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Our aim was to determine whether perinatal DNA methylation is associated with later progression to type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Reduced representation bisulphite sequencing (RRBS) analysis was performed on umbilical cord blood samples collected within the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study. Children later diagnosed with type 1 diabetes and\/or who tested positive for multiple islet autoantibodies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943) were compared with control individuals (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200979) who remained autoantibody-negative throughout the DIPP follow-up until 15 years of age. Potential confounding factors related to the pregnancy and the mother were included in the analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No differences in the umbilical cord blood methylation patterns were observed between the cases and controls at a false discovery rate &lt;0.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\/interpretation<\/jats:title>\n                    <jats:p>Based on our results, differences between children who progress to type 1 diabetes and those who remain healthy throughout childhood are not yet present in the perinatal DNA methylome. However, we cannot exclude the possibility that such differences would be found in a larger dataset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00125-022-05726-1","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T01:02:43Z","timestamp":1655514163000},"page":"1534-1540","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Umbilical cord blood DNA methylation in children who later develop type 1 diabetes"],"prefix":"10.1007","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3382-7966","authenticated-orcid":false,"given":"Essi","family":"Laajala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2539-2296","authenticated-orcid":false,"given":"Ubaid 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