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XQ performed the experiments, conducted bioinformatics analysis, and drafted the initial manuscript. ZM and SC performed the experiments, analysed the data, and reviewed the manuscript critically for clinical relevance. YS and CN reviewed and revised the manuscript for methodological rigour. FL and HZ revised the manuscript and reviewed it critically for intellectual content. All authors read and approved the manuscript. HZ is responsible for the integrity of the work as a whole.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}}]}}