{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:12:45Z","timestamp":1793304765920,"version":"4.5.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Institutes of Health Human Islet Research Network Consortium on Beta Cell Death & Survival from Pancreatic \u03b2-Cell Gene Networks to Therapy","award":["U01 DK127786"],"award-info":[{"award-number":["U01 DK127786"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health NIDDK","doi-asserted-by":"crossref","award":["NIDDK grants RO1DK126444"],"award-info":[{"award-number":["NIDDK grants RO1DK126444"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health NIDDK","doi-asserted-by":"crossref","award":["RO1DK133881-01"],"award-info":[{"award-number":["RO1DK133881-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100022690","name":"JDRF","doi-asserted-by":"publisher","award":["3-SRA-2022-1201-S-B [1]"],"award-info":[{"award-number":["3-SRA-2022-1201-S-B [1]"]}],"id":[{"id":"10.13039\/100022690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022690","name":"JDRF","doi-asserted-by":"publisher","award":["3-SRA-2022-1201-S-B [2]"],"award-info":[{"award-number":["3-SRA-2022-1201-S-B [2]"]}],"id":[{"id":"10.13039\/100022690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1007\/s00125-025-06426-2","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T17:27:48Z","timestamp":1744478868000},"page":"1524-1529","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Exercise-induced meteorin-like protein protects human pancreatic beta cells from cytokine-induced apoptosis"],"prefix":"10.1007","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7789-3180","authenticated-orcid":false,"given":"Jos\u00e9 Maria","family":"Costa-Junior","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Coomans de Brach\u00e8ne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Any\u00efshai E.","family":"Musuaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila L.","family":"Zimath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Martin-Vazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junior G.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Carpentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitalie","family":"Faoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Klass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Cnop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decio L.","family":"Eizirik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"issue":"7","key":"6426_CR1","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41574-020-0355-7","volume":"16","author":"DL Eizirik","year":"2020","unstructured":"Eizirik DL, Pasquali L, Cnop M (2020) Pancreatic \u03b2-cells in type 1 and type 2 diabetes mellitus: different pathways to failure. Nat Rev Endocrinol 16(7):349\u2013362. https:\/\/doi.org\/10.1038\/s41574-020-0355-7","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"6426_CR2","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1113\/EP088220","volume":"105","author":"M Curran","year":"2020","unstructured":"Curran M, Drayson MT, Andrews RC et al (2020) The benefits of physical exercise for the health of the pancreatic \u03b2-cell: a review of the evidence. Exp Physiol 105(4):579\u2013589. https:\/\/doi.org\/10.1113\/EP088220","journal-title":"Exp Physiol"},{"issue":"3","key":"6426_CR3","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1096\/fj.201700710R","volume":"32","author":"FMM Paula","year":"2018","unstructured":"Paula FMM, Leite NC, Borck PC et al (2018) Exercise training protects human and rodent \u03b2 cells against endoplasmic reticulum stress and apoptosis. FASEB J 32(3):1524\u20131536. https:\/\/doi.org\/10.1096\/fj.201700710R","journal-title":"FASEB J"},{"issue":"3","key":"6426_CR4","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/s00125-022-05837-9","volume":"66","author":"A Coomans de Brach\u00e8ne","year":"2023","unstructured":"Coomans de Brach\u00e8ne A, Scoubeau C, Musuaya AE et al (2023) Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes. Diabetologia 66(3):450\u2013460. https:\/\/doi.org\/10.1007\/s00125-022-05837-9","journal-title":"Diabetologia"},{"key":"6426_CR5","doi-asserted-by":"publisher","first-page":"1098570","DOI":"10.3389\/fimmu.2023.1098570","volume":"14","author":"Z Li","year":"2023","unstructured":"Li Z, Gao Z, Sun T et al (2023) Meteorin-like\/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: a comprehensive review of preclinical and clinical studies. Front Immunol 14:1098570. https:\/\/doi.org\/10.3389\/fimmu.2023.1098570","journal-title":"Front Immunol"},{"issue":"6","key":"6426_CR6","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.cell.2014.03.065","volume":"157","author":"RR