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Zhou and W. Zhao of Shanghai Jiao Tong University. The computations in this paper were run on the Siyuan-1 cluster supported by the Center for High Performance Computing at Shanghai Jiao Tong University. We are grateful for the working group of the 4C study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Acknowledgements"}},{"value":"Data described in the manuscript, the code book and analytic code will be made available upon request pending application and approval.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"This work was supported by the Ministry of Science and Technology of China (grant nos. 2022YFC2505202, 2023YFC2506704, 2023ZD0508402), the National Natural Science Foundation of China (grant nos. 82370810, 91857205, 82088102, 82170819, 82372347, 82400939 and 82200998), the Science and Technology Committee of Shanghai (grant nos. 22Y31900300, 23Y11908400 and 23JS1400900), the Shanghai Rising-Star Programm (grant no. 24QA2708000),\u00a0the Clinical Research Project of Shanghai Municipal Health Commission (grant no. 20224Y0087) and the Innovative Research Team of High-Level Local Universities in Shanghai.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 relationships and activities"}},{"value":"JL, GN, YB and WW conceived and designed the study. XJ, HL and YD did the statistical analysis. SY Wang, YD, XJ and JL drafted the manuscript. SY Wang, YY Zhu, ML, YX, MX, FH, FS, XG, YM, LC, TZ, LS, QS, XY, LY, GQ, QW, GC, XT, ZG, RH, ZL, YQ, LC, XH, YH, QL, GW, Yinfei Zhang, CL, YW, SL Wu, TY, HD, Yifang Zhang, HW, J Zheng, TW, ZZ and JJ Zhao contributed to acquisition, analysis or interpretation of data. All authors revised the report and approved the final version before submission. JL, GN, YB and WW are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}}]}}