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Associations of daily walking, stair climbing, running, standing and sitting time with a composite cardiometabolic health score (based on standardised <jats:italic>z<\/jats:italic> scores) and individual cardiometabolic markers (BMI, waist circumference, triglycerides, HDL-cholesterol, HbA<jats:sub>1c<\/jats:sub> and total cholesterol) were examined cross-sectionally using generalised linear modelling and cubic splines.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We observed more favourable composite cardiometabolic health (i.e. <jats:italic>z<\/jats:italic> score &lt;0) with approximately 64 min\/day walking (<jats:italic>z<\/jats:italic> score [95% CI] \u22120.14 [\u22120.25, \u22120.02]) and 5 min\/day stair climbing (\u22120.14 [\u22120.24, \u22120.03]). We observed an equivalent magnitude of association at 2.6 h\/day standing. Any amount of running was associated with better composite cardiometabolic health. We did not observe an upper limit to the magnitude of the dose\u2013response associations for any activity type or standing. There was an inverse dose\u2013response association between sitting time and composite cardiometabolic health that became markedly less favourable when daily durations exceeded 12.1 h\/day. Associations for sitting time were no longer significant after excluding participants with prevalent CVD or medication use. The dose\u2013response pattern was generally consistent between activity and posture types and individual cardiometabolic health markers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions\/interpretation<\/jats:title>\n                <jats:p>In this first activity type-specific analysis of device-based physical activity, ~64 min\/day of walking and ~5.0 min\/day of stair climbing were associated with a favourable cardiometabolic risk profile. The deleterious associations of sitting time were fully attenuated after exclusion of participants with prevalent CVD and medication use. Our findings on cardiometabolic health and durations of different activities of daily living and posture may guide future interventions involving lifestyle modification.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00125-024-06090-y","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T20:33:49Z","timestamp":1710362029000},"page":"1051-1065","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Relationship of device measured physical activity type and posture with cardiometabolic health markers: pooled dose\u2013response associations from the Prospective Physical Activity, Sitting and Sleep Consortium"],"prefix":"10.1007","volume":"67","author":[{"given":"Matthew N.","family":"Ahmadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna M.","family":"Blodgett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Atkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Wen","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"del Pozo Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Suorsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmee A.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Pulsford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregore I.","family":"Mielke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasan","family":"Hettiarachchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick H. 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Obesity 28(8):1536\u20131549. https:\/\/doi.org\/10.1002\/oby.22857","journal-title":"Obesity"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-024-06090-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00125-024-06090-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-024-06090-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T11:03:39Z","timestamp":1714388619000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00125-024-06090-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,13]]},"references-count":86,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["6090"],"URL":"https:\/\/doi.org\/10.1007\/s00125-024-06090-y","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,13]]},"assertion":[{"value":"24 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The data on which this research is based were drawn from six observational studies. The research included data from the Australian Longitudinal Study on Women\u2019s Health (ALSWH) from the University of Newcastle, Australia, and the University of Queensland, Australia. We are grateful to the Australian Government Department of Health for funding and to the women who provided the survey data. We thank the following ProPASS collaborators for their contributions to the manuscript: C. Stehouwer, H. Savelberg, B. de Galan, C. van de Kallen (all Department of Internal Medicine, Maastricht University Medical Centre, the Netherlands) and T. M. H. Eijsvogels (Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands; Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, UK).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Acknowledgements"}},{"value":"All data requests will need to provide a methodologically sound justification and will require approval from the ProPASS Consortium.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"This study was funded by the British Heart Foundation (SP\/F\/20\/150002). The establishment of the ProPASS Consortium was supported by an unrestricted 2018-20 grant from PAL Technologies (Glasgow, UK). Several aspects of the ProPASS Consortium methods used in this paper were funded by a National Health and Medical Research Council Ideas Grant (APP1194510). The Charles Perkins Centre (University of Sydney, Australia) and the National Research Centre for the Working Environment (Copenhagen, Denmark) co-funded the technical proof-of-concept study of the ProPASS Consortium that enabled pooling of data from different brands of wearables. MH is supported through the NIHR University College London Hospitals Biomedical Research Centre (NIHR203328). ES is funded by a National Health and Medical Research Council Investigator Grant (APP1194510). BdPC is supported by the Government of Andalusia, Research Talent Recruitment Programme (EMERGIA 2020\/00158). GIM is supported by a National Health and Medical Research Council Investigator Grant (APP2008702). GDM is supported by a National Health and Medical Research Council Principal Research Fellowship (APP1121844). FIREA is supported by the Academy of Finland (286294, 294154, 319246, 332030), Ministry of Education and Culture, Juho Vainio Foundation and Finnish State Grants for Clinical Research. ActiPASS development was partly funded by FORTE, the Swedish Research Council for Health, Working Life and Welfare (2021\u201301561). ALSWH is funded by the Australian Government Department of Health and Aged Care, and its substudy, from which accelerometry and clinical data were obtained, was funded by a National Health and Medical Research Council Project Grant (APP1129592). MNA is supported by the National Heart Foundation (APP107158)","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 relationships and activities"}},{"value":"MNA, JMB, MH, ES, LBS, AH, AK and VR were responsible for the concept and design of the study. All authors performed the acquisition, analysis, and\/or interpretation of data and drafted and revised the manuscript for important intellectual content. All authors approved the final version of the manuscript to be published. MNA, MH and ES are the guarantors of this work.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}}]}}