{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:35:43Z","timestamp":1780634143631,"version":"3.54.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T00:00:00Z","timestamp":1686355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T00:00:00Z","timestamp":1686355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070812"],"award-info":[{"award-number":["82070812"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and technology innovation Program of Hunan Province","award":["2020RC4044"],"award-info":[{"award-number":["2020RC4044"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s00125-023-05938-z","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T05:01:37Z","timestamp":1686373297000},"page":"1532-1543","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Recovery of intracellular glucose uptake in T cells during partial remission of type 1 diabetes"],"prefix":"10.1007","volume":"66","author":[{"given":"Rong","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-7983","authenticated-orcid":false,"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,10]]},"reference":[{"issue":"3","key":"5938_CR1","doi-asserted-by":"publisher","first-page":"Itc33","DOI":"10.7326\/aitc202203150","volume":"175","author":"FZ Syed","year":"2022","unstructured":"Syed FZ (2022) Type 1 diabetes mellitus. Ann Intern Med 175(3):Itc33-itc48. https:\/\/doi.org\/10.7326\/aitc202203150","journal-title":"Ann Intern Med"},{"issue":"2","key":"5938_CR2","doi-asserted-by":"publisher","first-page":"e3207","DOI":"10.1002\/dmrr.3207","volume":"36","author":"T Zhong","year":"2020","unstructured":"Zhong T, Tang R, Gong S, Li J, Li X, Zhou Z (2020) The remission phase in type 1 diabetes: changing epidemiology, definitions, and emerging immuno-metabolic mechanisms. Diabetes Metab Res Rev 36(2):e3207. https:\/\/doi.org\/10.1002\/dmrr.3207","journal-title":"Diabetes Metab Res Rev"},{"issue":"4","key":"5938_CR3","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/MED.0b013e32832e0693","volume":"16","author":"H Aly","year":"2009","unstructured":"Aly H, Gottlieb P (2009) The honeymoon phase: intersection of metabolism and immunology. Curr Opin Endocrinol Diabetes Obes 16(4):286\u2013292. https:\/\/doi.org\/10.1097\/MED.0b013e32832e0693","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"5","key":"5938_CR4","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1159\/000479030","volume":"88","author":"M Fonolleda","year":"2017","unstructured":"Fonolleda M, Murillo M, V\u00e1zquez F, Bel J, Vives-Pi M (2017) Remission phase in paediatric type 1 diabetes: new understanding and emerging biomarkers. Horm Res Paediatr 88(5):307\u2013315. https:\/\/doi.org\/10.1159\/000479030","journal-title":"Horm Res Paediatr"},{"key":"5938_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.trsl.2019.03.002","volume":"210","author":"A Villalba","year":"2019","unstructured":"Villalba A, Fonolleda M, Murillo M et al (2019) Partial remission and early stages of pediatric type 1 diabetes display immunoregulatory changes. A pilot study. Transl Res 210:8\u201325. https:\/\/doi.org\/10.1016\/j.trsl.2019.03.002","journal-title":"Transl Res"},{"key":"5938_CR6","doi-asserted-by":"publisher","first-page":"824","DOI":"10.3389\/fendo.2019.00824","volume":"10","author":"R Tang","year":"2019","unstructured":"Tang R, Zhong T, Wu C, Zhou Z, Li X (2019) The remission phase in type 1 diabetes: role of hyperglycemia rectification in immune modulation. Front Endocrinol (Lausanne) 10:824. https:\/\/doi.org\/10.3389\/fendo.2019.00824","journal-title":"Front Endocrinol (Lausanne)"},{"key":"5938_CR7","doi-asserted-by":"publisher","first-page":"611522","DOI":"10.3389\/fimmu.2020.611522","volume":"11","author":"L Gomez-Mu\u00f1oz","year":"2020","unstructured":"Gomez-Mu\u00f1oz L, Perna-Barrull D, Villalba A et al (2020) NK cell subsets changes in partial remission and early stages of pediatric type 1 diabetes. Front Immunol 11:611522. https:\/\/doi.org\/10.3389\/fimmu.2020.611522","journal-title":"Front Immunol"},{"issue":"6","key":"5938_CR8","doi-asserted-by":"publisher","first-page":"dgaa130","DOI":"10.1210\/clinem\/dgaa130","volume":"105","author":"X