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Selected artwork (eye, cell membrane, proteins, nucleus, enzymes, proteins, transcription, junctions) shown in the graphic abstract were used from or adapted from pictures provided by Servier Medical Art (Servier,\n                      \n                      ), Creative Commons Attribution 4.0 International License (CC BY 4.0).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Acknowledgements"}},{"value":"The raw data generated in this study are available from the corresponding authors on reasonable request.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"This study was supported by the National Natural Science Foundation of China (NSFC81870670, 82171078 and 82070975), the Shanghai Science and Technology Development Foundation (18411965100), and the Shanghai Shenkang Hospital Development Center (SHDC2020CR5014-003).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 relationships and activities"}},{"value":"QC and W-wC conceived and designed the study, supervised all aspects of the work, critically revised the manuscript for important intellectual content and approved the final version. QY performed experiments, conducted the bioinformatics analysis, analysed the data, drafted the initial manuscript and approved the final version. W-wC designed and performed key experiments, critically revised the manuscript for intellectual content and approved the final version. XH acquired and interpreted the clinical data and samples, critically revised the manuscript for clinical relevance and approved the final version. P-wZ performed experiments and contributed to analysis of data, critically revised the manuscript for methodological rigour and approved the final version. Y-jW and RZ performed experiments, contributed to data interpretation, critically revised the manuscript and approved the final version. QC assumes full responsibility for the integrity of the work.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}