"given":"Mogens","family":"Fenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-0961","authenticated-orcid":false,"given":"Jan","family":"Frystyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-2036","authenticated-orcid":false,"given":"Bolette","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3805","authenticated-orcid":false,"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7621-3131","authenticated-orcid":false,"given":"Thomas M.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5017-1815","authenticated-orcid":false,"given":"Sten","family":"Madsbad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1312-7364","authenticated-orcid":false,"given":"Faidon","family":"Magkos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2409-9725","authenticated-orcid":false,"given":"Henrik S.","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6827-7036","authenticated-orcid":false,"given":"Steen B.","family":"Haugaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-0583","authenticated-orcid":false,"given":"Thure","family":"Krarup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"issue":"9922","key":"5628_CR1","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/S0140-6736(13)62154-6","volume":"383","author":"SE Kahn","year":"2014","unstructured":"Kahn SE, Cooper ME, Del Prato S (2014) Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet 383(9922):1068\u20131083. https:\/\/doi.org\/10.1016\/S0140-6736(13)62154-6","journal-title":"Lancet"},{"issue":"5","key":"5628_CR2","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/S2213-8587(19)30068-3","volume":"7","author":"MEJ Lean","year":"2019","unstructured":"Lean MEJ, Leslie WS, Barnes AC et al (2019) Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes Endocrinol 7(5):344\u2013355. https:\/\/doi.org\/10.1016\/S2213-8587(19)30068-3","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"9","key":"5628_CR3","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/j.jand.2015.02.031","volume":"115","author":"MJ Franz","year":"2015","unstructured":"Franz MJ, Boucher JL, Rutten-Ramos S, VanWormer JJ (2015) Lifestyle weight-loss intervention outcomes in overweight and obese adults with type 2 diabetes: a systematic review and meta-analysis of randomized clinical trials. J Acad Nutr Diet 115(9):1447\u20131463. https:\/\/doi.org\/10.1016\/j.jand.2015.02.031","journal-title":"J Acad Nutr Diet"},{"issue":"Suppl 2","key":"5628_CR4","doi-asserted-by":"publisher","first-page":"S357","DOI":"10.2337\/dc09-S339","volume":"32","author":"SR Heller","year":"2009","unstructured":"Heller SR, Group AC (2009) A summary of the ADVANCE trial. Diabetes Care 32(Suppl 2):S357\u2013S361. https:\/\/doi.org\/10.2337\/dc09-S339","journal-title":"Diabetes Care"},{"issue":"10","key":"5628_CR5","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/S2213-8587(17)30176-6","volume":"5","author":"A Baum","year":"2017","unstructured":"Baum A, Scarpa J, Bruzelius E, Tamler R, Basu S, Faghmous J (2017) Targeting weight loss interventions to reduce cardiovascular complications of type 2 diabetes: a machine learning-based post-hoc analysis of heterogeneous treatment effects in the Look AHEAD trial. Lancet Diabetes Endocrinol 5(10):808\u2013815. https:\/\/doi.org\/10.1016\/S2213-8587(17)30176-6","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"Suppl 1","key":"5628_CR6","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.2337\/dc20-S005","volume":"43","author":"American Diabetes Association","year":"2020","unstructured":"American Diabetes Association (2020) 5. Facilitating behavior change and well-being to improve health outcomes: standards of medical Care in Diabetes-2020. Diabetes Care 43(Suppl 1):S48\u2013S65. https:\/\/doi.org\/10.2337\/dc20-S005","journal-title":"Diabetes Care"},{"issue":"6","key":"5628_CR7","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/s0939-4753(04)80028-0","volume":"14","author":"JI Mann","year":"2004","unstructured":"Mann JI, De Leeuw I, Hermansen K et al (2004) Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus. Nutr Metab Cardiovasc Dis 