Rao","year":"2014","unstructured":"Rao RR, Long JZ, White JP et al (2014) Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 157(6):1279\u20131291. https:\/\/doi.org\/10.1016\/j.cell.2014.03.065","journal-title":"Cell"},{"issue":"9","key":"6426_CR7","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1172\/JCI58447","volume":"121","author":"P Ravassard","year":"2011","unstructured":"Ravassard P, Hazhouz Y, Pechberty S et al (2011) A genetically engineered human pancreatic \u03b2 cell line exhibiting glucose-inducible insulin secretion. J Clin Invest 121(9):3589\u20133597. https:\/\/doi.org\/10.1172\/JCI58447","journal-title":"J Clin Invest"},{"key":"6426_CR8","doi-asserted-by":"publisher","first-page":"967765","DOI":"10.3389\/fcell.2022.967765","volume":"10","author":"F Fantuzzi","year":"2022","unstructured":"Fantuzzi F, Toivonen S, Schiavo AA et al (2022) In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo. Front Cell Dev Biol 10:967765. https:\/\/doi.org\/10.3389\/fcell.2022.967765","journal-title":"Front Cell Dev Biol"},{"issue":"3\u20134","key":"6426_CR9","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1080\/19382014.2021.1948282","volume":"13","author":"MI Alvelos","year":"2021","unstructured":"Alvelos MI, Szymczak F, Castela \u00c2 et al (2021) A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis. Islets 13(3\u20134):51\u201365. https:\/\/doi.org\/10.1080\/19382014.2021.1948282","journal-title":"Islets"},{"key":"6426_CR10","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1038\/s42255-024-01130-8","volume":"6","author":"P Carapeto","year":"2024","unstructured":"Carapeto P, Iwasaki K, Hela F et al (2024) Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence. Nat Metab 6:1976\u20131990. https:\/\/doi.org\/10.1038\/s42255-024-01130-8","journal-title":"Nat Metab"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-025-06426-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00125-025-06426-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-025-06426-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:02:26Z","timestamp":1775952146000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00125-025-06426-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,12]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["6426"],"URL":"https:\/\/doi.org\/10.1007\/s00125-025-06426-2","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,12]]},"assertion":[{"value":"14 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"We thank Y. Cai, J. Capitaine, A. Mariscal, I. Millard, N. Belmahjoubi and N. Pachera (ULB Center for Diabetes Research, Universit\u00e9 libre de Bruxelles, Brussels, Belgium) for their excellent technical support. Some of the data were presented as an abstract at the 60th EASD Annual Meeting in 2024.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Acknowledgements"}},{"value":"The data that support the findings of the present study are available from the corresponding author on reasonable request.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"This research was supported by grants from Breakthrough T1D (formerly JDRF International) (3-SRA-2022-1201-S-B 1 and 3-SRA-2022-1201-S-B 2); the National Institutes of Health \u2013 Human Islet Research Network Consortium on Beta Cell Death & Survival from Pancreatic \u03b2-Cell Gene Networks to Therapy (HIRN-CBDS) (grant U01 DK127786); and the National Institutes of Health National Institute of Diabetes and Digestive Kidney Diseases (NIDDK) (grants RO1DK126444 and RO1DK133881-01).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 relationships and activities"}},{"value":"JMC-J was involved in the conceptualisation of the study, experimental design, data collection and analysis and drafted the manuscript. ACdB, AEM, PLZ, EM-V and JGO carried out the experimental work and revised the manuscript. JC, VF and MK designed and implemented the training protocol, including participant recruitment, screening, randomisation, conducting maximal incremental tests, monitoring training sessions and coordinating blood sampling; they also revised the manuscript. MC and DLE contributed to developing the original research idea, oversaw the design and experimental work and participated in the interpretation of the results. DLE took responsibility for manuscript writing and revision. MC revised the manuscript. All authors approved the final version of the manuscript. JMC-J serves as the guarantor of this work, ensuring full access to all study data and taking responsibility for the integrity of the data and the accuracy of the analyses.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}