{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:11:01Z","timestamp":1793880661324,"version":"4.7.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"ERC Consolidator grant","award":["ERC Consolidator grant (CrossPeriBrain"],"award-info":[{"award-number":["ERC Consolidator grant (CrossPeriBrain"]}]},{"name":"ERC Consolidator grant","award":["Project 10"],"award-info":[{"award-number":["Project 10"]}]},{"name":"Universit\u00e4tsklinikum Ulm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/hypothesis<\/jats:title>\n                    <jats:p>The aim of this study was to assess the frequency and metabolic characteristics of post-OGTT hypoglycaemia during an OGTT in individuals newly diagnosed with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed 97 extended (180 min) 75 g OGTTs from individuals newly diagnosed with type 2 diabetes. Glucose, insulin and C-peptide were measured at fasting and post-challenge time points. Insulin sensitivity was assessed using the oral glucose insulin sensitivity (OGIS) index and beta cell function was measured using the insulinogenic index (IGI) and Stumvoll\u2019s second-phase index. All participants were assigned to the Ahlqvist diabetes clusters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Post-OGTT hypoglycaemia (glucose \u22643.9 mmol\/l at 180 min) occurred in 8.2% of the OGTTs analysed. Compared with individuals without hypoglycaemia, individuals with post-OGTT hypoglycaemia had a significantly lower BMI and higher insulin sensitivity, without differences in beta cell function. All individuals with hypoglycaemia were assigned to the mild obesity- or age-related diabetes Ahlqvist clusters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\/interpretation<\/jats:title>\n                    <jats:p>Post-OGTT hypoglycaemia is present in a subset of individuals newly diagnosed with type 2 diabetes and is associated with higher insulin sensitivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00125-026-06719-0","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T22:39:46Z","timestamp":1774651186000},"page":"1818-1822","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post-OGTT hypoglycaemia in newly diagnosed type 2 diabetes: frequency, characteristics and cluster assignment"],"prefix":"10.1007","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8452-2744","authenticated-orcid":false,"given":"Rebecca","family":"Spies","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisa","family":"Ufer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza","family":"Sabia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-8365","authenticated-orcid":false,"given":"Julia","family":"Hummel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5732-2287","authenticated-orcid":false,"given":"Andreas","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6120-0191","authenticated-orcid":false,"given":"Robert","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8462-3832","authenticated-orcid":false,"given":"Martin","family":"Heni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"issue":"4","key":"6719_CR1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3390\/jpm11040276","volume":"11","author":"M Hall","year":"2021","unstructured":"Hall M, Walicka M, Panczyk M, Traczyk I (2021) Metabolic parameters in patients with suspected reactive hypoglycemia. J Pers Med 11(4):276. https:\/\/doi.org\/10.3390\/jpm11040276","journal-title":"J Pers Med"},{"issue":"1","key":"6719_CR2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0889-8529(18)30396-7","volume":"18","author":"FD Hofeldt","year":"1989","unstructured":"Hofeldt FD (1989) Reactive hypoglycemia. Endocrinol Metab Clin North Am 18(1):185\u2013201","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"3","key":"6719_CR3","doi-asserted-by":"publisher","first-page":"215","DOI":"10.14744\/SEMB.2019.59455","volume":"53","author":"Y Altunta\u015f","year":"2019","unstructured":"Altunta\u015f Y (2019) Postprandial reactive hypoglycemia. Sisli Etfal Hastan Tip Bul 53(3):215\u2013220. https:\/\/doi.org\/10.14744\/SEMB.2019.59455","journal-title":"Sisli Etfal Hastan Tip Bul"},{"issue":"3","key":"6719_CR4","doi-asserted-by":"publisher","first-page":"295","DOI":"10.2337\/diacare.23.3.295","volume":"23","author":"M Stumvoll","year":"2000","unstructured":"Stumvoll M, Mitrakou A, Pimenta W et al (2000) Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 23(3):295\u2013301. https:\/\/doi.org\/10.2337\/diacare.23.3.295","journal-title":"Diabetes Care"},{"issue":"7","key":"6719_CR5","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man. 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Lancet Diabetes Endocrinol 6(5):361\u2013369. https:\/\/doi.org\/10.1016\/S2213-8587(18)30051-2","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"6719_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2337\/diab.15.1.1","volume":"15","author":"KE Sussman","year":"1966","unstructured":"Sussman KE, Stimmler L, Birenboim H (1966) Plasma insulin levels during reactive hypoglycemia. Diabetes 15(1):1\u20134. https:\/\/doi.org\/10.2337\/diab.15.1.1","journal-title":"Diabetes"},{"issue":"9","key":"6719_CR11","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/S2213-8587(19)30187-1","volume":"7","author":"OP Zaharia","year":"2019","unstructured":"Zaharia OP, Strassburger K, Strom A et al (2019) Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study. Lancet Diabetes Endocrinol 7(9):684\u2013694. https:\/\/doi.org\/10.1016\/S2213-8587(19)30187-1","journal-title":"Lancet Diabetes Endocrinol"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-026-06719-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00125-026-06719-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-026-06719-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:41:35Z","timestamp":1780584095000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00125-026-06719-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["6719"],"URL":"https:\/\/doi.org\/10.1007\/s00125-026-06719-0","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]},"assertion":[{"value":"29 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"We thank the individuals whose data were included in this analysis. We are especially grateful to the clinical and laboratory staff at University Hospital Ulm for their dedicated and thoughtful work that made this study possible.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Acknowledgements"}},{"value":"The data generated during the current study are not publicly available because of privacy and ethical restrictions.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"Open Access funding enabled and organized by Projekt DEAL. This work was in part supported by an ERC Consolidator grant (CrossPeriBrain, Project 101125605, to MH). The views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Outside the current work, RW reports honoraria during the past 36 months for lectures\/presentations\/speaker\u2019s bureaus from Daiichi Sankyo, Eli Lilly, Boehringer Ingelheim, Novo Nordisk, Sanofi-Aventis and Synlab; travel support from Eli Lilly, Novo Nordisk, Daiichi Sankyo and Sanofi-Aventis; and honoraria for advisory boards from Eli Lilly, Boehringer Ingelheim and Sanofi-Aventis. GU reports lecture fees from Boehringer Ingelheim and travel support from Ipsen, Lilly and Boehringer Ingelheim. Outside the current work, RSa reports presentations\/speaker\u2019s fees from Amgen. She has also served on advisory boards for Sobi, Recordati Rare Diseases and Novartis. MH reports lecture fees from Amryt\/Chiesi, AstraZeneca, Bayer, Boehringer Ingelheim, Daiichi Sankyo, Lilly, Novartis, Novo Nordisk and Sanofi-Aventis. He has also served on advisory boards for Amryt\/Chiesi and Boehringer Ingelheim. The authors declare that there are no other relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 relationships and activities"}},{"value":"RSp collected and analysed data and drafted the manuscript. GU and RSa collected data and contributed to discussion and revised the manuscript. JH contributed to the statistical analysis and the selection of patients who fulfilled the inclusion criteria from the initial dataset\u00a0and revised the manuscript. AP and RW contributed to data interpretation\/discussion and revised the manuscript. MH collected data and drafted the manuscript. He supervised this work and is the guarantor for this work. All authors approved the final version of the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution statement"}}]}}