{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:43:48Z","timestamp":1792165428598,"version":"4.4.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"US Public Health Service","award":["R01 DK97830"],"award-info":[{"award-number":["R01 DK97830"]}]},{"name":"CF-Trust","award":["SRC-CFRD 019"],"award-info":[{"award-number":["SRC-CFRD 019"]}]},{"name":"National Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Aims\/hypothesis<\/jats:title>\n                <jats:p>The aim of this study was to investigate insulin secretion, insulin sensitivity, disposition index and insulin clearance by glucose tolerance status in individuals with cystic fibrosis (CF) and exocrine pancreatic insufficiency.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In a cross-sectional study, we conducted an extended (ten samples) OGTT in individuals with pancreatic-insufficient CF (PI-CF). Participants were divided into normal glucose tolerance (NGT), early glucose intolerance (EGI), impaired glucose tolerance (IGT) and CF-related diabetes (CFRD) groups. We used three different oral minimal models to assess insulin secretion, insulin sensitivity and insulin clearance during the OGTT. We evaluated insulin secretion using total secretion (\u03a6 total), first-phase secretion (\u03a6 dynamic) and second-phase secretion (\u03a6 static) from the model, and we estimated the disposition index by multiplying \u03a6 total and insulin sensitivity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among 61 participants (NGT 21%, EGI 33%, IGT 16%, CFRD 30%), insulin secretion indices (\u03a6 total, dynamic and static) were significantly lower in the CFRD group compared with the other groups. Insulin sensitivity declined with worsening in glucose tolerance (<jats:italic>p<\/jats:italic> value for trend &lt;0.001) and the disposition index declined between NGT and EGI and between IGT and CFRD. Those with CFRD had elevated insulin clearance compared with NGT (<jats:italic>p<\/jats:italic>=0.019) and low insulin secretion (\u03a6 total) was also associated with high insulin clearance (<jats:italic>p<\/jats:italic>&lt;0.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions\/interpretation<\/jats:title>\n                <jats:p>In individuals with PI-CF, disposition index declined with incremental impairment in glucose tolerance due to a reduction in both insulin secretion and insulin sensitivity. Moreover in CF, reduced insulin secretion was associated with higher insulin clearance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00125-024-06220-6","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T15:03:31Z","timestamp":1722611011000},"page":"2188-2198","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Insulin sensitivity, disposition index and insulin clearance in cystic fibrosis: a cross-sectional study"],"prefix":"10.1007","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-5262","authenticated-orcid":false,"given":"Bibi U.","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2398-3575","authenticated-orcid":false,"given":"Inger H. M.","family":"Mathiesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke","family":"Krogh-Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terese L.","family":"Katzenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tacjana","family":"Pressler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2893-3211","authenticated-orcid":false,"given":"James A. M.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9253-838X","authenticated-orcid":false,"given":"Michael R.","family":"Rickels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Almdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8561-0155","authenticated-orcid":false,"given":"Daniel","family":"Faurholt-Jepsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darko","family":"Stefanovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"issue":"5","key":"6220_CR1","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.jpeds.2004.12.039","volume":"146","author":"BC Marshall","year":"2005","unstructured":"Marshall BC, Butler SM, Stoddard M et al (2005) Epidemiology of cystic fibrosis-related diabetes. J Pediatr 146(5):681\u2013687. https:\/\/doi.org\/10.1016\/j.jpeds.2004.12.039","journal-title":"J