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Lozano (The University of Texas MD Anderson Cancer Center, Houston, TX, USA) for generously providing the genetically modified mice carrying humanised\n                      MDM2\n                      SNP309T\/T or G\/G.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Acknowledgements"}},{"value":"The datasets generated and\/or analysed during the current study are available from the corresponding authors upon reasonable request. Any resource generated and\/or analysed during the study is also available from the corresponding authors upon reasonable request.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"This work was supported by grants from the National Natural Science Foundation of China (82070989 to HL), the Shenzhen Medical Research Fund (C2401036 to XY), the Shenzhen Science and Technology Program (SGDX20211123120001001 to XY and HL), the Guangdong Basic and Applied Basic Research Foundation (2024A1515012974 to XY), the Introduction Plan of High-Level Foreign Experts (G2022026027L to GM and HL), the Major Program of the Medical Science Challenging Plan of Henan Province (SBGJ202102190 to GM), the National Natural Science Foundation of China (8227109 to WW), the Ningxia Natural Science Foundation (2024AAC03209 to YY), the Foreign Expert Project of Hainan Province (G20241024015E and H20260407020E to XH and HL), the Hainan Provincial Natural Science Foundation of China (821RC1126 to XH), the Health Commission of Shanxi Province (2020004 to YD), the Shanxi Scholarship Council of China (2022-203 to YD), the Shanxi Bethune Hospital Education and Teaching Reform Foundation (2022Jx22 to YD), the Shanxi Bethune Hospital Foundation (2021RC005 to YD), the Project of the Shanxi Province Education Department (J20230459 to YD), the Open Project of the Shanxi Key Laboratory of Ophthalmology (2023SXKLOS01 to YD), and the Shanxi Medical Doctor Association Research Project (YSXH-QL2024YK002 to YD). The funding bodies had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"BV is a consultant for iOnctur (Geneva, Switzerland) and Venthera (Palo Alto, CA, USA) and has received speaker fees from Gilead (Foster City, CA. USA). The remaining authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 relationships and activities"}},{"value":"HL, XY and JL conceptualised the study; GM, WW, YD, YY, XH, HJ, ZP, JM, FY and ZG determined the methodology; GM, WW, YD, YY, XH, HJ, ZP, JM, FY and ZG acquired data; GM, WW, YD, YY, XH, HJ, ZP, JM, FY, ZG, BV, JL, XY and HL carried out formal analysis and interpretation of data; GM, WW, YD, YY, XH, HJ, ZP, JM, FY and ZG carried out investigation; GM, WW and YD wrote the original draft; HL, XY, JL and BV reviewed and edited the original draft; HL, JL, GM and YD carried out supervision; HL, XY, JL, GM, WW, YD, YY and XH acquired funding. All authors made substantial contributions to the work, critically reviewed and approved the final version of the manuscript, and agree to be accountable for all aspects of the work, in full accordance with the ICMJE authorship criteria. HL is the guarantor of this work, with full access to all study data, and takes responsibility for the integrity of the data and the accuracy of the analysis.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}}]}}