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We thank K. Pfriem and H. Kleinert (PLID, Dresden, Germany) for administrative support. We thank the Electron Microscopy and Histology Facility, a Core Facility of the CMCB Technology Platform at TU Dresden, for their services.","order":1,"name":"Ethics","label":"Acknowledgements","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"Work in the authors\u2019 laboratories is supported by funds to MS from the German Center for Diabetes Research (DZD e.V.) by the German Ministry for Research, Technology, and Space (BMBFTR), and the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement no. 115797 (INNODIA) and no. 945268 (INNODIA HARVEST). This Joint Undertaking received support from the European Union's Horizon 2020 research and innovation programme under grant agreement no. 1010954433, European Federation of Pharmaceutical Industries and Associations, JDRF (now Breakthrough T1D), and The Leona M. and Harry B. Helmsley Charitable Trust. It was also further supported by the European Union\u2019s Horizon Europe research and innovation program under grant agreement no. 1010954433 (Intercept-T2D). Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them. AM and PS are supported by the DZD NEXT Young Talent Program. We thank the Janelia Visiting Scientist Program (HHMI) for supporting the collaboration between MS, AM, SAD, IEM and AW.","order":2,"name":"Ethics","label":"Funding","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":3,"name":"Ethics","label":"Authors\u2019 relationships and activities","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"All authors performed the literature search, drafted and edited the manuscript and critically revised it for important conceptual content. AM created the figures. All authors approved the final version of the manuscript for publication.","order":4,"name":"Ethics","label":"Contribution statement","group":{"name":"EthicsHeading","label":"Ethics"}}]}}