14(6):373\u2013394. https:\/\/doi.org\/10.1016\/s0939-4753(04)80028-0","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"5","key":"5628_CR8","doi-asserted-by":"publisher","first-page":"731","DOI":"10.2337\/dci19-0014","volume":"42","author":"AB Evert","year":"2019","unstructured":"Evert AB, Dennison M, Gardner CD et al (2019) Nutrition therapy for adults with diabetes or prediabetes: a consensus report. Diabetes Care 42(5):731\u2013754. https:\/\/doi.org\/10.2337\/dci19-0014","journal-title":"Diabetes Care"},{"issue":"3","key":"5628_CR9","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/s41430-017-0019-4","volume":"72","author":"R Huntriss","year":"2018","unstructured":"Huntriss R, Campbell M, Bedwell C (2018) The interpretation and effect of a low-carbohydrate diet in the management of type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials. Eur J Clin Nutr 72(3):311\u2013325. https:\/\/doi.org\/10.1038\/s41430-017-0019-4","journal-title":"Eur J Clin Nutr"},{"issue":"11","key":"5628_CR10","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1007\/s00125-019-4956-4","volume":"62","author":"MJ Skytte","year":"2019","unstructured":"Skytte MJ, Samkani A, Petersen AD et al (2019) A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: a randomised controlled trial. Diabetologia 62(11):2066\u20132078. https:\/\/doi.org\/10.1007\/s00125-019-4956-4","journal-title":"Diabetologia"},{"issue":"3","key":"5628_CR11","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.cmet.2018.01.005","volume":"27","author":"A Mardinoglu","year":"2018","unstructured":"Mardinoglu A, Wu H, Bjornson E et al (2018) An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans. Cell Metab 27(3):559\u2013571 e555. https:\/\/doi.org\/10.1016\/j.cmet.2018.01.005","journal-title":"Cell Metab"},{"issue":"2","key":"5628_CR12","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1056\/NEJMoa1212914","volume":"369","author":"ARG Look","year":"2013","unstructured":"Look ARG, Wing RR, Bolin P et al (2013) Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med 369(2):145\u2013154. https:\/\/doi.org\/10.1056\/NEJMoa1212914","journal-title":"N Engl J Med"},{"issue":"2","key":"5628_CR13","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1093\/ajcn\/51.2.241","volume":"51","author":"MD Mifflin","year":"1990","unstructured":"Mifflin MD, St Jeor ST, Hill LA, Scott BJ, Daugherty SA, Koh YO (1990) A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr 51(2):241\u2013247. https:\/\/doi.org\/10.1093\/ajcn\/51.2.241","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"5628_CR14","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/sj.ijo.0803720","volume":"32","author":"KD Hall","year":"2008","unstructured":"Hall KD (2008) What is the required energy deficit per unit weight loss? Int J Obes 32(3):573\u2013576. https:\/\/doi.org\/10.1038\/sj.ijo.0803720","journal-title":"Int J Obes"},{"issue":"8","key":"5628_CR15","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","volume":"35","author":"CL Craig","year":"2003","unstructured":"Craig CL, Marshall AL, Sjostrom M et al (2003) International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 35(8):1381\u20131395. https:\/\/doi.org\/10.1249\/01.MSS.0000078924.61453.FB","journal-title":"Med Sci Sports Exerc"},{"issue":"12","key":"5628_CR16","doi-asserted-by":"publisher","first-page":"e0243918","DOI":"10.1371\/journal.pone.0243918","volume":"15","author":"ER Carlsson","year":"2020","unstructured":"Carlsson ER, Fenger M, Henriksen T et al (2020) Reduction of oxidative stress on DNA and RNA in obese patients after roux-en-Y gastric bypass surgery-an observational cohort study of changes in urinary markers. PLoS One 15(12):e0243918. https:\/\/doi.org\/10.1371\/journal.pone.0243918","journal-title":"PLoS One"},{"issue":"8","key":"5628_CR17","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.acra.2017.02.010","volume":"24","author":"E Chabanova","year":"2017","unstructured":"Chabanova E, Fonvig CE, Bojsoe C, Holm JC, Thomsen HS (2017) (1)H MRS assessment of hepatic fat content: comparison between Normal- and excess-weight children and adolescents. Acad Radiol 24(8):982\u2013987. https:\/\/doi.org\/10.1016\/j.acra.2017.02.010","journal-title":"Acad