Li","year":"2020","unstructured":"Li X, Zhong T, Tang R et al (2020) PD-1 and PD-L1 expression in peripheral CD4\/CD8+ T cells is restored in the partial remission phase in type 1 diabetes. J Clin Endocrinol Metab 105(6):dgaa130. https:\/\/doi.org\/10.1210\/clinem\/dgaa130","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"5938_CR9","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/s41423-021-00792-8","volume":"19","author":"JM Marchingo","year":"2022","unstructured":"Marchingo JM, Cantrell DA (2022) Protein synthesis, degradation, and energy metabolism in T cell immunity. Cell Mol Immunol 19(3):303\u2013315. https:\/\/doi.org\/10.1038\/s41423-021-00792-8","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"5938_CR10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.immuni.2020.09.014","volume":"54","author":"C Diskin","year":"2021","unstructured":"Diskin C, Ryan TAJ, O\u2019Neill LAJ (2021) Modification of proteins by metabolites in immunity. Immunity 54(1):19\u201331. https:\/\/doi.org\/10.1016\/j.immuni.2020.09.014","journal-title":"Immunity"},{"issue":"1","key":"5938_CR11","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2021.12.012","volume":"55","author":"NM Chapman","year":"2022","unstructured":"Chapman NM, Chi H (2022) Metabolic adaptation of lymphocytes in immunity and disease. Immunity 55(1):14\u201330. https:\/\/doi.org\/10.1016\/j.immuni.2021.12.012","journal-title":"Immunity"},{"issue":"3","key":"5938_CR12","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.cmet.2022.02.003","volume":"34","author":"SH M\u00f8ller","year":"2022","unstructured":"M\u00f8ller SH, Hsueh PC, Yu YR, Zhang L, Ho PC (2022) Metabolic programs tailor T cell immunity in viral infection, cancer, and aging. Cell Metab 34(3):378\u2013395. https:\/\/doi.org\/10.1016\/j.cmet.2022.02.003","journal-title":"Cell Metab"},{"key":"5938_CR13","doi-asserted-by":"publisher","first-page":"652771","DOI":"10.3389\/fimmu.2021.652771","volume":"12","author":"J Qiu","year":"2021","unstructured":"Qiu J, Wu B, Goodman SB, Berry GJ, Goronzy JJ, Weyand CM (2021) Metabolic control of autoimmunity and tissue inflammation in rheumatoid arthritis. Front Immunol 12:652771. https:\/\/doi.org\/10.3389\/fimmu.2021.652771","journal-title":"Front Immunol"},{"issue":"6","key":"5938_CR14","doi-asserted-by":"publisher","first-page":"575","DOI":"10.3390\/cells8060575","volume":"8","author":"M Kunkl","year":"2019","unstructured":"Kunkl M, Sambucci M, Ruggieri S et al (2019) CD28 autonomous signaling up-regulates C-myc expression and promotes glycolysis enabling inflammatory T cell responses in multiple sclerosis. Cells 8(6):575. https:\/\/doi.org\/10.3390\/cells8060575","journal-title":"Cells"},{"issue":"2 Pt C","key":"5938_CR15","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.molimm.2015.07.035","volume":"68","author":"M Galgani","year":"2015","unstructured":"Galgani M, De Rosa V, Matarese G (2015) T cell metabolism and susceptibility to autoimmune diseases. Mol Immunol 68(2 Pt C):558\u2013563. https:\/\/doi.org\/10.1016\/j.molimm.2015.07.035","journal-title":"Mol Immunol"},{"key":"5938_CR16","doi-asserted-by":"publisher","first-page":"914136","DOI":"10.3389\/fendo.2022.914136","volume":"13","author":"M Zhang","year":"2022","unstructured":"Zhang M, Zhou Y, Xie Z et al (2022) New developments in T cell immunometabolism and therapeutic implications for type 1 diabetes. Front Endocrinol (Lausanne) 13:914136. https:\/\/doi.org\/10.3389\/fendo.2022.914136","journal-title":"Front Endocrinol (Lausanne)"},{"key":"5938_CR17","doi-asserted-by":"publisher","first-page":"897047","DOI":"10.3389\/fimmu.2022.897047","volume":"13","author":"R Tang","year":"2022","unstructured":"Tang R, Zhong T, Fan L, Xie Y, Li J, Li X (2022) Enhanced T cell glucose uptake is associated with progression of beta-cell function in type 1 diabetes. Front Immunol 13:897047. https:\/\/doi.org\/10.3389\/fimmu.2022.897047","journal-title":"Front Immunol"},{"issue":"4","key":"5938_CR18","doi-asserted-by":"publisher","first-page":"109447","DOI":"10.1016\/j.celrep.2021.109447","volume":"36","author":"BS Kong","year":"2021","unstructured":"Kong BS, Min SH, Lee C, Cho YM (2021) Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes. Cell Rep 36(4):109447. https:\/\/doi.org\/10.1016\/j.celrep.2021.109447","journal-title":"Cell Rep"},{"issue":"5","key":"5938_CR19","doi-asserted-by":"publisher","first-page":"936","DOI":"10.2337\/db17-1390","volume":"67","author":"D Vignali","year":"2018","unstructured":"Vignali D, Cantarelli E, Bordignon C et al (2018) Detection and characterization of CD8(+) autoreactive memory stem T cells in patients with type 1 diabetes. Diabetes 67(5):936\u2013945. https:\/\/doi.org\/10.2337\/db17-1390","journal-title":"Diabetes"},{"issue":"7","key":"5938_CR20","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/(sici)1096-9136(199807)15:7<539::Aid-dia668>3.0.Co;2-s","volume":"15","author":"KG Alberti","year":"1998","unstructured":"Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15(7):539\u2013553. https:\/\/doi.org\/10.1002\/(sici)1096-9136(199807)15:7%3c539::Aid-dia668%3e3.0.Co;2-s","journal-title":"Diabet Med"},{"issue":"10","key":"5938_CR21","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1111\/1753-0407.13044","volume":"12","author":"T Zhong","year":"2020","unstructured":"Zhong T, Tang R, Xie Y, Liu F, Li X, Zhou Z (2020) Frequency, clinical characteristics, and determinants of partial remission in type 1 diabetes: different patterns in children and adults. J Diabetes 12(10):761\u2013768. https:\/\/doi.org\/10.1111\/1753-0407.13044","journal-title":"J Diabetes"},{"issue":"8","key":"5938_CR22","doi-asserted-by":"publisher","first-page":"e3461","DOI":"10.1002\/dmrr.3461","volume":"37","author":"M Shi","year":"2021","unstructured":"Shi M, Xie Y, Tang R, Zhong T, Zhou Z, Li X (2021) Three-phasic pattern of C-peptide decline in type 1 diabetes patients with partial remission. Diabetes Metab Res Rev 37(8):e3461. https:\/\/doi.org\/10.1002\/dmrr.3461","journal-title":"Diabetes Metab Res Rev"},{"issue":"4","key":"5938_CR23","doi-asserted-by":"publisher","first-page":"577","DOI":"10.2337\/dc16-1774","volume":"40","author":"X Li","year":"2017","unstructured":"Li X, Campbell-Thompson M, Wasserfall CH et al (2017) Serum trypsinogen levels in type 1 diabetes. Diabetes Care 40(4):577\u2013582. https:\/\/doi.org\/10.2337\/dc16-1774","journal-title":"Diabetes Care"},{"issue":"6","key":"5938_CR24","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/dmrr.2779","volume":"32","author":"G Huang","year":"2016","unstructured":"Huang G, Yin M, Xiang Y et al (2016) Persistence of glutamic acid decarboxylase antibody (GADA) is associated with clinical characteristics of latent autoimmune diabetes in adults: a prospective study with 3-year follow-up. Diabetes Metab Res Rev 32(6):615\u2013622. https:\/\/doi.org\/10.1002\/dmrr.2779","journal-title":"Diabetes Metab Res Rev"},{"issue":"3","key":"5938_CR25","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00125-018-4799-4","volume":"62","author":"X Shi","year":"2019","unstructured":"Shi X, Huang G, Wang Y et al (2019) Tetraspanin 7 autoantibodies predict progressive decline of beta cell function in individuals with LADA. Diabetologia 62(3):399\u2013407. https:\/\/doi.org\/10.1007\/s00125-018-4799-4","journal-title":"Diabetologia"},{"issue":"4","key":"5938_CR26","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1111\/dom.13595","volume":"21","author":"Y Xiang","year":"2019","unstructured":"Xiang Y, Huang G, Zhu Y et al (2019) Identification of autoimmune type 1 diabetes and multiple organ-specific autoantibodies in adult-onset non-insulin-requiring diabetes in China: a population-based multicentre nationwide survey. Diabetes Obes Metab 21(4):893\u2013902. https:\/\/doi.org\/10.1111\/dom.13595","journal-title":"Diabetes Obes Metab"},{"issue":"7851","key":"5938_CR27","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/s41586-020-03045-2","volume":"591","author":"MJ Watson","year":"2021","unstructured":"Watson MJ, Vignali PDA, Mullett SJ et al (2021) Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. Nature 591(7851):645\u2013651. https:\/\/doi.org\/10.1038\/s41586-020-03045-2","journal-title":"Nature"},{"issue":"5","key":"5938_CR28","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1002\/art.40785","volume":"71","author":"T