{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:03:04Z","timestamp":1792094584419,"version":"4.4.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation programme under the Marie Sk\u0142odowska-Curie","award":["801505"],"award-info":[{"award-number":["801505"]}]},{"name":"INNODIA","award":["115797"],"award-info":[{"award-number":["115797"]}]},{"name":"NIH grant","award":["U01DK127786"],"award-info":[{"award-number":["U01DK127786"]}]},{"DOI":"10.13039\/100008871","name":"JDRF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"INNODIA HARVEST","award":["945268"],"award-info":[{"award-number":["945268"]}]},{"name":"Walloon Region SPW-EER"},{"name":"Welbio-FNRS","award":["WELBIO-CR-2019C-04"],"award-info":[{"award-number":["WELBIO-CR-2019C-04"]}]},{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013322","name":"European Federation of Pharmaceutical Industries and Associations","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Innovate2CureType1-Dutch Diabetes Research Foundation","award":["2018.10.002"],"award-info":[{"award-number":["2018.10.002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s00125-023-05908-5","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T06:06:22Z","timestamp":1680069982000},"page":"1544-1556","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-\u03b1-induced human beta cell dysfunction and death"],"prefix":"10.1007","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0048-3589","authenticated-orcid":false,"given":"Arturo","family":"Roca-Rivada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3612-5908","authenticated-orcid":false,"given":"Sandra","family":"Mar\u00edn-Ca\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2200-4761","authenticated-orcid":false,"given":"Maikel L.","family":"Colli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-9186","authenticated-orcid":false,"given":"Chiara","family":"Vinci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6714-6221","authenticated-orcid":false,"given":"Toshiaki","family":"Sawatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6698-2962","authenticated-orcid":false,"given":"Lorella","family":"Marselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5112-1692","authenticated-orcid":false,"given":"Miriam","family":"Cnop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4907-0635","authenticated-orcid":false,"given":"Piero","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2453-5889","authenticated-orcid":false,"given":"Decio L.","family":"Eizirik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"issue":"2","key":"5908_CR1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.2337\/DCI18-0039","volume":"42","author":"K Cerolsaletti","year":"2019","unstructured":"Cerolsaletti K, Hao W, Greenbaum CJ (2019) Genetics coming of age in type 1 diabetes. Diabetes Care 42(2):189\u2013191. https:\/\/doi.org\/10.2337\/DCI18-0039","journal-title":"Diabetes Care"},{"issue":"7","key":"5908_CR2","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/S41574-020-0355-7","volume":"16","author":"DL Eizirik","year":"2020","unstructured":"Eizirik DL, Pasquali L, Cnop M (2020) Pancreatic \u03b2-cells in type 1 and type 2 diabetes mellitus: different pathways to failure. Nat Rev Endocrinol 16(7):349\u2013362. https:\/\/doi.org\/10.1038\/S41574-020-0355-7","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"5908_CR3","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/s41588-021-00880-5","volume":"53","author":"CC Robertson","year":"2021","unstructured":"Robertson CC, Inshaw JRJ, Onengut-Gumuscu S et al (2021) Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. Nat Genet 53(7):962\u2013971. https:\/\/doi.org\/10.1038\/s41588-021-00880-5","journal-title":"Nat