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Related preliminary data were presented as an abstract at the ADA\u2019s 84th Scientific Sessions meeting in 2024.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Acknowledgements"}},{"value":"The data are not publicly available due to language used in the consent forms of this legacy cohort that prohibits broad data sharing. Data may be made available under a data sharing agreement in accordance with University of Pittsburgh Institutional Review Board policies and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"Details on the software used to perform the Mendelian randomisation analyses are provided in the ESM\n                      \n                      .","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"The parent EDC study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health (grant no. R01-DK034818) and the Rossi Memorial Fund. The EDC DNAm sub-study was supported by the American Diabetes Association (grant no. 1-19-JDF-109). The funding agencies were not involved in study design, data collection, data analysis, interpretation or writing of the manuscript. JZ is supported by funding from the National Heart, Lung, and Blood Institute and National Institute of Diabetes and Digestive and Kidney Diseases (grant no. R01-HL161879).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 relationships and activities"}},{"value":"RGM and TJO designed the study. RGM, TJO and TC contributed to acquisition of funding and data. SO-G oversaw methylation array processing. JCM performed the methylation data processing and QC. JZ and RGM conducted the statistical analyses. JZ, RGM, JCM, SO-G, TJO and TC interpreted the data. JZ drafted the manuscript. All authors edited and critically reviewed the manuscript for intellectual content and approved the final version. RGM is the guarantor of this work.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}