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The authors thank the technical services provided by the Bioimage Core Facility of the National Core Facility Program for Biotechnology, Ministry of Science and Technology, Taiwan. We also thank Chih Ching Sun (Sheng Kung Girls\u2019\u00a0High School, Tainan, Taiwan) for assistance with schematic illustrations for Figs.\n                      \n                      a,\n                      \n                      a and ESM Figs\n                      \n                      a,\n                      \n                      a, and Elsevier for English language editing (order reference: ASLESTD1104615).","order":1,"name":"Ethics","label":"Acknowledgements","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"Public sharing of individual-level clinical laboratory data is not permitted due to disclosure restrictions within the informed consent provided by the participants. Experimental data will be shared with qualified researchers for the purpose of conducting scientifically sound analyses that are consistent with the aims of the original study and approved by the corresponding author and the institutional review board, where applicable. Requests should be directed to the corresponding author and should include a research proposal outlining the objectives, methodology and intended use of the data. Access will be provided through secure electronic transfer after execution of an appropriate data-sharing agreement. Data containing information that could compromise participant privacy or violate ethical or legal restrictions will not be shared.","order":2,"name":"Ethics","label":"Data availability","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"This study was founded by National Science and Technology Council, Taiwan (NSTC 113-2622-B-006-002, 113-2628-B-006-010, 114-2628-B-006-006, and 114-2622-B-006-004), National Cheng Kung University, Taiwan (D115-G2520) and National Cheng Kung University Hospital, Taiwan (NCKUH-11210019, NCKUH-11310019 and NCKUH-11304071). This research was also supported in part by Higher Education Sprout Project, Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University. The funders played no part in the conceptualisation, design, data collection, analysis, publication decisions or manuscript preparation.","order":3,"name":"Ethics","label":"Funding","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","label":"Authors\u2019 relationships and activities","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"SDD and H-YS contributed to the conception of the study. SDD, NQ and H-YS designed the study. SDD, NQ, JYP, C-PH, PS, QGH, KK, ZHM, H-CJ, H-TW, W-CL, L-CC, LML, LYS, S-RY and H-YS contributed to the acquisition, analysis and interpretation of data. SDD, NQ, JYP, PS, QGH, KK, ZHM, H-TW, L-CC, LML and H-YS drafted the article. C-PH, H-CJ, W-CL, LYS and S-RY critically reviewed the article for important intellectual content. All authors reviewed the manuscript and approved the final version for publication. H-YS is responsible for the integrity of the work as a whole.","order":5,"name":"Ethics","label":"Contribution statement","group":{"name":"EthicsHeading","label":"Ethics"}}]}}