Genet"},{"key":"5908_CR4","doi-asserted-by":"publisher","unstructured":"Santin I, Eizirik DL (2013) Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and \u03b2-cell apoptosis. Diabetes Obes Metab 15(Suppl 3):71\u201381. https:\/\/doi.org\/10.1111\/DOM.12162","DOI":"10.1111\/DOM.12162"},{"issue":"7","key":"5908_CR5","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.2337\/DB13-1443","volume":"63","author":"L Marroqu\u00ed","year":"2014","unstructured":"Marroqu\u00ed L, Santin I, Dos Santos RS, Marselli L, Marchetti P, Eizirik DL (2014) BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic \u03b2-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2. Diabetes 63(7):2516\u20132527. https:\/\/doi.org\/10.2337\/DB13-1443","journal-title":"Diabetes"},{"issue":"6","key":"5908_CR6","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.2337\/DB08-1510","volume":"58","author":"F Moore","year":"2009","unstructured":"Moore F, Colli ML, Cnop M et al (2009) PTPN2, a candidate gene for type 1 diabetes, modulates interferon-\u03b3-induced pancreatic \u03b2-cell apoptosis. Diabetes 58(6):1283. https:\/\/doi.org\/10.2337\/DB08-1510","journal-title":"Diabetes"},{"key":"5908_CR7","doi-asserted-by":"publisher","unstructured":"Sharp RC, Abdulrahim M, Naser ES, Naser SA (2015) Genetic variations of PTPN2 and PTPN22: role in the pathogenesis of type 1 diabetes and Crohn\u2019s Disease. Front Cell Infect Microbiol 5:95. https:\/\/doi.org\/10.3389\/FCIMB.2015.00095","DOI":"10.3389\/FCIMB.2015.00095"},{"issue":"2","key":"5908_CR8","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/J.1742-4658.2012.08563.X","volume":"280","author":"T Tiganis","year":"2013","unstructured":"Tiganis T (2013) PTP1B and TCPTP \u2013 nonredundant phosphatases in insulin signaling and glucose homeostasis. FEBS J 280(2):445\u2013458. https:\/\/doi.org\/10.1111\/J.1742-4658.2012.08563.X","journal-title":"FEBS J"},{"key":"5908_CR9","doi-asserted-by":"publisher","unstructured":"Santin I, Moore F, Colli ML et al (2011) PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic \u03b2-cell apoptosis via regulation of the BH3-only protein Bim. Diabetes 60(12):3279\u20133288. https:\/\/doi.org\/10.2337\/DB11-0758\/-\/DC1","DOI":"10.2337\/DB11-0758\/-\/DC1"},{"issue":"6","key":"5908_CR10","doi-asserted-by":"publisher","first-page":"866","DOI":"10.3390\/GENES12060866","volume":"12","author":"P Hoffmann","year":"2021","unstructured":"Hoffmann P, Lamerz D, Hill P, Kirchner M, Gauss A (2021) Gene polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in patients with Crohn\u2019s disease: on the way to personalized medicine? Genes (Basel) 12(6):866. https:\/\/doi.org\/10.3390\/GENES12060866","journal-title":"Genes (Basel)"},{"key":"5908_CR11","doi-asserted-by":"publisher","unstructured":"Sharp RC, Beg SA, Naser SA (2018) Polymorphisms in protein tyrosine phosphatase non-receptor type 2 and 22 (PTPN2\/22) are linked to hyper-proliferative T-cells and susceptibility to mycobacteria in rheumatoid arthritis. Front Cell Infect Microbiol 8:11. https:\/\/doi.org\/10.3389\/FCIMB.2018.00011","DOI":"10.3389\/FCIMB.2018.00011"},{"issue":"2","key":"5908_CR12","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3390\/GENES8020072","volume":"8","author":"J St\u00f8rling","year":"2017","unstructured":"St\u00f8rling J, Pociot F (2017) Type 1 diabetes candidate genes linked to pancreatic islet cell inflammation and beta-cell apoptosis. Genes (Basel) 8(2):72. https:\/\/doi.org\/10.3390\/GENES8020072","journal-title":"Genes (Basel)"},{"issue":"4","key":"5908_CR13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/S00251-010-0500-X","volume":"63","author":"L Espino-Paisan","year":"2011","unstructured":"Espino-Paisan L, de La Calle H, Fern\u00e1ndez-Arquero M et al (2011) A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes. Immunogenetics 63(4):255\u2013258. https:\/\/doi.org\/10.1007\/S00251-010-0500-X","journal-title":"Immunogenetics"},{"issue":"11","key":"5908_CR14","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1016\/J.NUMECD.2020.06.013","volume":"30","author":"L Miele","year":"2020","unstructured":"Miele L, Giorgio V, Liguori A et al (2020) Genetic susceptibility of increased intestinal permeability is associated with progressive liver disease and diabetes in patients with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 30(11):2103\u20132110. https:\/\/doi.org\/10.1016\/J.NUMECD.2020.06.013","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"1","key":"5908_CR15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/PEDI.12351","volume":"18","author":"JS Pierce","year":"2017","unstructured":"Pierce JS, Kozikowski C, Lee JM, Wysocki T (2017) Type 1 diabetes in very young children: a model of parent and child influences on management and outcomes. Pediatr Diabetes 18(1):17. https:\/\/doi.org\/10.1111\/PEDI.12351","journal-title":"Pediatr Diabetes"},{"issue":"7","key":"5908_CR16","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1007\/s00125-008-0999-7","volume":"51","author":"F Ortis","year":"2008","unstructured":"Ortis F, Pirot P, Naamane N et al (2008) Induction of nuclear factor-\u03baB and its downstream genes by TNF-\u03b1 and IL-1\u03b2 has a pro-apoptotic role in pancreatic beta cells. Diabetologia 51(7):1213\u20131225. https:\/\/doi.org\/10.1007\/s00125-008-0999-7","journal-title":"Diabetologia"},{"issue":"7","key":"5908_CR17","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/J.FEBSLET.2012.02.021","volume":"586","author":"F Ortis","year":"2012","unstructured":"Ortis F, Miani M, Colli ML et al (2012) Differential usage of NF-\u03baB activating signals by IL-1\u03b2 and TNF-\u03b1 in pancreatic beta cells. FEBS Lett 586(7):984\u2013989. https:\/\/doi.org\/10.1016\/J.FEBSLET.2012.02.021","journal-title":"FEBS Lett"},{"issue":"5","key":"5908_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/IJMS22052719","volume":"22","author":"DI Jang","year":"2021","unstructured":"Jang DI, Lee AH, Shin HY et al (2021) The role of tumor necrosis factor alpha (TNF-\u03b1) in autoimmune disease and current TNF-\u03b1 inhibitors in therapeutics. Int J Mol Sci 22(5):1\u201316. https:\/\/doi.org\/10.3390\/IJMS22052719","journal-title":"Int J Mol Sci"},{"issue":"6","key":"5908_CR19","doi-asserted-by":"publisher","first-page":"21082","DOI":"10.1136\/BMJOPEN-2017-021082","volume":"8","author":"K Kr\u00fcger","year":"2018","unstructured":"Kr\u00fcger K, Burmester GR, Wassenberg S, Bohl-B\u00fchler M, Thomas MH (2018) Effectiveness and safety of golimumab in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis under real-life clinical conditions: non-interventional GO-NICE study in Germany. BMJ Open 8(6):21082. https:\/\/doi.org\/10.1136\/BMJOPEN-2017-021082","journal-title":"BMJ Open"},{"issue":"21","key":"5908_CR20","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1056\/NEJMoa2006136","volume":"383","author":"T Quattrin","year":"2020","unstructured":"Quattrin T, Haller MJ, Steck AK et al (2020) Golimumab and beta-cell function in youth with new-onset type 1 diabetes. N Engl J Med 383(21):2007\u20132017. https:\/\/doi.org\/10.1056\/NEJMoa2006136","journal-title":"N Engl J Med"},{"key":"5908_CR21","doi-asserted-by":"publisher","first-page":"104118","DOI":"10.1016\/J.EBIOM.2022.104118","volume":"82","author":"P Achenbach","year":"2022","unstructured":"Achenbach P, Hippich M, Zapardiel-Gonzalo J et al (2022) A classification and regression tree analysis identifies subgroups of childhood type 1 diabetes. EBioMedicine 