Pediatr"},{"issue":"8","key":"6220_CR2","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1111\/j.1651-2227.1994.tb13156.x","volume":"83","author":"S Lanng","year":"1994","unstructured":"Lanng S, Thorsteinsson B, Nerup J, Koch C (1994) Diabetes mellitus in cystic fibrosis: Effect of insulin therapy on lung function and infections. Acta Paediatr Int J Paediatr 83(8):849\u2013853. https:\/\/doi.org\/10.1111\/j.1651-2227.1994.tb13156.x","journal-title":"Acta Paediatr Int J Paediatr"},{"issue":"1","key":"6220_CR3","doi-asserted-by":"publisher","first-page":"R35","DOI":"10.1530\/JOE-18-0468","volume":"241","author":"AW Norris","year":"2019","unstructured":"Norris AW, Ode KL, Merjaneh L et al (2019) Survival in a bad neighborhood: Pancreatic islets in cystic fibrosis. J Endocrinol 241(1):R35\u2013R50. https:\/\/doi.org\/10.1530\/JOE-18-0468","journal-title":"J Endocrinol"},{"issue":"7","key":"6220_CR4","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1111\/pedi.12700","volume":"19","author":"SC Nyirjesy","year":"2018","unstructured":"Nyirjesy SC, Sheikh S, Hadjiliadis D et al (2018) \u03b2-Cell secretory defects are present in pancreatic insufficient cystic fibrosis with 1-hour oral glucose tolerance test glucose \u2265155 mg\/dL. Pediatr Diabetes 19(7):1173\u20131182. https:\/\/doi.org\/10.1111\/pedi.12700","journal-title":"Pediatr Diabetes"},{"issue":"1","key":"6220_CR5","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1530\/EJE-10-1003","volume":"165","author":"A Battezzati","year":"2011","unstructured":"Battezzati A, Mari A, Zazzeron L et al (2011) Identification of insulin secretory defects and insulin resistance during oral glucose tolerance test in a cohort of cystic fibrosis patients. Eur J Endocrinol 165(1):69\u201376. https:\/\/doi.org\/10.1530\/EJE-10-1003","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"6220_CR6","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.2337\/diab.43.8.1020","volume":"43","author":"A Moran","year":"1994","unstructured":"Moran A, Pyzdrowski KL, Weinreb J et al (1994) Insulin sensitivity in cystic fibrosis. Diabetes 43(8):1020\u20131026. https:\/\/doi.org\/10.2337\/diab.43.8.1020","journal-title":"Diabetes"},{"issue":"1","key":"6220_CR7","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1210\/jc.79.1.80","volume":"79","author":"A Austin","year":"1994","unstructured":"Austin A, Kalhan SC, Orenstein D, Nixon P, Arslanian S (1994) Roles of insulin resistance and \u03b2-cell dysfunction in the pathogenesis of glucose intolerance in cystic fibrosis. J Clin Endocrinol Metab 79(1):80\u201385. https:\/\/doi.org\/10.1210\/jc.79.1.80","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"6220_CR8","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.jcf.2016.04.004","volume":"15","author":"VV Boudreau","year":"2016","unstructured":"Boudreau VV, Coriati AA, Hammana I et al (2016) Variation of glucose tolerance in adult patients with cystic fibrosis: What is the potential contribution of insulin sensitivity? J Cyst Fibros 15(6):839\u2013845. https:\/\/doi.org\/10.1016\/j.jcf.2016.04.004","journal-title":"J Cyst Fibros"},{"issue":"4","key":"6220_CR9","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.jcf.2019.01.009","volume":"18","author":"J Colomba","year":"2019","unstructured":"Colomba J, Boudreau V, Lehoux-Dubois C et al (2019) The main mechanism associated with progression of glucose intolerance in older patients with cystic fibrosis is insulin resistance and not reduced insulin secretion capacity. J Cyst Fibros 18(4):551\u2013556. https:\/\/doi.org\/10.1016\/j.jcf.2019.01.009","journal-title":"J Cyst Fibros"},{"key":"6220_CR10","doi-asserted-by":"publisher","first-page":"117955142110382","DOI":"10.1177\/11795514211038259","volume":"14","author":"BU Nielsen","year":"2021","unstructured":"Nielsen BU, Faurholt-Jepsen D, Oturai PS et al (2021) Associations between glucose tolerance, insulin secretion, muscle and fat mass in cystic fibrosis. Clin Med Insights Endocrinol Diabetes 14:117955142110382. https:\/\/doi.org\/10.1177\/11795514211038259","journal-title":"Clin Med Insights Endocrinol Diabetes"},{"issue":"3","key":"6220_CR11","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1046\/j.1464-5491.2002.00666.x","volume":"19","author":"B Yung","year":"2002","unstructured":"Yung