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Zhao\u2019s laboratory at Sun Yat-sen University for the help with techniques.","order":1,"name":"Ethics","label":"Acknowledgements","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"The RNA-seq data are available as GEO series GSE213919.","order":2,"name":"Ethics","label":"Data availability","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"This work was funded by Shenzhen Medical Academy of Research and Translation (D2403006), Shenzhen Science and Technology Program (JCYJ20240813151248062), Shenzhen Science and Technology Program (RCBS20231211090749088), the Natural Science Foundation of China (31970934), Shenzhen Science and Technology Program (JCYJ20230807115759013), Guangdong Basic and Applied Basic Research Foundation (2023A1515111128), Shenzhen Nanshan District Health System Science and Technology Major Project Postdoc Fund (NSZD2024025) and the Fundamental Research Funds for the Central Universities to QPW.","order":3,"name":"Ethics","label":"Funding","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","label":"Authors\u2019 relationships and activities","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"RXZ and QPW designed the research. RXZ, ZCY and XYZ performed mouse experiments and analysed data. RXZ and BW performed cell experiments and analysed data. RXZ, ZYL and CJ performed fly experiments and biochemical experiments and analysed data. AQL performed RNA-seq and data analysis. YCS and GN participated in the study design and reviewed the manuscript. RXZ and QPW wrote the manuscript. QPW acquired funding. QPW is responsible for the integrity of the work as a whole. All authors reviewed the manuscript and approved the final version submitted for publication.","order":5,"name":"Ethics","label":"Contribution statement","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}