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We also particularly thank\u00a0N. Dandan (Academy Of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China) for her expert guidance and invaluable assistance in technical operations and troubleshooting.","order":1,"name":"Ethics","label":"Acknowledgements","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"This paper reanalysed the existing publicly available liquid biopsy proteomics data originally published as Table S7 by Wolf et al [\n                      \n                      ]. Source data are provided within our paper.","order":2,"name":"Ethics","label":"Data availability","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"This work was supported by\u00a0grants from the National Natural Science Foundation of China (no. 82374110, no. 82173959, no. 82204713), the Science and Technology Department of the State Administration of Traditional Chinese Medicine and the Zhejiang Provincial Administration of Traditional Chinese Medicine jointly built technology plan projects (no. GZY-ZJ-KJ-24065), the Natural Science Foundation of Zhejiang Province (no. LY23H280005), Zhejiang Province Traditional Chinese Medicine Science and Technology project (no.2023ZR080), and the Research Project of Zhejiang Chinese Medical University (no. 2024JKZKTS25).","order":3,"name":"Ethics","label":"Funding","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","label":"Authors\u2019 relationships and activities","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"ZL conceived the project, designed experiments, performed PAS staining, immunofluorescence experiments, analysed data and drafted the initial manuscript. HY performed immunofluorescence experiment, analysed data and drafted the Methods section. KZ performed H&E staining, Co-IP experiments and reviewed\u00a0the paper critically for important intellectual content. LS wrote the methodology of bioinformatics and performed bioinformatics analysis. YW performed western blotting experiments, macromolecular docking and critically reviewed the manuscript. YY, JZ and SL conducted animal experiments and participated in drafting the graphical abstract, and reviewing the paper critically for important intellectual content. QW, LJ and JC participated in drafting the Methods section, assisted with western blotting and immunofluorescence experiments, and analysed the corresponding experimental results. QL contributed to study design and data analysis, and\u00a0to reviewing the paper critically for important intellectual content. WH contributed to study design and data analysis, and critically reviewed the manuscript. MY contributed to the study's conception through critical discussions and revised the manuscript. LZ conceived the study, revised the manuscript and is the guarantor of this work. All authors have reviewed and approved the final version to be published.","order":5,"name":"Ethics","label":"Contribution statement","group":{"name":"EthicsHeading","label":"Ethics"}}]}}