{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:31:59Z","timestamp":1792729919595,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100008966","name":"Soci\u00e9t\u00e9 Francophone du Diab\u00e8te","doi-asserted-by":"publisher","award":["R16038EE"],"award-info":[{"award-number":["R16038EE"]}],"id":[{"id":"10.13039\/501100008966","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["U1239"],"award-info":[{"award-number":["U1239"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["Diabnet"],"award-info":[{"award-number":["Diabnet"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007527","name":"Universit\u00e9 de Rouen","doi-asserted-by":"publisher","award":["U1239"],"award-info":[{"award-number":["U1239"]}],"id":[{"id":"10.13039\/501100007527","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DEA 20140629966"],"award-info":[{"award-number":["DEA 20140629966"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00125-022-05706-5","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T07:02:21Z","timestamp":1651042941000},"page":"1198-1211","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The 26RFa (QRFP)\/GPR103 neuropeptidergic system in mice relays insulin signalling into the brain to regulate glucose homeostasis"],"prefix":"10.1007","volume":"65","author":[{"given":"Mouna","family":"El Mehdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saloua","family":"Takhlidjt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lodie","family":"Dev\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Arabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Anne","family":"Le Solliec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Maucotel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"B\u00e9nani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Nedelec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Duparc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Lefranc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Leprince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Anouar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebtan","family":"Pr\u00e9vost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Chartrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Picot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"5706_CR1","volume-title":"Le\u00e7ons de physiologie exp\u00e9rimentales appliqu\u00e9es \u00e0 la m\u00e9decine","author":"C Bernard","year":"1854","unstructured":"Bernard C (1854) Le\u00e7ons de physiologie exp\u00e9rimentales appliqu\u00e9es \u00e0 la m\u00e9decine. JB Bailli\u00e8re, Paris"},{"key":"5706_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature12709","volume":"503","author":"MW Schwartz","year":"2013","unstructured":"Schwartz MW, Seeley RJ, Tsch\u00f6p MH et al (2013) Cooperation between brain and islet in glucose homeostasis and diabetes. Nature 503:59\u201366. https:\/\/doi.org\/10.1038\/nature12709","journal-title":"Nature"},{"key":"5706_CR3","doi-asserted-by":"publisher","first-page":"34981","DOI":"10.1074\/jbc.R113.506782","volume":"288","author":"M Carey","year":"2013","unstructured":"Carey M, Kehlenbrink S, Hawkins M (2013) Evidence for central regulation of glucose metabolism. J Biol Chem 288:34981\u201334988. https:\/\/doi.org\/10.1074\/jbc.R113.506782","journal-title":"J Biol Chem"},{"issue":"3","key":"5706_CR4","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.cmet.2013.08.004","volume":"18","author":"T Fujikawa","year":"2013","unstructured":"Fujikawa T, Berglund ED, Patel VR et al (2013) Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab 18(3):431\u2013444. https:\/\/doi.org\/10.1016\/j.cmet.2013.08.004","journal-title":"Cell Metab"},{"key":"5706_CR5","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1038\/nm1202-798","volume":"8","author":"S Obici","year":"2002","unstructured":"Obici S, Zhang BB, Karkanias G et al (2002) Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 8:1376\u20131382. https:\/\/doi.org\/10.1038\/nm1202-798","journal-title":"Nat Med"},{"key":"5706_CR6","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1126\/science.1112085","volume":"309","author":"TK Lam","year":"2005","unstructured":"Lam TK, Gutierrez-Juarez R, Pocai A et al (2005) Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 309:943\u2013947. https:\/\/doi.org\/10.1126\/science.1112085","journal-title":"Science"},{"key":"5706_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1507\/endocrj.EJ15-0540","volume":"63","author":"H Inoue","year":"2016","unstructured":"Inoue H (2016) Central insulin-mediated regulation of HGP. Endocr J 63:1\u20137. https:\/\/doi.org\/10.1507\/endocrj.EJ15-0540","journal-title":"Endocr J"},{"key":"5706_CR8","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.cmet.2005.10.009","volume":"2","author":"GJ Morton","year":"2005","unstructured":"Morton GJ, Gelling RW, Niswender KD et al (2005) Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab 2:411\u2013420. https:\/\/doi.org\/10.1016\/j.cmet.2005.10.009","journal-title":"Cell