B, Noormohamed FH, Kemp M, Hooper J, Lant AF, Hodson ME (2002) Cystic fibrosis-related diabetes: the role of peripheral insulin resistance and \u03b2-cell dysfunction. Diabet Med 19(3):221\u2013226. https:\/\/doi.org\/10.1046\/j.1464-5491.2002.00666.x","journal-title":"Diabet Med"},{"issue":"6","key":"6220_CR12","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.jpeds.2007.05.012","volume":"151","author":"DA Elder","year":"2007","unstructured":"Elder DA, Wooldridge JL, Dolan LM, D\u2019Alessio DA (2007) Glucose tolerance, insulin secretion, and insulin sensitivity in children and adolescents with cystic fibrosis and no prior history of diabetes. J Pediatr 151(6):653\u2013658. https:\/\/doi.org\/10.1016\/j.jpeds.2007.05.012","journal-title":"J Pediatr"},{"key":"6220_CR13","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1210\/clinem\/dgac020","volume":"107","author":"A Moheet","year":"2022","unstructured":"Moheet A, Moran A (2022) New concepts in the pathogenesis of cystic fibrosis-related diabetes. J Clin Endocrinol Metab 107:1503\u20131509. https:\/\/doi.org\/10.1210\/clinem\/dgac020","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"6220_CR14","doi-asserted-by":"publisher","first-page":"e1793","DOI":"10.1210\/clinem\/dgaa932","volume":"106","author":"C Piona","year":"2021","unstructured":"Piona C, Volpi S, Zusi C et al (2021) Glucose tolerance stages in cystic fibrosis are identified by a unique pattern of defects of beta-cell function. J Clin Endocrinol Metab 106(4):e1793\u2013e1802. https:\/\/doi.org\/10.1210\/clinem\/dgaa932","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"6220_CR15","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1136\/bmjdrc-2019-001149","volume":"8","author":"T Okura","year":"2020","unstructured":"Okura T, Fujioka Y, Nakamura R et al (2020) Hepatic insulin clearance is increased in patients with high HbA1c type 2 diabetes: a preliminary report. BMJ Open Diabetes Res Care 8(1):1149. https:\/\/doi.org\/10.1136\/bmjdrc-2019-001149","journal-title":"BMJ Open Diabetes Res Care"},{"issue":"1","key":"6220_CR16","doi-asserted-by":"publisher","first-page":"101","DOI":"10.2337\/dc12-0101","volume":"36","author":"C Lorenzo","year":"2013","unstructured":"Lorenzo C, Hanley AJG, Wagenknecht LE et al (2013) Relationship of insulin sensitivity, insulin secretion, and adiposity with insulin clearance in amultiethnic population: the insulin resistance atherosclerosis study. Diabetes Care 36(1):101\u2013103. https:\/\/doi.org\/10.2337\/dc12-0101","journal-title":"Diabetes Care"},{"issue":"3","key":"6220_CR17","doi-asserted-by":"publisher","first-page":"E349","DOI":"10.1152\/ajpendo.1988.254.3.E349","volume":"254","author":"H Tillil","year":"1988","unstructured":"Tillil H, Shapiro ET, Miller MA et al (1988) Dose-dependent effects of oral and intravenous glucose on insulin secretion and clearance in normal humans. Am J Physiol Metab 254(3):E349\u2013E357. https:\/\/doi.org\/10.1152\/ajpendo.1988.254.3.E349","journal-title":"Am J Physiol Metab"},{"issue":"2","key":"6220_CR18","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1365-2265.1994.tb02533.x","volume":"41","author":"S Lanng","year":"1994","unstructured":"Lanng S, Thorsteinsson B, Roder ME, Nerup J, Koch C (1994) Insulin sensitivity and insulin clearance in cystic fibrosis patients with normal and diabetic glucose tolerance. Clin Endocrinol (Oxf) 41(2):217\u2013223. https:\/\/doi.org\/10.1111\/j.1365-2265.1994.tb02533.x","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"6220_CR19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0026-0495(94)90239-9","volume":"43","author":"T Ahmad","year":"1994","unstructured":"Ahmad T, Nelson R, Taylor R (1994) Insulin sensitivity and metabolic clearance rate of insulin in cystic fibrosis. Metabolism 43(2):163\u2013167. https:\/\/doi.org\/10.1016\/0026-0495(94)90239-9","journal-title":"Metabolism"},{"key":"6220_CR20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1152\/ajpendo.00645.2007","volume":"294","author":"R Muniyappa","year":"2008","unstructured":"Muniyappa R, Lee S, Chen H, Quon MJ (2008) Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 