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Jiang of the Third Military Medical University, China, for his help in the experiments. We also thank all the participants who made this research possible.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Acknowledgements"}},{"value":"RNA-seq data have been deposited in the GSA human database (\n                      \n                      ) under accession number HRA003649.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"This study was supported by the National Natural Science Foundation of China (grant numbers 81570694 and 82000417) and the Natural Science Foundation of Shandong (grant number ZR2014HL029).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"MQG, FW (Fei Wang), YJD, FW (Fang Wang), LLX, YC, RL, YGW and SFL are current employees at the Affiliated Hospital of Qingdao University, China. The other authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 relationships and activities"}},{"value":"SFL, YGW and JZ were responsible for study conception and design. JNC, CW, YJD, FW (Fei Wang), FW (Fang Wang), LZ, HG, JJZ, RL and SKL were responsible for data acquisition and analysis. MQG, LLX and YC performed the data interpretation. MQG, LLX, YC and FW (Fei Wang) drafted the article. SFL, YGW, JZ, JNC, CW, YJD, FW (Fang Wang), LZ, HG, JJZ, RL and SKL critically reviewed the article. All authors approved the final version of this manuscript to be published. SFL is responsible for the integrity of the work as a whole.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}