Koga","year":"2019","unstructured":"Koga T, Sato T, Furukawa K et al (2019) Promotion of calcium\/calmodulin-dependent protein kinase 4 by GLUT1-dependent glycolysis in systemic lupus erythematosus. Arthritis Rheumatol 71(5):766\u2013772. https:\/\/doi.org\/10.1002\/art.40785","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"5938_CR29","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/cei.13344","volume":"197","author":"EYM Lau","year":"2019","unstructured":"Lau EYM, Carroll EC, Callender LA et al (2019) Type 2 diabetes is associated with the accumulation of senescent T cells. Clin Exp Immunol 197(2):205\u2013213. https:\/\/doi.org\/10.1111\/cei.13344","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"5938_CR30","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/s2213-8587(18)30112-8","volume":"7","author":"MA Atkinson","year":"2019","unstructured":"Atkinson MA, Roep BO, Posgai A, Wheeler DCS, Peakman M (2019) The challenge of modulating \u03b2-cell autoimmunity in type 1 diabetes. Lancet Diabetes Endocrinol 7(1):52\u201364. https:\/\/doi.org\/10.1016\/s2213-8587(18)30112-8","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"6554","key":"5938_CR31","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1126\/science.abh1654","volume":"373","author":"JA Bluestone","year":"2021","unstructured":"Bluestone JA, Buckner JH, Herold KC (2021) Immunotherapy: building a bridge to a cure for type 1 diabetes. Science 373(6554):510\u2013516. https:\/\/doi.org\/10.1126\/science.abh1654","journal-title":"Science"},{"issue":"21","key":"5938_CR32","doi-asserted-by":"publisher","first-page":"11230","DOI":"10.1074\/jbc.M115.713362","volume":"291","author":"JW Garyu","year":"2016","unstructured":"Garyu JW, Uduman M, Stewart A et al (2016) Characterization of diabetogenic CD8+ T cells: immune therapy with metabolic blockade. J Biol Chem 291(21):11230\u201311240. https:\/\/doi.org\/10.1074\/jbc.M115.713362","journal-title":"J Biol Chem"},{"key":"5938_CR33","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1146\/annurev-immunol-042617-053019","volume":"36","author":"RIK Geltink","year":"2018","unstructured":"Geltink RIK, Kyle RL, Pearce EL (2018) Unraveling the complex interplay between T cell metabolism and function. Annu Rev Immunol 36:461\u2013488. https:\/\/doi.org\/10.1146\/annurev-immunol-042617-053019","journal-title":"Annu Rev Immunol"},{"issue":"9","key":"5938_CR34","doi-asserted-by":"publisher","first-page":"e0183887","DOI":"10.1371\/journal.pone.0183887","volume":"12","author":"HM Granados","year":"2017","unstructured":"Granados HM, Draghi A 2nd, Tsurutani N et al (2017) Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes. PLoS One 12(9):e0183887. https:\/\/doi.org\/10.1371\/journal.pone.0183887","journal-title":"PLoS One"},{"issue":"7","key":"5938_CR35","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.2337\/dc18-0465","volume":"41","author":"BM Shields","year":"2018","unstructured":"Shields BM, McDonald TJ, Oram R et al (2018) C-peptide decline in type 1 diabetes has two phases: an initial exponential fall and a subsequent stable phase. Diabetes Care 41(7):1486\u20131492. https:\/\/doi.org\/10.2337\/dc18-0465","journal-title":"Diabetes Care"},{"issue":"8","key":"5938_CR36","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.2337\/db11-1538","volume":"61","author":"CJ Greenbaum","year":"2012","unstructured":"Greenbaum CJ, Beam CA, Boulware D et al (2012) Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite type 1 diabetes TrialNet data. Diabetes 61(8):2066\u20132073. https:\/\/doi.org\/10.2337\/db11-1538","journal-title":"Diabetes"},{"key":"5938_CR37","doi-asserted-by":"publisher","first-page":"669456","DOI":"10.3389\/fimmu.2021.669456","volume":"12","author":"CP Martins","year":"2021","unstructured":"Martins CP, New LA, O\u2019Connor EC et al (2021) Glycolysis inhibition induces functional and metabolic exhaustion of CD4(+) T cells in type 1 diabetes. Front Immunol 12:669456. https:\/\/doi.org\/10.3389\/fimmu.2021.669456","journal-title":"Front Immunol"},{"issue":"4","key":"5938_CR38","doi-asserted-by":"publisher","first-page":"e0175549","DOI":"10.1371\/journal.pone.0175549","volume":"12","author":"DM