294:15\u201326. https:\/\/doi.org\/10.1152\/ajpendo.00645.2007","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"6220_CR21","doi-asserted-by":"publisher","first-page":"150","DOI":"10.2337\/diabetes.50.1.150","volume":"50","author":"E Breda","year":"2001","unstructured":"Breda E, Cavaghan MK, Toffolo G, Polonsky KS, Cobelli C (2001) Oral glucose tolerance test minimal model indexes of \u03b2-cell function and insulin sensitivity. Diabetes 50(1):150\u2013158. https:\/\/doi.org\/10.2337\/diabetes.50.1.150","journal-title":"Diabetes"},{"issue":"5","key":"6220_CR22","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1109\/10.995680","volume":"49","author":"C Dalla Man","year":"2002","unstructured":"Dalla Man C, Caumo A, Cobelli C (2002) The oral glucose minimal model: Estimation of insulin sensitivity from a meal test. IEEE Trans Biomed Eng 49(5):419\u2013429. https:\/\/doi.org\/10.1109\/10.995680","journal-title":"IEEE Trans Biomed Eng"},{"issue":"3","key":"6220_CR23","doi-asserted-by":"publisher","first-page":"373","DOI":"10.2337\/diabetes.49.3.373","volume":"49","author":"RM Watanabe","year":"2000","unstructured":"Watanabe RM, Bergman RN (2000) Accurate measurement of endogenous insulin secretion does not require separate assessment of C-peptide kinetics. Diabetes 49(3):373\u2013382. https:\/\/doi.org\/10.2337\/diabetes.49.3.373","journal-title":"Diabetes"},{"issue":"5","key":"6220_CR24","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1210\/edrv.19.5.0349","volume":"19","author":"WC Duckworth","year":"1998","unstructured":"Duckworth WC, Bennett RG, Hamel FG (1998) Insulin degradation: progress and potential. Endocr Rev 19(5):608\u2013624. https:\/\/doi.org\/10.1210\/edrv.19.5.0349","journal-title":"Endocr Rev"},{"key":"6220_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/9286303","volume":"2016","author":"T Geragotou","year":"2016","unstructured":"Geragotou T, Jainandunsing S, \u00d6zcan B et al (2016) The relationship of metabolic syndrome traits with beta-cell function and insulin sensitivity by oral minimal model assessment in south Asian and European families residing in the Netherlands. J Diabetes Res 2016:1\u20139. https:\/\/doi.org\/10.1155\/2016\/9286303","journal-title":"J Diabetes Res"},{"issue":"11","key":"6220_CR26","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.2337\/diabetes.54.11.3265","volume":"54","author":"CD Man","year":"2005","unstructured":"Man CD, Campioni M, Polonsky KS et al (2005) Two-hour seven-sample oral glucose tolerance test and meal protocol: Minimal model assessment of \u03b2-cell responsivity and insulin sensitivity in nondiabetic individuals. Diabetes 54(11):3265\u20133273. https:\/\/doi.org\/10.2337\/diabetes.54.11.3265","journal-title":"Diabetes"},{"issue":"1","key":"6220_CR27","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1749-6632.2002.tb04262.x","volume":"967","author":"E Tom\u00e1s","year":"2002","unstructured":"Tom\u00e1s E, Lin YS, Dagher Z et al (2002) Hyperglycemia and insulin resistance: possible mechanisms. Ann N Y Acad Sci 967(1):43\u201351. https:\/\/doi.org\/10.1111\/j.1749-6632.2002.tb04262.x","journal-title":"Ann N Y Acad Sci"},{"issue":"Supplement_2","key":"6220_CR28","doi-asserted-by":"publisher","first-page":"S262","DOI":"10.2337\/dc08-s264","volume":"31","author":"MH Shanik","year":"2008","unstructured":"Shanik MH, Xu Y, \u0160krha J, Dankner R, Zick Y, Roth J (2008) Insulin resistance and hyperinsulinemia. Diabetes Care 31(Supplement_2):S262\u2013S268. https:\/\/doi.org\/10.2337\/dc08-s264","journal-title":"Diabetes Care"},{"issue":"3","key":"6220_CR29","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1530\/eje.0.1300253","volume":"130","author":"D Cucinotta","year":"1994","unstructured":"Cucinotta D, De Luca F, Gigante A et al (1994) No changes of insulin sensitivity in cystic fibrosis patients with different degrees of glucose tolerance: an epidemiological and longitudinal study. Eur J Endocrinol 130(3):253\u2013258. https:\/\/doi.org\/10.1530\/eje.0.1300253","journal-title":"Eur J Endocrinol"},{"key":"6220_CR30","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.2337\/db15-1373","volume":"65","author":"DC Polidori","year":"2016","unstructured":"Polidori DC, Bergman RN, Chung ST, Sumner AE (2016) Hepatic and extrahepatic insulin clearance are differentially regulated: results from a novel model-based. Diabetes 