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Ca\n                      2+\n                      staining images were generated in the Core Optical Imaging Facility, which is supported by UT Health San Antonio and NIH-NCI P30 CA54174. We would like to acknowledge E. Wang (Optical Imaging Core Facility, UT Health San Antonio, San Antonio, TX, USA), for his tremendous assistance in performing the live-cell Ca\n                      2+\n                      imaging. Our graphical abstract was created with BioRender.com. Parts of this study were presented in the Poster Sessions at the 82nd Scientific Session of the American Diabetes Association, New Orleans, LA, USA, 3\u20137 June 2022.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Acknowledgements"}},{"value":"The authors declare that the data supporting the findings of this study are available within the paper and its ESM files. Should any raw data files be needed in another format, they are available from the corresponding author upon reasonable request.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"This work was supported in part by grants from the NIH (R01DK134637) and the Baptist Health Foundation of San Antonio (2020 Strategic to Mission). DDM is supported by NIH NRSA Fellowship (T32 GM148752).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 relationships and activities"}},{"value":"LQD contributed to the conception and design of the project, and to the interpretation of data, and drafted and reviewed the article. FL, JB, RD, JCL-A, SM and JLL contributed to the conception of the work and reviewed the article critically for intellectual content. DDM contributed to the study's conception and design, performed experiments, conducted data analysis and wrote the manuscript. JR, CW, JTH and MRS made substantial contributions to the design of the work, the acquisition and interpretation of data and reviewed the article. All authors gave their final approval of the version to be published. LQD is responsible for the integrity of the work as a whole.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}