Metab"},{"key":"5706_CR9","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.1007\/s00018-010-0414-7","volume":"67","author":"SD Jordan","year":"2010","unstructured":"Jordan SD, K\u00f6nner AC, Br\u00fcning JC (2010) Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. Cell Mol Life Sci 67:3255\u20133273. https:\/\/doi.org\/10.1007\/s00018-010-0414-7","journal-title":"Cell Mol Life Sci"},{"key":"5706_CR10","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.cmet.2010.03.002","volume":"11","author":"JW Hill","year":"2010","unstructured":"Hill JW, Elias CF, Fukuda M et al (2010) Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab 11:286\u2013297. https:\/\/doi.org\/10.1016\/j.cmet.2010.03.002","journal-title":"Cell Metab"},{"key":"5706_CR11","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.cmet.2007.05.004","volume":"5","author":"AC K\u00f6nner","year":"2007","unstructured":"K\u00f6nner AC, Janoschek R, Plum L et al (2007) Insulin action in AgRP-expressing neurons is required for suppression of HGP. Cell Metab 5:438\u2013449. https:\/\/doi.org\/10.1016\/j.cmet.2007.05.004","journal-title":"Cell Metab"},{"key":"5706_CR12","doi-asserted-by":"publisher","first-page":"15247","DOI":"10.1073\/pnas.2434676100","volume":"100","author":"N Chartrel","year":"2003","unstructured":"Chartrel N, Dujardin C, Anouar Y et al (2003) Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc Natl Acad Sci U S A 100:15247\u201315252. https:\/\/doi.org\/10.1073\/pnas.2434676100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5706_CR13","doi-asserted-by":"publisher","first-page":"46387","DOI":"10.1074\/jbc.M305270200","volume":"278","author":"S Fukusumi","year":"2003","unstructured":"Fukusumi S, Yoshida H, Fujii R et al (2003) A new peptidic ligand and its receptor regulating adrenal function in rats. J Biol Chem 278:46387\u201346395. https:\/\/doi.org\/10.1074\/jbc.M305270200","journal-title":"J Biol Chem"},{"key":"5706_CR14","doi-asserted-by":"publisher","first-page":"27652","DOI":"10.1074\/jbc.M302945200","volume":"278","author":"Y Jiang","year":"2003","unstructured":"Jiang Y, Luo L, Gustafson EL et al (2003) Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. J Biol Chem 278:27652\u201327657. https:\/\/doi.org\/10.1074\/jbc.M302945200","journal-title":"J Biol Chem"},{"key":"5706_CR15","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.yfrne.2011.04.001","volume":"32","author":"N Chartrel","year":"2011","unstructured":"Chartrel N, Alonzeau J, Alexandre D et al (2011) The RFamide neuropeptide 26RFa and its role in the control of neuroendocrine functions. Front Neuroendocrinol 32:387\u2013397. https:\/\/doi.org\/10.1016\/j.yfrne.2011.04.001","journal-title":"Front Neuroendocrinol"},{"key":"5706_CR16","doi-asserted-by":"publisher","first-page":"7438","DOI":"10.1073\/pnas.0602371103","volume":"103","author":"S Takayasu","year":"2006","unstructured":"Takayasu S, Sakurai T, Iwasaki S et al (2006) A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. Proc Natl Acad Sci U S A 103:7438\u20137443. https:\/\/doi.org\/10.1073\/pnas.0602371103","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"20","key":"5706_CR17","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1111\/bph.13907","volume":"174","author":"J Leprince","year":"2017","unstructured":"Leprince J, Bagnol D, Bureau R et al (2017) The Arg-Phe-amide peptide 26RFa\/glutamine RF-amide peptide and its receptor: IUPHAR Review 24. Br J Pharmacol 174(20):3573\u20133607. https:\/\/doi.org\/10.1111\/bph.13907","journal-title":"Br J Pharmacol"},{"key":"5706_CR18","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1111\/j.1471-4159.2006.04090.x","volume":"99","author":"F Bruzzone","year":"2006","unstructured":"Bruzzone F, Lectez B, Tollemer H et al (2006) Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord. J Neurochem 99:616\u2013627. https:\/\/doi.org\/10.1111\/j.1471-4159.2006.04090.x","journal-title":"J Neurochem"},{"key":"5706_CR19","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/cne.21400","volume":"503","author":"F Bruzzone","year":"2007","unstructured":"Bruzzone F, Lectez B, Alexandre D et al (2007) Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat. J Comp Neurol 503:573\u2013591. https:\/\/doi.org\/10.1002\/cne.21400","journal-title":"J Comp Neurol"},{"key":"5706_CR20","doi-asserted-by":"publisher","first-page":"2916","DOI":"10.1210\/en.2005-1580","volume":"147","author":"R Moriya","year":"2006","unstructured":"Moriya R, Sano H, Umeda T et al (2006) RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice. Endocrinology 147:2916\u20132922. https:\/\/doi.org\/10.1210\/en.2005-1580","journal-title":"Endocrinology"},{"key":"5706_CR21","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1210\/en.2008-1432","volume":"150","author":"B Lectez","year":"2009","unstructured":"Lectez B, Jeandel L, El-Yamani FZ et al (2009) The orexigenic activity of the hypothalamic neuropeptide 26RFa is mediated by the neuropeptide Y and proopiomelanocortin neurons of the arcuate nucleus. Endocrinology 