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Fujiwara (K. I. Stainer Inc., Kumamoto, Japan) for histological analyses.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Acknowledgements"}},{"value":"The datasets generated during and\/or analysed during the current study are included in the published article and are available from the corresponding author on reasonable request.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"The present study was financially supported in part by Grant-in-Aid for JSPS Fellows 2023 (to TT), Japan Agency for Medical Research and Development, Translational Research Program seed A, 2023 (to HT and MO), the Higo Bank Innovation Support Program, 2021 (to EA), Japan Agency for Medical Research and Development, Seeds Development and Research Platform Division \u2018Translational Research Program\u2019, 2018 (to MO), Kyushu\/University-launched Start-up Promotion Fostering Fund (GAP Fund), 2018 (to MO) and the Japan Society of Promotion of Science Grant-in-Aid for Scientific Research (B), 2017 (to MO).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 relationships and activities"}},{"value":"TT and HT designed and performed experiments, analysed results, prepared graphs and figures and edited the manuscript. NM, YA, TW, RN, TFSA, TB, MT, TK, MF, MO and EA contributed to the acquisition, analysis and interpretation of data and critically revised the article for valuable intellectual content. HT conceived the study and wrote and edited the manuscript. All authors read and approved the final version of the manuscript. HT and EA are the guarantors of this work.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}