82:104118. https:\/\/doi.org\/10.1016\/J.EBIOM.2022.104118","journal-title":"EBioMedicine"},{"issue":"9","key":"5908_CR22","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1172\/JCI58447","volume":"121","author":"P Ravassard","year":"2011","unstructured":"Ravassard P, Hazhouz Y, Pechberty S et al (2011) A genetically engineered human pancreatic \u03b2 cell line exhibiting glucose-inducible insulin secretion. J Clin Invest 121(9):3589\u20133597. https:\/\/doi.org\/10.1172\/JCI58447","journal-title":"J Clin Invest"},{"issue":"10","key":"5908_CR23","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1007\/s00125-015-3669-6","volume":"58","author":"F Brozzi","year":"2015","unstructured":"Brozzi F, Nardelli TR, Lopes M et al (2015) Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms. Diabetologia 58(10):2307\u20132316. https:\/\/doi.org\/10.1007\/s00125-015-3669-6","journal-title":"Diabetologia"},{"issue":"4","key":"5908_CR24","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1007\/S00125-018-4546-X","volume":"61","author":"P Marchetti","year":"2018","unstructured":"Marchetti P, Suleiman M, Marselli L (2018) Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource. Diabetologia 61(4):770\u2013774. https:\/\/doi.org\/10.1007\/S00125-018-4546-X","journal-title":"Diabetologia"},{"key":"5908_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/ELIFE.06990","volume":"4","author":"L Marroqui","year":"2015","unstructured":"Marroqui L, Lopes M, dos Santos RS et al (2015) Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic \u03b1 and \u03b2 cells. Elife 4:1\u201323. https:\/\/doi.org\/10.7554\/ELIFE.06990","journal-title":"Elife"},{"issue":"1","key":"5908_CR26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/S13287-019-1523-3","volume":"11","author":"S Demine","year":"2020","unstructured":"Demine S, Schiavo AA, Mar\u00edn-Ca\u00f1as S, Marchetti P, Cnop M, Eizirik DL (2020) Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells. Stem Cell Res Ther 11(1):7. https:\/\/doi.org\/10.1186\/S13287-019-1523-3","journal-title":"Stem Cell Res Ther"},{"issue":"37","key":"5908_CR27","doi-asserted-by":"publisher","first-page":"eabn5732","DOI":"10.1126\/SCIADV.ABN5732","volume":"8","author":"F Szymczak","year":"2022","unstructured":"Szymczak F, Alvelos MI, Mar\u00edn-Ca\u00f1as S et al (2022) Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic \u03b2 cells. Sci Adv 8(37):eabn5732. https:\/\/doi.org\/10.1126\/SCIADV.ABN5732","journal-title":"Sci Adv"},{"issue":"1","key":"5908_CR28","doi-asserted-by":"publisher","first-page":"6363","DOI":"10.1038\/S41467-022-34069-Z","volume":"13","author":"V Chandra","year":"2022","unstructured":"Chandra V, Ibrahim H, Halliez C et al (2022) The type 1 diabetes gene TYK2 regulates \u03b2-cell development and its responses to interferon-\u03b1. Nat Commun 13(1):6363. https:\/\/doi.org\/10.1038\/S41467-022-34069-Z","journal-title":"Nat Commun"},{"issue":"3","key":"5908_CR29","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1530\/EJE-20-0636","volume":"184","author":"M Lytrivi","year":"2021","unstructured":"Lytrivi M, Sen\u00e9e V, Salpea P et al (2021) DNAJC3 deficiency induces \u03b2-cell mitochondrial apoptosis and causes syndromic young-onset diabetes. Eur J Endocrinol 184(3):455\u2013468. https:\/\/doi.org\/10.1530\/EJE-20-0636","journal-title":"Eur J Endocrinol"},{"issue":"19","key":"5908_CR30","doi-asserted-by":"publisher","first-page":"10302","DOI":"10.1093\/NAR\/GKY839","volume":"46","author":"C Cosentino","year":"2018","unstructured":"Cosentino C, Toivonen S, Villamil ED et al (2018) Pancreatic \u03b2-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes. Nucleic Acids Res 46(19):10302\u201310318. https:\/\/doi.org\/10.1093\/NAR\/GKY839","journal-title":"Nucleic Acids