Radiol"},{"issue":"1","key":"5628_CR18","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.4081\/pr.2012.e11","volume":"4","author":"CE Fonvig","year":"2012","unstructured":"Fonvig CE, Bille DS, Chabanova E, Nielsen TR, Thomsen HS, Holm JC (2012) Muscle fat content and abdominal adipose tissue distribution investigated by magnetic resonance spectroscopy and imaging in obese children and youths. Pediatr Rep 4(1):e11. https:\/\/doi.org\/10.4081\/pr.2012.e11","journal-title":"Pediatr Rep"},{"issue":"8","key":"5628_CR19","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.2337\/dci19-0028","volume":"42","author":"T Battelino","year":"2019","unstructured":"Battelino T, Danne T, Bergenstal RM et al (2019) Clinical targets for continuous glucose monitoring data interpretation: recommendations from the international consensus on time in range. Diabetes Care 42(8):1593\u20131603. https:\/\/doi.org\/10.2337\/dci19-0028","journal-title":"Diabetes Care"},{"issue":"3","key":"5628_CR20","doi-asserted-by":"publisher","first-page":"921S","DOI":"10.1093\/jn\/133.3.921S","volume":"133 Suppl 3","author":"SA Bingham","year":"2003","unstructured":"Bingham SA (2003) Urine nitrogen as a biomarker for the validation of dietary protein intake. J Nutr 133 Suppl 3(3):921S\u2013924S. https:\/\/doi.org\/10.1093\/jn\/133.3.921S","journal-title":"J Nutr"},{"issue":"Suppl 1","key":"5628_CR21","doi-asserted-by":"publisher","first-page":"S66","DOI":"10.2337\/dc20-S006","volume":"43","author":"American Diabetes Association","year":"2020","unstructured":"American Diabetes Association (2020) 6. Glycemic targets: standards of medical Care in Diabetes-2020. Diabetes Care 43(Suppl 1):S66\u2013S76. https:\/\/doi.org\/10.2337\/dc20-S006","journal-title":"Diabetes Care"},{"issue":"8","key":"5628_CR22","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.2337\/dc16-0513","volume":"39","author":"F Qian","year":"2016","unstructured":"Qian F, Korat AA, Malik V, Hu FB (2016) Metabolic effects of monounsaturated fatty acid-enriched diets compared with carbohydrate or polyunsaturated fatty acid-enriched diets in patients with type 2 diabetes: a systematic review and Meta-analysis of randomized controlled trials. Diabetes Care 39(8):1448\u20131457. https:\/\/doi.org\/10.2337\/dc16-0513","journal-title":"Diabetes Care"},{"issue":"2","key":"5628_CR23","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.metabol.2014.10.004","volume":"64","author":"FQ Nuttall","year":"2015","unstructured":"Nuttall FQ, Almokayyad RM, Gannon MC (2015) Comparison of a carbohydrate-free diet vs. fasting on plasma glucose, insulin and glucagon in type 2 diabetes. Metabolism 64(2):253\u2013262. https:\/\/doi.org\/10.1016\/j.metabol.2014.10.004","journal-title":"Metabolism"},{"issue":"8","key":"5628_CR24","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1017\/S0007114518000521","volume":"119","author":"A Samkani","year":"2018","unstructured":"Samkani A, Skytte MJ, Kandel D et al (2018) A carbohydrate-reduced high-protein diet acutely decreases postprandial and diurnal glucose excursions in type 2 diabetes patients. Br J Nutr 119(8):910\u2013917. https:\/\/doi.org\/10.1017\/S0007114518000521","journal-title":"Br J Nutr"},{"issue":"3","key":"5628_CR25","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1210\/jc.2005-1005","volume":"91","author":"F Cavalot","year":"2006","unstructured":"Cavalot F, Petrelli A, Traversa M et al (2006) Postprandial blood glucose is a stronger predictor of cardiovascular events than fasting blood glucose in type 2 diabetes mellitus, particularly in women: lessons from the san Luigi Gonzaga diabetes study. J Clin Endocrinol Metab 91(3):813\u2013819. https:\/\/doi.org\/10.1210\/jc.2005-1005","journal-title":"J Clin Endocrinol Metab"},{"key":"5628_CR26","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.clnesp.2020.07.002","volume":"39","author":"MN Thomsen","year":"2020","unstructured":"Thomsen MN, Skytte MJ, Astrup A et al (2020) The clinical effects of a carbohydrate-reduced high-protein diet on glycaemic variability in metformin-treated patients with type 2 diabetes mellitus: a randomised controlled study. Clin Nutr ESPEN 39:46\u201352. https:\/\/doi.org\/10.1016\/j.clnesp.2020.07.002","journal-title":"Clin Nutr ESPEN"},{"issue":"4","key":"5628_CR27","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1111\/dom.13164","volume":"20","author":"J Tay","year":"2018","unstructured":"Tay J, Thompson CH, Luscombe-Marsh ND et al (2018) Effects of an energy-restricted low-carbohydrate, high unsaturated fat\/low saturated fat diet versus a high-carbohydrate, low-fat diet in type 2 diabetes: a 2-year randomized clinical trial. Diabetes Obes Metab 20(4):858\u2013871. https:\/\/doi.org\/10.1111\/dom.13164","journal-title":"Diabetes Obes Metab"},{"issue":"1","key":"5628_CR28","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2337\/dc07-1463","volume":"31","author":"A Kotronen","year":"2008","unstructured":"Kotronen A, Juurinen L, Hakkarainen A et al (2008) Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects. Diabetes Care 31(1):165\u2013169. https:\/\/doi.org\/10.2337\/dc07-1463","journal-title":"Diabetes Care"},{"issue":"5","key":"5628_CR29","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1172\/JCI23621","volume":"115","author":"KL Donnelly","year":"2005","unstructured":"Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115(5):1343\u20131351. https:\/\/doi.org\/10.1172\/JCI23621","journal-title":"J Clin Invest"},{"issue":"1","key":"5628_CR30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/ajcn\/77.1.43","volume":"77","author":"JM Schwarz","year":"2003","unstructured":"Schwarz JM, Linfoot P, Dare D, Aghajanian K (2003) Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am J Clin Nutr 77(1):43\u201350. https:\/\/doi.org\/10.1093\/ajcn\/77.1.43","journal-title":"Am J Clin Nutr"},{"issue":"7","key":"5628_CR31","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.2337\/dc12-0033","volume":"35","author":"L Bozzetto","year":"2012","unstructured":"Bozzetto L, Prinster A, Annuzzi G et al (2012) Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients. Diabetes Care 35(7):1429\u20131435. https:\/\/doi.org\/10.2337\/dc12-0033","journal-title":"Diabetes Care"},{"issue":"2","key":"5628_CR32","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s13679-021-00430-4","volume":"10","author":"K Sandby","year":"2021","unstructured":"Sandby K, Geiker NRW, Dalamaga M, Gronbaek H, Magkos F (2021) Efficacy of dietary manipulations for depleting intrahepatic triglyceride content: implications for the Management of non-alcoholic Fatty Liver Disease. Curr Obes Rep 10(2):125\u2013133. https:\/\/doi.org\/10.1007\/s13679-021-00430-4","journal-title":"Curr Obes Rep"},{"issue":"5","key":"5628_CR33","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1053\/j.gastro.2009.01.048","volume":"136","author":"E Kirk","year":"2009","unstructured":"Kirk E, Reeds DN, Finck BN, Mayurranjan SM, Patterson BW, Klein S (2009) Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology 136(5):1552\u20131560. https:\/\/doi.org\/10.1053\/j.gastro.2009.01.048","journal-title":"Gastroenterology"},{"issue":"5","key":"5628_CR34","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1002\/hep.24242","volume":"53","author":"S Haufe","year":"2011","unstructured":"Haufe S, Engeli S, Kast P et al (2011) Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects. Hepatology 53(5):1504\u20131514. https:\/\/doi.org\/10.1002\/hep.24242","journal-title":"Hepatology"},{"issue":"12","key":"5628_CR35","doi-asserted-by":"publisher","first-page":"3846","DOI":"10.3390\/nu12123846","volume":"12","author":"J Inaishi","year":"2020","unstructured":"Inaishi J, Saisho Y (2020) Beta-cell mass in obesity and type 2 diabetes, and its relation to pancreas fat: a Mini-review. Nutrients 12(12):3846. https:\/\/doi.org\/10.3390\/nu12123846","journal-title":"Nutrients"},{"issue":"12","key":"5628_CR36","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S2213-8587(20)30303-X","volume":"8","author":"A Al-Mrabeh","year":"2020","unstructured":"Al-Mrabeh A, Hollingsworth KG, Shaw JAM et al (2020) 2-year remission of type 2 diabetes and pancreas morphology: a post-hoc analysis of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes Endocrinol 8(12):939\u2013948. https:\/\/doi.org\/10.1016\/S2213-8587(20)30303-X","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"5","key":"5628_CR37","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.jacl.2019.08.003","volume":"13","author":"CF Kirkpatrick","year":"2019","unstructured":"Kirkpatrick CF, Bolick JP, Kris-Etherton PM et al (2019) Review of current evidence and clinical recommendations on the effects of low-carbohydrate and very-low-carbohydrate (including ketogenic) diets for the management of body weight and other cardiometabolic risk factors: a scientific statement from the National Lipid Association Nutrition and lifestyle task force. J Clin Lipidol 13(5):689\u2013711 e681. https:\/\/doi.org\/10.1016\/j.jacl.2019.08.003","journal-title":"J Clin Lipidol"},{"issue":"5","key":"5628_CR38","doi-asserted-by":"publisher","first-page":"e002934","DOI":"10.1136\/bmjopen-2013-002934","volume":"3","author":"U Nezu","year":"2013","unstructured":"Nezu U, Kamiyama H, Kondo Y, Sakuma M, Morimoto T, Ueda S (2013) Effect of low-protein diet on kidney function in diabetic nephropathy: meta-analysis of randomised controlled trials. BMJ Open 3(5):e002934. https:\/\/doi.org\/10.1136\/bmjopen-2013-002934","journal-title":"BMJ Open"},{"key":"5628_CR39","doi-asserted-by":"publisher","first-page":"m4743","DOI":"10.1136\/bmj.m4743","volume":"372","author":"JZ Goldenberg","year":"2021","unstructured":"Goldenberg JZ, Day A, Brinkworth GD et al (2021) Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: systematic review and meta-analysis of published and unpublished randomized trial data. BMJ 372:m4743. https:\/\/doi.org\/10.1136\/bmj.m4743","journal-title":"BMJ"},{"key":"5628_CR40","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1743-7075-7-64","volume":"7","author":"MC Gannon","year":"2010","unstructured":"Gannon MC, Hoover H, Nuttall FQ (2010) Further decrease in glycated hemoglobin following ingestion of a LoBAG30 diet for 10 weeks compared to 5 weeks in people with untreated type 2 diabetes. Nutr Metab (Lond) 7:64. https:\/\/doi.org\/10.1186\/1743-7075-7-64","journal-title":"Nutr Metab (Lond)"},{"issue":"12","key":"5628_CR41","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1111\/nure.12076","volume":"71","author":"FM Silva","year":"2013","unstructured":"Silva FM, Kramer CK, de Almeida JC, Steemburgo T, Gross JL, Azevedo MJ (2013) Fiber intake and glycemic control in patients with type 2 diabetes mellitus: a systematic review with meta-analysis of randomized controlled trials. Nutr Rev 71(12):790\u2013801. https:\/\/doi.org\/10.1111\/nure.12076","journal-title":"Nutr Rev"},{"issue":"4","key":"5628_CR42","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1159\/000331214","volume":"58","author":"L Schwingshackl","year":"2011","unstructured":"Schwingshackl L, Strasser B, Hoffmann G (2011) Effects of monounsaturated fatty acids on glycaemic control in patients with abnormal glucose metabolism: a systematic review and meta-analysis. Ann Nutr Metab 58(4):290\u2013296. https:\/\/doi.org\/10.1159\/000331214","journal-title":"Ann Nutr Metab"},{"key":"5628_CR43","doi-asserted-by":"publisher","unstructured":"Alzahrani AH, Skytte MJ, Samkani A et al (2021) Body weight and metabolic risk factors in patients with type 2 diabetes on a self-selected high-protein low-carbohydrate diet. Eur J Nutr 60(8):4473\u20134482. https:\/\/doi.org\/10.1007\/s00394-021-02605-0","DOI":"10.1007\/s00394-021-02605-0"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-021-05628-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00125-021-05628-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-021-05628-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T20:03:42Z","timestamp":1673035422000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00125-021-05628-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,7]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["5628"],"URL":"https:\/\/doi.org\/10.1007\/s00125-021-05628-8","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,7]]},"assertion":[{"value":"25 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}