Previte","year":"2017","unstructured":"Previte DM, O\u2019Connor EC, Novak EA, Martins CP, Mollen KP, Piganelli JD (2017) Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation. PLoS One 12(4):e0175549. https:\/\/doi.org\/10.1371\/journal.pone.0175549","journal-title":"PLoS One"},{"issue":"2","key":"5938_CR39","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.taap.2014.12.016","volume":"284","author":"YS Lee","year":"2015","unstructured":"Lee YS, Kim D, Lee EK, Kim S, Choi CS, Jun HS (2015) Sodium meta-arsenite prevents the development of autoimmune diabetes in NOD mice. Toxicol Appl Pharmacol 284(2):254\u2013261. https:\/\/doi.org\/10.1016\/j.taap.2014.12.016","journal-title":"Toxicol Appl Pharmacol"},{"key":"5938_CR40","doi-asserted-by":"publisher","first-page":"6692","DOI":"10.1038\/ncomms7692","volume":"6","author":"N Patsoukis","year":"2015","unstructured":"Patsoukis N, Bardhan K, Chatterjee P et al (2015) PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat Commun 6:6692. https:\/\/doi.org\/10.1038\/ncomms7692","journal-title":"Nat Commun"},{"issue":"1","key":"5938_CR41","doi-asserted-by":"publisher","first-page":"e20182232","DOI":"10.1084\/jem.20182232","volume":"218","author":"CL Tan","year":"2021","unstructured":"Tan CL, Kuchroo JR, Sage PT et al (2021) PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance. J Exp Med 218(1):e20182232. https:\/\/doi.org\/10.1084\/jem.20182232","journal-title":"J Exp Med"},{"issue":"5","key":"5938_CR42","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s00125-020-05107-6","volume":"63","author":"P Sen","year":"2020","unstructured":"Sen P, Dickens AM, L\u00f3pez-Basc\u00f3n MA et al (2020) Metabolic alterations in immune cells associate with progression to type 1 diabetes. Diabetologia 63(5):1017\u20131031. https:\/\/doi.org\/10.1007\/s00125-020-05107-6","journal-title":"Diabetologia"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-023-05938-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00125-023-05938-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-023-05938-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:01:42Z","timestamp":1717977702000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00125-023-05938-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,10]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["5938"],"URL":"https:\/\/doi.org\/10.1007\/s00125-023-05938-z","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,10]]},"assertion":[{"value":"10 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"We thank all participants of the study. The authors would like to express gratitude to Professor Xilin Yang (Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China) for his assistance with statistical analysis, and Professor R. David Leslie (Department of Diabetes and Metabolic Medicine, Blizard Institute, London, UK) for his generous help with language editing, which greatly contributed to the clarity and precision of this manuscript.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Acknowledgements"}},{"value":"The original contributions presented in the study are included in the article\/supplementary material. Further inquiries can be directed to the corresponding author.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"This work was supported by National Natural Science Foundation of China (Grant No. 82070812), the science and technology innovation Program of Hunan Province (2020RC4044). The funder was not involved in the design of the study; the collection, analysis and interpretation of data; writing the report; and did not impose any restrictions regarding the publication of the report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 relationships and activities"}},{"value":"XLi, RT and TZ designed the study, analysed and interpreted data, and drafted and revised the manuscript. RT, KL and XLin conducted the experiments, acquired and analysed data, discussed the results and revised the manuscript. All authors have reviewed and approved the final version. XLi is the guarantor of this work.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}