150:2342\u20132350. https:\/\/doi.org\/10.1210\/en.2008-1432","journal-title":"Endocrinology"},{"key":"5706_CR22","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.2337\/db13-1522","volume":"63","author":"R Granata","year":"2014","unstructured":"Granata R, Settanni F, Trovato L et al (2014) RFamide peptides 43RFa and 26RFa both promote survival of pancreatic \u03b2-cells and human pancreatic islets but exert opposite effects on insulin secretion. Diabetes 63:2380\u20132393. https:\/\/doi.org\/10.2337\/db13-1522","journal-title":"Diabetes"},{"key":"5706_CR23","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.2337\/db14-1864","volume":"64","author":"G Pr\u00e9vost","year":"2015","unstructured":"Pr\u00e9vost G, Jeandel L, Arabo A et al (2015) Hypothalamic Neuropeptide 26RFa Acts as an Incretin to Regulate Glucose Homeostasis. Diabetes 64:2805\u20132816. https:\/\/doi.org\/10.2337\/db14-1864","journal-title":"Diabetes"},{"key":"5706_CR24","doi-asserted-by":"publisher","unstructured":"Pr\u00e9vost G, Picot M, Le Solliec MA et al (2019) The neuropeptide 26RFa in the human gut and pancreas: potential involvement in glucose homeostasis. Endocr Connect 8:941\u2013951. https:\/\/doi.org\/10.1530\/EC-19-0247","DOI":"10.1530\/EC-19-0247"},{"issue":"1","key":"5706_CR25","doi-asserted-by":"publisher","first-page":"E147","DOI":"10.1152\/ajpendo.00540.2018","volume":"317","author":"G Pr\u00e9vost","year":"2019","unstructured":"Pr\u00e9vost G, Arabo A, Le Solliec MA et al (2019) Neuropeptide 26RFa (QRFP) is a key regulator of glucose homeostasis and its activity is markedly altered in obese\/hyperglycemic mice. Am J Physiol Endocrinol Metab 317(1):E147\u2013E157. https:\/\/doi.org\/10.1152\/ajpendo.00540.2018","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"5706_CR26","doi-asserted-by":"publisher","first-page":"e000942","DOI":"10.1136\/bmjdrc-2019-000942","volume":"8","author":"M El Mehdi","year":"2020","unstructured":"El Mehdi M, Takhlidjt S, Khiar F et al (2020) Glucose homeostasis is impaired in mice deficient for the neuropeptide 26RFa (QRFP). BMJ Open Diabetes Res Care 8:e000942. https:\/\/doi.org\/10.1136\/bmjdrc-2019-000942","journal-title":"BMJ Open Diabetes Res Care"},{"key":"5706_CR27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1210\/en.2012-1891","volume":"154","author":"KK Ryan","year":"2013","unstructured":"Ryan KK, Kohli R, Gutierrez-Aguilar R et al (2013) Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats. Endocrinology 154:9\u201315. https:\/\/doi.org\/10.1210\/en.2012-1891","journal-title":"Endocrinology"},{"key":"5706_CR28","doi-asserted-by":"publisher","first-page":"E701","DOI":"10.1152\/ajpendo.00024.2003","volume":"285","author":"RL Prigeon","year":"2003","unstructured":"Prigeon RL, Quddusi S, Paty B et al (2003) Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect. Am J Physiol Endocrinol Metab 285:E701\u2013E707. https:\/\/doi.org\/10.1152\/ajpendo.00024.2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"5706_CR29","doi-asserted-by":"publisher","first-page":"459","DOI":"10.2337\/db14-0695","volume":"64","author":"H Tsuneki","year":"2015","unstructured":"Tsuneki H, Tokai E, Nakamura Y et al (2015) Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice. Diabetes 64:459\u2013470. https:\/\/doi.org\/10.2337\/db14-0695","journal-title":"Diabetes"},{"key":"5706_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.npep.2018.02.002","volume":"68","author":"M Rani","year":"2018","unstructured":"Rani M, Kumar R, Krishan P (2018) Role of orexins in the central and peripheral regulation of glucose homeostasis: Evidences & mechanisms. Neuropeptides 68:1\u20136. https:\/\/doi.org\/10.1016\/j.npep.2018.02.002","journal-title":"Neuropeptides"},{"key":"5706_CR31","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.cell.2016.02.044","volume":"165","author":"SM Steculorum","year":"2016","unstructured":"Steculorum SM, Ruud J, Karakasilioti I et al (2016) AgRP neurons control systemic insulin sensitivity via myostatin expression in brown adipose tissue. Cell 165:125\u2013138. https:\/\/doi.org\/10.1016\/j.cell.2016.02.044","journal-title":"Cell"},{"key":"5706_CR32","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/s41574-021-00498-x","volume":"17","author":"T Scherer","year":"2021","unstructured":"Scherer T, Sakamoto K, Buettner C (2021) Brain insulin signaling in metabolic homeostasis and disease. Nat Rev Endocrinol 17:468\u2013483. https:\/\/doi.org\/10.1038\/s41574-021-00498-x","journal-title":"Nat Rev Endocrinol"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-022-05706-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00125-022-05706-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-022-05706-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T23:04:59Z","timestamp":1682550299000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00125-022-05706-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,27]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["5706"],"URL":"https:\/\/doi.org\/10.1007\/s00125-022-05706-5","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,27]]},"assertion":[{"value":"7 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}