65:1556\u20131564. https:\/\/doi.org\/10.2337\/db15-1373","journal-title":"Diabetes"},{"issue":"1","key":"6220_CR31","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1038\/s41598-017-01469-x","volume":"7","author":"H Kaga","year":"2017","unstructured":"Kaga H, Tamura Y, Takeno K et al (2017) Correlates of insulin clearance in apparently healthy non-obese Japanese men. Sci Rep 7(1):1462. https:\/\/doi.org\/10.1038\/s41598-017-01469-x","journal-title":"Sci Rep"},{"issue":"4","key":"6220_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1056\/EVIDoa2100052","volume":"1","author":"S Sugiyama","year":"2022","unstructured":"Sugiyama S, Jinnouchi H, Hieshima K et al (2022) Potential identification of type 2 diabetes with elevated insulin clearance. NEJM Evid 1(4):1\u20139. https:\/\/doi.org\/10.1056\/EVIDoa2100052","journal-title":"NEJM Evid"},{"issue":"9","key":"6220_CR33","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.2337\/diabetes.50.9.2001","volume":"50","author":"LL Kjems","year":"2001","unstructured":"Kjems LL, Kirby BM, Welsh EM et al (2001) Decrease in \u03b2-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig. Diabetes 50(9):2001\u20132012. https:\/\/doi.org\/10.2337\/diabetes.50.9.2001","journal-title":"Diabetes"},{"key":"6220_CR34","doi-asserted-by":"publisher","first-page":"3014","DOI":"10.2337\/diabetes.52.7.1738","volume":"52","author":"R Basu","year":"2003","unstructured":"Basu R, Breda E, Oberg AL et al (2003) Erratum: mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance (Diabetes (2003) 52 (1738-1748)). Diabetes 52:3014. https:\/\/doi.org\/10.2337\/diabetes.52.7.1738","journal-title":"Diabetes"},{"issue":"8","key":"6220_CR35","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1210\/jc.2015-1512","volume":"100","author":"A Battezzati","year":"2015","unstructured":"Battezzati A, Bedogni G, Zazzeron L et al (2015) Age- and sex-dependent distribution of OGTT-related variables in a population of cystic fibrosis patients. J Clin Endocrinol Metab 100(8):2963\u20132971. https:\/\/doi.org\/10.1210\/jc.2015-1512","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-024-06220-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00125-024-06220-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-024-06220-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T08:03:15Z","timestamp":1732176195000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00125-024-06220-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,2]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["6220"],"URL":"https:\/\/doi.org\/10.1007\/s00125-024-06220-6","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,2]]},"assertion":[{"value":"2 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Thanks to R. M\u00f8ller and D. Hass at the Department of Infectious Diseases, Rigshospitalet for their help with the data collection. Thanks to T. McDonald and staff at the Exeter Clinical Laboratory International, Blood Sciences, Royal Devon and Exeter Hospital, University of Exeter Medical School for performing the biochemical analyses.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Acknowledgements"}},{"value":"The datasets generated during and\/or analysed during the current study are not publicly available due to reasons of sensitivity and data protection regulations but are available from the corresponding author upon reasonable request. Data are located in controlled access data storage in REDCap at Region Hovedstaden, Denmark.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"Open access funding provided by National Hospital. The study was supported by a grant from the CF-Trust (SRC-CFRD 019). MRR and DS are supported by US Public Health Service research grant R01 DK97830 (to MRR).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"TPA holds stocks in Novo Nordisk. All other authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 relationships and activities"}},{"value":"BUN, JAMS, MRR, DF-J and DS designed the study. BUN was responsible for data acquisition and BUN and DS performed data analysis. BUN, IHMM, RK-M, TLK, TP, JAMS, MRR, TPA, DF-J and DS interpreted the data, contributed to drafting the manuscript and approved the final version. BUN is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}}]}}