Res"},{"key":"5908_CR31","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.3389\/FCELL.2022.967765","volume":"10","author":"F Fantuzzi","year":"2022","unstructured":"Fantuzzi F, Toivonen S, Schiavo AA et al (2022) In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo. Front Cell Dev Biol 10:1537. https:\/\/doi.org\/10.3389\/FCELL.2022.967765","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"5908_CR32","doi-asserted-by":"publisher","first-page":"653","DOI":"10.2337\/DB21-0443","volume":"71","author":"B Elvira","year":"2022","unstructured":"Elvira B, Vandenbempt V, Bauz\u00e1-Martinez J et al (2022) PTPN2 regulates the interferon signaling and endoplasmic reticulum stress response in pancreatic \u03b2-cells in autoimmune diabetes. Diabetes 71(4):653\u2013668. https:\/\/doi.org\/10.2337\/DB21-0443","journal-title":"Diabetes"},{"issue":"8","key":"5908_CR33","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1210\/EN.2017-00104","volume":"158","author":"RS dos Santos","year":"2017","unstructured":"dos Santos RS, Marroqui L, Grieco FA et al (2017) Protective role of complement C3 against cytokine-mediated \u03b2-cell apoptosis. Endocrinology 158(8):2503. https:\/\/doi.org\/10.1210\/EN.2017-00104","journal-title":"Endocrinology"},{"issue":"7","key":"5908_CR34","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1172\/JCI118950","volume":"98","author":"A Hoorens","year":"1996","unstructured":"Hoorens A, van de Casteele M, Kl\u00f6ppel G, Pipeleers D (1996) Glucose promotes survival of rat pancreatic cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J Clin Invest 98(7):1568\u20131574. https:\/\/doi.org\/10.1172\/JCI118950","journal-title":"J Clin Invest"},{"issue":"4","key":"5908_CR35","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1006\/CYTO.1998.0426","volume":"11","author":"L Overbergh","year":"1999","unstructured":"Overbergh L, Valckx D, Waer M, Mathieu C (1999) Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine 11(4):305\u2013312. https:\/\/doi.org\/10.1006\/CYTO.1998.0426","journal-title":"Cytokine"},{"issue":"1","key":"5908_CR36","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0092-8674(03)00757-8","volume":"115","author":"Y Deng","year":"2003","unstructured":"Deng Y, Ren X, Yang L, Lin Y, Wu X (2003) A JNK-dependent pathway is required for TNF\u03b1-induced apoptosis. Cell 115(1):61\u201370. https:\/\/doi.org\/10.1016\/S0092-8674(03)00757-8","journal-title":"Cell"},{"issue":"C","key":"5908_CR37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/B978-0-12-385114-7.00004-0","volume":"490","author":"CM Oslowski","year":"2011","unstructured":"Oslowski CM, Urano F (2011) Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol 490(C):71. https:\/\/doi.org\/10.1016\/B978-0-12-385114-7.00004-0","journal-title":"Methods Enzymol"},{"issue":"7","key":"5908_CR38","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1016\/J.CELREP.2018.01.052","volume":"22","author":"MR Spalinger","year":"2018","unstructured":"Spalinger MR, Manzini R, Hering L et al (2018) PTPN2 regulates inflammasome activation and controls onset of intestinal inflammation and Colon Cancer. Cell Rep 22(7):1835. https:\/\/doi.org\/10.1016\/J.CELREP.2018.01.052","journal-title":"Cell Rep"},{"issue":"11","key":"5908_CR39","doi-asserted-by":"publisher","first-page":"945","DOI":"10.3390\/DIAGNOSTICS10110945","volume":"10","author":"CE Szabo","year":"2020","unstructured":"Szabo CE, Man OI, Istrate A et al (2020) Role of adiponectin and tumor necrosis factor-alpha in the pathogenesis and evolution of type 1 diabetes Mellitus in Children and Adolescents. Diagnostics (Basel) 10(11):945. https:\/\/doi.org\/10.3390\/DIAGNOSTICS10110945","journal-title":"Diagnostics (Basel)"},{"issue":"17","key":"5908_CR40","doi-asserted-by":"publisher","first-page":"10025","DOI":"10.3390\/IJMS231710025","volume":"23","author":"J Song","year":"2022","unstructured":"Song J, Lan J, Tang J, Luo N (2022) PTPN2 in the immunity and tumor immunotherapy: a concise review. Int J Mol Sci 23(17):10025. https:\/\/doi.org\/10.3390\/IJMS231710025","journal-title":"Int J Mol Sci"},{"issue":"2","key":"5908_CR41","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3892\/BR.2012.42","volume":"1","author":"X Ma","year":"2013","unstructured":"Ma X, Xu S (2013) TNF inhibitor therapy for rheumatoid arthritis. Biomed Rep 1(2):177. https:\/\/doi.org\/10.3892\/BR.2012.42","journal-title":"Biomed Rep"},{"issue":"8","key":"5908_CR42","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.3390\/IJMS19082244","volume":"19","author":"SO Adegbola","year":"2018","unstructured":"Adegbola SO, Sahnan K, Warusavitarne J, Hart A, Tozer P (2018) Anti-TNF therapy in Crohn\u2019s disease. Int J Mol Sci 19(8):2244. https:\/\/doi.org\/10.3390\/IJMS19082244","journal-title":"Int J Mol Sci"},{"issue":"5","key":"5908_CR43","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1053\/J.GASTRO.2020.07.040","volume":"159","author":"M Parlato","year":"2020","unstructured":"Parlato M, Nian Q, Charbit-Henrion F et al (2020) Loss-of-function mutation in PTPN2 causes aberrant activation of JAK signaling via STAT and very early onset intestinal inflammation. Gastroenterology 159(5):1968\u20131971.e4. https:\/\/doi.org\/10.1053\/J.GASTRO.2020.07.040","journal-title":"Gastroenterology"},{"issue":"8","key":"5908_CR44","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.3390\/CELLS9081802","volume":"9","author":"R Nakano","year":"2020","unstructured":"Nakano R, Nakayama T, Sugiya H (2020) Biological properties of JNK3 and its function in neurons, astrocytes, pancreatic \u03b2-cells and cardiovascular cells. Cells 9(8):1802. https:\/\/doi.org\/10.3390\/CELLS9081802","journal-title":"Cells"},{"issue":"5","key":"5908_CR45","doi-asserted-by":"publisher","first-page":"e35997","DOI":"10.1371\/JOURNAL.PONE.0035997","volume":"7","author":"S Abdelli","year":"2012","unstructured":"Abdelli S, Bonny C (2012) JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling. PLoS One 7(5):e35997. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0035997","journal-title":"PLoS One"},{"issue":"9","key":"5908_CR46","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1007\/S00125-009-1431-7","volume":"52","author":"S Abdelli","year":"2009","unstructured":"Abdelli S, Puyal J, Bielmann C et al (2009) JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis. Diabetologia 52(9):1871\u20131880. https:\/\/doi.org\/10.1007\/S00125-009-1431-7","journal-title":"Diabetologia"},{"key":"5908_CR47","doi-asserted-by":"publisher","first-page":"814854","DOI":"10.1155\/2014\/814854","volume":"2014","author":"H Ezanno","year":"2014","unstructured":"Ezanno H, Pawlowski V, Abdelli S et al (2014) JNK3 is required for the cytoprotective effect of exendin 4. J Diabetes Res 2014:814854. https:\/\/doi.org\/10.1155\/2014\/814854","journal-title":"J Diabetes Res"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-023-05908-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00125-023-05908-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-023-05908-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T20:02:12Z","timestamp":1711656132000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00125-023-05908-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,29]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["5908"],"URL":"https:\/\/doi.org\/10.1007\/s00125-023-05908-5","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,29]]},"assertion":[{"value":"7 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}