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Summary statistics of the GWAS on metabolites are available in the GWAS Catalog. Data from this study may be requested through the authors via an application process and shared through an institutional data-sharing agreement.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"This research is supported by the Singapore Ministry of Health\u2019s National Medical Research Council under its Open Fund Large Collaborative Grant (NMRC\/OFLCG\/001\/2017 and MOH-001327-02). The Diabetic Cohort (DC) is supported by individual research and clinical scientist award schemes from the National Medical Research Council (NMRC) and the Biomedical Research Council (BMRC) of Singapore, and infrastructure funding from the Singapore Ministry of Health (Population Health Metrics and Analytics [PHMA]), National University of Singapore and National University Health System, Singapore. The Diabetic Nephropathy (DN) cohort is supported by the Alexandra Health Fund (STAR grants 18203, 20201 and 23201). The Singapore Study of Macro-angiopathy and Micro-vascular Reactivity in Type 2 Diabetes (SMART2D) is supported by NMRC grants (MOH-00066, MOH-000714 -01, MOH-001327-02 and OFLCG\/001\/2017) and the Alexandra Health Fund (STAR grants 18203 and 20201).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 relationships and activities"}},{"value":"YC, FT, MRW, XS, SCL and EST conceived and designed the study. YC, HWLK and RLG analysed the data. YC, FT, XS, SCL and EST drafted the manuscript. All authors contributed to the writing of the article, provided support for the analysis and interpretation of results, critically revised the article and approved the final article. XS, SCL and EST are responsible for the integrity of the work as a whole.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}